C60 fullerene and its nanocomplexes with anticancer drugs modulate circulating phagocyte functions and dramatically increase ROS generation in transformed monocytes View Full Text


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Article Info

DATE

2018-10-31

AUTHORS

Larysa M. Skivka, Svitlana V. Prylutska, Mariia P. Rudyk, Nataliia M. Khranovska, Ievgeniia V. Opeida, Vasyl V. Hurmach, Yuriy I. Prylutskyy, Leonid F. Sukhodub, Uwe Ritter

ABSTRACT

BackgroundC60 fullerene-based nanoformulations are proposed to have a direct toxic effect on tumor cells. Previous investigations demonstrated that C60 fullerene used alone or being conjugated with chemotherapeutic agents possesses a potent anticancer activity. The main aim of this study was to investigate the effect of C60 fullerene and its nanocomplexes with anticancer drugs on human phagocyte metabolic profile in vitro.MethodsAnalysis of the metabolic profile of phagocytes exposed to C60 fullerene in vitro revealed augmented phagocytic activity and down-regulated reactive nitrogen species generation in these cells. Additionally, cytofluorimetric analysis showed that C60 fullerene can exert direct cytotoxic effect on normal and transformed phagocytes through the vigorous induction of intracellular reactive oxygen species generation.ResultsCytotoxic action as well as the pro-oxidant effect of C60 fullerene was more pronounced toward malignant phagocytes. At the same time, C60 fullerenes have the ability to down-regulate the pro-oxidant effect of cisplatin on normal cells. These results indicate that C60 fullerenes may influence phagocyte metabolism and have both pro-oxidant and antioxidant properties.ConclusionsThe antineoplastic effect of C60 fullerene has been observed by direct toxic effect on tumor cells, as well as through the modulation of the functions of effector cells of antitumor immunity. More... »

PAGES

8

References to SciGraph publications

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    https://www.ncbi.nlm.nih.gov/pubmed/30416604


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    26 schema:description BackgroundC60 fullerene-based nanoformulations are proposed to have a direct toxic effect on tumor cells. Previous investigations demonstrated that C60 fullerene used alone or being conjugated with chemotherapeutic agents possesses a potent anticancer activity. The main aim of this study was to investigate the effect of C60 fullerene and its nanocomplexes with anticancer drugs on human phagocyte metabolic profile in vitro.MethodsAnalysis of the metabolic profile of phagocytes exposed to C60 fullerene in vitro revealed augmented phagocytic activity and down-regulated reactive nitrogen species generation in these cells. Additionally, cytofluorimetric analysis showed that C60 fullerene can exert direct cytotoxic effect on normal and transformed phagocytes through the vigorous induction of intracellular reactive oxygen species generation.ResultsCytotoxic action as well as the pro-oxidant effect of C60 fullerene was more pronounced toward malignant phagocytes. At the same time, C60 fullerenes have the ability to down-regulate the pro-oxidant effect of cisplatin on normal cells. These results indicate that C60 fullerenes may influence phagocyte metabolism and have both pro-oxidant and antioxidant properties.ConclusionsThe antineoplastic effect of C60 fullerene has been observed by direct toxic effect on tumor cells, as well as through the modulation of the functions of effector cells of antitumor immunity.
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    33 MethodsAnalysis
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    39 agents
    40 aim
    41 analysis
    42 anticancer activity
    43 anticancer drugs
    44 antineoplastic effects
    45 antioxidant properties
    46 antitumor immunity
    47 cells
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    49 cisplatin
    50 cytofluorimetric analysis
    51 cytotoxic effects
    52 direct cytotoxic effect
    53 direct toxic effect
    54 drugs
    55 effect
    56 effector cells
    57 fullerenes
    58 function
    59 generation
    60 immunity
    61 induction
    62 intracellular reactive oxygen species (ROS) generation
    63 investigation
    64 main aim
    65 metabolic profile
    66 metabolism
    67 modulation
    68 monocytes
    69 nanocomplexes
    70 nanoformulations
    71 nitrogen species generation
    72 normal cells
    73 oxygen species generation
    74 phagocyte function
    75 phagocyte metabolism
    76 phagocytes
    77 phagocytic activity
    78 potent anticancer activity
    79 previous investigations
    80 pro-oxidant effects
    81 profile
    82 properties
    83 reactive nitrogen species generation
    84 reactive oxygen species generation
    85 results
    86 same time
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    93 schema:name C60 fullerene and its nanocomplexes with anticancer drugs modulate circulating phagocyte functions and dramatically increase ROS generation in transformed monocytes
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