Complex of C60 Fullerene with Doxorubicin as a Promising Agent in Antitumor Therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Svitlana V. Prylutska, Larysa M. Skivka, Gennadiy V. Didenko, Yuriy I. Prylutskyy, Maxim P. Evstigneev, Grygoriy P. Potebnya, Rostyslav R. Panchuk, Rostyslav S. Stoika, Uwe Ritter, Peter Scharff

ABSTRACT

The main aim of this work was to evaluate the effect of doxorubicin in complex with C60 fullerene (C60 + Dox) on the growth and metastasis of Lewis lung carcinoma in mice and to perform a primary screening of the potential mechanisms of C60 + Dox complex action. We found that volume of tumor from mice treated with the C60 + Dox complex was 1.4 times less than that in control untreated animals. The number of metastatic foci in lungs of animals treated with C60 + Dox complex was two times less than that in control untreated animals. Western blot analysis of tumor lysates revealed a significant decrease in the level of heat-shock protein 70 in animals treated with C60 + Dox complex. Moreover, the treatment of tumor-bearing mice was accompanied by the increase of cytotoxic activity of immune cells. Thus, the potential mechanisms of antitumor effect of C60 + Dox complex include both its direct action on tumor cells by inducing cell death and increasing of stress sensitivity and an immunomodulating effect. The obtained results provide a scientific basis for further application of C60 + Dox nanocomplexes as treatment agents in cancer chemotherapy. More... »

PAGES

499

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s11671-015-1206-7

DOI

http://dx.doi.org/10.1186/s11671-015-1206-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052658781

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26714861


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