Ontology type: schema:ScholarlyArticle
2019-12
AUTHORSLeila Saremi, Shirin Lotfipanah, Masumeh Mohammadi, Hassan Hosseinzadeh, Mina Fathi-Kazerooni, Behrooz Johari, Zohreh Saltanatpour
ABSTRACTBackground: The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Several studies have demonstrated a significant association between Pro12Ala polymorphism of the PPAR-γ2 gene and metabolic disorders. Therefore, this study aimed to evaluate the association of Pro12Ala polymorphism with increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus. Methods: This cross-sectional study was performed on 145 healthy control subjects and 145 NAFLD patients with a history of type 2 diabetes. Pro12Ala polymorphism genotyping was performed using PCR-restriction fragment length polymorphism (RFLP) technique with the Bs1I restriction enzyme. Results: Our results demonstrated that CC and GG genotypes of Pro12Ala were found in the participants, but there was no statistically significant difference between NAFLD patients and healthy controls (P = 0.64 and χ2 = 0.21). Conclusion: This study suggests that Pro12Ala polymorphism of the PPAR-γ2 gene cannot be considered as a risk factor for NAFLD in the Iranian population. More... »
PAGES12
http://scigraph.springernature.com/pub.10.1186/s11658-019-0138-0
DOIhttp://dx.doi.org/10.1186/s11658-019-0138-0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112766954
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30923554
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Islamic Azad University, Science and Research Branch",
"id": "https://www.grid.ac/institutes/grid.472472.0",
"name": [
"Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran"
],
"type": "Organization"
},
"familyName": "Saremi",
"givenName": "Leila",
"type": "Person"
},
{
"affiliation": {
"name": [
"Farhangian University, Shahid Mofatteh Teacher Education Paradise, Tehran, Iran"
],
"type": "Organization"
},
"familyName": "Lotfipanah",
"givenName": "Shirin",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Islamic Azad University, Science and Research Branch",
"id": "https://www.grid.ac/institutes/grid.472472.0",
"name": [
"Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran"
],
"type": "Organization"
},
"familyName": "Mohammadi",
"givenName": "Masumeh",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yazd University",
"id": "https://www.grid.ac/institutes/grid.413021.5",
"name": [
"Department of Biology, Faculty of Science, Yazd University, Yazd, Iran"
],
"type": "Organization"
},
"familyName": "Hosseinzadeh",
"givenName": "Hassan",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tehran University of Medical Sciences",
"id": "https://www.grid.ac/institutes/grid.411705.6",
"name": [
"Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran"
],
"type": "Organization"
},
"familyName": "Fathi-Kazerooni",
"givenName": "Mina",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Zanjan University of Medical Sciences",
"id": "https://www.grid.ac/institutes/grid.469309.1",
"name": [
"Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran"
],
"type": "Organization"
},
"familyName": "Johari",
"givenName": "Behrooz",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tehran University of Medical Sciences",
"id": "https://www.grid.ac/institutes/grid.411705.6",
"name": [
"Medical Genetic Center, Endocrinology and Metabolism Research Institute (EMRI), Tehran University of Medical Sciences (TUMS), Tehran, Iran"
],
"type": "Organization"
},
"familyName": "Saltanatpour",
"givenName": "Zohreh",
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00296-006-0175-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000829581",
"https://doi.org/10.1007/s00296-006-0175-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00296-006-0175-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000829581",
"https://doi.org/10.1007/s00296-006-0175-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001250051268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001153018",
"https://doi.org/10.1007/s001250051268"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001250051268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001153018",
"https://doi.org/10.1007/s001250051268"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mcg.0000000000000116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003448284"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mcg.0000000000000116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003448284"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mcg.0000000000000116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003448284"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00296-005-0013-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006379140",
"https://doi.org/10.1007/s00296-005-0013-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00296-005-0013-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006379140",
"https://doi.org/10.1007/s00296-005-0013-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/db11-0231",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008215793"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/dc06-0513",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010485650"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.52.12.3010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011481198"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2009.01.050",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012153222"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2013/452061",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020727756"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/3099",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021923714",
"https://doi.org/10.1038/3099"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/3099",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021923714",
"https://doi.org/10.1038/3099"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/gtmb.2013.0503",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023123599"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1478-3231.2007.01483.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025140418"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1478-3231.2007.01483.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025140418"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10620-011-1994-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027001523",
"https://doi.org/10.1007/s10620-011-1994-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12072-010-9225-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031497324",
"https://doi.org/10.1007/s12072-010-9225-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.51.8.2341",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034258469"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-230x-10-102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034755411",
"https://doi.org/10.1186/1471-230x-10-102"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci28003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036640763"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mce.2011.09.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036919654"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.gene.2012.09.067",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038589665"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.biopha.2016.02.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039272739"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf03345355",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039833537",
"https://doi.org/10.1007/bf03345355"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.med.57.121304.131428",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044987211"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2298/abs1303809c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045614570"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hep.22726",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047403286"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/j.1572-0241.2001.04667.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047986226",
"https://doi.org/10.1111/j.1572-0241.2001.04667.x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4103/0971-6866.116126",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048339688"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1620/tjem.227.253",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048697862"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.gene.2013.06.091",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051757676"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/dia.2011.0277",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059249629"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/dna.2012.1947",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059252840"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmjgast-2014-000019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062809634"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmjgast-2014-000019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062809634"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem.85.5.6610",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064323541"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3748/wjg.14.22",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071360263"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3748/wjg.v16.i46.5830",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071367275"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3906/sag-1409-88",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071569662"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4183/aeb.2015.13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072347638"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7860/jcdr/2016/16494.7331",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074083014"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077257681",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077437784",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077654960",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3760/cma.j.issn.1003-9406.2009.01.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077846529"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.14715/cmb/2016.62.12.21",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1079360511"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.17306/j.afs.2017.0442",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084360054"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.17306/j.afs.0554",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104270089"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "Background: The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Several studies have demonstrated a significant association between Pro12Ala polymorphism of the PPAR-\u03b32 gene and metabolic disorders. Therefore, this study aimed to evaluate the association of Pro12Ala polymorphism with increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus.\nMethods: This cross-sectional study was performed on 145 healthy control subjects and 145 NAFLD patients with a history of type 2 diabetes. Pro12Ala polymorphism genotyping was performed using PCR-restriction fragment length polymorphism (RFLP) technique with the Bs1I restriction enzyme.\nResults: Our results demonstrated that CC and GG genotypes of Pro12Ala were found in the participants, but there was no statistically significant difference between NAFLD patients and healthy controls (P\u2009=\u20090.64 and \u03c72\u2009=\u20090.21).\nConclusion: This study suggests that Pro12Ala polymorphism of the PPAR-\u03b32 gene cannot be considered as a risk factor for NAFLD in the Iranian population.",
"genre": "research_article",
"id": "sg:pub.10.1186/s11658-019-0138-0",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1115467",
"issn": [
"1425-8153",
"1689-1392"
],
"name": "Cellular & Molecular Biology Letters",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "24"
}
],
"name": "The Pro12Ala polymorphism in the PPAR\u00ad\u03b32 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus",
"pagination": "12",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"cbbc560fe55fbe7af19e9411e6f079f8eae0e11edc9e78f310c3b7de9415d8ca"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30923554"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9607427"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s11658-019-0138-0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112766954"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s11658-019-0138-0",
"https://app.dimensions.ai/details/publication/pub.1112766954"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:55",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130811_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs11658-019-0138-0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0138-0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0138-0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0138-0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0138-0'
This table displays all metadata directly associated to this object as RDF triples.
254 TRIPLES
21 PREDICATES
73 URIs
21 LITERALS
9 BLANK NODES