Piperlongumine-Eluting Gastrointestinal Stent Using Reactive Oxygen Species-Sensitive Nanofiber Mats for Inhibition of Cholangiocarcinoma Cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02-18

AUTHORS

Hyung Ha Jang, Su Bum Park, Jeong Sup Hong, Hye Lim Lee, Yeon Hui Song, Jungsoo Kim, Yun Hye Jung, Chan Kim, Doo-Man Kim, Sang Eun Lee, Young-Il Jeong, Dae Hwan Kang

ABSTRACT

BACKGROUND: The aim of this study is to fabricate drug-eluting gastrointestinal (GI) stent using reactive oxygen species (ROS)-sensitive nanofiber mats for treatment of cholangiocarcinoma (CCA) cell. A ROS-producing agent, piperlongumine (PL)-incorporated nanofiber mats were investigated for drug-eluting stent (DES) application. METHODS: Selenocystamine-conjugated methoxy poly(ethylene glycol) (MePEG) was conjugated with poly(L-lactide) (PLA) to produce block copolymer (LEse block copolymer). Various ratios of poly(ε-caprolactone) (PCL) and LEse block copolymer were dissolved in organic solvent with PL, and then nanofiber mats were fabricated by electro-spinning techniques. RESULTS: The higher amount of LEse in the blend of PCL/LEse resulted in the formation of granules while PCL alone showed fine nanofiber structure. Nanofiber mats composed of PCL/LEse polymer blend showed ROS-sensitive drug release, i.e., PL release rate from nanofiber mats was accelerated in the presence of hydrogen peroxide (H2O2) while nanofiber mats of PCL alone have small changes in drug release rate, indicating that PL-incorporated nanofiber membranes have ROS responsiveness. PL itself and PL released from nanofiber mats showed almost similar anticancer activity against various CCA cells. Furthermore, PL released from nanofiber mats properly produced ROS generation and induced apoptosis of CCA cells as well as PL itself. In HuCC-T1 cell-bearing mice, PL-incorporated nanofiber mats showed improvement in anticancer activity. CONCLUSION: PL-incorporated ROS-sensitive nanofiber mats were coated onto GI stent and showed improved anticancer activity with ROS responsiveness. We suggested PL-incorporated ROS-sensitive nanofiber mats as a promising candidate for local treatment of CCA cells. More... »

PAGES

58

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s11671-019-2887-0

DOI

http://dx.doi.org/10.1186/s11671-019-2887-0

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https://app.dimensions.ai/details/publication/pub.1112212644

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30778693


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29 LEse polymer blend
30 Lese
31 Oxygen Species-Sensitive Nanofiber Mats
32 PCL
33 PCL/LEse
34 PCL/LEse polymer blend
35 PL
36 PL release rate
37 ROS
38 ROS generation
39 ROS responsiveness
40 ROS-sensitive drug release
41 ROS-sensitive nanofiber mats
42 Reactive Oxygen Species-Sensitive Nanofiber Mats
43 Selenocystamine-conjugated methoxy
44 Species-Sensitive Nanofiber Mats
45 activity
46 agents
47 aim
48 amount
49 anticancer activity
50 apoptosis
51 applications
52 blends
53 block copolymers
54 candidates
55 cell-bearing mice
56 cells
57 changes
58 cholangiocarcinoma cells
59 copolymers
60 drug release
61 drug release rate
62 drug-eluting gastrointestinal
63 drug-eluting stent (DES) application
64 electro
65 fine nanofiber structure
66 formation
67 formation of granules
68 gastrointestinal
69 gastrointestinal stents
70 generation
71 granules
72 high amounts
73 hydrogen peroxide
74 improved anticancer activity
75 improvement
76 induced apoptosis
77 inhibition
78 local treatment
79 mats
80 membrane
81 methoxy
82 mice
83 nanofiber mats
84 nanofiber membranes
85 nanofiber structure
86 organic solvents
87 oxygen species
88 peroxide
89 piperlongumine
90 polymer blends
91 presence
92 promising candidate
93 rate
94 ratio
95 reactive oxygen species
96 release
97 release rate
98 responsiveness
99 sensitive nanofiber mats
100 similar anticancer activity
101 small changes
102 solvent
103 species
104 stent application
105 stents
106 structure
107 study
108 technique
109 treatment
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