Cyclin-dependent kinases View Full Text


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Article Info

DATE

2014-06-30

AUTHORS

Marcos Malumbres

ABSTRACT

Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few cyclins, consistent with functional specialization during evolution. This review summarizes how, although CDKs are traditionally separated into cell-cycle or transcriptional CDKs, these activities are frequently combined in many family members. Not surprisingly, deregulation of this family of proteins is a hallmark of several diseases, including cancer, and drug-targeted inhibition of specific members has generated very encouraging results in clinical trials. More... »

PAGES

122-122

References to SciGraph publications

  • 2003-08-17. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice in NATURE GENETICS
  • 2003-07. Xpd/Ercc2 regulates CAK activity and mitotic progression in NATURE
  • 2007-07. CDC25 phosphatases in cancer cells: key players? Good targets? in NATURE REVIEWS CANCER
  • 2009-03. Cell cycle, CDKs and cancer: a changing paradigm in NATURE REVIEWS CANCER
  • 2005-07-10. Cdc2–cyclin E complexes regulate the G1/S phase transition in NATURE CELL BIOLOGY
  • 2007-08. Cdk1 is sufficient to drive the mammalian cell cycle in NATURE
  • 2012-08-26. Exome sequencing of hepatitis B virus–associated hepatocellular carcinoma in NATURE GENETICS
  • 2004-09-20. Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs in BMC GENOMICS
  • 2009-11. Cyclin-dependent kinases: a family portrait in NATURE CELL BIOLOGY
  • 2001-12. To cycle or not to cycle: a critical decision in cancer in NATURE REVIEWS CANCER
  • 2012-10-14. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-09-14. E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8 in NATURE
  • 2014-01-17. Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages in BMC EVOLUTIONARY BIOLOGY
  • 2012-04-18. Cyclin K goes with Cdk12 and Cdk13 in CELL DIVISION
  • 2008-09-14. CDK8 is a colorectal cancer oncogene that regulates β-catenin activity in NATURE
  • 2011-10-23. Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription in NATURE CELL BIOLOGY
  • 2011-05-16. A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility in ONCOGENE
  • 2011-12-12. Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription in SCIENTIFIC REPORTS
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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25180339


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