Modeling, validation and verification of three-dimensional cell-scaffold contacts from terabyte-sized images View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Peter Bajcsy, Soweon Yoon, Stephen J. Florczyk, Nathan A. Hotaling, Mylene Simon, Piotr M. Szczypinski, Nicholas J. Schaub, Carl G. Simon, Mary Brady, Ram D. Sriram

ABSTRACT

BACKGROUND: Cell-scaffold contact measurements are derived from pairs of co-registered volumetric fluorescent confocal laser scanning microscopy (CLSM) images (z-stacks) of stained cells and three types of scaffolds (i.e., spun coat, large microfiber, and medium microfiber). Our analysis of the acquired terabyte-sized collection is motivated by the need to understand the nature of the shape dimensionality (1D vs 2D vs 3D) of cell-scaffold interactions relevant to tissue engineers that grow cells on biomaterial scaffolds. RESULTS: We designed five statistical and three geometrical contact models, and then down-selected them to one from each category using a validation approach based on physically orthogonal measurements to CLSM. The two selected models were applied to 414 z-stacks with three scaffold types and all contact results were visually verified. A planar geometrical model for the spun coat scaffold type was validated from atomic force microscopy images by computing surface roughness of 52.35 nm ±31.76 nm which was 2 to 8 times smaller than the CLSM resolution. A cylindrical model for fiber scaffolds was validated from multi-view 2D scanning electron microscopy (SEM) images. The fiber scaffold segmentation error was assessed by comparing fiber diameters from SEM and CLSM to be between 0.46% to 3.8% of the SEM reference values. For contact verification, we constructed a web-based visual verification system with 414 pairs of images with cells and their segmentation results, and with 4968 movies with animated cell, scaffold, and contact overlays. Based on visual verification by three experts, we report the accuracy of cell segmentation to be 96.4% with 94.3% precision, and the accuracy of cell-scaffold contact for a statistical model to be 62.6% with 76.7% precision and for a geometrical model to be 93.5% with 87.6% precision. CONCLUSIONS: The novelty of our approach lies in (1) representing cell-scaffold contact sites with statistical intensity and geometrical shape models, (2) designing a methodology for validating 3D geometrical contact models and (3) devising a mechanism for visual verification of hundreds of 3D measurements. The raw and processed data are publicly available from https://isg.nist.gov/deepzoomweb/data/ together with the web -based verification system. More... »

PAGES

526

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12859-017-1928-x

DOI

http://dx.doi.org/10.1186/s12859-017-1928-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1093055676

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29183290


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0299", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Algorithms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biocompatible Materials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imaging, Three-Dimensional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Internet", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenchymal Stromal Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Atomic Force", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Confocal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron, Scanning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Scaffolds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "User-Computer Interface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X-Ray Microtomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institute of Standards and Technology", 
          "id": "https://www.grid.ac/institutes/grid.94225.38", 
          "name": [
            "Information Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bajcsy", 
        "givenName": "Peter", 
        "id": "sg:person.015715766477.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015715766477.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Standards and Technology", 
          "id": "https://www.grid.ac/institutes/grid.94225.38", 
          "name": [
            "Information Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA", 
            "Dakota Consulting Inc, Silver Spring, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Soweon", 
        "id": "sg:person.011773731316.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011773731316.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Central Florida", 
          "id": "https://www.grid.ac/institutes/grid.170430.1", 
          "name": [
            "Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA", 
            "Department of Materials Science & Engineering, University of Central Florida, Orlando, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Florczyk", 
        "givenName": "Stephen J.", 
        "id": "sg:person.01171046475.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171046475.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "National Eye Institute, National Institute of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hotaling", 
        "givenName": "Nathan A.", 
        "id": "sg:person.01344012344.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344012344.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Standards and Technology", 
          "id": "https://www.grid.ac/institutes/grid.94225.38", 
          "name": [
            "Information Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simon", 
        "givenName": "Mylene", 
        "id": "sg:person.01150632175.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150632175.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lodz University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.412284.9", 
          "name": [
            "Lodz University of Technology, \u0141\u00f3d\u017a, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szczypinski", 
        "givenName": "Piotr M.", 
        "id": "sg:person.013652127411.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013652127411.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Standards and Technology", 
          "id": "https://www.grid.ac/institutes/grid.94225.38", 
          "name": [
            "Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schaub", 
        "givenName": "Nicholas J.", 
        "id": "sg:person.0723261330.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723261330.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Standards and Technology", 
          "id": "https://www.grid.ac/institutes/grid.94225.38", 
          "name": [
            "Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simon", 
        "givenName": "Carl G.", 
        "id": "sg:person.01152304610.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152304610.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Standards and Technology", 
          "id": "https://www.grid.ac/institutes/grid.94225.38", 
          "name": [
            "Information Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brady", 
        "givenName": "Mary", 
        "id": "sg:person.0715216532.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715216532.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Standards and Technology", 
          "id": "https://www.grid.ac/institutes/grid.94225.38", 
          "name": [
            "Information Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sriram", 
        "givenName": "Ram D.", 
        "id": "sg:person.010734560711.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010734560711.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jbm.a.34593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000474419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bfb0029240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000799691", 
          "https://doi.org/10.1007/bfb0029240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adhm.201300207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001134052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jmi.12132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003580981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cgip.1994.1042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003736210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2012.02.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004792840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1117/1.1631315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006606685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2010.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007960575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.2000.9844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008253360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2015.06.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010055817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2818.2006.01706.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011935284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmat2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012162596", 
          "https://doi.org/10.1038/nmat2013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1529/biophysj.106.089441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012202015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012716211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2014.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015926092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1534-5807(04)00075-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016167288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jmi.12303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016591504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1529/biophysj.103.038422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017631680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a008151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019244024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bfb0056195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020734805", 
          "https://doi.org/10.1007/bfb0056195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-540-79982-5_44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024497265", 
          "https://doi.org/10.1007/978-3-540-79982-5_44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026706357", 
          "https://doi.org/10.1038/nmeth.2019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2010.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026846762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2011.08.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027083912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2015.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029554500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/154405910508400502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033029615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/154405910508400502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033029615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2016.01.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035390402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2010.03.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037279531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.a.10079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039066313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0903269107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039316535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2818.2010.03482.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043573348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmat3586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050356823", 
          "https://doi.org/10.1038/nmat3586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12859-015-0762-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053438602", 
          "https://doi.org/10.1186/s12859-015-0762-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2008.0227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059315084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/tmi.2007.913135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061695152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/tpami.2004.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061742726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.276.5317.1425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/iembs.2011.6091910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078504151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/sbec.2016.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093892230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/icip.2005.1530266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1094438702"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Cell-scaffold contact measurements are derived from pairs of co-registered volumetric fluorescent confocal laser scanning microscopy (CLSM) images (z-stacks) of stained cells and three types of scaffolds (i.e., spun coat, large microfiber, and medium microfiber). Our analysis of the acquired terabyte-sized collection is motivated by the need to understand the nature of the shape dimensionality (1D vs 2D vs 3D) of cell-scaffold interactions relevant to tissue engineers that grow cells on biomaterial scaffolds.\nRESULTS: We designed five statistical and three geometrical contact models, and then down-selected them to one from each category using a validation approach based on physically orthogonal measurements to CLSM. The two selected models were applied to 414 z-stacks with three scaffold types and all contact results were visually verified. A planar geometrical model for the spun coat scaffold type was validated from atomic force microscopy images by computing surface roughness of 52.35\u00a0nm \u00b131.76\u00a0nm which was 2 to 8 times smaller than the CLSM resolution. A cylindrical model for fiber scaffolds was validated from multi-view 2D scanning electron microscopy (SEM) images. The fiber scaffold segmentation error was assessed by comparing fiber diameters from SEM and CLSM to be between 0.46% to 3.8% of the SEM reference values. For contact verification, we constructed a web-based visual verification system with 414 pairs of images with cells and their segmentation results, and with 4968 movies with animated cell, scaffold, and contact overlays. Based on visual verification by three experts, we report the accuracy of cell segmentation to be 96.4% with 94.3% precision, and the accuracy of cell-scaffold contact for a statistical model to be 62.6% with 76.7% precision and for a geometrical model to be 93.5% with 87.6% precision.\nCONCLUSIONS: The novelty of our approach lies in (1) representing cell-scaffold contact sites with statistical intensity and geometrical shape models, (2) designing a methodology for validating 3D geometrical contact models and (3) devising a mechanism for visual verification of hundreds of 3D measurements. The raw and processed data are publicly available from https://isg.nist.gov/deepzoomweb/data/ together with the web -based verification system.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12859-017-1928-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2683017", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439628", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023786", 
        "issn": [
          "1471-2105"
        ], 
        "name": "BMC Bioinformatics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Modeling, validation and verification of three-dimensional cell-scaffold contacts from terabyte-sized images", 
    "pagination": "526", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "26f142650d4791b904ebf69d245c66e5c0a1263b955d41e800346546dd616c8d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29183290"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100965194"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12859-017-1928-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1093055676"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12859-017-1928-x", 
      "https://app.dimensions.ai/details/publication/pub.1093055676"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000602.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s12859-017-1928-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12859-017-1928-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12859-017-1928-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12859-017-1928-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12859-017-1928-x'


 

This table displays all metadata directly associated to this object as RDF triples.

337 TRIPLES      21 PREDICATES      85 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12859-017-1928-x schema:about N2155b8df2b1549beb7fecddc7a72ea9e
2 N4235386e9e2a4c7da76a1e85a4ca2e18
3 N493ec7d2814940a8999e032bee2579e7
4 N5c0f7fc752934de58a902a9eb50d7e1a
5 N6136ef7235ff42709ec3c2d11e08c5c5
6 N7467a11635b04427905405e444db11e0
7 N7dfc805d91b042d78b3d442c902f52be
8 N7e63458ecd1845a4afae5f9dd631557c
9 N8ace3813e5d441e5b8c1755f2fa01f74
10 N8c3766cdc0294aa4b93027b52513bbd3
11 N932b411da7694026afdfc2e0421571bc
12 N96af1e5ee42a4068b87e8872f818279a
13 Nd0be437149154105b72424daff53fd9c
14 Ne1e6794cee004fe385382dbf41bf2d7a
15 Neebea65159bd4d6bb20bfe4b4f152809
16 Nff5ee1ad2a27417fb7c7f81c6b0e0355
17 anzsrc-for:02
18 anzsrc-for:0299
19 schema:author N686b032faf9c4f8ab963fab3b50d0937
20 schema:citation sg:pub.10.1007/978-3-540-79982-5_44
21 sg:pub.10.1007/bfb0029240
22 sg:pub.10.1007/bfb0056195
23 sg:pub.10.1038/nmat2013
24 sg:pub.10.1038/nmat3586
25 sg:pub.10.1038/nmeth.2019
26 sg:pub.10.1186/s12859-015-0762-2
27 https://doi.org/10.1002/adhm.201300207
28 https://doi.org/10.1002/cyto.a.10079
29 https://doi.org/10.1002/jbm.a.34593
30 https://doi.org/10.1006/cgip.1994.1042
31 https://doi.org/10.1006/dbio.2000.9844
32 https://doi.org/10.1016/j.actbio.2010.02.006
33 https://doi.org/10.1016/j.biomaterials.2009.01.009
34 https://doi.org/10.1016/j.biomaterials.2010.03.024
35 https://doi.org/10.1016/j.biomaterials.2011.08.054
36 https://doi.org/10.1016/j.biomaterials.2012.02.048
37 https://doi.org/10.1016/j.biomaterials.2015.05.015
38 https://doi.org/10.1016/j.bpj.2010.07.006
39 https://doi.org/10.1016/j.devcel.2016.01.022
40 https://doi.org/10.1016/j.jconrel.2015.06.039
41 https://doi.org/10.1016/j.stem.2014.01.013
42 https://doi.org/10.1016/s1534-5807(04)00075-9
43 https://doi.org/10.1073/pnas.0903269107
44 https://doi.org/10.1089/ten.tea.2008.0227
45 https://doi.org/10.1101/cshperspect.a008151
46 https://doi.org/10.1109/icip.2005.1530266
47 https://doi.org/10.1109/iembs.2011.6091910
48 https://doi.org/10.1109/sbec.2016.58
49 https://doi.org/10.1109/tmi.2007.913135
50 https://doi.org/10.1109/tpami.2004.44
51 https://doi.org/10.1111/j.1365-2818.2006.01706.x
52 https://doi.org/10.1111/j.1365-2818.2010.03482.x
53 https://doi.org/10.1111/jmi.12132
54 https://doi.org/10.1111/jmi.12303
55 https://doi.org/10.1117/1.1631315
56 https://doi.org/10.1126/science.276.5317.1425
57 https://doi.org/10.1177/154405910508400502
58 https://doi.org/10.1529/biophysj.103.038422
59 https://doi.org/10.1529/biophysj.106.089441
60 schema:datePublished 2017-12
61 schema:datePublishedReg 2017-12-01
62 schema:description BACKGROUND: Cell-scaffold contact measurements are derived from pairs of co-registered volumetric fluorescent confocal laser scanning microscopy (CLSM) images (z-stacks) of stained cells and three types of scaffolds (i.e., spun coat, large microfiber, and medium microfiber). Our analysis of the acquired terabyte-sized collection is motivated by the need to understand the nature of the shape dimensionality (1D vs 2D vs 3D) of cell-scaffold interactions relevant to tissue engineers that grow cells on biomaterial scaffolds. RESULTS: We designed five statistical and three geometrical contact models, and then down-selected them to one from each category using a validation approach based on physically orthogonal measurements to CLSM. The two selected models were applied to 414 z-stacks with three scaffold types and all contact results were visually verified. A planar geometrical model for the spun coat scaffold type was validated from atomic force microscopy images by computing surface roughness of 52.35 nm ±31.76 nm which was 2 to 8 times smaller than the CLSM resolution. A cylindrical model for fiber scaffolds was validated from multi-view 2D scanning electron microscopy (SEM) images. The fiber scaffold segmentation error was assessed by comparing fiber diameters from SEM and CLSM to be between 0.46% to 3.8% of the SEM reference values. For contact verification, we constructed a web-based visual verification system with 414 pairs of images with cells and their segmentation results, and with 4968 movies with animated cell, scaffold, and contact overlays. Based on visual verification by three experts, we report the accuracy of cell segmentation to be 96.4% with 94.3% precision, and the accuracy of cell-scaffold contact for a statistical model to be 62.6% with 76.7% precision and for a geometrical model to be 93.5% with 87.6% precision. CONCLUSIONS: The novelty of our approach lies in (1) representing cell-scaffold contact sites with statistical intensity and geometrical shape models, (2) designing a methodology for validating 3D geometrical contact models and (3) devising a mechanism for visual verification of hundreds of 3D measurements. The raw and processed data are publicly available from https://isg.nist.gov/deepzoomweb/data/ together with the web -based verification system.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf Nbe1d1ee6cb424f13a22851d35a1ec4f1
67 Ne03dc0818bf24f58a19b41f53e1a6aab
68 sg:journal.1023786
69 schema:name Modeling, validation and verification of three-dimensional cell-scaffold contacts from terabyte-sized images
70 schema:pagination 526
71 schema:productId N6d5eaedc961c48b383ef68d093d42749
72 N86bf8485885740a4b2dfb651db552fc7
73 N94e6208404ba4133a6786579b534139f
74 Nb6c2de8f9f1040ed98ccdd3e42a802e9
75 Nc9aa2d315ed344419fd6f83615b00552
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093055676
77 https://doi.org/10.1186/s12859-017-1928-x
78 schema:sdDatePublished 2019-04-11T02:30
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher Nf07cfd9599244c558ed2d28a886c30c6
81 schema:url http://link.springer.com/10.1186/s12859-017-1928-x
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N1ceca941f7c64dc3828f6f12ff09273c schema:name National Eye Institute, National Institute of Health, Bethesda, MD, USA
86 rdf:type schema:Organization
87 N20c7584b44e84b7aa5ad6180d7b33534 rdf:first sg:person.01150632175.24
88 rdf:rest Ne0ace55d945d401198db257e36b9047f
89 N2155b8df2b1549beb7fecddc7a72ea9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Young Adult
91 rdf:type schema:DefinedTerm
92 N4235386e9e2a4c7da76a1e85a4ca2e18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Microscopy, Electron, Scanning
94 rdf:type schema:DefinedTerm
95 N442b235de31c4066a5c89334ad73e5bb rdf:first sg:person.010734560711.45
96 rdf:rest rdf:nil
97 N45bcc581652b433ea17558bef5fa1a1f rdf:first sg:person.011773731316.16
98 rdf:rest N98346a0872404d21a6840dab3c3d1e51
99 N493ec7d2814940a8999e032bee2579e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Algorithms
101 rdf:type schema:DefinedTerm
102 N5c0f7fc752934de58a902a9eb50d7e1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Models, Biological
104 rdf:type schema:DefinedTerm
105 N5fe2d07b02044a738f1b2e7033946f3e rdf:first sg:person.0715216532.46
106 rdf:rest N442b235de31c4066a5c89334ad73e5bb
107 N6136ef7235ff42709ec3c2d11e08c5c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Microscopy, Atomic Force
109 rdf:type schema:DefinedTerm
110 N686b032faf9c4f8ab963fab3b50d0937 rdf:first sg:person.015715766477.14
111 rdf:rest N45bcc581652b433ea17558bef5fa1a1f
112 N6d5eaedc961c48b383ef68d093d42749 schema:name readcube_id
113 schema:value 26f142650d4791b904ebf69d245c66e5c0a1263b955d41e800346546dd616c8d
114 rdf:type schema:PropertyValue
115 N6e4e766c26a74e87896387c77b36165b rdf:first sg:person.0723261330.92
116 rdf:rest Nc186538d18cf4f80b5d88ad42d0083f4
117 N7467a11635b04427905405e444db11e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Microscopy, Confocal
119 rdf:type schema:DefinedTerm
120 N7dfc805d91b042d78b3d442c902f52be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Male
122 rdf:type schema:DefinedTerm
123 N7e63458ecd1845a4afae5f9dd631557c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Internet
125 rdf:type schema:DefinedTerm
126 N86bf8485885740a4b2dfb651db552fc7 schema:name pubmed_id
127 schema:value 29183290
128 rdf:type schema:PropertyValue
129 N8ace3813e5d441e5b8c1755f2fa01f74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Humans
131 rdf:type schema:DefinedTerm
132 N8c3766cdc0294aa4b93027b52513bbd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Tissue Scaffolds
134 rdf:type schema:DefinedTerm
135 N932b411da7694026afdfc2e0421571bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name User-Computer Interface
137 rdf:type schema:DefinedTerm
138 N94e6208404ba4133a6786579b534139f schema:name dimensions_id
139 schema:value pub.1093055676
140 rdf:type schema:PropertyValue
141 N96af1e5ee42a4068b87e8872f818279a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name X-Ray Microtomography
143 rdf:type schema:DefinedTerm
144 N98346a0872404d21a6840dab3c3d1e51 rdf:first sg:person.01171046475.33
145 rdf:rest Nf8ab200da8324b169026f43d9f32823e
146 Nb6c2de8f9f1040ed98ccdd3e42a802e9 schema:name doi
147 schema:value 10.1186/s12859-017-1928-x
148 rdf:type schema:PropertyValue
149 Nbe1d1ee6cb424f13a22851d35a1ec4f1 schema:volumeNumber 18
150 rdf:type schema:PublicationVolume
151 Nc186538d18cf4f80b5d88ad42d0083f4 rdf:first sg:person.01152304610.05
152 rdf:rest N5fe2d07b02044a738f1b2e7033946f3e
153 Nc9aa2d315ed344419fd6f83615b00552 schema:name nlm_unique_id
154 schema:value 100965194
155 rdf:type schema:PropertyValue
156 Nd0be437149154105b72424daff53fd9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Imaging, Three-Dimensional
158 rdf:type schema:DefinedTerm
159 Ne03dc0818bf24f58a19b41f53e1a6aab schema:issueNumber 1
160 rdf:type schema:PublicationIssue
161 Ne0ace55d945d401198db257e36b9047f rdf:first sg:person.013652127411.49
162 rdf:rest N6e4e766c26a74e87896387c77b36165b
163 Ne1e6794cee004fe385382dbf41bf2d7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Biocompatible Materials
165 rdf:type schema:DefinedTerm
166 Neebea65159bd4d6bb20bfe4b4f152809 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Bone Marrow Cells
168 rdf:type schema:DefinedTerm
169 Nf07cfd9599244c558ed2d28a886c30c6 schema:name Springer Nature - SN SciGraph project
170 rdf:type schema:Organization
171 Nf8ab200da8324b169026f43d9f32823e rdf:first sg:person.01344012344.02
172 rdf:rest N20c7584b44e84b7aa5ad6180d7b33534
173 Nff5ee1ad2a27417fb7c7f81c6b0e0355 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Mesenchymal Stromal Cells
175 rdf:type schema:DefinedTerm
176 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
177 schema:name Physical Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:0299 schema:inDefinedTermSet anzsrc-for:
180 schema:name Other Physical Sciences
181 rdf:type schema:DefinedTerm
182 sg:grant.2439628 http://pending.schema.org/fundedItem sg:pub.10.1186/s12859-017-1928-x
183 rdf:type schema:MonetaryGrant
184 sg:grant.2683017 http://pending.schema.org/fundedItem sg:pub.10.1186/s12859-017-1928-x
185 rdf:type schema:MonetaryGrant
186 sg:journal.1023786 schema:issn 1471-2105
187 schema:name BMC Bioinformatics
188 rdf:type schema:Periodical
189 sg:person.010734560711.45 schema:affiliation https://www.grid.ac/institutes/grid.94225.38
190 schema:familyName Sriram
191 schema:givenName Ram D.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010734560711.45
193 rdf:type schema:Person
194 sg:person.01150632175.24 schema:affiliation https://www.grid.ac/institutes/grid.94225.38
195 schema:familyName Simon
196 schema:givenName Mylene
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150632175.24
198 rdf:type schema:Person
199 sg:person.01152304610.05 schema:affiliation https://www.grid.ac/institutes/grid.94225.38
200 schema:familyName Simon
201 schema:givenName Carl G.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152304610.05
203 rdf:type schema:Person
204 sg:person.01171046475.33 schema:affiliation https://www.grid.ac/institutes/grid.170430.1
205 schema:familyName Florczyk
206 schema:givenName Stephen J.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171046475.33
208 rdf:type schema:Person
209 sg:person.011773731316.16 schema:affiliation https://www.grid.ac/institutes/grid.94225.38
210 schema:familyName Yoon
211 schema:givenName Soweon
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011773731316.16
213 rdf:type schema:Person
214 sg:person.01344012344.02 schema:affiliation N1ceca941f7c64dc3828f6f12ff09273c
215 schema:familyName Hotaling
216 schema:givenName Nathan A.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344012344.02
218 rdf:type schema:Person
219 sg:person.013652127411.49 schema:affiliation https://www.grid.ac/institutes/grid.412284.9
220 schema:familyName Szczypinski
221 schema:givenName Piotr M.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013652127411.49
223 rdf:type schema:Person
224 sg:person.015715766477.14 schema:affiliation https://www.grid.ac/institutes/grid.94225.38
225 schema:familyName Bajcsy
226 schema:givenName Peter
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015715766477.14
228 rdf:type schema:Person
229 sg:person.0715216532.46 schema:affiliation https://www.grid.ac/institutes/grid.94225.38
230 schema:familyName Brady
231 schema:givenName Mary
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715216532.46
233 rdf:type schema:Person
234 sg:person.0723261330.92 schema:affiliation https://www.grid.ac/institutes/grid.94225.38
235 schema:familyName Schaub
236 schema:givenName Nicholas J.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723261330.92
238 rdf:type schema:Person
239 sg:pub.10.1007/978-3-540-79982-5_44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024497265
240 https://doi.org/10.1007/978-3-540-79982-5_44
241 rdf:type schema:CreativeWork
242 sg:pub.10.1007/bfb0029240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000799691
243 https://doi.org/10.1007/bfb0029240
244 rdf:type schema:CreativeWork
245 sg:pub.10.1007/bfb0056195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020734805
246 https://doi.org/10.1007/bfb0056195
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nmat2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012162596
249 https://doi.org/10.1038/nmat2013
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nmat3586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050356823
252 https://doi.org/10.1038/nmat3586
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nmeth.2019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026706357
255 https://doi.org/10.1038/nmeth.2019
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/s12859-015-0762-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053438602
258 https://doi.org/10.1186/s12859-015-0762-2
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/adhm.201300207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001134052
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/cyto.a.10079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039066313
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/jbm.a.34593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000474419
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1006/cgip.1994.1042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003736210
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1006/dbio.2000.9844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008253360
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.actbio.2010.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026846762
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.biomaterials.2009.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012716211
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.biomaterials.2010.03.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037279531
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.biomaterials.2011.08.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027083912
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.biomaterials.2012.02.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004792840
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.biomaterials.2015.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029554500
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.bpj.2010.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007960575
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.devcel.2016.01.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035390402
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.jconrel.2015.06.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010055817
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.stem.2014.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015926092
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/s1534-5807(04)00075-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016167288
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1073/pnas.0903269107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039316535
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1089/ten.tea.2008.0227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059315084
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1101/cshperspect.a008151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019244024
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1109/icip.2005.1530266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1094438702
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1109/iembs.2011.6091910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078504151
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1109/sbec.2016.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093892230
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1109/tmi.2007.913135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061695152
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1109/tpami.2004.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061742726
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/j.1365-2818.2006.01706.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011935284
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1111/j.1365-2818.2010.03482.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043573348
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1111/jmi.12132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003580981
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1111/jmi.12303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016591504
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1117/1.1631315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006606685
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1126/science.276.5317.1425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556863
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1177/154405910508400502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033029615
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1529/biophysj.103.038422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017631680
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1529/biophysj.106.089441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012202015
325 rdf:type schema:CreativeWork
326 https://www.grid.ac/institutes/grid.170430.1 schema:alternateName University of Central Florida
327 schema:name Department of Materials Science & Engineering, University of Central Florida, Orlando, FL, USA
328 Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA
329 rdf:type schema:Organization
330 https://www.grid.ac/institutes/grid.412284.9 schema:alternateName Lodz University of Technology
331 schema:name Lodz University of Technology, Łódź, Poland
332 rdf:type schema:Organization
333 https://www.grid.ac/institutes/grid.94225.38 schema:alternateName National Institute of Standards and Technology
334 schema:name Dakota Consulting Inc, Silver Spring, MD, USA
335 Information Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA
336 Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA
337 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...