BreakTrans: uncovering the genomic architecture of gene fusions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08

AUTHORS

Ken Chen, Nicholas E Navin, Yong Wang, Heather K Schmidt, John W Wallis, Beifang Niu, Xian Fan, Hao Zhao, Michael D McLellan, Katherine A Hoadley, Elaine R Mardis, Timothy J Ley, Charles M Perou, Richard K Wilson, Li Ding

ABSTRACT

Producing gene fusions through genomic structural rearrangements is a major mechanism for tumor evolution. Therefore, accurately detecting gene fusions and the originating rearrangements is of great importance for personalized cancer diagnosis and targeted therapy. We present a tool, BreakTrans, that systematically maps predicted gene fusions to structural rearrangements. Thus, BreakTrans not only validates both types of predictions, but also provides mechanistic interpretations. BreakTrans effectively validates known fusions and discovers novel events in a breast cancer cell line. Applying BreakTrans to 43 breast cancer samples in The Cancer Genome Atlas identifies 90 genomically validated gene fusions. BreakTrans is available at http://bioinformatics.mdanderson.org/main/BreakTrans. More... »

PAGES

r87

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2013-14-8-r87

    DOI

    http://dx.doi.org/10.1186/gb-2013-14-8-r87

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020931850

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23972288


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