Ontology type: schema:ScholarlyArticle Open Access: True
2021-07-08
AUTHORSA. Taherian, N. Esfandiari, S. Rouhani
ABSTRACTBackgroundBreast cancer is one of the most challenging cancers among women which is considered one of the most lethal cancers to this date. From the time that cancer has been discovered, finding the best therapeutic method is still an ongoing process. As a novel therapeutic method, nanomedicine has brought a vast number of materials that could versatilely be used as a drug carrier. The purpose of this study is to develop a novel black pomegranate peel extract loaded with chitosan-coated magnetic nanoparticles to treat breast cancer cells.ResultsThe morphology and size distribution of the nanoparticles studied by dynamic light scattering, atomic force microscopy, scanning, and transitional electron microscopy showed the spherical shape of the nanoparticles and their promising size range. Studies by Fourier transform infrared spectroscopy, X-ray diffraction, vibrating sample magnetometer, and zeta sizer confirmed the synthesis, substantial crystallinity, magnetic potential of the nanoparticles, and their satisfactory stability. The DPPH assay revealed that the obtained black pomegranate peel extract has 60% free radical scavenging activity. The cytotoxicity studies by MTT and LDH assay carried out on NIH/3T3, MBA-MB-231, and 4T1 cells confirmed that the magnetic nanoparticles had no significant cytotoxicity on the cells. However, the drug-loaded nanoparticles could significantly eradicate cancerous cells which had more efficiency comparing to free drug. Furthermore, free drug and drug-loaded nanoparticles had no toxic effect on normal cells.ConclusionOwing to the results achieved from this study, the novel drug-loaded nanoparticles are compatible to be used for breast cancer treatment and could potentially be used for further in vivo studies. More... »
PAGES15
http://scigraph.springernature.com/pub.10.1186/s12645-021-00086-8
DOIhttp://dx.doi.org/10.1186/s12645-021-00086-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1139562517
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Chemical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Technology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0303",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Macromolecular and Materials Chemistry",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Physical Chemistry (incl. Structural)",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1007",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Nanotechnology",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran",
"id": "http://www.grid.ac/institutes/grid.412502.0",
"name": [
"Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran"
],
"type": "Organization"
},
"familyName": "Taherian",
"givenName": "A.",
"id": "sg:person.013551223247.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013551223247.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran",
"id": "http://www.grid.ac/institutes/grid.412502.0",
"name": [
"Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran"
],
"type": "Organization"
},
"familyName": "Esfandiari",
"givenName": "N.",
"id": "sg:person.0677147325.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677147325.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Organic Colorants, Institute for Color Science and Technology, Tehran, Iran",
"id": "http://www.grid.ac/institutes/grid.459642.8",
"name": [
"Department of Organic Colorants, Institute for Color Science and Technology, Tehran, Iran"
],
"type": "Organization"
},
"familyName": "Rouhani",
"givenName": "S.",
"id": "sg:person.0726577717.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726577717.48"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nrc.2016.108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039839307",
"https://doi.org/10.1038/nrc.2016.108"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12645-020-00059-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1126015980",
"https://doi.org/10.1186/s12645-020-00059-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13204-015-0429-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017248702",
"https://doi.org/10.1007/s13204-015-0429-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00396-012-2669-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017206636",
"https://doi.org/10.1007/s00396-012-2669-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13277-015-3867-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041472420",
"https://doi.org/10.1007/s13277-015-3867-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12645-018-0037-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101712126",
"https://doi.org/10.1186/s12645-018-0037-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41392-019-0068-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1120694830",
"https://doi.org/10.1038/s41392-019-0068-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41392-017-0004-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101544935",
"https://doi.org/10.1038/s41392-017-0004-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13104-018-3960-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1111064118",
"https://doi.org/10.1186/s13104-018-3960-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12645-010-0002-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036508836",
"https://doi.org/10.1007/s12645-010-0002-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s41664-020-00149-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1132319247",
"https://doi.org/10.1007/s41664-020-00149-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1472-6882-12-200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012388788",
"https://doi.org/10.1186/1472-6882-12-200"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13020-018-0177-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103408200",
"https://doi.org/10.1186/s13020-018-0177-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12645-018-0036-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100690141",
"https://doi.org/10.1186/s12645-018-0036-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11095-016-1958-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021785826",
"https://doi.org/10.1007/s11095-016-1958-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12645-020-00066-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1131755085",
"https://doi.org/10.1186/s12645-020-00066-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11947-018-2195-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1108010620",
"https://doi.org/10.1007/s11947-018-2195-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-018-25852-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103817493",
"https://doi.org/10.1038/s41598-018-25852-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/natrevmats.2017.24",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085219934",
"https://doi.org/10.1038/natrevmats.2017.24"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1743-8977-11-20",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007642560",
"https://doi.org/10.1186/1743-8977-11-20"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-07-08",
"datePublishedReg": "2021-07-08",
"description": "BackgroundBreast cancer is one of the most challenging cancers among women which is considered one of the most lethal cancers to this date. From the time that cancer has been discovered, finding the best therapeutic method is still an ongoing process. As a novel therapeutic method, nanomedicine has brought a vast number of materials that could versatilely be used as a drug carrier. The purpose of this study is to develop a novel black pomegranate peel extract loaded with chitosan-coated magnetic nanoparticles to treat breast cancer cells.ResultsThe morphology and size distribution of the nanoparticles studied by dynamic light scattering, atomic force microscopy, scanning, and transitional electron microscopy showed the spherical shape of the nanoparticles and their promising size range. Studies by Fourier transform infrared spectroscopy, X-ray diffraction, vibrating sample magnetometer, and zeta sizer confirmed the synthesis, substantial crystallinity, magnetic potential of the nanoparticles, and their satisfactory stability. The DPPH assay revealed that the obtained black pomegranate peel extract has 60% free radical scavenging activity. The cytotoxicity studies by MTT and LDH assay carried out on NIH/3T3, MBA-MB-231, and 4T1 cells confirmed that the magnetic nanoparticles had no significant cytotoxicity on the cells. However, the drug-loaded nanoparticles could significantly eradicate cancerous cells which had more efficiency comparing to free drug. Furthermore, free drug and drug-loaded nanoparticles had no toxic effect on normal cells.ConclusionOwing to the results achieved from this study, the novel drug-loaded nanoparticles are compatible to be used for breast cancer treatment and could potentially be used for further in vivo studies.",
"genre": "article",
"id": "sg:pub.10.1186/s12645-021-00086-8",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1042272",
"issn": [
"1868-6958",
"1868-6966"
],
"name": "Cancer Nanotechnology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "12"
}
],
"keywords": [
"drug-loaded nanoparticles",
"magnetic nanoparticles",
"chitosan-coated magnetic nanoparticles",
"transitional electron microscopy",
"chitosan-coated magnetic nanoparticles",
"cancer drug delivery",
"atomic force microscopy",
"free drug",
"dynamic light scattering",
"pomegranate peel extract",
"breast cancer drug delivery",
"X-ray diffraction",
"zeta sizer",
"sample magnetometer",
"peel extract",
"nanoparticles",
"force microscopy",
"drug carriers",
"drug delivery",
"MBA-MB-231",
"substantial crystallinity",
"spherical shape",
"electron microscopy",
"Fourier transform",
"cytotoxicity studies",
"light scattering",
"free radical scavenging activity",
"satisfactory stability",
"radical scavenging activity",
"size distribution",
"size range",
"microscopy",
"significant cytotoxicity",
"cancerous cells",
"scavenging activity",
"nanomedicine",
"novel therapeutic method",
"more efficiency",
"magnetometer",
"spectroscopy",
"cancer treatment",
"diffraction",
"synthesis",
"crystallinity",
"transform",
"breast cancer cells",
"carriers",
"morphology",
"therapeutic methods",
"vivo studies",
"LDH",
"challenging cancers",
"vast number",
"stability",
"sizer",
"delivery",
"extract",
"cancer cells",
"efficiency",
"normal cells",
"toxic effects",
"materials",
"cytotoxicity",
"drugs",
"cells",
"scattering",
"MTT",
"method",
"scanning",
"NIH/3T3",
"range",
"breast cancer treatment",
"potential",
"shape",
"activity",
"process",
"study",
"best therapeutic method",
"time",
"effect",
"results",
"distribution",
"BackgroundBreast cancer",
"number",
"treatment",
"date",
"cancer",
"purpose",
"lethal cancers",
"magnetic potential",
"ongoing process",
"women"
],
"name": "Breast cancer drug delivery by novel drug-loaded chitosan-coated magnetic nanoparticles",
"pagination": "15",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1139562517"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12645-021-00086-8"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12645-021-00086-8",
"https://app.dimensions.ai/details/publication/pub.1139562517"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:29",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_920.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s12645-021-00086-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00086-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00086-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00086-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12645-021-00086-8'
This table displays all metadata directly associated to this object as RDF triples.
258 TRIPLES
22 PREDICATES
139 URIs
108 LITERALS
6 BLANK NODES