Systems medicine and integrated care to combat chronic noncommunicable diseases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-07

AUTHORS

Jean Bousquet, Josep M Anto, Peter J Sterk, Ian M Adcock, Kian Fan Chung, Josep Roca, Alvar Agusti, Chris Brightling, Anne Cambon-Thomsen, Alfredo Cesario, Sonia Abdelhak, Stylianos E Antonarakis, Antoine Avignon, Andrea Ballabio, Eugenio Baraldi, Alexander Baranov, Thomas Bieber, Joël Bockaert, Samir Brahmachari, Christian Brambilla, Jacques Bringer, Michel Dauzat, Ingemar Ernberg, Leonardo Fabbri, Philippe Froguel, David Galas, Takashi Gojobori, Peter Hunter, Christian Jorgensen, Francine Kauffmann, Philippe Kourilsky, Marek L Kowalski, Doron Lancet, Claude Le Pen, Jacques Mallet, Bongani Mayosi, Jacques Mercier, Andres Metspalu, Joseph H Nadeau, Grégory Ninot, Denis Noble, Mehmet Öztürk, Susanna Palkonen, Christian Préfaut, Klaus Rabe, Eric Renard, Richard G Roberts, Boleslav Samolinski, Holger J Schünemann, Hans-Uwe Simon, Marcelo Bento Soares, Giulio Superti-Furga, Jesper Tegner, Sergio Verjovski-Almeida, Peter Wellstead, Olaf Wolkenhauer, Emiel Wouters, Rudi Balling, Anthony J Brookes, Dominique Charron, Christophe Pison, Zhu Chen, Leroy Hood, Charles Auffray

ABSTRACT

We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems. More... »

PAGES

43

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gm259

    DOI

    http://dx.doi.org/10.1186/gm259

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047202783

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21745417


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    934 Department of Infection, Immunity and Inflammation, University of Leicester, Sciences Building, University Road, LE1 9HN, Leicester, UK
    935 rdf:type schema:Organization
     




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