Longer trinucleotide repeats of androgen receptor are associated with higher testosterone and low oxytocin levels in diabetic premature ejaculatory dysfunction ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Yousaf Latif Khan, Rosa Maria Marquez Gonzalez, Muhammad Aslamkhan, Gerardo Rodriguez Gonzalez, Hikmet Hakan Aydin

ABSTRACT

Background: Despite its worldwide high occurrence, the obscurity regarding the description, epidemiology and management of premature ejaculation remains provocative. It is well established that male premature ejaculatory dysfunction is an increasing problem due to spontaneous ejaculation across a variety of general and clinical subjects. The main goal of this study was to determine the relationships between trinucleotide repeats of the androgen receptor (AR), sex steroids, and pituitary hormones with sexual function in men with type 2 diabetes mellitus (DM) and reported with acquired premature ejaculation (PE). Methods: A total of 150 normal and 250 PE + DM subjects were enrolled in this study. Each subject was invited to fill out an elaborative questionnaire to acquire precise selective information regarding BMI, duration of PE + DM, self-reported Intra-Vaginal Ejaculatory Latency Time (IELT), sexual and mental health status by using the premature ejaculation diagnostic tool (PEDT) and Beck Depression Inventory-II (BDI-II). Pearson's correlation analysis was used to analyze the relationship between clinical, hormonal, and genetic variables. Ward's minimum variance cluster analysis and principal component analysis were used for evaluation of dependence between genetic, clinical, and demographic parameters. Results: The patients who have the lowest number of (≤21) (CAG)n repeats have higher serum oxytocin levels (114.2 pg/ml; n = 54, 43.2%) than the controls (69.18 pg/ml; n = 22, 17.6%) and the patients with the highest (≥26) number of (CAG)n repeats (62.9 pg/ml; n = 108, 43.2%).On the other hand, patients who have the highest numbers of (CAG)n repeats (≥26) have higher serum testosterone (6.1 ng/ml; n = 108, 43.2% of cohort) lower prolactin (3.01 ng/ml; n = 108, 43.2% of cohort) levels than the controls and patients with the lowest numbers (≤21) of (CAG)n repeats and their TSH (1.53 mIU/L, P < 0.05) levels are lower than those of controls. In the Pearson correlation model, self-estimated IELT demonstrated significantly negative correlation with both (CAG)n and (GCC)n repeats (r = - 0.16, p = 0.0001; r = - 0.19, p = 0.0001) respectively. These repeats have positive correlation with PEDT (r = 0.28, p = 0.0001: r = 0.24, p = 0.0001, whole model) and inversely correlated with BDI-II (r = - 0.25, p = 0.0001). Conclusion: This study indicates that androgen receptor polymorphism modulates the endocrine effect on ejaculatory reflex and depends strongly on its "cofactors". Moreover, our results also confirmed an association between long tri-nucleotide repeats of androgen receptor, sex steroids, pituitary, and thyroid hormones in relation to acquired premature ejaculatory dysfunction in diabetic patients. However, endocrine regulation of PE reflex is a complex phenomenon that requires further investigation. More... »

PAGES

3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12610-018-0068-0

DOI

http://dx.doi.org/10.1186/s12610-018-0068-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101153561

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29556396


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Lahore Institute of fertility and Endocrinology, Hameed Latif Hospital, 14 \u2013 Abu Bakar Block, New Garden Town, Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khan", 
        "givenName": "Haroon Latif", 
        "id": "sg:person.07644252137.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07644252137.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rashid Latif Medical College", 
          "id": "https://www.grid.ac/institutes/grid.459922.1", 
          "name": [
            "Lahore Institute of fertility and Endocrinology, Hameed Latif Hospital, 14 \u2013 Abu Bakar Block, New Garden Town, Lahore, Pakistan", 
            "Department of Human Genetics and Molecular biology, University of Health Sciences, -54600, Lahore, Pakistan", 
            "Institute of Molecular Biology and Biotechnology, The University of Lahore, 54600, Lahore, Pakistan", 
            "Department of Medical Education, Rashid Latif Medical College, Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bhatti", 
        "givenName": "Shahzad", 
        "id": "sg:person.01162176430.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162176430.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Lahore Institute of fertility and Endocrinology, Hameed Latif Hospital, 14 \u2013 Abu Bakar Block, New Garden Town, Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abbas", 
        "givenName": "Sana", 
        "id": "sg:person.015626415221.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015626415221.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Lahore Institute of fertility and Endocrinology, Hameed Latif Hospital, 14 \u2013 Abu Bakar Block, New Garden Town, Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khan", 
        "givenName": "Yousaf Latif", 
        "id": "sg:person.012034573537.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012034573537.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mexican Social Security Institute", 
          "id": "https://www.grid.ac/institutes/grid.419157.f", 
          "name": [
            "Centro de investigacion Biomedica de Occidente, IMSS, Uiversidad de Guadalajara, Jalisco Maxico, Guadalajara, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez", 
        "givenName": "Rosa Maria Marquez", 
        "id": "sg:person.013427534537.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013427534537.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Health Sciences Lahore", 
          "id": "https://www.grid.ac/institutes/grid.412956.d", 
          "name": [
            "Department of Human Genetics and Molecular biology, University of Health Sciences, -54600, Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aslamkhan", 
        "givenName": "Muhammad", 
        "id": "sg:person.01017351377.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017351377.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mexican Social Security Institute", 
          "id": "https://www.grid.ac/institutes/grid.419157.f", 
          "name": [
            "Universidad De Guadalajara CIBO, IMSS, Sierra Mojada 800 Independencia, 44340, Guadalajara, Jalisco Maxicom, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez", 
        "givenName": "Gerardo Rodriguez", 
        "id": "sg:person.011470434503.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011470434503.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ege University", 
          "id": "https://www.grid.ac/institutes/grid.8302.9", 
          "name": [
            "Department of Medical Biochemistry, Ege University School of Medicine, Bornova, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aydin", 
        "givenName": "Hikmet Hakan", 
        "id": "sg:person.01043352211.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043352211.40"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1743-6109.2009.01701.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000816283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2164/jandrol.05070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002169020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.1.01860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004145071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/andr.12068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004148913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004333053", 
          "https://doi.org/10.1038/onc.2013.235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004333053", 
          "https://doi.org/10.1038/onc.2013.235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0138848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004554872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrurol.2015.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005325657", 
          "https://doi.org/10.1038/nrurol.2015.13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-200767110-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007406388", 
          "https://doi.org/10.2165/00003495-200767110-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2016.11.074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007709679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.esxm.2016.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011873891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0269881112473788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012042349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0269881112473788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012042349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(87)91333-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012303743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(87)91333-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012303743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11783-014-0679-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015192347", 
          "https://doi.org/10.1007/s11783-014-0679-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0447.2012.01870.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015443509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0447.2012.01870.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015443509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2015.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018968593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11154-015-9322-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021281805", 
          "https://doi.org/10.1007/s11154-015-9322-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1743-6109.2012.02735.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021613714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13685538.2015.1004049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022303538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/cmaj.140688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022862047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/aps.2014.18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025297311", 
          "https://doi.org/10.1038/aps.2014.18"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2605.2010.01059.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025548894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yhbeh.2016.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025561291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yhbeh.2016.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025561291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsxm.2016.11.262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025919814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jsm.12504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026528161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/brv.12175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027452315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1743-6109.2011.02521.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028657838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2007.01.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029260719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/14767058.2015.1077513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029320213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijir.3901250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031525597", 
          "https://doi.org/10.1038/sj.ijir.3901250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijir.3901250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031525597", 
          "https://doi.org/10.1038/sj.ijir.3901250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-3601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031837444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21037/tau.2016.07.06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032147770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hrp.0b013e3182a75b7d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035522619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hrp.0b013e3182a75b7d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035522619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1743-6109.2005.20350.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035699314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.euf.2016.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037107020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psyneuen.2008.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037116532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/smrj.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038146917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-physiol-030212-183656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042466948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21037/tau.2016.05.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043618736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12991-015-0074-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050961258", 
          "https://doi.org/10.1186/s12991-015-0074-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0278-6133.20.2.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051211374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0278-6133.20.2.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051211374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pbb.2013.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052640850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2014-4434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064295642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/60.1.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082611267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m117.779041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084153229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-319-46086-4_14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084687814", 
          "https://doi.org/10.1007/978-3-319-46086-4_14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsxm.2017.03.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085002548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2017.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085082683", 
          "https://doi.org/10.1038/npp.2017.76"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsxm.2017.04.171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085606989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.euf.2016.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090778610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.euf.2016.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090778610"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Background: Despite its worldwide high occurrence, the obscurity regarding the description, epidemiology and management of premature ejaculation remains provocative. It is well established that male premature ejaculatory dysfunction is an increasing problem due to spontaneous ejaculation across a variety of general and clinical subjects. The main goal of this study was to determine the relationships between trinucleotide repeats of the\u00a0androgen receptor (AR), sex steroids, and pituitary hormones with sexual function in men with type 2 diabetes mellitus (DM) and reported with acquired premature ejaculation (PE).\nMethods: A total of 150 normal and 250 PE\u2009+\u2009DM subjects were enrolled in this study. Each subject was invited to fill out an elaborative questionnaire to acquire precise selective information regarding BMI, duration of PE\u2009+\u2009DM, self-reported Intra-Vaginal Ejaculatory Latency Time (IELT), sexual and mental health status by using the premature ejaculation diagnostic tool (PEDT) and Beck Depression Inventory-II (BDI-II). Pearson's correlation analysis was used to analyze the relationship\u00a0between clinical, hormonal, and genetic variables. Ward's minimum variance cluster analysis and principal component analysis were used for evaluation of dependence between genetic, clinical, and demographic parameters.\nResults: The patients who have the lowest number of (\u226421) (CAG)n repeats have higher serum oxytocin levels (114.2\u00a0pg/ml; n\u00a0=\u200954, 43.2%) than the controls (69.18\u00a0pg/ml; n\u00a0=\u200922, 17.6%) and the patients with the highest (\u226526) number of (CAG)n repeats (62.9\u00a0pg/ml; n\u00a0=\u2009108, 43.2%).On the other hand, patients who have the highest numbers of (CAG)n repeats (\u226526) have higher serum testosterone (6.1\u00a0ng/ml; n\u2009=\u2009108, 43.2% of cohort) lower prolactin (3.01\u00a0ng/ml; n\u2009=\u2009108, 43.2% of cohort) levels than the controls and patients with the lowest numbers (\u226421) of (CAG)n repeats and their TSH (1.53 mIU/L, P\u00a0<\u20090.05) levels are lower than those of controls. In the Pearson correlation model, self-estimated IELT demonstrated significantly negative correlation with both (CAG)n and (GCC)n repeats (r\u2009=\u2009-\u20090.16, p\u00a0=\u20090.0001; r\u2009=\u2009-\u20090.19, p\u2009=\u20090.0001) respectively. These repeats have positive correlation with PEDT (r\u2009=\u20090.28, p\u2009=\u20090.0001: r\u2009=\u20090.24, p\u2009=\u20090.0001, whole model) and inversely correlated with BDI-II (r\u2009=\u2009-\u20090.25, p\u2009=\u20090.0001).\nConclusion: This study indicates that androgen receptor polymorphism modulates the endocrine effect on ejaculatory reflex and depends strongly on its \"cofactors\". Moreover, our results also confirmed an association between long tri-nucleotide repeats of androgen receptor, sex steroids, pituitary, and thyroid hormones in relation to\u00a0 acquired premature ejaculatory dysfunction in diabetic patients. However, endocrine regulation of PE reflex is a complex phenomenon that requires further investigation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12610-018-0068-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1050675", 
        "issn": [
          "1166-2654", 
          "2051-4190"
        ], 
        "name": "Basic and Clinical Andrology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Longer trinucleotide repeats of androgen receptor are associated with higher testosterone and low oxytocin levels in diabetic premature ejaculatory dysfunction patients", 
    "pagination": "3", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6472f432dcfbfc02787941972d2576ef8e41e0061b1b5fad3fca5273e4d920d6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29556396"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101640161"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12610-018-0068-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101153561"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12610-018-0068-0", 
      "https://app.dimensions.ai/details/publication/pub.1101153561"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60357_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12610-018-0068-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12610-018-0068-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12610-018-0068-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12610-018-0068-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12610-018-0068-0'


 

This table displays all metadata directly associated to this object as RDF triples.

295 TRIPLES      21 PREDICATES      78 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12610-018-0068-0 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N9181491ce9014ebab64dc64262959a2a
4 schema:citation sg:pub.10.1007/978-3-319-46086-4_14
5 sg:pub.10.1007/s11154-015-9322-3
6 sg:pub.10.1007/s11783-014-0679-4
7 sg:pub.10.1038/aps.2014.18
8 sg:pub.10.1038/npp.2017.76
9 sg:pub.10.1038/nrurol.2015.13
10 sg:pub.10.1038/onc.2013.235
11 sg:pub.10.1038/sj.ijir.3901250
12 sg:pub.10.1186/s12991-015-0074-y
13 sg:pub.10.2165/00003495-200767110-00006
14 https://doi.org/10.1002/smrj.49
15 https://doi.org/10.1016/0006-8993(87)91333-3
16 https://doi.org/10.1016/j.biopsych.2015.05.003
17 https://doi.org/10.1016/j.esxm.2016.04.002
18 https://doi.org/10.1016/j.euf.2016.02.001
19 https://doi.org/10.1016/j.eururo.2007.01.028
20 https://doi.org/10.1016/j.jsxm.2016.11.262
21 https://doi.org/10.1016/j.jsxm.2017.03.040
22 https://doi.org/10.1016/j.jsxm.2017.04.171
23 https://doi.org/10.1016/j.juro.2016.11.074
24 https://doi.org/10.1016/j.pbb.2013.12.004
25 https://doi.org/10.1016/j.psyneuen.2008.01.014
26 https://doi.org/10.1016/j.yhbeh.2016.10.012
27 https://doi.org/10.1037/0278-6133.20.2.112
28 https://doi.org/10.1074/jbc.m117.779041
29 https://doi.org/10.1093/ajcn/60.1.23
30 https://doi.org/10.1097/hrp.0b013e3182a75b7d
31 https://doi.org/10.1111/andr.12068
32 https://doi.org/10.1111/brv.12175
33 https://doi.org/10.1111/j.1365-2605.2010.01059.x
34 https://doi.org/10.1111/j.1600-0447.2012.01870.x
35 https://doi.org/10.1111/j.1743-6109.2005.20350.x
36 https://doi.org/10.1111/j.1743-6109.2009.01701.x
37 https://doi.org/10.1111/j.1743-6109.2011.02521.x
38 https://doi.org/10.1111/j.1743-6109.2012.02735.x
39 https://doi.org/10.1111/jsm.12504
40 https://doi.org/10.1146/annurev-physiol-030212-183656
41 https://doi.org/10.1158/1078-0432.ccr-12-3601
42 https://doi.org/10.1177/0269881112473788
43 https://doi.org/10.1210/en.2006-1237
44 https://doi.org/10.1210/jc.2014-4434
45 https://doi.org/10.1371/journal.pone.0138848
46 https://doi.org/10.1503/cmaj.140688
47 https://doi.org/10.1530/eje.1.01860
48 https://doi.org/10.21037/tau.2016.05.16
49 https://doi.org/10.21037/tau.2016.07.06
50 https://doi.org/10.2164/jandrol.05070
51 https://doi.org/10.3109/13685538.2015.1004049
52 https://doi.org/10.3109/14767058.2015.1077513
53 schema:datePublished 2018-12
54 schema:datePublishedReg 2018-12-01
55 schema:description Background: Despite its worldwide high occurrence, the obscurity regarding the description, epidemiology and management of premature ejaculation remains provocative. It is well established that male premature ejaculatory dysfunction is an increasing problem due to spontaneous ejaculation across a variety of general and clinical subjects. The main goal of this study was to determine the relationships between trinucleotide repeats of the androgen receptor (AR), sex steroids, and pituitary hormones with sexual function in men with type 2 diabetes mellitus (DM) and reported with acquired premature ejaculation (PE). Methods: A total of 150 normal and 250 PE + DM subjects were enrolled in this study. Each subject was invited to fill out an elaborative questionnaire to acquire precise selective information regarding BMI, duration of PE + DM, self-reported Intra-Vaginal Ejaculatory Latency Time (IELT), sexual and mental health status by using the premature ejaculation diagnostic tool (PEDT) and Beck Depression Inventory-II (BDI-II). Pearson's correlation analysis was used to analyze the relationship between clinical, hormonal, and genetic variables. Ward's minimum variance cluster analysis and principal component analysis were used for evaluation of dependence between genetic, clinical, and demographic parameters. Results: The patients who have the lowest number of (≤21) (CAG)n repeats have higher serum oxytocin levels (114.2 pg/ml; n = 54, 43.2%) than the controls (69.18 pg/ml; n = 22, 17.6%) and the patients with the highest (≥26) number of (CAG)n repeats (62.9 pg/ml; n = 108, 43.2%).On the other hand, patients who have the highest numbers of (CAG)n repeats (≥26) have higher serum testosterone (6.1 ng/ml; n = 108, 43.2% of cohort) lower prolactin (3.01 ng/ml; n = 108, 43.2% of cohort) levels than the controls and patients with the lowest numbers (≤21) of (CAG)n repeats and their TSH (1.53 mIU/L, P < 0.05) levels are lower than those of controls. In the Pearson correlation model, self-estimated IELT demonstrated significantly negative correlation with both (CAG)n and (GCC)n repeats (r = - 0.16, p = 0.0001; r = - 0.19, p = 0.0001) respectively. These repeats have positive correlation with PEDT (r = 0.28, p = 0.0001: r = 0.24, p = 0.0001, whole model) and inversely correlated with BDI-II (r = - 0.25, p = 0.0001). Conclusion: This study indicates that androgen receptor polymorphism modulates the endocrine effect on ejaculatory reflex and depends strongly on its "cofactors". Moreover, our results also confirmed an association between long tri-nucleotide repeats of androgen receptor, sex steroids, pituitary, and thyroid hormones in relation to  acquired premature ejaculatory dysfunction in diabetic patients. However, endocrine regulation of PE reflex is a complex phenomenon that requires further investigation.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N20b7013d93904994bed331e5f56ec06a
60 N67b3fc300c244ff99b44ff9a58a9662d
61 sg:journal.1050675
62 schema:name Longer trinucleotide repeats of androgen receptor are associated with higher testosterone and low oxytocin levels in diabetic premature ejaculatory dysfunction patients
63 schema:pagination 3
64 schema:productId N145502216c304eeab05a536f21d8a2b0
65 N234ca672efda4c2c9a16941be799f038
66 Nae9baa8f8d40443cb231abf8ee1315db
67 Nb49543e2c1cd4fa7b2babf89d980a273
68 Nc4ce8f6d075348fda4458b6313112e1f
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101153561
70 https://doi.org/10.1186/s12610-018-0068-0
71 schema:sdDatePublished 2019-04-11T11:03
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N569963e61c25483f93e8375592803412
74 schema:url https://link.springer.com/10.1186%2Fs12610-018-0068-0
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N012c3cb3004e458ab7fd3da997964e5f rdf:first sg:person.01017351377.73
79 rdf:rest Nd56fe0feadaf4832a52648b6a22928ed
80 N145502216c304eeab05a536f21d8a2b0 schema:name readcube_id
81 schema:value 6472f432dcfbfc02787941972d2576ef8e41e0061b1b5fad3fca5273e4d920d6
82 rdf:type schema:PropertyValue
83 N20b7013d93904994bed331e5f56ec06a schema:volumeNumber 28
84 rdf:type schema:PublicationVolume
85 N234ca672efda4c2c9a16941be799f038 schema:name pubmed_id
86 schema:value 29556396
87 rdf:type schema:PropertyValue
88 N2db0a07210d6450bbada8867670f9793 schema:name Lahore Institute of fertility and Endocrinology, Hameed Latif Hospital, 14 – Abu Bakar Block, New Garden Town, Lahore, Pakistan
89 rdf:type schema:Organization
90 N33df5b1d24814c1f981e0a0e96bcec74 rdf:first sg:person.012034573537.99
91 rdf:rest Nf83c4523401f42c1836c5af01b5ec109
92 N43a4d086902d48bba003f71f7dd80a3b schema:name Lahore Institute of fertility and Endocrinology, Hameed Latif Hospital, 14 – Abu Bakar Block, New Garden Town, Lahore, Pakistan
93 rdf:type schema:Organization
94 N44550df127024d4798dcbbd335b7f616 rdf:first sg:person.01043352211.40
95 rdf:rest rdf:nil
96 N569963e61c25483f93e8375592803412 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N67b3fc300c244ff99b44ff9a58a9662d schema:issueNumber 1
99 rdf:type schema:PublicationIssue
100 N831ae85f160a469096f1b6b76eefcc5b rdf:first sg:person.015626415221.67
101 rdf:rest N33df5b1d24814c1f981e0a0e96bcec74
102 N8848c1704e26419689e1f4c5614e2dcc rdf:first sg:person.01162176430.74
103 rdf:rest N831ae85f160a469096f1b6b76eefcc5b
104 N9181491ce9014ebab64dc64262959a2a rdf:first sg:person.07644252137.82
105 rdf:rest N8848c1704e26419689e1f4c5614e2dcc
106 Nae9baa8f8d40443cb231abf8ee1315db schema:name nlm_unique_id
107 schema:value 101640161
108 rdf:type schema:PropertyValue
109 Nb49543e2c1cd4fa7b2babf89d980a273 schema:name dimensions_id
110 schema:value pub.1101153561
111 rdf:type schema:PropertyValue
112 Nc4ce8f6d075348fda4458b6313112e1f schema:name doi
113 schema:value 10.1186/s12610-018-0068-0
114 rdf:type schema:PropertyValue
115 Nd56fe0feadaf4832a52648b6a22928ed rdf:first sg:person.011470434503.10
116 rdf:rest N44550df127024d4798dcbbd335b7f616
117 Ne32bb92566b149ac9165707206ec63d0 schema:name Lahore Institute of fertility and Endocrinology, Hameed Latif Hospital, 14 – Abu Bakar Block, New Garden Town, Lahore, Pakistan
118 rdf:type schema:Organization
119 Nf83c4523401f42c1836c5af01b5ec109 rdf:first sg:person.013427534537.51
120 rdf:rest N012c3cb3004e458ab7fd3da997964e5f
121 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
122 schema:name Medical and Health Sciences
123 rdf:type schema:DefinedTerm
124 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
125 schema:name Clinical Sciences
126 rdf:type schema:DefinedTerm
127 sg:journal.1050675 schema:issn 1166-2654
128 2051-4190
129 schema:name Basic and Clinical Andrology
130 rdf:type schema:Periodical
131 sg:person.01017351377.73 schema:affiliation https://www.grid.ac/institutes/grid.412956.d
132 schema:familyName Aslamkhan
133 schema:givenName Muhammad
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017351377.73
135 rdf:type schema:Person
136 sg:person.01043352211.40 schema:affiliation https://www.grid.ac/institutes/grid.8302.9
137 schema:familyName Aydin
138 schema:givenName Hikmet Hakan
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043352211.40
140 rdf:type schema:Person
141 sg:person.011470434503.10 schema:affiliation https://www.grid.ac/institutes/grid.419157.f
142 schema:familyName Gonzalez
143 schema:givenName Gerardo Rodriguez
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011470434503.10
145 rdf:type schema:Person
146 sg:person.01162176430.74 schema:affiliation https://www.grid.ac/institutes/grid.459922.1
147 schema:familyName Bhatti
148 schema:givenName Shahzad
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162176430.74
150 rdf:type schema:Person
151 sg:person.012034573537.99 schema:affiliation N2db0a07210d6450bbada8867670f9793
152 schema:familyName Khan
153 schema:givenName Yousaf Latif
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012034573537.99
155 rdf:type schema:Person
156 sg:person.013427534537.51 schema:affiliation https://www.grid.ac/institutes/grid.419157.f
157 schema:familyName Gonzalez
158 schema:givenName Rosa Maria Marquez
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013427534537.51
160 rdf:type schema:Person
161 sg:person.015626415221.67 schema:affiliation N43a4d086902d48bba003f71f7dd80a3b
162 schema:familyName Abbas
163 schema:givenName Sana
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015626415221.67
165 rdf:type schema:Person
166 sg:person.07644252137.82 schema:affiliation Ne32bb92566b149ac9165707206ec63d0
167 schema:familyName Khan
168 schema:givenName Haroon Latif
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07644252137.82
170 rdf:type schema:Person
171 sg:pub.10.1007/978-3-319-46086-4_14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084687814
172 https://doi.org/10.1007/978-3-319-46086-4_14
173 rdf:type schema:CreativeWork
174 sg:pub.10.1007/s11154-015-9322-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021281805
175 https://doi.org/10.1007/s11154-015-9322-3
176 rdf:type schema:CreativeWork
177 sg:pub.10.1007/s11783-014-0679-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015192347
178 https://doi.org/10.1007/s11783-014-0679-4
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/aps.2014.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025297311
181 https://doi.org/10.1038/aps.2014.18
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/npp.2017.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085082683
184 https://doi.org/10.1038/npp.2017.76
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/nrurol.2015.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005325657
187 https://doi.org/10.1038/nrurol.2015.13
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/onc.2013.235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004333053
190 https://doi.org/10.1038/onc.2013.235
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/sj.ijir.3901250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031525597
193 https://doi.org/10.1038/sj.ijir.3901250
194 rdf:type schema:CreativeWork
195 sg:pub.10.1186/s12991-015-0074-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1050961258
196 https://doi.org/10.1186/s12991-015-0074-y
197 rdf:type schema:CreativeWork
198 sg:pub.10.2165/00003495-200767110-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007406388
199 https://doi.org/10.2165/00003495-200767110-00006
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/smrj.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038146917
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/0006-8993(87)91333-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012303743
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.biopsych.2015.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018968593
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.esxm.2016.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011873891
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.euf.2016.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037107020
210 https://app.dimensions.ai/details/publication/pub.1090778610
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.eururo.2007.01.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029260719
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.jsxm.2016.11.262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025919814
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.jsxm.2017.03.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085002548
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.jsxm.2017.04.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085606989
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.juro.2016.11.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007709679
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.pbb.2013.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052640850
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.psyneuen.2008.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037116532
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.yhbeh.2016.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025561291
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1037/0278-6133.20.2.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051211374
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1074/jbc.m117.779041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084153229
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1093/ajcn/60.1.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082611267
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1097/hrp.0b013e3182a75b7d schema:sameAs https://app.dimensions.ai/details/publication/pub.1035522619
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/andr.12068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004148913
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/brv.12175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027452315
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1111/j.1365-2605.2010.01059.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025548894
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1600-0447.2012.01870.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015443509
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1743-6109.2005.20350.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035699314
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.1743-6109.2009.01701.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000816283
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1111/j.1743-6109.2011.02521.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028657838
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1111/j.1743-6109.2012.02735.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021613714
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/jsm.12504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026528161
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1146/annurev-physiol-030212-183656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042466948
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1158/1078-0432.ccr-12-3601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031837444
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1177/0269881112473788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012042349
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1210/en.2006-1237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248319
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1210/jc.2014-4434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064295642
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1371/journal.pone.0138848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004554872
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1503/cmaj.140688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022862047
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1530/eje.1.01860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004145071
269 rdf:type schema:CreativeWork
270 https://doi.org/10.21037/tau.2016.05.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043618736
271 rdf:type schema:CreativeWork
272 https://doi.org/10.21037/tau.2016.07.06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032147770
273 rdf:type schema:CreativeWork
274 https://doi.org/10.2164/jandrol.05070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002169020
275 rdf:type schema:CreativeWork
276 https://doi.org/10.3109/13685538.2015.1004049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022303538
277 rdf:type schema:CreativeWork
278 https://doi.org/10.3109/14767058.2015.1077513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029320213
279 rdf:type schema:CreativeWork
280 https://www.grid.ac/institutes/grid.412956.d schema:alternateName University of Health Sciences Lahore
281 schema:name Department of Human Genetics and Molecular biology, University of Health Sciences, -54600, Lahore, Pakistan
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.419157.f schema:alternateName Mexican Social Security Institute
284 schema:name Centro de investigacion Biomedica de Occidente, IMSS, Uiversidad de Guadalajara, Jalisco Maxico, Guadalajara, Mexico
285 Universidad De Guadalajara CIBO, IMSS, Sierra Mojada 800 Independencia, 44340, Guadalajara, Jalisco Maxicom, Mexico
286 rdf:type schema:Organization
287 https://www.grid.ac/institutes/grid.459922.1 schema:alternateName Rashid Latif Medical College
288 schema:name Department of Human Genetics and Molecular biology, University of Health Sciences, -54600, Lahore, Pakistan
289 Department of Medical Education, Rashid Latif Medical College, Lahore, Pakistan
290 Institute of Molecular Biology and Biotechnology, The University of Lahore, 54600, Lahore, Pakistan
291 Lahore Institute of fertility and Endocrinology, Hameed Latif Hospital, 14 – Abu Bakar Block, New Garden Town, Lahore, Pakistan
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.8302.9 schema:alternateName Ege University
294 schema:name Department of Medical Biochemistry, Ege University School of Medicine, Bornova, Izmir, Turkey
295 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...