Ameliorating potency of Chenopodium album Linn. and vitamin C against mercuric chloride-induced oxidative stress in testes of Sprague Dawley rats View Full Text


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Article Info

DATE

2019-11-23

AUTHORS

Sarwat Jahan, Tayyaba Azad, Amina Ayub, Asad Ullah, Tayyaba Afsar, Ali Almajwal, Suhail Razak

ABSTRACT

BackgroundMercury has been documented as an industrial risk that posed a serious danger to human health. Mercury exposure results in oxidative stress that may lead to the pathogenesis of male reproductive dysfunction. The present study investigated the ameliorating potential of Chenopodium album L. and vitamin C against mercuric chloride-induced oxidative deterioration of reproductive functions in adult male rats.MethodsGroup 1 (control) received saline. Group 2 received Mercury (0.15 mg/kg b.w, i.p) dissolved in distilled water. Groups 3 and 4 were given oral gavage of vitamin C (200 mg/kg b.w) and the ethanolic extract of C. album (200 mg/kg b.w) respectively, along with Mercury (0.15 mg/kg b.w, i.p). Group 5 was treated only with C. album (200 mg/kg b.w). After 30 days of the treatment, the rats were dissected and their testicular tissue and the cauda epididymis were used for biochemical analysis while blood plasma was used for protein determination.ResultsThe applied dose-treatment of Mercury-induced oxidative stress in the testis and cauda epididymis tissues of the rats was apparent by a noteworthy decrease in total protein, CAT, SOD, POD, and GST values while there was increase in ROS and TBARS levels. Furthermore, Mercury decreases daily sperm production and enhanced sperm DNA damage as noticeable by an increase in the head and tail length of comets and decrease in intact DNA. There was no significant effect on the body weight and the weight of the reproductive tissues. Treatment with C. album significantly ameliorated the total protein, ROS, and TBARS content. Similarly, the level of CAT, SOD, POD, and GST was significantly improved and the daily sperm production was significantly increased. Furthermore, C. album administration significantly protected Mercury-induced sperm DNA damage. The results of the extract treatment group were compared with those of vitamin C in detoxifying the oxidative stress and restoring the sperm parameters.ConclusionC. album showed protection against Mercury-induced oxidative stress by ameliorating antioxidant enzyme activity, daily sperm production, and DNA damage in rat testes. This suggests that C. album could be beneficial against toxicity induced by an environmental toxicant. More... »

PAGES

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References to SciGraph publications

  • 2018-11-21. Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats in BMC UROLOGY
  • 2009-11-25. Histological and morphometric analyses of seasonal testicular variations in the Jungle Crow (Corvus macrorhynchos) in ANATOMICAL SCIENCE INTERNATIONAL
  • 2006-09. Effect of methyl mercury induced free radical stress on nucleic acids and protein: Implications on cognitive and motor functions in INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
  • 2015-04-07. Chenopodium album Linn: review of nutritive value and biological properties in JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
  • 2019-06-07. Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children’s Study (JECS) in ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
  • 1999-10-01. Toxicity of mercury in JOURNAL OF HUMAN HYPERTENSION
  • 1975. Hormonal Regulation of the Seminiferous Tubule Function in HORMONAL REGULATION OF SPERMATOGENESIS
  • 1997-08. A stereological study of dorsal root ganglion cells and nerve root fibers from rats treated with inorganic mercury in ACTA NEUROPATHOLOGICA
  • 1995. Mercury Toxicity in TOXICOLOGY OF METALS
  • 2017-06-12. Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2019-05-17. Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan in ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
  • 2017-12-21. Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats in BMC CANCER
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    33 schema:description BackgroundMercury has been documented as an industrial risk that posed a serious danger to human health. Mercury exposure results in oxidative stress that may lead to the pathogenesis of male reproductive dysfunction. The present study investigated the ameliorating potential of Chenopodium album L. and vitamin C against mercuric chloride-induced oxidative deterioration of reproductive functions in adult male rats.MethodsGroup 1 (control) received saline. Group 2 received Mercury (0.15 mg/kg b.w, i.p) dissolved in distilled water. Groups 3 and 4 were given oral gavage of vitamin C (200 mg/kg b.w) and the ethanolic extract of C. album (200 mg/kg b.w) respectively, along with Mercury (0.15 mg/kg b.w, i.p). Group 5 was treated only with C. album (200 mg/kg b.w). After 30 days of the treatment, the rats were dissected and their testicular tissue and the cauda epididymis were used for biochemical analysis while blood plasma was used for protein determination.ResultsThe applied dose-treatment of Mercury-induced oxidative stress in the testis and cauda epididymis tissues of the rats was apparent by a noteworthy decrease in total protein, CAT, SOD, POD, and GST values while there was increase in ROS and TBARS levels. Furthermore, Mercury decreases daily sperm production and enhanced sperm DNA damage as noticeable by an increase in the head and tail length of comets and decrease in intact DNA. There was no significant effect on the body weight and the weight of the reproductive tissues. Treatment with C. album significantly ameliorated the total protein, ROS, and TBARS content. Similarly, the level of CAT, SOD, POD, and GST was significantly improved and the daily sperm production was significantly increased. Furthermore, C. album administration significantly protected Mercury-induced sperm DNA damage. The results of the extract treatment group were compared with those of vitamin C in detoxifying the oxidative stress and restoring the sperm parameters.ConclusionC. album showed protection against Mercury-induced oxidative stress by ameliorating antioxidant enzyme activity, daily sperm production, and DNA damage in rat testes. This suggests that C. album could be beneficial against toxicity induced by an environmental toxicant.
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    40 C. album
    41 Chenopodium album L.
    42 Chenopodium album Linn
    43 DNA
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    45 Dawley
    46 GST
    47 GST values
    48 L.
    49 Linn
    50 MethodsGroup 1
    51 ROS
    52 ResultsThe
    53 SOD
    54 Sprague-Dawley
    55 TBARS content
    56 TBARS levels
    57 activity
    58 administration
    59 adult male rats
    60 album
    61 analysis
    62 antioxidant enzyme activities
    63 biochemical analysis
    64 blood plasma
    65 body weight
    66 cats
    67 cauda epididymis
    68 comets
    69 content
    70 daily sperm production
    71 damage
    72 danger
    73 days
    74 decrease
    75 deterioration
    76 determination
    77 distilled water
    78 dysfunction
    79 effect
    80 environmental toxicants
    81 enzyme activity
    82 epididymis
    83 epididymis tissues
    84 ethanolic extract
    85 exposure
    86 extract
    87 extract treatment group
    88 function
    89 gavage
    90 group
    91 group 2
    92 group 3
    93 group 5
    94 head
    95 health
    96 human health
    97 increase
    98 industrial risks
    99 intact DNA
    100 length
    101 levels
    102 levels of CAT
    103 male rats
    104 male reproductive dysfunction
    105 mercuric chloride-induced oxidative stress
    106 mercury
    107 mercury exposure
    108 noteworthy decrease
    109 oral gavage
    110 oxidative deterioration
    111 oxidative stress
    112 parameters
    113 pathogenesis
    114 plasma
    115 pods
    116 potency
    117 potential
    118 present study
    119 production
    120 protection
    121 protein
    122 protein determination
    123 rat testis
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    125 reproductive dysfunction
    126 reproductive function
    127 reproductive tissues
    128 results
    129 risk
    130 saline
    131 serious danger
    132 significant effect
    133 sperm DNA damage
    134 sperm parameters
    135 sperm production
    136 stress
    137 study
    138 tail length
    139 testicular tissue
    140 testis
    141 tissue
    142 total protein
    143 toxicants
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    145 treatment
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    147 values
    148 vitamin C
    149 water
    150 weight
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