Synergistic action of curcumin and cisplatin on spinel ferrite/hierarchical MCM-41 nanocomposite against MCF-7, HeLa and HCT 116 cancer cell line View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-11-27

AUTHORS

B. Rabindran Jermy, D. Almohazey, W. A. Alamoudi, R. M. Palanivel, Nora AlSudairi, H. Dafalla, A. A. Almofleh, T. M. Alfareed, Vijaya Ravinayagam

ABSTRACT

BackgroundPlatinum-based drugs are widely used in cancer therapy, but are known for toxic side effects and resistance. Combinational drug delivery represents an effective chemotherapeutic strategy, but often leads to an increased toxicity. Aim of this study is to test the co-delivery of cisplatin with natural antioxidants on hierarchial porous large surface area hexagonal nanocarriers for synergistic action.ResultsA series of structured mesoporous materials were impregnated with magnetic spinel ferrite (30% CuFe2O4) and then coated with curcumin (25% wt/wt). Mesosilicalite and MCM-41 with high curcumin release abilities were functionalized with cisplatin (5% wt/wt) for synergistic effect of combinational drugs. The cytotoxic efficiency of our nanocomposites was tested on cell viability of MCF7 (human breast cancer), human cervical cancer (HeLa), colorectal cancer (HCT116), and HFF (human foreskin fibroblasts) cell lines using the MTT cell viability assay. At a concentration of 0.1 mg/ml, CuFe2O4/mesosilicalite/curcumin/cisplatin resulted in 89.53% reduction in viability in MCF7, 94.03% in HeLa, 64% in HCT116 and 87% in HFF; whereas, CuFe2O4/MCM-41/curcumin/cisplatin resulted in 76% reduction in viability in MCF7, 64.46% in HeLa, 64% in HCT116 and 24% in HFF. The EC50 for CuFe2O4/mesosilicalite/curcumin/cisplatin was 81.23 µg/ml in MCF7, 47.55 µg/ml in HeLa, 48.96 µg/ml in HCT116 and 76.83 µg/ml in HFF. The EC50 for CuFe2O4/MCM-41/curcumin/cisplatin was 72.51 µg/ml in MCF7, 58.6 µg/ml in HeLa, 62.58 µg/ml in HCT116 and 154.2 µg/ml in HFF. Furthermore, cells treated with both nanocomposites had a high number of cleaved Caspase 3-positive cells suggesting that the reduction in cell viability was triggered by activating the apoptotic signaling pathway.ConclusionOur results show that CuFe2O4/MCM-41/curcumin/cisplatin is a better candidate for combinational drug therapy due to its lowest EC50 value and the wider difference in EC50 (a fold change) between cancerous and non-cancerous cell line. More... »

PAGES

33

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12645-021-00106-7

DOI

http://dx.doi.org/10.1186/s12645-021-00106-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1143366732


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jermy", 
        "givenName": "B. Rabindran", 
        "id": "sg:person.013112302035.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013112302035.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 3144, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 3144, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Almohazey", 
        "givenName": "D.", 
        "id": "sg:person.01215162414.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215162414.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroscience Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Department of Neuroscience Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alamoudi", 
        "givenName": "W. A.", 
        "id": "sg:person.015701343654.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015701343654.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Deanship of Quality and Academic Accreditation, Imam Abdulrahman Bin Faisal University, Post Box No. 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Deanship of Quality and Academic Accreditation, Imam Abdulrahman Bin Faisal University, Post Box No. 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palanivel", 
        "givenName": "R. M.", 
        "id": "sg:person.016665300035.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016665300035.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cell and Molecular Biology, Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Cell and Molecular Biology, Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "AlSudairi", 
        "givenName": "Nora", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Engineering Research (CER), King Fahd University of Petroleum and Minerals, 31261, Dhahran, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.412135.0", 
          "name": [
            "College of Engineering Research (CER), King Fahd University of Petroleum and Minerals, 31261, Dhahran, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dafalla", 
        "givenName": "H.", 
        "id": "sg:person.015635350455.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015635350455.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Almofleh", 
        "givenName": "A. A.", 
        "id": "sg:person.010125270514.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010125270514.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alfareed", 
        "givenName": "T. M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Deanship of Scientific Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Deanship of Scientific Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ravinayagam", 
        "givenName": "Vijaya", 
        "id": "sg:person.01171663075.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171663075.56"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1206940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042691731", 
          "https://doi.org/10.1038/sj.onc.1206940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-017-3874-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085615012", 
          "https://doi.org/10.1007/s11051-017-3874-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-019-42498-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1113378337", 
          "https://doi.org/10.1038/s41598-019-42498-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-019-54284-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1122953060", 
          "https://doi.org/10.1038/s41598-019-54284-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-11-27", 
    "datePublishedReg": "2021-11-27", 
    "description": "BackgroundPlatinum-based drugs are widely used in cancer therapy, but are known for toxic side effects and resistance. Combinational drug delivery represents an effective chemotherapeutic strategy, but often leads to an increased toxicity. Aim of this study is to test the co-delivery of cisplatin with natural antioxidants on hierarchial porous large surface area hexagonal nanocarriers for synergistic action.ResultsA series of structured mesoporous materials were impregnated with magnetic spinel ferrite (30% CuFe2O4) and then coated with curcumin (25% wt/wt). Mesosilicalite and MCM-41 with high curcumin release abilities were functionalized with cisplatin (5% wt/wt) for synergistic effect of combinational drugs. The cytotoxic efficiency of our nanocomposites was tested on cell viability of MCF7 (human breast cancer), human cervical cancer (HeLa), colorectal cancer (HCT116), and HFF (human foreskin fibroblasts) cell lines using the MTT cell viability assay. At a concentration of 0.1\u00a0mg/ml, CuFe2O4/mesosilicalite/curcumin/cisplatin resulted in 89.53% reduction in viability in MCF7, 94.03% in HeLa, 64% in HCT116 and 87% in HFF; whereas, CuFe2O4/MCM-41/curcumin/cisplatin resulted in 76% reduction in viability in MCF7, 64.46% in HeLa, 64% in HCT116 and 24% in HFF. The EC50 for CuFe2O4/mesosilicalite/curcumin/cisplatin was 81.23\u00a0\u00b5g/ml in MCF7, 47.55\u00a0\u00b5g/ml in HeLa, 48.96\u00a0\u00b5g/ml in HCT116 and 76.83\u00a0\u00b5g/ml in HFF. The EC50 for CuFe2O4/MCM-41/curcumin/cisplatin was 72.51\u00a0\u00b5g/ml in MCF7, 58.6\u00a0\u00b5g/ml in HeLa, 62.58\u00a0\u00b5g/ml in HCT116 and 154.2\u00a0\u00b5g/ml in HFF. Furthermore, cells treated with both nanocomposites had a high number of cleaved Caspase 3-positive cells suggesting that the reduction in cell viability was triggered by activating the apoptotic signaling pathway.ConclusionOur results show that CuFe2O4/MCM-41/curcumin/cisplatin is a better candidate for combinational drug therapy due to its lowest EC50 value and the wider difference in EC50 (a fold change) between cancerous and non-cancerous cell line.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12645-021-00106-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1042272", 
        "issn": [
          "1868-6958", 
          "1868-6966"
        ], 
        "name": "Cancer Nanotechnology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "keywords": [
      "cell lines", 
      "cell viability", 
      "combinational drug therapy", 
      "human cervical cancer", 
      "toxic side effects", 
      "effective chemotherapeutic strategy", 
      "cancer cell lines", 
      "cervical cancer", 
      "combinational drug delivery", 
      "colorectal cancer", 
      "drug therapy", 
      "side effects", 
      "MTT cell viability", 
      "combinational drugs", 
      "synergistic action", 
      "ConclusionOur results", 
      "chemotherapeutic strategies", 
      "cisplatin", 
      "apoptotic signaling pathways", 
      "HFF cell lines", 
      "cancer therapy", 
      "MCF-7", 
      "signaling pathways", 
      "therapy", 
      "MCF7", 
      "cancer", 
      "ResultsA series", 
      "EC50", 
      "HCT116", 
      "HCT-116 cancer cell lines", 
      "cytotoxic efficiency", 
      "non-cancerous cell lines", 
      "drugs", 
      "EC50 values", 
      "lower EC50 values", 
      "natural antioxidants", 
      "HFF", 
      "curcumin", 
      "HeLa", 
      "BackgroundPlatinum", 
      "higher number", 
      "cells", 
      "viability", 
      "drug delivery", 
      "reduction", 
      "toxicity", 
      "action", 
      "antioxidants", 
      "synergistic effect", 
      "wide differences", 
      "delivery", 
      "effect", 
      "pathway", 
      "lines", 
      "caspases", 
      "differences", 
      "study", 
      "good candidate", 
      "resistance", 
      "concentration", 
      "release ability", 
      "nanocarriers", 
      "candidates", 
      "ability", 
      "strategies", 
      "number", 
      "series", 
      "results", 
      "values", 
      "materials", 
      "MCM", 
      "structured mesoporous materials", 
      "efficiency", 
      "magnetic spinel ferrite", 
      "MCM-41", 
      "mesoporous materials", 
      "spinel ferrites", 
      "nanocomposites", 
      "ferrite"
    ], 
    "name": "Synergistic action of curcumin and cisplatin on spinel ferrite/hierarchical MCM-41 nanocomposite against MCF-7, HeLa and HCT 116 cancer cell line", 
    "pagination": "33", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1143366732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12645-021-00106-7"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12645-021-00106-7", 
      "https://app.dimensions.ai/details/publication/pub.1143366732"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_886.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12645-021-00106-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00106-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00106-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00106-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00106-7'


 

This table displays all metadata directly associated to this object as RDF triples.

220 TRIPLES      22 PREDICATES      108 URIs      96 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12645-021-00106-7 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Ne5119927faac4c9e84114f1edd39ea10
4 schema:citation sg:pub.10.1007/s11051-017-3874-y
5 sg:pub.10.1038/s41598-019-42498-y
6 sg:pub.10.1038/s41598-019-54284-x
7 sg:pub.10.1038/sj.onc.1206940
8 schema:datePublished 2021-11-27
9 schema:datePublishedReg 2021-11-27
10 schema:description BackgroundPlatinum-based drugs are widely used in cancer therapy, but are known for toxic side effects and resistance. Combinational drug delivery represents an effective chemotherapeutic strategy, but often leads to an increased toxicity. Aim of this study is to test the co-delivery of cisplatin with natural antioxidants on hierarchial porous large surface area hexagonal nanocarriers for synergistic action.ResultsA series of structured mesoporous materials were impregnated with magnetic spinel ferrite (30% CuFe2O4) and then coated with curcumin (25% wt/wt). Mesosilicalite and MCM-41 with high curcumin release abilities were functionalized with cisplatin (5% wt/wt) for synergistic effect of combinational drugs. The cytotoxic efficiency of our nanocomposites was tested on cell viability of MCF7 (human breast cancer), human cervical cancer (HeLa), colorectal cancer (HCT116), and HFF (human foreskin fibroblasts) cell lines using the MTT cell viability assay. At a concentration of 0.1 mg/ml, CuFe2O4/mesosilicalite/curcumin/cisplatin resulted in 89.53% reduction in viability in MCF7, 94.03% in HeLa, 64% in HCT116 and 87% in HFF; whereas, CuFe2O4/MCM-41/curcumin/cisplatin resulted in 76% reduction in viability in MCF7, 64.46% in HeLa, 64% in HCT116 and 24% in HFF. The EC50 for CuFe2O4/mesosilicalite/curcumin/cisplatin was 81.23 µg/ml in MCF7, 47.55 µg/ml in HeLa, 48.96 µg/ml in HCT116 and 76.83 µg/ml in HFF. The EC50 for CuFe2O4/MCM-41/curcumin/cisplatin was 72.51 µg/ml in MCF7, 58.6 µg/ml in HeLa, 62.58 µg/ml in HCT116 and 154.2 µg/ml in HFF. Furthermore, cells treated with both nanocomposites had a high number of cleaved Caspase 3-positive cells suggesting that the reduction in cell viability was triggered by activating the apoptotic signaling pathway.ConclusionOur results show that CuFe2O4/MCM-41/curcumin/cisplatin is a better candidate for combinational drug therapy due to its lowest EC50 value and the wider difference in EC50 (a fold change) between cancerous and non-cancerous cell line.
11 schema:genre article
12 schema:inLanguage en
13 schema:isAccessibleForFree true
14 schema:isPartOf N4a3d5996d0194ce5a0dbdd4adef85beb
15 Nccd22ea98ad7453aacd2dfb331ff0272
16 sg:journal.1042272
17 schema:keywords BackgroundPlatinum
18 ConclusionOur results
19 EC50
20 EC50 values
21 HCT-116 cancer cell lines
22 HCT116
23 HFF
24 HFF cell lines
25 HeLa
26 MCF-7
27 MCF7
28 MCM
29 MCM-41
30 MTT cell viability
31 ResultsA series
32 ability
33 action
34 antioxidants
35 apoptotic signaling pathways
36 cancer
37 cancer cell lines
38 cancer therapy
39 candidates
40 caspases
41 cell lines
42 cell viability
43 cells
44 cervical cancer
45 chemotherapeutic strategies
46 cisplatin
47 colorectal cancer
48 combinational drug delivery
49 combinational drug therapy
50 combinational drugs
51 concentration
52 curcumin
53 cytotoxic efficiency
54 delivery
55 differences
56 drug delivery
57 drug therapy
58 drugs
59 effect
60 effective chemotherapeutic strategy
61 efficiency
62 ferrite
63 good candidate
64 higher number
65 human cervical cancer
66 lines
67 lower EC50 values
68 magnetic spinel ferrite
69 materials
70 mesoporous materials
71 nanocarriers
72 nanocomposites
73 natural antioxidants
74 non-cancerous cell lines
75 number
76 pathway
77 reduction
78 release ability
79 resistance
80 results
81 series
82 side effects
83 signaling pathways
84 spinel ferrites
85 strategies
86 structured mesoporous materials
87 study
88 synergistic action
89 synergistic effect
90 therapy
91 toxic side effects
92 toxicity
93 values
94 viability
95 wide differences
96 schema:name Synergistic action of curcumin and cisplatin on spinel ferrite/hierarchical MCM-41 nanocomposite against MCF-7, HeLa and HCT 116 cancer cell line
97 schema:pagination 33
98 schema:productId N38eaaf6388a3497a9975ad036f13ab5c
99 Nd16a9e183e4348d1b91de72f8d421941
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1143366732
101 https://doi.org/10.1186/s12645-021-00106-7
102 schema:sdDatePublished 2022-06-01T22:22
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher Nbe94f7e0f9d94ed7bf89aed8fb97d8ce
105 schema:url https://doi.org/10.1186/s12645-021-00106-7
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N03287960661b45d6b642d63300a22a13 rdf:first sg:person.015635350455.45
110 rdf:rest N838bc965b32741ceac9c9a0b860cea15
111 N0e8a6b7b1bce40549ddd186d5cdf2782 rdf:first N85a244d44bf644f5ba7b00646c501984
112 rdf:rest Ne5157d992d1e49758581bc5d1e8816c8
113 N1ac9388c6fe541ff869f545c38e68805 rdf:first N6fc4311d26cd4bcfaee8db36accb939a
114 rdf:rest N03287960661b45d6b642d63300a22a13
115 N38eaaf6388a3497a9975ad036f13ab5c schema:name doi
116 schema:value 10.1186/s12645-021-00106-7
117 rdf:type schema:PropertyValue
118 N4993d11a8e484975af2beffc0014e4a3 rdf:first sg:person.01215162414.88
119 rdf:rest N66b8367939a446179c0693ee87c3af87
120 N4a3d5996d0194ce5a0dbdd4adef85beb schema:volumeNumber 12
121 rdf:type schema:PublicationVolume
122 N66b8367939a446179c0693ee87c3af87 rdf:first sg:person.015701343654.10
123 rdf:rest N7b6006c5fee444db8a97e24a61386672
124 N6fc4311d26cd4bcfaee8db36accb939a schema:affiliation grid-institutes:grid.411975.f
125 schema:familyName AlSudairi
126 schema:givenName Nora
127 rdf:type schema:Person
128 N7b6006c5fee444db8a97e24a61386672 rdf:first sg:person.016665300035.36
129 rdf:rest N1ac9388c6fe541ff869f545c38e68805
130 N838bc965b32741ceac9c9a0b860cea15 rdf:first sg:person.010125270514.74
131 rdf:rest N0e8a6b7b1bce40549ddd186d5cdf2782
132 N85a244d44bf644f5ba7b00646c501984 schema:affiliation grid-institutes:grid.411975.f
133 schema:familyName Alfareed
134 schema:givenName T. M.
135 rdf:type schema:Person
136 Nbe94f7e0f9d94ed7bf89aed8fb97d8ce schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 Nccd22ea98ad7453aacd2dfb331ff0272 schema:issueNumber 1
139 rdf:type schema:PublicationIssue
140 Nd16a9e183e4348d1b91de72f8d421941 schema:name dimensions_id
141 schema:value pub.1143366732
142 rdf:type schema:PropertyValue
143 Ne5119927faac4c9e84114f1edd39ea10 rdf:first sg:person.013112302035.42
144 rdf:rest N4993d11a8e484975af2beffc0014e4a3
145 Ne5157d992d1e49758581bc5d1e8816c8 rdf:first sg:person.01171663075.56
146 rdf:rest rdf:nil
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
151 schema:name Oncology and Carcinogenesis
152 rdf:type schema:DefinedTerm
153 sg:journal.1042272 schema:issn 1868-6958
154 1868-6966
155 schema:name Cancer Nanotechnology
156 schema:publisher Springer Nature
157 rdf:type schema:Periodical
158 sg:person.010125270514.74 schema:affiliation grid-institutes:grid.411975.f
159 schema:familyName Almofleh
160 schema:givenName A. A.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010125270514.74
162 rdf:type schema:Person
163 sg:person.01171663075.56 schema:affiliation grid-institutes:grid.411975.f
164 schema:familyName Ravinayagam
165 schema:givenName Vijaya
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171663075.56
167 rdf:type schema:Person
168 sg:person.01215162414.88 schema:affiliation grid-institutes:grid.411975.f
169 schema:familyName Almohazey
170 schema:givenName D.
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215162414.88
172 rdf:type schema:Person
173 sg:person.013112302035.42 schema:affiliation grid-institutes:grid.411975.f
174 schema:familyName Jermy
175 schema:givenName B. Rabindran
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013112302035.42
177 rdf:type schema:Person
178 sg:person.015635350455.45 schema:affiliation grid-institutes:grid.412135.0
179 schema:familyName Dafalla
180 schema:givenName H.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015635350455.45
182 rdf:type schema:Person
183 sg:person.015701343654.10 schema:affiliation grid-institutes:grid.411975.f
184 schema:familyName Alamoudi
185 schema:givenName W. A.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015701343654.10
187 rdf:type schema:Person
188 sg:person.016665300035.36 schema:affiliation grid-institutes:grid.411975.f
189 schema:familyName Palanivel
190 schema:givenName R. M.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016665300035.36
192 rdf:type schema:Person
193 sg:pub.10.1007/s11051-017-3874-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1085615012
194 https://doi.org/10.1007/s11051-017-3874-y
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/s41598-019-42498-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1113378337
197 https://doi.org/10.1038/s41598-019-42498-y
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/s41598-019-54284-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1122953060
200 https://doi.org/10.1038/s41598-019-54284-x
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/sj.onc.1206940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042691731
203 https://doi.org/10.1038/sj.onc.1206940
204 rdf:type schema:CreativeWork
205 grid-institutes:grid.411975.f schema:alternateName Cell and Molecular Biology, Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia
206 Deanship of Quality and Academic Accreditation, Imam Abdulrahman Bin Faisal University, Post Box No. 1982, 31441, Dammam, Saudi Arabia
207 Deanship of Scientific Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia
208 Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia
209 Department of Neuroscience Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia
210 Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 3144, Dammam, Saudi Arabia
211 schema:name Cell and Molecular Biology, Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia
212 Deanship of Quality and Academic Accreditation, Imam Abdulrahman Bin Faisal University, Post Box No. 1982, 31441, Dammam, Saudi Arabia
213 Deanship of Scientific Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia
214 Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia
215 Department of Neuroscience Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia
216 Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 3144, Dammam, Saudi Arabia
217 rdf:type schema:Organization
218 grid-institutes:grid.412135.0 schema:alternateName College of Engineering Research (CER), King Fahd University of Petroleum and Minerals, 31261, Dhahran, Saudi Arabia
219 schema:name College of Engineering Research (CER), King Fahd University of Petroleum and Minerals, 31261, Dhahran, Saudi Arabia
220 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...