Pelvic exenteration in gynecologic cancer: complications and oncological outcome View Full Text


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Article Info

DATE

2019-01-28

AUTHORS

Víctor Lago, Ines Poveda, Pablo Padilla-Iserte, Eduardo Simón-Sanz, Álvaro García-Granero, Jose Luis Pontones, Luis Matute, Santiago Domingo

ABSTRACT

IntroductionPelvic exenteration (PE) is indicated in cases of unresponsive, recurrent pelvic cancer or for palliative intent. Despite the fact that the surgery is associated with a high rate of morbidity, it is currently the only real option that can effect a cure.Material and methodsPatients who underwent PE between January 2011 and July 2017 in our centre were retrospectively reviewed. Data related to surgery, complications and outcomes were recorded.ResultsTwenty-three patients were included. PE was performed due to recurrent gynaecological cancer, persistence of disease and after first diagnosis in 19 (82%), 2 (9%) and 2 patients (9%), respectively. Total PE was performed in 15 cases (65%), followed by anterior PE in 5 cases (22%) and posterior PE in 3 cases (13%). Early grade II, III and IV complications occurred in 15 (65%), 5 (22%) and 2 patients (9%), respectively. No mortality was observed within 30 days. Medium-late grade II, III, IV and V complications occurred in 15 (65%), 11 (48%), 3 (13%) and 2 cases (9%), respectively. Two patients died after > 30-day period from surgery-related complications. The overall survival (OS) and disease-free survival (DFS) at 48 months after PE was 41.6% and 30.8% respectively.ConclusionsPE provides about a 40% 4-year survival chance in a selected group of patients. The early-complications rate and 30-day mortality were acceptable. Nevertheless, the medium-late complication grades II–V were 65, 48, 18 and 9%, respectively. We must focus on identifying those patients who could potentially benefit most from PE. More... »

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References to SciGraph publications

  • 2010-06-19. Palliative pelvic exenteration for patients with gynecological malignancies in ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • 2011-11-01. Complications associated with urinary diversion in NATURE REVIEWS UROLOGY
  • 2014-09-08. Surgical results of pelvic exenteration in the treatment of gynecologic cancer in WORLD JOURNAL OF SURGICAL ONCOLOGY
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    http://scigraph.springernature.com/pub.10.1186/s10397-019-1055-y

    DOI

    http://dx.doi.org/10.1186/s10397-019-1055-y

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    https://app.dimensions.ai/details/publication/pub.1111752642


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