Nanoparticles derived from insect exoskeleton modulates NLRP3 inflammasome complex activation in cervical cancer cell line model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-08-11

AUTHORS

Rituparna Chakraborty, Ujjal Bose, Goutam Pawaskar, Satish Rao Bola Sadashiva, Ritu Raval

ABSTRACT

BackgroundImmune evasion is an important hallmark of cancer progression and tumourigenesis. Among the cancer types, cervical cancer has very high global prevalence, severely affecting female reproductive health. Its preponderance is also observed in the Indian health sector.ResultsThe NLRP3 inflammasome, an intracellular complex regulates the innate immune activity and a variant gene of it has been significantly associated with cervical cancer development. We aimed to evaluate the potential role of our chitosan engineered nanoparticles (CSNP) and gallic acid conjugated chitosan (gCSNP), to modulate the NLRP3 inflammasome complex in cervical cancer cell lines to explore their novel physicochemical properties. The encapsulation of gallic acid (GA) with chitosan was performed using ion gelation method. The CSNP and gCSNP nanoparticles ranged between 155 and 181 nm as determined by zeta sizer. The conjugations were validated by FTIR and XRD analysis. In the cervical cell line model, CSNP suppressed NLRP3 inflammasome activation in contrast to gCSNP at higher doses.ConclusionIn contrast to gCSNP, the CSNP not only demonstrated inhibitory effect on the expression of genes coding for the NLRP3 inflammasome complex (signal 1—priming), but also decreased relative expression of gene involved in the activation of NLRP3 inflammasome complex (signal 2—activation). Conjugation of gallic acid reversed the immunosuppressor mimicking action of CSNP in cervical cancer cell line. Future research can reveal the immunomodulatory mechanism of CSNP may have its translational significance as potential treatment strategies targeting immune evasion as an important hallmark of cancer.Graphical abstract More... »

PAGES

21

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12645-021-00090-y

DOI

http://dx.doi.org/10.1186/s12645-021-00090-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1140356502


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, Melaka Manipal Medical College, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India", 
          "id": "http://www.grid.ac/institutes/grid.480482.2", 
          "name": [
            "Department of Microbiology, Melaka Manipal Medical College, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chakraborty", 
        "givenName": "Rituparna", 
        "id": "sg:person.01302561652.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302561652.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, Melaka Manipal Medical College, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India", 
          "id": "http://www.grid.ac/institutes/grid.480482.2", 
          "name": [
            "Department of Pharmacology, Melaka Manipal Medical College, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bose", 
        "givenName": "Ujjal", 
        "id": "sg:person.015274234301.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015274234301.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India", 
          "id": "http://www.grid.ac/institutes/grid.411639.8", 
          "name": [
            "Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pawaskar", 
        "givenName": "Goutam", 
        "id": "sg:person.013672122731.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013672122731.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Directorate of Research, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India", 
          "id": "http://www.grid.ac/institutes/grid.411639.8", 
          "name": [
            "Directorate of Research, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bola Sadashiva", 
        "givenName": "Satish Rao", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Manipal Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India", 
          "id": "http://www.grid.ac/institutes/grid.411639.8", 
          "name": [
            "Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India", 
            "Manipal Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raval", 
        "givenName": "Ritu", 
        "id": "sg:person.0752370444.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752370444.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s40824-018-0133-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107254581", 
          "https://doi.org/10.1186/s40824-018-0133-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1012128907225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004189616", 
          "https://doi.org/10.1023/a:1012128907225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12943-018-0900-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109993485", 
          "https://doi.org/10.1186/s12943-018-0900-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038342228", 
          "https://doi.org/10.1038/nri2725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41568-019-0123-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1112580200", 
          "https://doi.org/10.1038/s41568-019-0123-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cmi.2015.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020412501", 
          "https://doi.org/10.1038/cmi.2015.95"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13045-017-0460-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084954695", 
          "https://doi.org/10.1186/s13045-017-0460-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13046-019-1266-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1117292966", 
          "https://doi.org/10.1186/s13046-019-1266-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024102922", 
          "https://doi.org/10.1038/nprot.2007.102"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-08-11", 
    "datePublishedReg": "2021-08-11", 
    "description": "BackgroundImmune evasion is an important hallmark of cancer progression and tumourigenesis. Among the cancer types, cervical cancer has very high global prevalence, severely affecting female reproductive health. Its preponderance is also observed in the Indian health sector.ResultsThe NLRP3 inflammasome, an intracellular complex regulates the innate immune activity and a variant gene of it has been significantly associated with cervical cancer development. We aimed to evaluate the potential role of our chitosan engineered nanoparticles (CSNP) and gallic acid conjugated chitosan (gCSNP), to modulate the NLRP3 inflammasome complex in cervical cancer cell lines to explore their novel physicochemical properties. The encapsulation of gallic acid (GA) with chitosan was performed using ion gelation method. The CSNP and gCSNP nanoparticles ranged between 155 and 181\u00a0nm as determined by zeta sizer. The conjugations were validated by FTIR and XRD analysis. In the cervical cell line model, CSNP suppressed NLRP3 inflammasome activation in contrast to gCSNP at higher doses.ConclusionIn contrast to gCSNP, the CSNP not only demonstrated inhibitory effect on the expression of genes coding for the NLRP3 inflammasome complex (signal 1\u2014priming), but also decreased relative expression of gene involved in the activation of NLRP3 inflammasome complex (signal 2\u2014activation). Conjugation of gallic acid reversed the immunosuppressor mimicking action of CSNP in cervical cancer cell line. Future research can reveal the immunomodulatory mechanism of CSNP may have its translational significance as potential treatment strategies targeting immune evasion as an important hallmark of cancer.Graphical abstract", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12645-021-00090-y", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1042272", 
        "issn": [
          "1868-6958", 
          "1868-6966"
        ], 
        "name": "Cancer Nanotechnology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "keywords": [
      "cervical cancer cell lines", 
      "NLRP3 inflammasome complex", 
      "cancer cell lines", 
      "cell line models", 
      "inflammasome complex", 
      "activation of NLRP3", 
      "cervical cancer development", 
      "female reproductive health", 
      "innate immune activity", 
      "important hallmark", 
      "NLRP3 inflammasome activation", 
      "high global prevalence", 
      "potential treatment strategy", 
      "cancer cell line models", 
      "cell lines", 
      "cervical cancer", 
      "immunomodulatory mechanisms", 
      "treatment strategies", 
      "inflammasome activation", 
      "immune activity", 
      "gallic acid", 
      "global prevalence", 
      "translational significance", 
      "immune evasion", 
      "reproductive health", 
      "high doses", 
      "ConclusionIn contrast", 
      "cancer types", 
      "cancer development", 
      "cancer progression", 
      "inhibitory effect", 
      "potential role", 
      "NLRP3", 
      "relative expression", 
      "expression of genes", 
      "cancer", 
      "health sector", 
      "complex activation", 
      "activation", 
      "variant genes", 
      "hallmark", 
      "Indian health sector", 
      "evasion", 
      "immunosuppressors", 
      "intracellular complexes", 
      "expression", 
      "prevalence", 
      "doses", 
      "progression", 
      "tumourigenesis", 
      "genes", 
      "ion gelation method", 
      "health", 
      "acid", 
      "preponderance", 
      "contrast", 
      "future research", 
      "CSNPs", 
      "line model", 
      "novel physicochemical properties", 
      "significance", 
      "activity", 
      "lines", 
      "role", 
      "conjugation", 
      "action", 
      "Abstract Nanoparticles", 
      "effect", 
      "zeta sizer", 
      "mechanism", 
      "nanoparticles", 
      "gelation method", 
      "development", 
      "strategies", 
      "XRD analysis", 
      "types", 
      "exoskeleton", 
      "analysis", 
      "complexes", 
      "physicochemical properties", 
      "model", 
      "chitosan", 
      "research", 
      "method", 
      "encapsulation", 
      "insect exoskeleton", 
      "FTIR", 
      "sizer", 
      "properties", 
      "sector"
    ], 
    "name": "Nanoparticles derived from insect exoskeleton modulates NLRP3 inflammasome complex activation in cervical cancer cell line model", 
    "pagination": "21", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1140356502"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12645-021-00090-y"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12645-021-00090-y", 
      "https://app.dimensions.ai/details/publication/pub.1140356502"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T10:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_909.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12645-021-00090-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00090-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00090-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00090-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00090-y'


 

This table displays all metadata directly associated to this object as RDF triples.

220 TRIPLES      22 PREDICATES      124 URIs      107 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12645-021-00090-y schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N5349570e6518495386b52c3e9c35ec98
4 schema:citation sg:pub.10.1023/a:1012128907225
5 sg:pub.10.1038/cmi.2015.95
6 sg:pub.10.1038/nprot.2007.102
7 sg:pub.10.1038/nri2725
8 sg:pub.10.1038/s41568-019-0123-y
9 sg:pub.10.1186/s12943-018-0900-3
10 sg:pub.10.1186/s13045-017-0460-9
11 sg:pub.10.1186/s13046-019-1266-0
12 sg:pub.10.1186/s40824-018-0133-y
13 schema:datePublished 2021-08-11
14 schema:datePublishedReg 2021-08-11
15 schema:description BackgroundImmune evasion is an important hallmark of cancer progression and tumourigenesis. Among the cancer types, cervical cancer has very high global prevalence, severely affecting female reproductive health. Its preponderance is also observed in the Indian health sector.ResultsThe NLRP3 inflammasome, an intracellular complex regulates the innate immune activity and a variant gene of it has been significantly associated with cervical cancer development. We aimed to evaluate the potential role of our chitosan engineered nanoparticles (CSNP) and gallic acid conjugated chitosan (gCSNP), to modulate the NLRP3 inflammasome complex in cervical cancer cell lines to explore their novel physicochemical properties. The encapsulation of gallic acid (GA) with chitosan was performed using ion gelation method. The CSNP and gCSNP nanoparticles ranged between 155 and 181 nm as determined by zeta sizer. The conjugations were validated by FTIR and XRD analysis. In the cervical cell line model, CSNP suppressed NLRP3 inflammasome activation in contrast to gCSNP at higher doses.ConclusionIn contrast to gCSNP, the CSNP not only demonstrated inhibitory effect on the expression of genes coding for the NLRP3 inflammasome complex (signal 1—priming), but also decreased relative expression of gene involved in the activation of NLRP3 inflammasome complex (signal 2—activation). Conjugation of gallic acid reversed the immunosuppressor mimicking action of CSNP in cervical cancer cell line. Future research can reveal the immunomodulatory mechanism of CSNP may have its translational significance as potential treatment strategies targeting immune evasion as an important hallmark of cancer.Graphical abstract
16 schema:genre article
17 schema:inLanguage en
18 schema:isAccessibleForFree true
19 schema:isPartOf N366b72c00a9c4629b9bcaad0b5a9b172
20 Ndc4eb1724fea4c0e90862f3ccb5f9074
21 sg:journal.1042272
22 schema:keywords Abstract Nanoparticles
23 CSNPs
24 ConclusionIn contrast
25 FTIR
26 Indian health sector
27 NLRP3
28 NLRP3 inflammasome activation
29 NLRP3 inflammasome complex
30 XRD analysis
31 acid
32 action
33 activation
34 activation of NLRP3
35 activity
36 analysis
37 cancer
38 cancer cell line models
39 cancer cell lines
40 cancer development
41 cancer progression
42 cancer types
43 cell line models
44 cell lines
45 cervical cancer
46 cervical cancer cell lines
47 cervical cancer development
48 chitosan
49 complex activation
50 complexes
51 conjugation
52 contrast
53 development
54 doses
55 effect
56 encapsulation
57 evasion
58 exoskeleton
59 expression
60 expression of genes
61 female reproductive health
62 future research
63 gallic acid
64 gelation method
65 genes
66 global prevalence
67 hallmark
68 health
69 health sector
70 high doses
71 high global prevalence
72 immune activity
73 immune evasion
74 immunomodulatory mechanisms
75 immunosuppressors
76 important hallmark
77 inflammasome activation
78 inflammasome complex
79 inhibitory effect
80 innate immune activity
81 insect exoskeleton
82 intracellular complexes
83 ion gelation method
84 line model
85 lines
86 mechanism
87 method
88 model
89 nanoparticles
90 novel physicochemical properties
91 physicochemical properties
92 potential role
93 potential treatment strategy
94 preponderance
95 prevalence
96 progression
97 properties
98 relative expression
99 reproductive health
100 research
101 role
102 sector
103 significance
104 sizer
105 strategies
106 translational significance
107 treatment strategies
108 tumourigenesis
109 types
110 variant genes
111 zeta sizer
112 schema:name Nanoparticles derived from insect exoskeleton modulates NLRP3 inflammasome complex activation in cervical cancer cell line model
113 schema:pagination 21
114 schema:productId N8bb5758beb6c4da8bd3e0558c9c61abf
115 N98754b474bce410f8721349bc1cfdd6f
116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1140356502
117 https://doi.org/10.1186/s12645-021-00090-y
118 schema:sdDatePublished 2022-05-10T10:31
119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
120 schema:sdPublisher N3e88483add9645499c1a33fca4a54f52
121 schema:url https://doi.org/10.1186/s12645-021-00090-y
122 sgo:license sg:explorer/license/
123 sgo:sdDataset articles
124 rdf:type schema:ScholarlyArticle
125 N008c292fa0cc4ee3bfb2dda2b50f7522 rdf:first N78bf6366b1674e508425bdb9f647cdb0
126 rdf:rest N2ade0131607c4ddba98833849ac06326
127 N2ade0131607c4ddba98833849ac06326 rdf:first sg:person.0752370444.86
128 rdf:rest rdf:nil
129 N366b72c00a9c4629b9bcaad0b5a9b172 schema:issueNumber 1
130 rdf:type schema:PublicationIssue
131 N3e88483add9645499c1a33fca4a54f52 schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N5349570e6518495386b52c3e9c35ec98 rdf:first sg:person.01302561652.93
134 rdf:rest Nc8061fdc960e43d78fa8d8f50705516f
135 N78bf6366b1674e508425bdb9f647cdb0 schema:affiliation grid-institutes:grid.411639.8
136 schema:familyName Bola Sadashiva
137 schema:givenName Satish Rao
138 rdf:type schema:Person
139 N7e7412defc7f43339e99f7efda2e1aab rdf:first sg:person.013672122731.72
140 rdf:rest N008c292fa0cc4ee3bfb2dda2b50f7522
141 N8bb5758beb6c4da8bd3e0558c9c61abf schema:name dimensions_id
142 schema:value pub.1140356502
143 rdf:type schema:PropertyValue
144 N98754b474bce410f8721349bc1cfdd6f schema:name doi
145 schema:value 10.1186/s12645-021-00090-y
146 rdf:type schema:PropertyValue
147 Nc8061fdc960e43d78fa8d8f50705516f rdf:first sg:person.015274234301.39
148 rdf:rest N7e7412defc7f43339e99f7efda2e1aab
149 Ndc4eb1724fea4c0e90862f3ccb5f9074 schema:volumeNumber 12
150 rdf:type schema:PublicationVolume
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
155 schema:name Oncology and Carcinogenesis
156 rdf:type schema:DefinedTerm
157 sg:journal.1042272 schema:issn 1868-6958
158 1868-6966
159 schema:name Cancer Nanotechnology
160 schema:publisher Springer Nature
161 rdf:type schema:Periodical
162 sg:person.01302561652.93 schema:affiliation grid-institutes:grid.480482.2
163 schema:familyName Chakraborty
164 schema:givenName Rituparna
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302561652.93
166 rdf:type schema:Person
167 sg:person.013672122731.72 schema:affiliation grid-institutes:grid.411639.8
168 schema:familyName Pawaskar
169 schema:givenName Goutam
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013672122731.72
171 rdf:type schema:Person
172 sg:person.015274234301.39 schema:affiliation grid-institutes:grid.480482.2
173 schema:familyName Bose
174 schema:givenName Ujjal
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015274234301.39
176 rdf:type schema:Person
177 sg:person.0752370444.86 schema:affiliation grid-institutes:grid.411639.8
178 schema:familyName Raval
179 schema:givenName Ritu
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752370444.86
181 rdf:type schema:Person
182 sg:pub.10.1023/a:1012128907225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004189616
183 https://doi.org/10.1023/a:1012128907225
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/cmi.2015.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020412501
186 https://doi.org/10.1038/cmi.2015.95
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/nprot.2007.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024102922
189 https://doi.org/10.1038/nprot.2007.102
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/nri2725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038342228
192 https://doi.org/10.1038/nri2725
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/s41568-019-0123-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1112580200
195 https://doi.org/10.1038/s41568-019-0123-y
196 rdf:type schema:CreativeWork
197 sg:pub.10.1186/s12943-018-0900-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109993485
198 https://doi.org/10.1186/s12943-018-0900-3
199 rdf:type schema:CreativeWork
200 sg:pub.10.1186/s13045-017-0460-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084954695
201 https://doi.org/10.1186/s13045-017-0460-9
202 rdf:type schema:CreativeWork
203 sg:pub.10.1186/s13046-019-1266-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1117292966
204 https://doi.org/10.1186/s13046-019-1266-0
205 rdf:type schema:CreativeWork
206 sg:pub.10.1186/s40824-018-0133-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1107254581
207 https://doi.org/10.1186/s40824-018-0133-y
208 rdf:type schema:CreativeWork
209 grid-institutes:grid.411639.8 schema:alternateName Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India
210 Directorate of Research, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India
211 Manipal Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India
212 schema:name Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India
213 Directorate of Research, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India
214 Manipal Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India
215 rdf:type schema:Organization
216 grid-institutes:grid.480482.2 schema:alternateName Department of Microbiology, Melaka Manipal Medical College, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India
217 Department of Pharmacology, Melaka Manipal Medical College, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India
218 schema:name Department of Microbiology, Melaka Manipal Medical College, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India
219 Department of Pharmacology, Melaka Manipal Medical College, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India
220 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...