Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04-30

AUTHORS

Miriam Sonnet, Rainer Claus, Natalia Becker, Manuela Zucknick, Jana Petersen, Daniel B Lipka, Christopher C Oakes, Mindaugas Andrulis, Amelie Lier, Michael D Milsom, Tania Witte, Lei Gu, Soo-Zin Kim-Wanner, Peter Schirmacher, Michael Wulfert, Norbert Gattermann, Michael Lübbert, Frank Rosenbauer, Michael Rehli, Lars Bullinger, Dieter Weichenhan, Christoph Plass

ABSTRACT

BackgroundAberrant DNA methylation is frequently found in human malignancies including acute myeloid leukemia (AML). While most studies focus on later disease stages, the onset of aberrant DNA methylation events and their dynamics during leukemic progression are largely unknown.MethodsWe screened genome-wide for aberrant CpG island methylation in three disease stages of a murine AML model that is driven by hypomorphic expression of the hematopoietic transcription factor PU.1. DNA methylation levels of selected genes were correlated with methylation levels of CD34+ cells and lineage negative, CD127-, c-Kit+, Sca-1+ cells; common myeloid progenitors; granulocyte-macrophage progenitors; and megakaryocyte-erythroid progenitors.ResultsWe identified 1,184 hypermethylated array probes covering 762 associated genes in the preleukemic stage. During disease progression, the number of hypermethylated genes increased to 5,465 in the late leukemic disease stage. Using publicly available data, we found a significant enrichment of PU.1 binding sites in the preleukemic hypermethylated genes, suggesting that shortage of PU.1 makes PU.1 binding sites in the DNA accessible for aberrant methylation. Many known AML associated genes such as RUNX1 and HIC1 were found among the preleukemic hypermethylated genes. Nine novel hypermethylated genes, FZD5, FZD8, PRDM16, ROBO3, CXCL14, BCOR, ITPKA, HES6 and TAL1, the latter four being potential PU.1 targets, were confirmed to be hypermethylated in human normal karyotype AML patients, underscoring the relevance of the mouse model for human AML.ConclusionsOur study identified early aberrantly methylated genes as potential contributors to onset and progression of AML. More... »

PAGES

34

References to SciGraph publications

  • 2009-11-05. Hes-6, an inhibitor of Hes-1, is regulated by 17β-estradiol and promotes breast cancer cell proliferation in BREAST CANCER RESEARCH
  • 1999-05-20. Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene in ONCOGENE
  • 2003-09-29. Epigenetic targets in hematopoietic malignancies in ONCOGENE
  • 2010-06-21. Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis in ONCOGENE
  • 2010-10-07. CEBPA methylation as a prognostic biomarker in patients with de novo acute myeloid leukemia in LEUKEMIA
  • 2008-02-11. Review: genetic models of acute myeloid leukaemia in ONCOGENE
  • 2004-05-16. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1 in NATURE GENETICS
  • 2012-08-17. The role of mutations in epigenetic regulators in myeloid malignancies in NATURE REVIEWS CANCER
  • 2013-01-07. Chemokine CXCL14 is associated with prognosis in patients with colorectal carcinoma after curative resection in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2006-05-15. Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression in MOLECULAR CANCER
  • 2005-11-27. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1 in NATURE GENETICS
  • 2002-08-05. DNA methylation in cancer: too much, but also too little in ONCOGENE
  • 2012-10-30. Enrichment of Methylated DNA by Methyl-CpG Immunoprecipitation in LYMPHOMA
  • 2011-07-25. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gm551

    DOI

    http://dx.doi.org/10.1186/gm551

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048868810

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24944583


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sonnet", 
            "givenName": "Miriam", 
            "id": "sg:person.0776434461.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776434461.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology/Oncology, University Medical Center, D-79106, Freiburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7708.8", 
              "name": [
                "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
                "Department of Hematology/Oncology, University Medical Center, D-79106, Freiburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Claus", 
            "givenName": "Rainer", 
            "id": "sg:person.0727645451.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727645451.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Biostatistics, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Biostatistics, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Becker", 
            "givenName": "Natalia", 
            "id": "sg:person.01144124122.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144124122.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Biostatistics, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Biostatistics, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zucknick", 
            "givenName": "Manuela", 
            "id": "sg:person.0706656070.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706656070.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petersen", 
            "givenName": "Jana", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lipka", 
            "givenName": "Daniel B", 
            "id": "sg:person.0654451402.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654451402.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oakes", 
            "givenName": "Christopher C", 
            "id": "sg:person.01015020064.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015020064.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Pathology, Institute of Pathology, University Heidelberg, D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General Pathology, Institute of Pathology, University Heidelberg, D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andrulis", 
            "givenName": "Mindaugas", 
            "id": "sg:person.01162242642.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162242642.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lier", 
            "givenName": "Amelie", 
            "id": "sg:person.01215160425.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215160425.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Milsom", 
            "givenName": "Michael D", 
            "id": "sg:person.01317230123.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317230123.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Witte", 
            "givenName": "Tania", 
            "id": "sg:person.0576424126.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576424126.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gu", 
            "givenName": "Lei", 
            "id": "sg:person.01160322451.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160322451.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim-Wanner", 
            "givenName": "Soo-Zin", 
            "id": "sg:person.01171150212.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171150212.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Pathology, Institute of Pathology, University Heidelberg, D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General Pathology, Institute of Pathology, University Heidelberg, D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schirmacher", 
            "givenName": "Peter", 
            "id": "sg:person.01072556301.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072556301.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine University, D-40225, D\u00fcsseldorf, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine University, D-40225, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wulfert", 
            "givenName": "Michael", 
            "id": "sg:person.01073242402.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073242402.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine University, D-40225, D\u00fcsseldorf, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine University, D-40225, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gattermann", 
            "givenName": "Norbert", 
            "id": "sg:person.01273447501.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology/Oncology, University Medical Center, D-79106, Freiburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7708.8", 
              "name": [
                "Department of Hematology/Oncology, University Medical Center, D-79106, Freiburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00fcbbert", 
            "givenName": "Michael", 
            "id": "sg:person.01153663723.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153663723.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Tumor Biology, Westf\u00e4lische Wilhelms Universit\u00e4t, D-48149, M\u00fcnster, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5949.1", 
              "name": [
                "Institute of Molecular Tumor Biology, Westf\u00e4lische Wilhelms Universit\u00e4t, D-48149, M\u00fcnster, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosenbauer", 
            "givenName": "Frank", 
            "id": "sg:person.01056242223.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056242223.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, University Hospital Regensburg, D-93042, Regensburg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.411941.8", 
              "name": [
                "Department of Hematology and Oncology, University Hospital Regensburg, D-93042, Regensburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rehli", 
            "givenName": "Michael", 
            "id": "sg:person.0656524365.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656524365.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine III, University of Ulm, D-89081, Ulm, Germany", 
              "id": "http://www.grid.ac/institutes/grid.6582.9", 
              "name": [
                "Department of Internal Medicine III, University of Ulm, D-89081, Ulm, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bullinger", 
            "givenName": "Lars", 
            "id": "sg:person.01173601565.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173601565.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weichenhan", 
            "givenName": "Dieter", 
            "id": "sg:person.0734762743.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734762743.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plass", 
            "givenName": "Christoph", 
            "id": "sg:person.01047735151.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047735151.14"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/1476-4598-5-16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033691518", 
              "https://doi.org/10.1186/1476-4598-5-16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046616734", 
              "https://doi.org/10.1038/onc.2010.255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015539375", 
              "https://doi.org/10.1038/onc.2011.316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-62703-269-8_11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002416565", 
              "https://doi.org/10.1007/978-1-62703-269-8_11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033974084", 
              "https://doi.org/10.1038/sj.onc.1205651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-11-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012253886", 
              "https://doi.org/10.1186/1479-5876-11-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025860592", 
              "https://doi.org/10.1038/sj.onc.1206814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr2446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033397056", 
              "https://doi.org/10.1186/bcr2446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2010.222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038599102", 
              "https://doi.org/10.1038/leu.2010.222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042261597", 
              "https://doi.org/10.1038/nrc3343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049216459", 
              "https://doi.org/10.1038/onc.2008.16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038571731", 
              "https://doi.org/10.1038/sj.onc.1202651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029451587", 
              "https://doi.org/10.1038/ng1679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007364258", 
              "https://doi.org/10.1038/ng1361"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-04-30", 
        "datePublishedReg": "2014-04-30", 
        "description": "BackgroundAberrant DNA methylation is frequently found in human malignancies including acute myeloid leukemia (AML). While most studies focus on later disease stages, the onset of aberrant DNA methylation events and their dynamics during leukemic progression are largely unknown.MethodsWe screened genome-wide for aberrant CpG island methylation in three disease stages of a murine AML model that is driven by hypomorphic expression of the hematopoietic transcription factor PU.1. DNA methylation levels of selected genes were correlated with methylation levels of CD34+ cells and lineage negative, CD127-, c-Kit+, Sca-1+ cells; common myeloid progenitors; granulocyte-macrophage progenitors; and megakaryocyte-erythroid progenitors.ResultsWe identified 1,184 hypermethylated array probes covering 762 associated genes in the preleukemic stage. During disease progression, the number of hypermethylated genes increased to 5,465 in the late leukemic disease stage. Using publicly available data, we found a significant enrichment of PU.1 binding sites in the preleukemic hypermethylated genes, suggesting that shortage of PU.1 makes PU.1 binding sites in the DNA accessible for aberrant methylation. Many known AML associated genes such as RUNX1 and HIC1 were found among the preleukemic hypermethylated genes. Nine novel hypermethylated genes, FZD5, FZD8, PRDM16, ROBO3, CXCL14, BCOR, ITPKA, HES6 and TAL1, the latter four being potential PU.1 targets, were confirmed to be hypermethylated in human normal karyotype AML patients, underscoring the relevance of the mouse model for human AML.ConclusionsOur study identified early aberrantly methylated genes as potential contributors to onset and progression of AML.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/gm551", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1040124", 
            "issn": [
              "1756-994X"
            ], 
            "name": "Genome Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "6"
          }
        ], 
        "keywords": [
          "aberrant DNA methylation events", 
          "DNA methylation events", 
          "methylation events", 
          "methylation levels", 
          "hematopoietic transcription factor PU", 
          "transcription factor PU", 
          "common myeloid progenitors", 
          "megakaryocyte-erythroid progenitors", 
          "aberrant CpG island methylation", 
          "DNA methylation levels", 
          "CpG island methylation", 
          "DNA methylation", 
          "hypomorphic expression", 
          "island methylation", 
          "genes", 
          "aberrant methylation", 
          "significant enrichment", 
          "granulocyte-macrophage progenitors", 
          "myeloid progenitors", 
          "methylation", 
          "Sca-1", 
          "human acute myeloid leukemia", 
          "progenitors", 
          "mouse model", 
          "human malignancies", 
          "progression of AML", 
          "leukemic progression", 
          "acute myeloid leukemia", 
          "TAL1", 
          "genome", 
          "cells", 
          "Hes6", 
          "lineages", 
          "ITPKA", 
          "HIC1", 
          "FZD5", 
          "RUNX1", 
          "FZD8", 
          "ROBO3", 
          "DNA", 
          "PRDM16", 
          "progression", 
          "sites", 
          "murine AML model", 
          "myeloid leukemia", 
          "BCOR", 
          "expression", 
          "preleukemic stage", 
          "stage", 
          "CXCL14", 
          "enrichment", 
          "AML model", 
          "most studies", 
          "target", 
          "potential contributors", 
          "events", 
          "ConclusionsOur study", 
          "levels", 
          "probe", 
          "late disease stages", 
          "CD34", 
          "leukemia", 
          "disease progression", 
          "PU", 
          "available data", 
          "dynamics", 
          "normal karyotype AML patients", 
          "study", 
          "number", 
          "ResultsWe", 
          "relevance", 
          "contributor", 
          "novel", 
          "AML patients", 
          "onset", 
          "disease stage", 
          "malignancy", 
          "data", 
          "model", 
          "array probe", 
          "shortage", 
          "MethodsWe", 
          "CD127", 
          "patients"
        ], 
        "name": "Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia", 
        "pagination": "34", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1048868810"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/gm551"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24944583"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/gm551", 
          "https://app.dimensions.ai/details/publication/pub.1048868810"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_631.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/gm551"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/gm551'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/gm551'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/gm551'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/gm551'


     

    This table displays all metadata directly associated to this object as RDF triples.

    371 TRIPLES      21 PREDICATES      123 URIs      101 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/gm551 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author Nddd2de570aa842c0aea17c6137e52065
    4 schema:citation sg:pub.10.1007/978-1-62703-269-8_11
    5 sg:pub.10.1038/leu.2010.222
    6 sg:pub.10.1038/ng1361
    7 sg:pub.10.1038/ng1679
    8 sg:pub.10.1038/nrc3343
    9 sg:pub.10.1038/onc.2008.16
    10 sg:pub.10.1038/onc.2010.255
    11 sg:pub.10.1038/onc.2011.316
    12 sg:pub.10.1038/sj.onc.1202651
    13 sg:pub.10.1038/sj.onc.1205651
    14 sg:pub.10.1038/sj.onc.1206814
    15 sg:pub.10.1186/1476-4598-5-16
    16 sg:pub.10.1186/1479-5876-11-6
    17 sg:pub.10.1186/bcr2446
    18 schema:datePublished 2014-04-30
    19 schema:datePublishedReg 2014-04-30
    20 schema:description BackgroundAberrant DNA methylation is frequently found in human malignancies including acute myeloid leukemia (AML). While most studies focus on later disease stages, the onset of aberrant DNA methylation events and their dynamics during leukemic progression are largely unknown.MethodsWe screened genome-wide for aberrant CpG island methylation in three disease stages of a murine AML model that is driven by hypomorphic expression of the hematopoietic transcription factor PU.1. DNA methylation levels of selected genes were correlated with methylation levels of CD34+ cells and lineage negative, CD127-, c-Kit+, Sca-1+ cells; common myeloid progenitors; granulocyte-macrophage progenitors; and megakaryocyte-erythroid progenitors.ResultsWe identified 1,184 hypermethylated array probes covering 762 associated genes in the preleukemic stage. During disease progression, the number of hypermethylated genes increased to 5,465 in the late leukemic disease stage. Using publicly available data, we found a significant enrichment of PU.1 binding sites in the preleukemic hypermethylated genes, suggesting that shortage of PU.1 makes PU.1 binding sites in the DNA accessible for aberrant methylation. Many known AML associated genes such as RUNX1 and HIC1 were found among the preleukemic hypermethylated genes. Nine novel hypermethylated genes, FZD5, FZD8, PRDM16, ROBO3, CXCL14, BCOR, ITPKA, HES6 and TAL1, the latter four being potential PU.1 targets, were confirmed to be hypermethylated in human normal karyotype AML patients, underscoring the relevance of the mouse model for human AML.ConclusionsOur study identified early aberrantly methylated genes as potential contributors to onset and progression of AML.
    21 schema:genre article
    22 schema:isAccessibleForFree true
    23 schema:isPartOf N5dfc0927ada247c995909a6961667cd1
    24 Nd83b05bea20343828ecc43fabb8aaa48
    25 sg:journal.1040124
    26 schema:keywords AML model
    27 AML patients
    28 BCOR
    29 CD127
    30 CD34
    31 CXCL14
    32 ConclusionsOur study
    33 CpG island methylation
    34 DNA
    35 DNA methylation
    36 DNA methylation events
    37 DNA methylation levels
    38 FZD5
    39 FZD8
    40 HIC1
    41 Hes6
    42 ITPKA
    43 MethodsWe
    44 PRDM16
    45 PU
    46 ROBO3
    47 RUNX1
    48 ResultsWe
    49 Sca-1
    50 TAL1
    51 aberrant CpG island methylation
    52 aberrant DNA methylation events
    53 aberrant methylation
    54 acute myeloid leukemia
    55 array probe
    56 available data
    57 cells
    58 common myeloid progenitors
    59 contributor
    60 data
    61 disease progression
    62 disease stage
    63 dynamics
    64 enrichment
    65 events
    66 expression
    67 genes
    68 genome
    69 granulocyte-macrophage progenitors
    70 hematopoietic transcription factor PU
    71 human acute myeloid leukemia
    72 human malignancies
    73 hypomorphic expression
    74 island methylation
    75 late disease stages
    76 leukemia
    77 leukemic progression
    78 levels
    79 lineages
    80 malignancy
    81 megakaryocyte-erythroid progenitors
    82 methylation
    83 methylation events
    84 methylation levels
    85 model
    86 most studies
    87 mouse model
    88 murine AML model
    89 myeloid leukemia
    90 myeloid progenitors
    91 normal karyotype AML patients
    92 novel
    93 number
    94 onset
    95 patients
    96 potential contributors
    97 preleukemic stage
    98 probe
    99 progenitors
    100 progression
    101 progression of AML
    102 relevance
    103 shortage
    104 significant enrichment
    105 sites
    106 stage
    107 study
    108 target
    109 transcription factor PU
    110 schema:name Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia
    111 schema:pagination 34
    112 schema:productId N0cd50ce97ab8425c9d28bdf86784cf07
    113 N23a5fcd1b120489db0dab0eaacd99683
    114 N77dff30703404be7b7ba627aa7d62775
    115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048868810
    116 https://doi.org/10.1186/gm551
    117 schema:sdDatePublished 2022-08-04T17:01
    118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    119 schema:sdPublisher Nc7abc28bd50c441b8c28766e720e427a
    120 schema:url https://doi.org/10.1186/gm551
    121 sgo:license sg:explorer/license/
    122 sgo:sdDataset articles
    123 rdf:type schema:ScholarlyArticle
    124 N0cd50ce97ab8425c9d28bdf86784cf07 schema:name pubmed_id
    125 schema:value 24944583
    126 rdf:type schema:PropertyValue
    127 N1d10d21033204b28a3b4b2db3f8baf88 rdf:first sg:person.0727645451.47
    128 rdf:rest N7fce1b73246848869e6f6ce4d5888e48
    129 N23a5fcd1b120489db0dab0eaacd99683 schema:name dimensions_id
    130 schema:value pub.1048868810
    131 rdf:type schema:PropertyValue
    132 N243cc9626add4caab8f2d2e56cc67d7e rdf:first sg:person.01056242223.01
    133 rdf:rest Nd8fcff626a8542c594fa2ea81a05bdc1
    134 N27ba54b310c449a38e7a93a9dddb5f00 rdf:first sg:person.0576424126.67
    135 rdf:rest N9014ae578b1343b9a36c6fe6771b5cad
    136 N28f3211e26d244139e3a5ce135756183 rdf:first sg:person.01273447501.34
    137 rdf:rest N7409899ea2ea49588613715256c69303
    138 N38cc2a1ecf86400b8de21eb5169bcd97 rdf:first sg:person.01215160425.30
    139 rdf:rest N9f81dad52df04586a084393bdb4aa89f
    140 N4a8363881967462f91561b3bc7507d87 rdf:first sg:person.0706656070.19
    141 rdf:rest Nf35ca1497dbb4d4686da497fa1883d6d
    142 N566a1956cd0c4f8591c69231f4d3cbf8 rdf:first sg:person.01072556301.62
    143 rdf:rest Nd30f1a28a7b149d39db3770f6d4cf325
    144 N5dfc0927ada247c995909a6961667cd1 schema:issueNumber 4
    145 rdf:type schema:PublicationIssue
    146 N630e4af6e37e4c00a7ea060431a11dd9 schema:affiliation grid-institutes:grid.7497.d
    147 schema:familyName Petersen
    148 schema:givenName Jana
    149 rdf:type schema:Person
    150 N7409899ea2ea49588613715256c69303 rdf:first sg:person.01153663723.53
    151 rdf:rest N243cc9626add4caab8f2d2e56cc67d7e
    152 N75e42d57f9f94eb4bd4582d67f40bed9 rdf:first sg:person.01047735151.14
    153 rdf:rest rdf:nil
    154 N77bc1189794b4177af9cc093d005d332 rdf:first sg:person.0654451402.12
    155 rdf:rest Nfa299ffc54d042fea08f53aba1d4f042
    156 N77dff30703404be7b7ba627aa7d62775 schema:name doi
    157 schema:value 10.1186/gm551
    158 rdf:type schema:PropertyValue
    159 N7fce1b73246848869e6f6ce4d5888e48 rdf:first sg:person.01144124122.19
    160 rdf:rest N4a8363881967462f91561b3bc7507d87
    161 N7fe0793704c24beea80b0e88e59b9429 rdf:first sg:person.01162242642.90
    162 rdf:rest N38cc2a1ecf86400b8de21eb5169bcd97
    163 N9014ae578b1343b9a36c6fe6771b5cad rdf:first sg:person.01160322451.91
    164 rdf:rest Naf2ba39722574ecbaf660c984b667866
    165 N948e2eeead644004b4d02ddf97af5b0c rdf:first sg:person.01173601565.99
    166 rdf:rest Ncebbcd6466d74a31960d7bd384b47729
    167 N9f81dad52df04586a084393bdb4aa89f rdf:first sg:person.01317230123.36
    168 rdf:rest N27ba54b310c449a38e7a93a9dddb5f00
    169 Naf2ba39722574ecbaf660c984b667866 rdf:first sg:person.01171150212.13
    170 rdf:rest N566a1956cd0c4f8591c69231f4d3cbf8
    171 Nc7abc28bd50c441b8c28766e720e427a schema:name Springer Nature - SN SciGraph project
    172 rdf:type schema:Organization
    173 Ncebbcd6466d74a31960d7bd384b47729 rdf:first sg:person.0734762743.18
    174 rdf:rest N75e42d57f9f94eb4bd4582d67f40bed9
    175 Nd30f1a28a7b149d39db3770f6d4cf325 rdf:first sg:person.01073242402.72
    176 rdf:rest N28f3211e26d244139e3a5ce135756183
    177 Nd83b05bea20343828ecc43fabb8aaa48 schema:volumeNumber 6
    178 rdf:type schema:PublicationVolume
    179 Nd8fcff626a8542c594fa2ea81a05bdc1 rdf:first sg:person.0656524365.57
    180 rdf:rest N948e2eeead644004b4d02ddf97af5b0c
    181 Nddd2de570aa842c0aea17c6137e52065 rdf:first sg:person.0776434461.74
    182 rdf:rest N1d10d21033204b28a3b4b2db3f8baf88
    183 Nf35ca1497dbb4d4686da497fa1883d6d rdf:first N630e4af6e37e4c00a7ea060431a11dd9
    184 rdf:rest N77bc1189794b4177af9cc093d005d332
    185 Nfa299ffc54d042fea08f53aba1d4f042 rdf:first sg:person.01015020064.41
    186 rdf:rest N7fe0793704c24beea80b0e88e59b9429
    187 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    188 schema:name Biological Sciences
    189 rdf:type schema:DefinedTerm
    190 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    191 schema:name Genetics
    192 rdf:type schema:DefinedTerm
    193 sg:journal.1040124 schema:issn 1756-994X
    194 schema:name Genome Medicine
    195 schema:publisher Springer Nature
    196 rdf:type schema:Periodical
    197 sg:person.01015020064.41 schema:affiliation grid-institutes:grid.7497.d
    198 schema:familyName Oakes
    199 schema:givenName Christopher C
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015020064.41
    201 rdf:type schema:Person
    202 sg:person.01047735151.14 schema:affiliation grid-institutes:grid.7497.d
    203 schema:familyName Plass
    204 schema:givenName Christoph
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047735151.14
    206 rdf:type schema:Person
    207 sg:person.01056242223.01 schema:affiliation grid-institutes:grid.5949.1
    208 schema:familyName Rosenbauer
    209 schema:givenName Frank
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056242223.01
    211 rdf:type schema:Person
    212 sg:person.01072556301.62 schema:affiliation grid-institutes:grid.7700.0
    213 schema:familyName Schirmacher
    214 schema:givenName Peter
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072556301.62
    216 rdf:type schema:Person
    217 sg:person.01073242402.72 schema:affiliation grid-institutes:grid.411327.2
    218 schema:familyName Wulfert
    219 schema:givenName Michael
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073242402.72
    221 rdf:type schema:Person
    222 sg:person.01144124122.19 schema:affiliation grid-institutes:grid.7497.d
    223 schema:familyName Becker
    224 schema:givenName Natalia
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144124122.19
    226 rdf:type schema:Person
    227 sg:person.01153663723.53 schema:affiliation grid-institutes:grid.7708.8
    228 schema:familyName Lübbert
    229 schema:givenName Michael
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153663723.53
    231 rdf:type schema:Person
    232 sg:person.01160322451.91 schema:affiliation grid-institutes:grid.7497.d
    233 schema:familyName Gu
    234 schema:givenName Lei
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160322451.91
    236 rdf:type schema:Person
    237 sg:person.01162242642.90 schema:affiliation grid-institutes:grid.7700.0
    238 schema:familyName Andrulis
    239 schema:givenName Mindaugas
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162242642.90
    241 rdf:type schema:Person
    242 sg:person.01171150212.13 schema:affiliation grid-institutes:grid.7497.d
    243 schema:familyName Kim-Wanner
    244 schema:givenName Soo-Zin
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171150212.13
    246 rdf:type schema:Person
    247 sg:person.01173601565.99 schema:affiliation grid-institutes:grid.6582.9
    248 schema:familyName Bullinger
    249 schema:givenName Lars
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173601565.99
    251 rdf:type schema:Person
    252 sg:person.01215160425.30 schema:affiliation grid-institutes:grid.7497.d
    253 schema:familyName Lier
    254 schema:givenName Amelie
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215160425.30
    256 rdf:type schema:Person
    257 sg:person.01273447501.34 schema:affiliation grid-institutes:grid.411327.2
    258 schema:familyName Gattermann
    259 schema:givenName Norbert
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34
    261 rdf:type schema:Person
    262 sg:person.01317230123.36 schema:affiliation grid-institutes:grid.7497.d
    263 schema:familyName Milsom
    264 schema:givenName Michael D
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317230123.36
    266 rdf:type schema:Person
    267 sg:person.0576424126.67 schema:affiliation grid-institutes:grid.7497.d
    268 schema:familyName Witte
    269 schema:givenName Tania
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576424126.67
    271 rdf:type schema:Person
    272 sg:person.0654451402.12 schema:affiliation grid-institutes:grid.7497.d
    273 schema:familyName Lipka
    274 schema:givenName Daniel B
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654451402.12
    276 rdf:type schema:Person
    277 sg:person.0656524365.57 schema:affiliation grid-institutes:grid.411941.8
    278 schema:familyName Rehli
    279 schema:givenName Michael
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656524365.57
    281 rdf:type schema:Person
    282 sg:person.0706656070.19 schema:affiliation grid-institutes:grid.7497.d
    283 schema:familyName Zucknick
    284 schema:givenName Manuela
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706656070.19
    286 rdf:type schema:Person
    287 sg:person.0727645451.47 schema:affiliation grid-institutes:grid.7708.8
    288 schema:familyName Claus
    289 schema:givenName Rainer
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727645451.47
    291 rdf:type schema:Person
    292 sg:person.0734762743.18 schema:affiliation grid-institutes:grid.7497.d
    293 schema:familyName Weichenhan
    294 schema:givenName Dieter
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734762743.18
    296 rdf:type schema:Person
    297 sg:person.0776434461.74 schema:affiliation grid-institutes:grid.7497.d
    298 schema:familyName Sonnet
    299 schema:givenName Miriam
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776434461.74
    301 rdf:type schema:Person
    302 sg:pub.10.1007/978-1-62703-269-8_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002416565
    303 https://doi.org/10.1007/978-1-62703-269-8_11
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/leu.2010.222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038599102
    306 https://doi.org/10.1038/leu.2010.222
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/ng1361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007364258
    309 https://doi.org/10.1038/ng1361
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/ng1679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029451587
    312 https://doi.org/10.1038/ng1679
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/nrc3343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042261597
    315 https://doi.org/10.1038/nrc3343
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/onc.2008.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049216459
    318 https://doi.org/10.1038/onc.2008.16
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/onc.2010.255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046616734
    321 https://doi.org/10.1038/onc.2010.255
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/onc.2011.316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015539375
    324 https://doi.org/10.1038/onc.2011.316
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/sj.onc.1202651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038571731
    327 https://doi.org/10.1038/sj.onc.1202651
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/sj.onc.1205651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033974084
    330 https://doi.org/10.1038/sj.onc.1205651
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/sj.onc.1206814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025860592
    333 https://doi.org/10.1038/sj.onc.1206814
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1186/1476-4598-5-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033691518
    336 https://doi.org/10.1186/1476-4598-5-16
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1186/1479-5876-11-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012253886
    339 https://doi.org/10.1186/1479-5876-11-6
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1186/bcr2446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033397056
    342 https://doi.org/10.1186/bcr2446
    343 rdf:type schema:CreativeWork
    344 grid-institutes:grid.411327.2 schema:alternateName Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine University, D-40225, Düsseldorf, Germany
    345 schema:name Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine University, D-40225, Düsseldorf, Germany
    346 rdf:type schema:Organization
    347 grid-institutes:grid.411941.8 schema:alternateName Department of Hematology and Oncology, University Hospital Regensburg, D-93042, Regensburg, Germany
    348 schema:name Department of Hematology and Oncology, University Hospital Regensburg, D-93042, Regensburg, Germany
    349 rdf:type schema:Organization
    350 grid-institutes:grid.5949.1 schema:alternateName Institute of Molecular Tumor Biology, Westfälische Wilhelms Universität, D-48149, Münster, Germany
    351 schema:name Institute of Molecular Tumor Biology, Westfälische Wilhelms Universität, D-48149, Münster, Germany
    352 rdf:type schema:Organization
    353 grid-institutes:grid.6582.9 schema:alternateName Department of Internal Medicine III, University of Ulm, D-89081, Ulm, Germany
    354 schema:name Department of Internal Medicine III, University of Ulm, D-89081, Ulm, Germany
    355 rdf:type schema:Organization
    356 grid-institutes:grid.7497.d schema:alternateName Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany
    357 Division of Biostatistics, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany
    358 Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany
    359 Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany
    360 schema:name Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany
    361 Division of Biostatistics, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany
    362 Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany
    363 Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany
    364 rdf:type schema:Organization
    365 grid-institutes:grid.7700.0 schema:alternateName Department of General Pathology, Institute of Pathology, University Heidelberg, D-69120, Heidelberg, Germany
    366 schema:name Department of General Pathology, Institute of Pathology, University Heidelberg, D-69120, Heidelberg, Germany
    367 rdf:type schema:Organization
    368 grid-institutes:grid.7708.8 schema:alternateName Department of Hematology/Oncology, University Medical Center, D-79106, Freiburg, Germany
    369 schema:name Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany
    370 Department of Hematology/Oncology, University Medical Center, D-79106, Freiburg, Germany
    371 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...