Hypoxia protects against the cell death triggered by oxovanadium–galactomannan complexes in HepG2 cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Monique Meyenberg Cunha-de Padua, Guilhermina Rodrigues Noleto, Carmen Lucia de Oliveira Petkowicz, Silvia Maria Suter Correia Cadena, Frédéric Bost, Jacques Pouysségur, Nathalie M. Mazure

ABSTRACT

Background: Polysaccharides from various sources have been used in traditional medicine for centuries. The beneficial pharmacological effects of plant-derived polysaccharides include anti-tumor activity. Methods: Here, we evaluated the anti-cancer effect of the MSAGM:VO complex under hypoxic conditions (1% oxygen). MSAGM:VO is a complex of the hydrolysate of galactomannan (MSAGM) from Schizolobium amazonicum with oxovanadium (IV/V). The hepatocellular carcinoma (HCC) cell line HepG2 was selected as HCC are one of the most hypoxic solid tumors. Results: Our results showed that the strong apoptotic activity of MSAGM:VO observed in HepG2 cells under normoxic conditions was completely lost under hypoxic conditions. We found a dynamic balance between the pro- and anti-apoptotic members of the Bcl-2 protein family. The expressions of anti-apoptotic Mcl-1 and Bcl-XL increased in hypoxia, whereas the expression of pro-apoptotic Bax decreased. MSAGM:VO strongly induced autophagy, which was previously characterized as a pro-survival mechanism in hypoxia. These results demonstrate total elimination of the anti-cancer activity of MSAGM:VO with activation of autophagy under conditions of hypoxia. Conclusion: Although this study is a proof-of-concept of the impact of hypoxia on the potential of polysaccharides, further study is encouraged. The anti-tumor activity of polysaccharides could be achieved in normoxia or through raising the activity of the immune system. In addition, combination strategies for therapy with anti-autophagic drugs could be proposed. More... »

PAGES

18

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s11658-019-0135-3

DOI

http://dx.doi.org/10.1186/s11658-019-0135-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112840258

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30949212


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire", 
          "id": "https://www.grid.ac/institutes/grid.462370.4", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Brazil", 
            "Institute for Research on Cancer and Aging of Nice, CNRS-UMR 7284-Inserm U1081, University of Nice Sophia-Antipolis, Centre Antoine Lacassagne, 33 Ave. de Valombrose, 06189, Nice, France", 
            "Present Address: INSERM U1065, C3M, 151 Route de St Antoine de Ginesti\u00e8re, BP2 3194, 06204, Nice Cedex 03, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meyenberg Cunha-de Padua", 
        "givenName": "Monique", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noleto", 
        "givenName": "Guilhermina Rodrigues", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Oliveira Petkowicz", 
        "givenName": "Carmen Lucia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cadena", 
        "givenName": "Silvia Maria Suter Correia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire", 
          "id": "https://www.grid.ac/institutes/grid.462370.4", 
          "name": [
            "Present Address: INSERM U1065, C3M, 151 Route de St Antoine de Ginesti\u00e8re, BP2 3194, 06204, Nice Cedex 03, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bost", 
        "givenName": "Fr\u00e9d\u00e9ric", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scientific Centre of Monaco", 
          "id": "https://www.grid.ac/institutes/grid.452353.6", 
          "name": [
            "Institute for Research on Cancer and Aging of Nice, CNRS-UMR 7284-Inserm U1081, University of Nice Sophia-Antipolis, Centre Antoine Lacassagne, 33 Ave. de Valombrose, 06189, Nice, France", 
            "Medical Biology Department, Centre Scientifique de Monaco (CSM), Monaco, Monaco"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pouyss\u00e9gur", 
        "givenName": "Jacques", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire", 
          "id": "https://www.grid.ac/institutes/grid.462370.4", 
          "name": [
            "Institute for Research on Cancer and Aging of Nice, CNRS-UMR 7284-Inserm U1081, University of Nice Sophia-Antipolis, Centre Antoine Lacassagne, 33 Ave. de Valombrose, 06189, Nice, France", 
            "Present Address: INSERM U1065, C3M, 151 Route de St Antoine de Ginesti\u00e8re, BP2 3194, 06204, Nice Cedex 03, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazure", 
        "givenName": "Nathalie M.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2147/jhc.s61146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005649601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinorgbio.2013.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010386931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cbi.2006.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014311777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5897/ajb2003.000-1123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014808832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2319-4170.138318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014860042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-7827-10-104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015448834", 
          "https://doi.org/10.1186/1477-7827-10-104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.02246-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016427684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018799319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018799319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.7.2875-2889.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018906872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/oncsis.2015.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023064918", 
          "https://doi.org/10.1038/oncsis.2015.50"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023231275", 
          "https://doi.org/10.1038/nature04871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023231275", 
          "https://doi.org/10.1038/nature04871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023231275", 
          "https://doi.org/10.1038/nature04871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-3940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023239887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejmech.2014.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025124302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2010.01.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025154086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.imlet.2006.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025765017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.16.9082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025952609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.carbpol.2012.07.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026233386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinorgbio.2015.03.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026955216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2011.01642.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027521705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2005.00065.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029284650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20030613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033567346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.21984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033764373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.21984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033764373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.46.32631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035211390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinorgbio.2009.01.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036583821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01402-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037699149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01402-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037699149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m805997200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037745935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1541-4337.12161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039446933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1040-8428(01)00221-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041150175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.carres.2016.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041834061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.carres.2016.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041834061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00166-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051726150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1015566312032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052359646", 
          "https://doi.org/10.1023/a:1015566312032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/bjr.20130676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064565224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.5278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072290526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074881940", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1684/bdc.2011.1360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078401775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080900437", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijbiomac.2017.03.090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084079459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.carbpol.2017.06.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085915110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.carbpol.2017.06.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085915110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-017-1387-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090283906", 
          "https://doi.org/10.1007/s10495-017-1387-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-017-1387-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090283906", 
          "https://doi.org/10.1007/s10495-017-1387-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-017-1421-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091566007", 
          "https://doi.org/10.1007/s10495-017-1421-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Background: Polysaccharides from various sources have been used in traditional medicine for centuries. The beneficial pharmacological effects of plant-derived polysaccharides include anti-tumor activity.\nMethods: Here, we evaluated the anti-cancer effect of the MSAGM:VO complex under hypoxic conditions (1% oxygen). MSAGM:VO is a complex of the hydrolysate of galactomannan (MSAGM) from Schizolobium amazonicum with oxovanadium (IV/V). The hepatocellular carcinoma (HCC) cell line HepG2 was selected as HCC are one of the most hypoxic solid tumors.\nResults: Our results showed that the strong apoptotic activity of MSAGM:VO observed in HepG2 cells under normoxic conditions was completely lost under hypoxic conditions. We found a dynamic balance between the pro- and anti-apoptotic members of the Bcl-2 protein family. The expressions of anti-apoptotic Mcl-1 and Bcl-XL increased in hypoxia, whereas the expression of pro-apoptotic Bax decreased. MSAGM:VO strongly induced autophagy, which was previously characterized as a pro-survival mechanism in hypoxia. These results demonstrate total elimination of the anti-cancer activity of MSAGM:VO with activation of autophagy under conditions of hypoxia.\nConclusion: Although this study is a proof-of-concept of the impact of hypoxia on the potential of polysaccharides, further study is encouraged. The anti-tumor activity of polysaccharides could be achieved in normoxia or through raising the activity of the immune system. In addition, combination strategies for therapy with anti-autophagic drugs could be proposed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s11658-019-0135-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1115467", 
        "issn": [
          "1425-8153", 
          "1689-1392"
        ], 
        "name": "Cellular & Molecular Biology Letters", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "Hypoxia protects against the cell death triggered by oxovanadium\u2013galactomannan complexes in HepG2 cells", 
    "pagination": "18", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s11658-019-0135-3"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "43c43a2c65b67f122b66b551fdb2a81b4ad55aa2e1d95caec1553aa943460394"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112840258"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9607427"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30949212"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s11658-019-0135-3", 
      "https://app.dimensions.ai/details/publication/pub.1112840258"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91456_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs11658-019-0135-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0135-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0135-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0135-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0135-3'


 

This table displays all metadata directly associated to this object as RDF triples.

237 TRIPLES      21 PREDICATES      69 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s11658-019-0135-3 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nc79d79c82b484b4b92d1b60017447366
4 schema:citation sg:pub.10.1007/s10495-017-1387-x
5 sg:pub.10.1007/s10495-017-1421-z
6 sg:pub.10.1023/a:1015566312032
7 sg:pub.10.1038/nature04871
8 sg:pub.10.1038/oncsis.2015.50
9 sg:pub.10.1186/1477-7827-10-104
10 https://app.dimensions.ai/details/publication/pub.1074881940
11 https://app.dimensions.ai/details/publication/pub.1080900437
12 https://doi.org/10.1002/jcb.20683
13 https://doi.org/10.1002/jcp.21984
14 https://doi.org/10.1016/j.canlet.2010.01.030
15 https://doi.org/10.1016/j.carbpol.2012.07.026
16 https://doi.org/10.1016/j.carbpol.2017.06.027
17 https://doi.org/10.1016/j.carres.2016.02.008
18 https://doi.org/10.1016/j.cbi.2006.08.006
19 https://doi.org/10.1016/j.ejmech.2014.12.003
20 https://doi.org/10.1016/j.ijbiomac.2017.03.090
21 https://doi.org/10.1016/j.imlet.2006.01.009
22 https://doi.org/10.1016/j.jinorgbio.2009.01.018
23 https://doi.org/10.1016/j.jinorgbio.2013.10.009
24 https://doi.org/10.1016/j.jinorgbio.2015.03.016
25 https://doi.org/10.1016/s1040-8428(01)00221-9
26 https://doi.org/10.1073/pnas.97.16.9082
27 https://doi.org/10.1074/jbc.274.46.32631
28 https://doi.org/10.1074/jbc.m805997200
29 https://doi.org/10.1084/jem.20030613
30 https://doi.org/10.1111/1541-4337.12161
31 https://doi.org/10.1111/j.1349-7006.2005.00065.x
32 https://doi.org/10.1111/j.1462-5822.2011.01642.x
33 https://doi.org/10.1128/mcb.00166-09
34 https://doi.org/10.1128/mcb.01402-14
35 https://doi.org/10.1128/mcb.02246-06
36 https://doi.org/10.1128/mcb.24.7.2875-2889.2004
37 https://doi.org/10.1158/0008-5472.can-11-3940
38 https://doi.org/10.1259/bjr.20130676
39 https://doi.org/10.1684/bdc.2011.1360
40 https://doi.org/10.2147/jhc.s61146
41 https://doi.org/10.4103/2319-4170.138318
42 https://doi.org/10.4161/auto.5278
43 https://doi.org/10.5897/ajb2003.000-1123
44 schema:datePublished 2019-12
45 schema:datePublishedReg 2019-12-01
46 schema:description Background: Polysaccharides from various sources have been used in traditional medicine for centuries. The beneficial pharmacological effects of plant-derived polysaccharides include anti-tumor activity. Methods: Here, we evaluated the anti-cancer effect of the MSAGM:VO complex under hypoxic conditions (1% oxygen). MSAGM:VO is a complex of the hydrolysate of galactomannan (MSAGM) from Schizolobium amazonicum with oxovanadium (IV/V). The hepatocellular carcinoma (HCC) cell line HepG2 was selected as HCC are one of the most hypoxic solid tumors. Results: Our results showed that the strong apoptotic activity of MSAGM:VO observed in HepG2 cells under normoxic conditions was completely lost under hypoxic conditions. We found a dynamic balance between the pro- and anti-apoptotic members of the Bcl-2 protein family. The expressions of anti-apoptotic Mcl-1 and Bcl-XL increased in hypoxia, whereas the expression of pro-apoptotic Bax decreased. MSAGM:VO strongly induced autophagy, which was previously characterized as a pro-survival mechanism in hypoxia. These results demonstrate total elimination of the anti-cancer activity of MSAGM:VO with activation of autophagy under conditions of hypoxia. Conclusion: Although this study is a proof-of-concept of the impact of hypoxia on the potential of polysaccharides, further study is encouraged. The anti-tumor activity of polysaccharides could be achieved in normoxia or through raising the activity of the immune system. In addition, combination strategies for therapy with anti-autophagic drugs could be proposed.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N3aecb853e8864edda68a797f1e9c5476
51 Nd9006fc6bd6d40dcac0a14318b931c2e
52 sg:journal.1115467
53 schema:name Hypoxia protects against the cell death triggered by oxovanadium–galactomannan complexes in HepG2 cells
54 schema:pagination 18
55 schema:productId N1a2b4ac9f62942e896da1f09caa70c07
56 N7c05c9071ce74c23a30c4474d14ac946
57 Nb4ce51c6a9814d2dad7ad53132bc593f
58 Nd8103c4e13314c2faf3154d97cbd1fe0
59 Nde5b0d872efa4617bc8a55ef5c840796
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112840258
61 https://doi.org/10.1186/s11658-019-0135-3
62 schema:sdDatePublished 2019-04-15T09:02
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N7f0f1745e766460f942b1ea2faa1e8db
65 schema:url https://link.springer.com/10.1186%2Fs11658-019-0135-3
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N040f7c32bb0b40af8d74f17804d7f523 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
70 schema:familyName Cadena
71 schema:givenName Silvia Maria Suter Correia
72 rdf:type schema:Person
73 N047025028d5f4bd9becf5b96c2e850ba schema:affiliation https://www.grid.ac/institutes/grid.462370.4
74 schema:familyName Mazure
75 schema:givenName Nathalie M.
76 rdf:type schema:Person
77 N0d3f3b5f8fcd4e3bbfd8ded0550e62b3 rdf:first N0e17246935394eb7b82a9f76509aa52e
78 rdf:rest N731134979b254e79af741e2f39bd78eb
79 N0e17246935394eb7b82a9f76509aa52e schema:affiliation https://www.grid.ac/institutes/grid.452353.6
80 schema:familyName Pouysségur
81 schema:givenName Jacques
82 rdf:type schema:Person
83 N164d629cd77b43eb8fb9523590865f10 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
84 schema:familyName Noleto
85 schema:givenName Guilhermina Rodrigues
86 rdf:type schema:Person
87 N1a2b4ac9f62942e896da1f09caa70c07 schema:name pubmed_id
88 schema:value 30949212
89 rdf:type schema:PropertyValue
90 N3aecb853e8864edda68a797f1e9c5476 schema:volumeNumber 24
91 rdf:type schema:PublicationVolume
92 N503471e4091b465da66233486aa233a0 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
93 schema:familyName de Oliveira Petkowicz
94 schema:givenName Carmen Lucia
95 rdf:type schema:Person
96 N5f9aeb4c76e843e987918c0e16380999 rdf:first N164d629cd77b43eb8fb9523590865f10
97 rdf:rest Nee3bfcecb7d040a5a64b5e8aaf11e0ea
98 N731134979b254e79af741e2f39bd78eb rdf:first N047025028d5f4bd9becf5b96c2e850ba
99 rdf:rest rdf:nil
100 N7c05c9071ce74c23a30c4474d14ac946 schema:name readcube_id
101 schema:value 43c43a2c65b67f122b66b551fdb2a81b4ad55aa2e1d95caec1553aa943460394
102 rdf:type schema:PropertyValue
103 N7f0f1745e766460f942b1ea2faa1e8db schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 Na7667386246c40588b2a47da4fc04bf1 schema:affiliation https://www.grid.ac/institutes/grid.462370.4
106 schema:familyName Bost
107 schema:givenName Frédéric
108 rdf:type schema:Person
109 Na7736ec620664e76a0b6c642524a275e rdf:first N040f7c32bb0b40af8d74f17804d7f523
110 rdf:rest Nb412dd0ea94848de9f7a9db9a395f371
111 Naae6d73acb9a4daab6779e316ab5aaf3 schema:affiliation https://www.grid.ac/institutes/grid.462370.4
112 schema:familyName Meyenberg Cunha-de Padua
113 schema:givenName Monique
114 rdf:type schema:Person
115 Nb412dd0ea94848de9f7a9db9a395f371 rdf:first Na7667386246c40588b2a47da4fc04bf1
116 rdf:rest N0d3f3b5f8fcd4e3bbfd8ded0550e62b3
117 Nb4ce51c6a9814d2dad7ad53132bc593f schema:name doi
118 schema:value 10.1186/s11658-019-0135-3
119 rdf:type schema:PropertyValue
120 Nc79d79c82b484b4b92d1b60017447366 rdf:first Naae6d73acb9a4daab6779e316ab5aaf3
121 rdf:rest N5f9aeb4c76e843e987918c0e16380999
122 Nd8103c4e13314c2faf3154d97cbd1fe0 schema:name dimensions_id
123 schema:value pub.1112840258
124 rdf:type schema:PropertyValue
125 Nd9006fc6bd6d40dcac0a14318b931c2e schema:issueNumber 1
126 rdf:type schema:PublicationIssue
127 Nde5b0d872efa4617bc8a55ef5c840796 schema:name nlm_unique_id
128 schema:value 9607427
129 rdf:type schema:PropertyValue
130 Nee3bfcecb7d040a5a64b5e8aaf11e0ea rdf:first N503471e4091b465da66233486aa233a0
131 rdf:rest Na7736ec620664e76a0b6c642524a275e
132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
133 schema:name Medical and Health Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
136 schema:name Oncology and Carcinogenesis
137 rdf:type schema:DefinedTerm
138 sg:journal.1115467 schema:issn 1425-8153
139 1689-1392
140 schema:name Cellular & Molecular Biology Letters
141 rdf:type schema:Periodical
142 sg:pub.10.1007/s10495-017-1387-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1090283906
143 https://doi.org/10.1007/s10495-017-1387-x
144 rdf:type schema:CreativeWork
145 sg:pub.10.1007/s10495-017-1421-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1091566007
146 https://doi.org/10.1007/s10495-017-1421-z
147 rdf:type schema:CreativeWork
148 sg:pub.10.1023/a:1015566312032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052359646
149 https://doi.org/10.1023/a:1015566312032
150 rdf:type schema:CreativeWork
151 sg:pub.10.1038/nature04871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023231275
152 https://doi.org/10.1038/nature04871
153 rdf:type schema:CreativeWork
154 sg:pub.10.1038/oncsis.2015.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023064918
155 https://doi.org/10.1038/oncsis.2015.50
156 rdf:type schema:CreativeWork
157 sg:pub.10.1186/1477-7827-10-104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015448834
158 https://doi.org/10.1186/1477-7827-10-104
159 rdf:type schema:CreativeWork
160 https://app.dimensions.ai/details/publication/pub.1074881940 schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1080900437 schema:CreativeWork
162 https://doi.org/10.1002/jcb.20683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018799319
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1002/jcp.21984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033764373
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.canlet.2010.01.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025154086
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.carbpol.2012.07.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026233386
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.carbpol.2017.06.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085915110
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.carres.2016.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041834061
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.cbi.2006.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014311777
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.ejmech.2014.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025124302
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.ijbiomac.2017.03.090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084079459
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.imlet.2006.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025765017
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.jinorgbio.2009.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036583821
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.jinorgbio.2013.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010386931
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.jinorgbio.2015.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026955216
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/s1040-8428(01)00221-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041150175
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1073/pnas.97.16.9082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025952609
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1074/jbc.274.46.32631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035211390
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1074/jbc.m805997200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037745935
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1084/jem.20030613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033567346
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1111/1541-4337.12161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039446933
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1111/j.1349-7006.2005.00065.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029284650
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1111/j.1462-5822.2011.01642.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027521705
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1128/mcb.00166-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051726150
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1128/mcb.01402-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037699149
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1128/mcb.02246-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016427684
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1128/mcb.24.7.2875-2889.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018906872
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1158/0008-5472.can-11-3940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023239887
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1259/bjr.20130676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064565224
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1684/bdc.2011.1360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078401775
217 rdf:type schema:CreativeWork
218 https://doi.org/10.2147/jhc.s61146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005649601
219 rdf:type schema:CreativeWork
220 https://doi.org/10.4103/2319-4170.138318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014860042
221 rdf:type schema:CreativeWork
222 https://doi.org/10.4161/auto.5278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290526
223 rdf:type schema:CreativeWork
224 https://doi.org/10.5897/ajb2003.000-1123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014808832
225 rdf:type schema:CreativeWork
226 https://www.grid.ac/institutes/grid.20736.30 schema:alternateName Federal University of Paraná
227 schema:name Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Brazil
228 rdf:type schema:Organization
229 https://www.grid.ac/institutes/grid.452353.6 schema:alternateName Scientific Centre of Monaco
230 schema:name Institute for Research on Cancer and Aging of Nice, CNRS-UMR 7284-Inserm U1081, University of Nice Sophia-Antipolis, Centre Antoine Lacassagne, 33 Ave. de Valombrose, 06189, Nice, France
231 Medical Biology Department, Centre Scientifique de Monaco (CSM), Monaco, Monaco
232 rdf:type schema:Organization
233 https://www.grid.ac/institutes/grid.462370.4 schema:alternateName Centre Méditerranéen de Médecine Moléculaire
234 schema:name Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Brazil
235 Institute for Research on Cancer and Aging of Nice, CNRS-UMR 7284-Inserm U1081, University of Nice Sophia-Antipolis, Centre Antoine Lacassagne, 33 Ave. de Valombrose, 06189, Nice, France
236 Present Address: INSERM U1065, C3M, 151 Route de St Antoine de Ginestière, BP2 3194, 06204, Nice Cedex 03, France
237 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...