Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02

AUTHORS

Michael Clarke, Amanda J Lohan, Bernard Liu, Ilias Lagkouvardos, Scott Roy, Nikhat Zafar, Claire Bertelli, Christina Schilde, Arash Kianianmomeni, Thomas R Bürglin, Christian Frech, Bernard Turcotte, Klaus O Kopec, John M Synnott, Caleb Choo, Ivan Paponov, Aliza Finkler, Chris Soon Heng Tan, Andrew P Hutchins, Thomas Weinmeier, Thomas Rattei, Jeffery SC Chu, Gregory Gimenez, Manuel Irimia, Daniel J Rigden, David A Fitzpatrick, Jacob Lorenzo-Morales, Alex Bateman, Cheng-Hsun Chiu, Petrus Tang, Peter Hegemann, Hillel Fromm, Didier Raoult, Gilbert Greub, Diego Miranda-Saavedra, Nansheng Chen, Piers Nash, Michael L Ginger, Matthias Horn, Pauline Schaap, Lis Caler, Brendan J Loftus

ABSTRACT

BACKGROUND: The Amoebozoa constitute one of the primary divisions of eukaryotes, encompassing taxa of both biomedical and evolutionary importance, yet its genomic diversity remains largely unsampled. Here we present an analysis of a whole genome assembly of Acanthamoeba castellanii (Ac) the first representative from a solitary free-living amoebozoan. RESULTS: Ac encodes 15,455 compact intron-rich genes, a significant number of which are predicted to have arisen through inter-kingdom lateral gene transfer (LGT). A majority of the LGT candidates have undergone a substantial degree of intronization and Ac appears to have incorporated them into established transcriptional programs. Ac manifests a complex signaling and cell communication repertoire, including a complete tyrosine kinase signaling toolkit and a comparable diversity of predicted extracellular receptors to that found in the facultatively multicellular dictyostelids. An important environmental host of a diverse range of bacteria and viruses, Ac utilizes a diverse repertoire of predicted pattern recognition receptors, many with predicted orthologous functions in the innate immune systems of higher organisms. CONCLUSIONS: Our analysis highlights the important role of LGT in the biology of Ac and in the diversification of microbial eukaryotes. The early evolution of a key signaling facility implicated in the evolution of metazoan multicellularity strongly argues for its emergence early in the Unikont lineage. Overall, the availability of an Ac genome should aid in deciphering the biology of the Amoebozoa and facilitate functional genomic studies in this important model organism and environmental host. More... »

PAGES

r11

References to SciGraph publications

  • 2004-12. Gene finding in novel genomes in BMC BIOINFORMATICS
  • 2005-08. Mechanisms associated with Acanthamoeba castellanii (T4) phagocytosis in PARASITOLOGY RESEARCH
  • 2008-10. GILT is a critical host factor for Listeria monocytogenes infection in NATURE
  • 2008-08. Horizontal gene transfer in eukaryotic evolution in NATURE REVIEWS GENETICS
  • 2005-10. Are innate immune signaling pathways in plants and animals conserved? in NATURE IMMUNOLOGY
  • 2011-02. Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum in GENOME BIOLOGY
  • 2008-12. Annotating genomes with massive-scale RNA sequencing in GENOME BIOLOGY
  • 2005-05. The genome of the social amoeba Dictyostelium discoideum in NATURE
  • 2004-02. Olfactory receptors in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1992. The Isolation of Wheat Mitochondrial DNA and RNA in SEED ANALYSIS
  • 2009-05. Conceptual Bases for Prey Biorecognition and Feeding Selectivity in the Microplanktonic Marine Phagotroph Oxyrrhis marina in MICROBIAL ECOLOGY
  • 2006-12. Multiple lineage specific expansions within the guanylyl cyclase gene family in BMC EVOLUTIONARY BIOLOGY
  • 2002-05. Evolution of the lectin–complement pathway and its role in innate immunity in NATURE REVIEWS IMMUNOLOGY
  • 2003-12. Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins in BMC GENOMICS
  • 2012-05. Interferon-inducible effector mechanisms in cell-autonomous immunity in NATURE REVIEWS IMMUNOLOGY
  • 2010-12. Taming of the shrewd: novel eukaryotic genes from RNA viruses in BMC BIOLOGY
  • 2004. Health Effects of Acanthamoeba spp. and Its Potential for Waterborne Transmission in REVIEWS OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2004-06. The Frizzled family: receptors for multiple signal transduction pathways in GENOME BIOLOGY
  • 2006. TIGRFAMs in ENCYCLOPEDIC REFERENCE OF GENOMICS AND PROTEOMICS IN MOLECULAR MEDICINE
  • 2008-10. Identification of genetic variants using bar-coded multiplexed sequencing in NATURE METHODS
  • 2002-12. Apollo: a sequence annotation editor in GENOME BIOLOGY
  • 2010-06. Calmodulin-binding transcription activator 1 mediates auxin signaling and responds to stresses in Arabidopsis in PLANTA
  • 2010-03. Soil bacteria and protozoa affect root branching via effects on the auxin and cytokinin balance in plants in PLANT AND SOIL
  • 2011-04-14. Homeodomain Subtypes and Functional Diversity in A HANDBOOK OF TRANSCRIPTION FACTORS
  • 2005-02. The genome of the protist parasite Entamoeba histolytica in NATURE
  • 2009-06. Soil amoebae rapidly change bacterial community composition in the rhizosphere of Arabidopsis thaliana in THE ISME JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2013-14-2-r11

    DOI

    http://dx.doi.org/10.1186/gb-2013-14-2-r11

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044291243

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23375108


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