Ontology type: schema:ScholarlyArticle
2019-12
AUTHORSMonique Meyenberg Cunha-de Padua, Guilhermina Rodrigues Noleto, Carmen Lucia de Oliveira Petkowicz, Silvia Maria Suter Correia Cadena, Frédéric Bost, Jacques Pouysségur, Nathalie M. Mazure
ABSTRACTBackground: Polysaccharides from various sources have been used in traditional medicine for centuries. The beneficial pharmacological effects of plant-derived polysaccharides include anti-tumor activity. Methods: Here, we evaluated the anti-cancer effect of the MSAGM:VO complex under hypoxic conditions (1% oxygen). MSAGM:VO is a complex of the hydrolysate of galactomannan (MSAGM) from Schizolobium amazonicum with oxovanadium (IV/V). The hepatocellular carcinoma (HCC) cell line HepG2 was selected as HCC are one of the most hypoxic solid tumors. Results: Our results showed that the strong apoptotic activity of MSAGM:VO observed in HepG2 cells under normoxic conditions was completely lost under hypoxic conditions. We found a dynamic balance between the pro- and anti-apoptotic members of the Bcl-2 protein family. The expressions of anti-apoptotic Mcl-1 and Bcl-XL increased in hypoxia, whereas the expression of pro-apoptotic Bax decreased. MSAGM:VO strongly induced autophagy, which was previously characterized as a pro-survival mechanism in hypoxia. These results demonstrate total elimination of the anti-cancer activity of MSAGM:VO with activation of autophagy under conditions of hypoxia. Conclusion: Although this study is a proof-of-concept of the impact of hypoxia on the potential of polysaccharides, further study is encouraged. The anti-tumor activity of polysaccharides could be achieved in normoxia or through raising the activity of the immune system. In addition, combination strategies for therapy with anti-autophagic drugs could be proposed. More... »
PAGES18
http://scigraph.springernature.com/pub.10.1186/s11658-019-0135-3
DOIhttp://dx.doi.org/10.1186/s11658-019-0135-3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112840258
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30949212
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire",
"id": "https://www.grid.ac/institutes/grid.462370.4",
"name": [
"Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Brazil",
"Institute for Research on Cancer and Aging of Nice, CNRS-UMR 7284-Inserm U1081, University of Nice Sophia-Antipolis, Centre Antoine Lacassagne, 33 Ave. de Valombrose, 06189, Nice, France",
"Present Address: INSERM U1065, C3M, 151 Route de St Antoine de Ginesti\u00e8re, BP2 3194, 06204, Nice Cedex 03, France"
],
"type": "Organization"
},
"familyName": "Meyenberg Cunha-de Padua",
"givenName": "Monique",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Brazil"
],
"type": "Organization"
},
"familyName": "Noleto",
"givenName": "Guilhermina Rodrigues",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Brazil"
],
"type": "Organization"
},
"familyName": "de Oliveira Petkowicz",
"givenName": "Carmen Lucia",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Brazil"
],
"type": "Organization"
},
"familyName": "Cadena",
"givenName": "Silvia Maria Suter Correia",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire",
"id": "https://www.grid.ac/institutes/grid.462370.4",
"name": [
"Present Address: INSERM U1065, C3M, 151 Route de St Antoine de Ginesti\u00e8re, BP2 3194, 06204, Nice Cedex 03, France"
],
"type": "Organization"
},
"familyName": "Bost",
"givenName": "Fr\u00e9d\u00e9ric",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Scientific Centre of Monaco",
"id": "https://www.grid.ac/institutes/grid.452353.6",
"name": [
"Institute for Research on Cancer and Aging of Nice, CNRS-UMR 7284-Inserm U1081, University of Nice Sophia-Antipolis, Centre Antoine Lacassagne, 33 Ave. de Valombrose, 06189, Nice, France",
"Medical Biology Department, Centre Scientifique de Monaco (CSM), Monaco, Monaco"
],
"type": "Organization"
},
"familyName": "Pouyss\u00e9gur",
"givenName": "Jacques",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire",
"id": "https://www.grid.ac/institutes/grid.462370.4",
"name": [
"Institute for Research on Cancer and Aging of Nice, CNRS-UMR 7284-Inserm U1081, University of Nice Sophia-Antipolis, Centre Antoine Lacassagne, 33 Ave. de Valombrose, 06189, Nice, France",
"Present Address: INSERM U1065, C3M, 151 Route de St Antoine de Ginesti\u00e8re, BP2 3194, 06204, Nice Cedex 03, France"
],
"type": "Organization"
},
"familyName": "Mazure",
"givenName": "Nathalie M.",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.2147/jhc.s61146",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005649601"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jinorgbio.2013.10.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010386931"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cbi.2006.08.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014311777"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5897/ajb2003.000-1123",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014808832"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4103/2319-4170.138318",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014860042"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1477-7827-10-104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015448834",
"https://doi.org/10.1186/1477-7827-10-104"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.02246-06",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016427684"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcb.20683",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018799319"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcb.20683",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018799319"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.24.7.2875-2889.2004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018906872"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/oncsis.2015.50",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023064918",
"https://doi.org/10.1038/oncsis.2015.50"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04871",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023231275",
"https://doi.org/10.1038/nature04871"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04871",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023231275",
"https://doi.org/10.1038/nature04871"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04871",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023231275",
"https://doi.org/10.1038/nature04871"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-11-3940",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023239887"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejmech.2014.12.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025124302"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.canlet.2010.01.030",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025154086"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.imlet.2006.01.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025765017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.97.16.9082",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025952609"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.carbpol.2012.07.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026233386"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jinorgbio.2015.03.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026955216"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1462-5822.2011.01642.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027521705"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.2005.00065.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029284650"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20030613",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033567346"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcp.21984",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033764373"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcp.21984",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033764373"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.274.46.32631",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035211390"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jinorgbio.2009.01.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036583821"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.01402-14",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037699149"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.01402-14",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037699149"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m805997200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037745935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/1541-4337.12161",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039446933"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1040-8428(01)00221-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041150175"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.carres.2016.02.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041834061"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.carres.2016.02.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041834061"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.00166-09",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051726150"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1015566312032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052359646",
"https://doi.org/10.1023/a:1015566312032"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1259/bjr.20130676",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064565224"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/auto.5278",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072290526"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074881940",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1684/bdc.2011.1360",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078401775"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080900437",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijbiomac.2017.03.090",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084079459"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.carbpol.2017.06.027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085915110"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.carbpol.2017.06.027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085915110"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10495-017-1387-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090283906",
"https://doi.org/10.1007/s10495-017-1387-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10495-017-1387-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090283906",
"https://doi.org/10.1007/s10495-017-1387-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10495-017-1421-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091566007",
"https://doi.org/10.1007/s10495-017-1421-z"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "Background: Polysaccharides from various sources have been used in traditional medicine for centuries. The beneficial pharmacological effects of plant-derived polysaccharides include anti-tumor activity.\nMethods: Here, we evaluated the anti-cancer effect of the MSAGM:VO complex under hypoxic conditions (1% oxygen). MSAGM:VO is a complex of the hydrolysate of galactomannan (MSAGM) from Schizolobium amazonicum with oxovanadium (IV/V). The hepatocellular carcinoma (HCC) cell line HepG2 was selected as HCC are one of the most hypoxic solid tumors.\nResults: Our results showed that the strong apoptotic activity of MSAGM:VO observed in HepG2 cells under normoxic conditions was completely lost under hypoxic conditions. We found a dynamic balance between the pro- and anti-apoptotic members of the Bcl-2 protein family. The expressions of anti-apoptotic Mcl-1 and Bcl-XL increased in hypoxia, whereas the expression of pro-apoptotic Bax decreased. MSAGM:VO strongly induced autophagy, which was previously characterized as a pro-survival mechanism in hypoxia. These results demonstrate total elimination of the anti-cancer activity of MSAGM:VO with activation of autophagy under conditions of hypoxia.\nConclusion: Although this study is a proof-of-concept of the impact of hypoxia on the potential of polysaccharides, further study is encouraged. The anti-tumor activity of polysaccharides could be achieved in normoxia or through raising the activity of the immune system. In addition, combination strategies for therapy with anti-autophagic drugs could be proposed.",
"genre": "research_article",
"id": "sg:pub.10.1186/s11658-019-0135-3",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1115467",
"issn": [
"1425-8153",
"1689-1392"
],
"name": "Cellular & Molecular Biology Letters",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "24"
}
],
"name": "Hypoxia protects against the cell death triggered by oxovanadium\u2013galactomannan complexes in HepG2 cells",
"pagination": "18",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s11658-019-0135-3"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"43c43a2c65b67f122b66b551fdb2a81b4ad55aa2e1d95caec1553aa943460394"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112840258"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9607427"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30949212"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s11658-019-0135-3",
"https://app.dimensions.ai/details/publication/pub.1112840258"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-15T09:02",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91456_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs11658-019-0135-3"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0135-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0135-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0135-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s11658-019-0135-3'
This table displays all metadata directly associated to this object as RDF triples.
237 TRIPLES
21 PREDICATES
69 URIs
21 LITERALS
9 BLANK NODES