JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jermy", 
        "givenName": "B. Rabindran", 
        "id": "sg:person.013112302035.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013112302035.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 3144, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 3144, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Almohazey", 
        "givenName": "D.", 
        "id": "sg:person.01215162414.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215162414.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroscience Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Department of Neuroscience Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alamoudi", 
        "givenName": "W. A.", 
        "id": "sg:person.015701343654.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015701343654.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Deanship of Quality and Academic Accreditation, Imam Abdulrahman Bin Faisal University, Post Box No. 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Deanship of Quality and Academic Accreditation, Imam Abdulrahman Bin Faisal University, Post Box No. 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palanivel", 
        "givenName": "R. M.", 
        "id": "sg:person.016665300035.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016665300035.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cell and Molecular Biology, Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Cell and Molecular Biology, Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "AlSudairi", 
        "givenName": "Nora", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Engineering Research (CER), King Fahd University of Petroleum and Minerals, 31261, Dhahran, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.412135.0", 
          "name": [
            "College of Engineering Research (CER), King Fahd University of Petroleum and Minerals, 31261, Dhahran, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dafalla", 
        "givenName": "H.", 
        "id": "sg:person.015635350455.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015635350455.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Almofleh", 
        "givenName": "A. A.", 
        "id": "sg:person.010125270514.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010125270514.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alfareed", 
        "givenName": "T. M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Deanship of Scientific Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.411975.f", 
          "name": [
            "Deanship of Scientific Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ravinayagam", 
        "givenName": "Vijaya", 
        "id": "sg:person.01171663075.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171663075.56"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1206940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042691731", 
          "https://doi.org/10.1038/sj.onc.1206940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-017-3874-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085615012", 
          "https://doi.org/10.1007/s11051-017-3874-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-019-42498-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1113378337", 
          "https://doi.org/10.1038/s41598-019-42498-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-019-54284-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1122953060", 
          "https://doi.org/10.1038/s41598-019-54284-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-11-27", 
    "datePublishedReg": "2021-11-27", 
    "description": "BackgroundPlatinum-based drugs are widely used in cancer therapy, but are known for toxic side effects and resistance. Combinational drug delivery represents an effective chemotherapeutic strategy, but often leads to an increased toxicity. Aim of this study is to test the co-delivery of cisplatin with natural antioxidants on hierarchial porous large surface area hexagonal nanocarriers for synergistic action.ResultsA series of structured mesoporous materials were impregnated with magnetic spinel ferrite (30% CuFe2O4) and then coated with curcumin (25% wt/wt). Mesosilicalite and MCM-41 with high curcumin release abilities were functionalized with cisplatin (5% wt/wt) for synergistic effect of combinational drugs. The cytotoxic efficiency of our nanocomposites was tested on cell viability of MCF7 (human breast cancer), human cervical cancer (HeLa), colorectal cancer (HCT116), and HFF (human foreskin fibroblasts) cell lines using the MTT cell viability assay. At a concentration of 0.1\u00a0mg/ml, CuFe2O4/mesosilicalite/curcumin/cisplatin resulted in 89.53% reduction in viability in MCF7, 94.03% in HeLa, 64% in HCT116 and 87% in HFF; whereas, CuFe2O4/MCM-41/curcumin/cisplatin resulted in 76% reduction in viability in MCF7, 64.46% in HeLa, 64% in HCT116 and 24% in HFF. The EC50 for CuFe2O4/mesosilicalite/curcumin/cisplatin was 81.23\u00a0\u00b5g/ml in MCF7, 47.55\u00a0\u00b5g/ml in HeLa, 48.96\u00a0\u00b5g/ml in HCT116 and 76.83\u00a0\u00b5g/ml in HFF. The EC50 for CuFe2O4/MCM-41/curcumin/cisplatin was 72.51\u00a0\u00b5g/ml in MCF7, 58.6\u00a0\u00b5g/ml in HeLa, 62.58\u00a0\u00b5g/ml in HCT116 and 154.2\u00a0\u00b5g/ml in HFF. Furthermore, cells treated with both nanocomposites had a high number of cleaved Caspase 3-positive cells suggesting that the reduction in cell viability was triggered by activating the apoptotic signaling pathway.ConclusionOur results show that CuFe2O4/MCM-41/curcumin/cisplatin is a better candidate for combinational drug therapy due to its lowest EC50 value and the wider difference in EC50 (a fold change) between cancerous and non-cancerous cell line.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12645-021-00106-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1042272", 
        "issn": [
          "1868-6958", 
          "1868-6966"
        ], 
        "name": "Cancer Nanotechnology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "keywords": [
      "cell lines", 
      "cell viability", 
      "combinational drug therapy", 
      "human cervical cancer", 
      "toxic side effects", 
      "effective chemotherapeutic strategy", 
      "cancer cell lines", 
      "cervical cancer", 
      "combinational drug delivery", 
      "colorectal cancer", 
      "drug therapy", 
      "side effects", 
      "MTT cell viability", 
      "combinational drugs", 
      "synergistic action", 
      "ConclusionOur results", 
      "chemotherapeutic strategies", 
      "cisplatin", 
      "apoptotic signaling pathways", 
      "HFF cell lines", 
      "cancer therapy", 
      "MCF-7", 
      "signaling pathways", 
      "therapy", 
      "MCF7", 
      "cancer", 
      "ResultsA series", 
      "EC50", 
      "HCT116", 
      "HCT-116 cancer cell lines", 
      "cytotoxic efficiency", 
      "non-cancerous cell lines", 
      "drugs", 
      "EC50 values", 
      "lower EC50 values", 
      "natural antioxidants", 
      "HFF", 
      "curcumin", 
      "HeLa", 
      "BackgroundPlatinum", 
      "higher number", 
      "cells", 
      "viability", 
      "drug delivery", 
      "reduction", 
      "toxicity", 
      "action", 
      "antioxidants", 
      "synergistic effect", 
      "wide differences", 
      "delivery", 
      "effect", 
      "pathway", 
      "lines", 
      "caspases", 
      "differences", 
      "study", 
      "good candidate", 
      "resistance", 
      "concentration", 
      "release ability", 
      "nanocarriers", 
      "candidates", 
      "ability", 
      "strategies", 
      "number", 
      "series", 
      "results", 
      "values", 
      "materials", 
      "MCM", 
      "structured mesoporous materials", 
      "efficiency", 
      "magnetic spinel ferrite", 
      "MCM-41", 
      "mesoporous materials", 
      "spinel ferrites", 
      "nanocomposites", 
      "ferrite"
    ], 
    "name": "Synergistic action of curcumin and cisplatin on spinel ferrite/hierarchical MCM-41 nanocomposite against MCF-7, HeLa and HCT 116 cancer cell line", 
    "pagination": "33", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1143366732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12645-021-00106-7"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12645-021-00106-7", 
      "https://app.dimensions.ai/details/publication/pub.1143366732"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_886.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12645-021-00106-7"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

220 TRIPLES      22 PREDICATES      108 URIs      96 LITERALS      6 BLANK NODES