Patterns of genomic differentiation between two Lake Victoria cichlid species, Haplochromis pyrrhocephalus and H. sp. ‘macula’ View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Shohei Takuno, Ryutaro Miyagi, Jun-ichi Onami, Shiho Takahashi-Kariyazono, Akie Sato, Herbert Tichy, Masato Nikaido, Mitsuto Aibara, Shinji Mizoiri, Hillary D. J. Mrosso, Semvua I. Mzighani, Norihiro Okada, Yohey Terai

ABSTRACT

BACKGROUND: The molecular basis of the incipient stage of speciation is still poorly understood. Cichlid fish species in Lake Victoria are a prime example of recent speciation events and a suitable system to study the adaptation and reproductive isolation of species. RESULTS: Here, we report the pattern of genomic differentiation between two Lake Victoria cichlid species collected in sympatry, Haplochromis pyrrhocephalus and H. sp. 'macula,' based on the pooled genome sequences of 20 individuals of each species. Despite their ecological differences, population genomics analyses demonstrate that the two species are very close to a single panmictic population due to extensive gene flow. However, we identified 21 highly differentiated short genomic regions with fixed nucleotide differences. At least 15 of these regions contained genes with predicted roles in adaptation and reproductive isolation, such as visual adaptation, circadian clock, developmental processes, adaptation to hypoxia, and sexual selection. The nonsynonymous fixed differences in one of these genes, LWS, were reported as substitutions causing shift in absorption spectra of LWS pigments. Fixed differences were found in the promoter regions of four other differentially expressed genes, indicating that these substitutions may alter gene expression levels. CONCLUSIONS: These diverged short genomic regions may have contributed to the differentiation of two ecologically different species. Moreover, the origins of adaptive variants within the differentiated regions predate the geological formation of Lake Victoria; thus Lake Victoria cichlid species diversified via selection on standing genetic variation. More... »

PAGES

68

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12862-019-1387-2

DOI

http://dx.doi.org/10.1186/s12862-019-1387-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112527547

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30832572


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