Determinants of polyunsaturated fatty acid concentrations in erythrocytes of pregnant Japanese women from a birth cohort study: study protocol and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04-04

AUTHORS

Shoji Saito, Terue Kawabata, Nozomi Tatsuta, Fumiko Kimura, Teruo Miyazawa, Satoshi Mizuno, Hidekazu Nishigori, Takahiro Arima, Yasuo Kagawa, Kouichi Yoshimasu, Kanami Tsuno, Yuki Ito, Michihiro Kamijima, Kunihiko Nakai, Nobuo Yaegashi,

ABSTRACT

BACKGROUND: N-3 polyunsaturated fatty acids (n-3 PUFA) may have multiple beneficial effects on the outcome of pregnancy, maternal health and child development. The present study introduced the protocol of a birth cohort study to examine the beneficial effects of n-3 PUFA status in pregnant Japanese women as an adjunct study of the Japan Environment and Children's Study (JECS). METHODS: The JECS participants in the coastal areas of Miyagi Prefecture were further invited to participate in this adjunct study, and 1,878 pregnant women were enrolled prior to delivery. Their n-3 PUFA status was evaluated with fatty acid profiles in erythrocytes of maternal blood collected from 1,623 mothers at 24-30 weeks of gestation and cord blood from 1,505 deliveries. RESULTS: The baseline results, including comprehensive data on the fatty acid status and determinants affecting the PUFA status, were analyzed. In stepwise multivariate analyses, the cord blood docosahexaenoic acid (DHA) level was found to be significantly influenced by the DHA level in maternal blood, the child's sex, and the gestational period. The maternal DHA level was influenced by fish intake, maternal age, and the prepregnancy body mass index. While cord blood eicosapentaenoic acid (EPA) was influenced by maternal EPA, fish intake, and season at birth, additional factors such as maternal education, household income, and smoking habits affected the maternal EPA content. CONCLUSION: Further studies are warranted to clarify the nutritional impacts of n-3 PUFA in pregnant Japanese women of the cohort study. More... »

PAGES

22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12199-017-0636-5

DOI

http://dx.doi.org/10.1186/s12199-017-0636-5

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https://app.dimensions.ai/details/publication/pub.1084612310

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29165130


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24 schema:description BACKGROUND: N-3 polyunsaturated fatty acids (n-3 PUFA) may have multiple beneficial effects on the outcome of pregnancy, maternal health and child development. The present study introduced the protocol of a birth cohort study to examine the beneficial effects of n-3 PUFA status in pregnant Japanese women as an adjunct study of the Japan Environment and Children's Study (JECS). METHODS: The JECS participants in the coastal areas of Miyagi Prefecture were further invited to participate in this adjunct study, and 1,878 pregnant women were enrolled prior to delivery. Their n-3 PUFA status was evaluated with fatty acid profiles in erythrocytes of maternal blood collected from 1,623 mothers at 24-30 weeks of gestation and cord blood from 1,505 deliveries. RESULTS: The baseline results, including comprehensive data on the fatty acid status and determinants affecting the PUFA status, were analyzed. In stepwise multivariate analyses, the cord blood docosahexaenoic acid (DHA) level was found to be significantly influenced by the DHA level in maternal blood, the child's sex, and the gestational period. The maternal DHA level was influenced by fish intake, maternal age, and the prepregnancy body mass index. While cord blood eicosapentaenoic acid (EPA) was influenced by maternal EPA, fish intake, and season at birth, additional factors such as maternal education, household income, and smoking habits affected the maternal EPA content. CONCLUSION: Further studies are warranted to clarify the nutritional impacts of n-3 PUFA in pregnant Japanese women of the cohort study.
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31 schema:keywords Children's Study
32 DHA levels
33 EPA content
34 Further studies
35 JECS participants
36 Japan Environment
37 Japanese women
38 Miyagi Prefecture
39 PUFA
40 PUFA status
41 Prefecture
42 acid
43 acid concentration
44 acid levels
45 acid profile
46 acid status
47 additional factors
48 adjunct study
49 age
50 analysis
51 area
52 baseline findings
53 baseline results
54 beneficial effects
55 birth
56 birth cohort study
57 blood
58 blood eicosapentaenoic acid
59 body mass index
60 child development
61 child sex
62 coastal areas
63 cohort study
64 comprehensive data
65 concentration
66 content
67 cord blood
68 cord blood eicosapentaenoic acid
69 data
70 delivery
71 determinants
72 development
73 education
74 effect
75 eicosapentaenoic acid
76 environment
77 erythrocytes
78 factors
79 fatty acid concentrations
80 fatty acid profile
81 fatty acid status
82 fatty acids
83 findings
84 fish intake
85 gestation
86 gestational period
87 habits
88 health
89 household income
90 impact
91 income
92 index
93 intake
94 levels
95 mass index
96 maternal DHA levels
97 maternal EPA content
98 maternal age
99 maternal blood
100 maternal education
101 maternal eicosapentaenoic acid
102 maternal health
103 mothers
104 multiple beneficial effects
105 multivariate analysis
106 nutritional impact
107 outcome of pregnancy
108 outcomes
109 participants
110 period
111 pregnancy
112 pregnant Japanese women
113 pregnant women
114 prepregnancy body mass index
115 present study
116 profile
117 protocol
118 results
119 season
120 sex
121 smoking habits
122 status
123 stepwise multivariate analysis
124 study
125 study protocol
126 weeks
127 weeks of gestation
128 women
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