C60 Fullerene as Promising Therapeutic Agent for the Prevention and Correction of Skeletal Muscle Functioning at Ischemic Injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

D. M. Nozdrenko, D. O. Zavodovskyi, T. Yu. Matvienko, S. Yu. Zay, K. I. Bogutska, Yu. I. Prylutskyy, U. Ritter, P. Scharff

ABSTRACT

The therapeutic effect of pristine C60 fullerene aqueous colloid solution (C60FAS) on the functioning of the rat soleus muscle at ischemic injury depending on the time of the general pathogenesis of muscular system and method of administration C60FAS in vivo was investigated. It was found that intravenous administration of C60FAS is the optimal for correction of speed macroparameters of contraction for ischemic muscle damage. At the same time, intramuscular administration of C60FAS shows pronounced protective effect in movements associated with the generation of maximum force responses or prolonged contractions, which increase the muscle fatigue level. Analysis of content concentration of creatine phosphokinase and lactate dehydrogenase enzymes in the blood of experimental animals indicates directly that C60FAS may be a promising therapeutic agent for the prevention and correction of ischemic-damaged skeletal muscle function. More... »

PAGES

115

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s11671-017-1876-4

DOI

http://dx.doi.org/10.1186/s11671-017-1876-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083826100

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28228000


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43 schema:description The therapeutic effect of pristine C<sub>60</sub> fullerene aqueous colloid solution (C<sub>60</sub>FAS) on the functioning of the rat soleus muscle at ischemic injury depending on the time of the general pathogenesis of muscular system and method of administration C<sub>60</sub>FAS in vivo was investigated. It was found that intravenous administration of C<sub>60</sub>FAS is the optimal for correction of speed macroparameters of contraction for ischemic muscle damage. At the same time, intramuscular administration of C<sub>60</sub>FAS shows pronounced protective effect in movements associated with the generation of maximum force responses or prolonged contractions, which increase the muscle fatigue level. Analysis of content concentration of creatine phosphokinase and lactate dehydrogenase enzymes in the blood of experimental animals indicates directly that C<sub>60</sub>FAS may be a promising therapeutic agent for the prevention and correction of ischemic-damaged skeletal muscle function.
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