Chromosome territories reposition during DNA damage-repair response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12-13

AUTHORS

Ishita S Mehta, Mugdha Kulashreshtha, Sandeep Chakraborty, Ullas Kolthur-Seetharam, Basuthkar J Rao

ABSTRACT

BACKGROUND: Local higher-order chromatin structure, dynamics and composition of the DNA are known to determine double-strand break frequencies and the efficiency of repair. However, how DNA damage response affects the spatial organization of chromosome territories is still unexplored. RESULTS: Our report investigates the effect of DNA damage on the spatial organization of chromosome territories within interphase nuclei of human cells. We show that DNA damage induces a large-scale spatial repositioning of chromosome territories that are relatively gene dense. This response is dose dependent, and involves territories moving from the nuclear interior to the periphery and vice versa. Furthermore, we have found that chromosome territory repositioning is contingent upon double-strand break recognition and damage sensing. Importantly, our results suggest that this is a reversible process where, following repair, chromosome territories re-occupy positions similar to those in undamaged control cells. CONCLUSIONS: Thus, our report for the first time highlights DNA damage-dependent spatial reorganization of whole chromosomes, which might be an integral aspect of cellular damage response. More... »

PAGES

r135-r135

References to SciGraph publications

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  • 2012-04-08. Increased chromosome mobility facilitates homology search during recombination in NATURE CELL BIOLOGY
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  • 2007-01-24. Chromosome territories in NATURE
  • 2005-08-30. The genome and the nucleus: a marriage made by evolution in CHROMOSOMA
  • 2012-11-15. Interphase chromosome positioning in in vitro porcine cells and ex vivo porcine tissues in BMC MOLECULAR AND CELL BIOLOGY
  • 2007-05-07. Positional stability of single double-strand breaks in mammalian cells in NATURE CELL BIOLOGY
  • 2001-04. Chromosome territories, nuclear architecture and gene regulation in mammalian cells in NATURE REVIEWS GENETICS
  • 2010-01-13. Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts in GENOME BIOLOGY
  • 2012-04-08. Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery in NATURE CELL BIOLOGY
  • 2013-05-05. Effect of nuclear architecture on the efficiency of double-strand break repair in NATURE CELL BIOLOGY
  • 2001-01. Chromosome regions enriched in hyperacetylated histone H4 are preferred sites for endonuclease- and radiation-induced breakpoints in CHROMOSOME RESEARCH
  • 2000-12. The many substrates and functions of ATM in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2013-14-12-r135

    DOI

    http://dx.doi.org/10.1186/gb-2013-14-12-r135

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040408722

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24330859


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