Gene expression changes with age in skin, adipose tissue, blood and brain View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07

AUTHORS

Daniel Glass, Ana Viñuela, Matthew N Davies, Adaikalavan Ramasamy, Leopold Parts, David Knowles, Andrew A Brown, Åsa K Hedman, Kerrin S Small, Alfonso Buil, Elin Grundberg, Alexandra C Nica, Paola Di Meglio, Frank O Nestle, Mina Ryten, the UK Brain Expression consortium, the MuTHER consortium, Richard Durbin, Mark I McCarthy, Panagiotis Deloukas, Emmanouil T Dermitzakis, Michael E Weale, Veronique Bataille, Tim D Spector

ABSTRACT

BACKGROUND: Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines in 856 female twins in the age range of 39-85 years. Additionally, we investigated genotypic variants involved in genotype-by-age interactions to understand how the genomic regulation of gene expression alters with age. RESULTS: Using a linear mixed model, differential expression with age was identified in 1,672 genes in skin and 188 genes in adipose tissue. Only two genes expressed in lymphoblastoid cell lines showed significant changes with age. Genes significantly regulated by age were compared with expression profiles in 10 brain regions from 100 postmortem brains aged 16 to 83 years. We identified only one age-related gene common to the three tissues. There were 12 genes that showed differential expression with age in both skin and brain tissue and three common to adipose and brain tissues. CONCLUSIONS: Skin showed the most age-related gene expression changes of all the tissues investigated, with many of the genes being previously implicated in fatty acid metabolism, mitochondrial activity, cancer and splicing. A significant proportion of age-related changes in gene expression appear to be tissue-specific with only a few genes sharing an age effect in expression across tissues. More research is needed to improve our understanding of the genetic influences on aging and the relationship with age-related diseases. More... »

PAGES

r75

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2013-14-7-r75

    DOI

    http://dx.doi.org/10.1186/gb-2013-14-7-r75

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035027502

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23889843


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