Hepatotoxicity and Drug/Chemical Interaction Toxicity of Nanoclay Particles in Mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-16

AUTHORS

Katsuhiro Isoda, Ryutaro Nagata, Tomoya Hasegawa, Yuichiro Taira, Ikuko Taira, Yoshimi Shimizu, Kazuo Isama, Tetsuji Nishimura, Isao Ishida

ABSTRACT

Nanomaterials are relatively new and unconventional materials with many useful properties, but their effects on biological systems are poorly understood. Nanoclay is a general term for layered mineral silicate nanoparticles that are ideally suited for use in clay-based nanocomposites. The potential biological hazards of nanoclays have not been addressed, however. Therefore, we investigated the in vivo effects and drug interactions of nanoclays. In mice, administration of nanoclay particles via the tail vein led to acute liver injury. Co-administration of nanoclay and carbon tetrachloride, paraquat, or cisplatin resulted in both liver and kidney injury. Our findings thus indicate that nanoclay particles are potentially hepato- and nephrotoxic. More... »

PAGES

199

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s11671-017-1956-5

DOI

http://dx.doi.org/10.1186/s11671-017-1956-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084249776

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28314361


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