Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Matthew Parker, Xiang Chen, Armita Bahrami, James Dalton, Michael Rusch, Gang Wu, John Easton, Nai-Kong Cheung, Michael Dyer, Elaine R Mardis, Richard K Wilson, Charles Mullighan, Richard Gilbertson, Suzanne J Baker, Gerard Zambetti, David W Ellison, James R Downing, Jinghui Zhang, Pediatric Cancer Genome Project

ABSTRACT

BACKGROUND: Telomeres are the protective arrays of tandem TTAGGG sequence and associated proteins at the termini of chromosomes. Telomeres shorten at each cell division due to the end-replication problem and are maintained above a critical threshold in malignant cancer cells to prevent cellular senescence or apoptosis. With the recent advances in massive parallel sequencing, assessing telomere content in the context of other cancer genomic aberrations becomes an attractive possibility. We present the first comprehensive analysis of telomeric DNA content change in tumors using whole-genome sequencing data from 235 pediatric cancers. RESULTS: To measure telomeric DNA content, we counted telomeric reads containing TTAGGGx4 or CCCTAAx4 and normalized to the average genomic coverage. Changes in telomeric DNA content in tumor genomes were clustered using a Bayesian Information Criterion to determine loss, no change, or gain. Using this approach, we found that the pattern of telomeric DNA alteration varies dramatically across the landscape of pediatric malignancies: telomere gain was found in 32% of solid tumors, 4% of brain tumors and 0% of hematopoietic malignancies. The results were validated by three independent experimental approaches and reveal significant association of telomere gain with the frequency of somatic sequence mutations and structural variations. CONCLUSIONS: Telomere DNA content measurement using whole-genome sequencing data is a reliable approach that can generate useful insights into the landscape of the cancer genome. Measuring the change in telomeric DNA during malignant progression is likely to be a useful metric when considering telomeres in the context of the whole genome. More... »

PAGES

r113

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/gb-2012-13-12-r113

DOI

http://dx.doi.org/10.1186/gb-2012-13-12-r113

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016157732

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23232254


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telomere", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parker", 
        "givenName": "Matthew", 
        "id": "sg:person.01272305533.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272305533.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Xiang", 
        "id": "sg:person.015526027337.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015526027337.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bahrami", 
        "givenName": "Armita", 
        "id": "sg:person.0621024167.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621024167.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dalton", 
        "givenName": "James", 
        "id": "sg:person.07621361737.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07621361737.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rusch", 
        "givenName": "Michael", 
        "id": "sg:person.01307135342.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307135342.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Gang", 
        "id": "sg:person.01125315303.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125315303.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "The Pediatric Cancer Genome Project, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Easton", 
        "givenName": "John", 
        "id": "sg:person.0721607077.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721607077.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheung", 
        "givenName": "Nai-Kong", 
        "id": "sg:person.011122030077.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011122030077.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dyer", 
        "givenName": "Michael", 
        "id": "sg:person.0723007550.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723007550.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Center at Washington University, Washington University, 4444 Forest Park Ave, 63108, St Louis, Missouri, USA", 
            "Department of Genetics, Washington University, 4444 Forest Park Ave, 63108, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mardis", 
        "givenName": "Elaine R", 
        "id": "sg:person.01023627236.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023627236.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Center at Washington University, Washington University, 4444 Forest Park Ave, 63108, St Louis, Missouri, USA", 
            "Department of Genetics, Washington University, 4444 Forest Park Ave, 63108, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Richard K", 
        "id": "sg:person.013076541047.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013076541047.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mullighan", 
        "givenName": "Charles", 
        "id": "sg:person.0671073025.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671073025.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gilbertson", 
        "givenName": "Richard", 
        "id": "sg:person.01024145163.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024145163.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baker", 
        "givenName": "Suzanne J", 
        "id": "sg:person.011551276412.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011551276412.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Biochemistry, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zambetti", 
        "givenName": "Gerard", 
        "id": "sg:person.0711416333.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711416333.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellison", 
        "givenName": "David W", 
        "id": "sg:person.0711352500.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711352500.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Downing", 
        "givenName": "James R", 
        "id": "sg:person.0776022700.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776022700.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jinghui", 
        "id": "sg:person.011367065707.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011367065707.90"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pediatric Cancer Genome Project", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1471-2164-11-244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000146260", 
          "https://doi.org/10.1186/1471-2164-11-244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2011-12-2-r18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000268052", 
          "https://doi.org/10.1186/gb-2011-12-2-r18"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000736346", 
          "https://doi.org/10.1038/nature10166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(97)00062-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001394077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.10.e47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001970199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2012.228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003051075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004171938", 
          "https://doi.org/10.1038/nmeth.1628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006487337", 
          "https://doi.org/10.1038/nature10725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006780793", 
          "https://doi.org/10.1038/nature10733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014616827", 
          "https://doi.org/10.1038/nature02118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014616827", 
          "https://doi.org/10.1038/nature02118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1480-9222-13-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015434742", 
          "https://doi.org/10.1186/1480-9222-13-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mad.2007.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015725592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btr032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017115352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bcmd.2000.0332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017820360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-200209000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018346654", 
          "https://doi.org/10.1203/00006450-200209000-00012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-12-3817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024017913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/17.10.977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029038829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/6.6.921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038411164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/07357900701208683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039488431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039570773", 
          "https://doi.org/10.1038/nature07385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1992.tb00081.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040601010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1992.tb00081.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040601010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2400889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045293622", 
          "https://doi.org/10.1038/sj.leu.2400889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2400889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045293622", 
          "https://doi.org/10.1038/sj.leu.2400889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.1102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048296872", 
          "https://doi.org/10.1038/ng.1102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)12681-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049829647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.03.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051418678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053062388", 
          "https://doi.org/10.1038/ng.2287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2007-1840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064290237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/000112761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069095771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074520988", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075271936", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076998666", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: Telomeres are the protective arrays of tandem TTAGGG sequence and associated proteins at the termini of chromosomes. Telomeres shorten at each cell division due to the end-replication problem and are maintained above a critical threshold in malignant cancer cells to prevent cellular senescence or apoptosis. With the recent advances in massive parallel sequencing, assessing telomere content in the context of other cancer genomic aberrations becomes an attractive possibility. We present the first comprehensive analysis of telomeric DNA content change in tumors using whole-genome sequencing data from 235 pediatric cancers.\nRESULTS: To measure telomeric DNA content, we counted telomeric reads containing TTAGGGx4 or CCCTAAx4 and normalized to the average genomic coverage. Changes in telomeric DNA content in tumor genomes were clustered using a Bayesian Information Criterion to determine loss, no change, or gain. Using this approach, we found that the pattern of telomeric DNA alteration varies dramatically across the landscape of pediatric malignancies: telomere gain was found in 32% of solid tumors, 4% of brain tumors and 0% of hematopoietic malignancies. The results were validated by three independent experimental approaches and reveal significant association of telomere gain with the frequency of somatic sequence mutations and structural variations.\nCONCLUSIONS: Telomere DNA content measurement using whole-genome sequencing data is a reliable approach that can generate useful insights into the landscape of the cancer genome. Measuring the change in telomeric DNA during malignant progression is likely to be a useful metric when considering telomeres in the context of the whole genome.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/gb-2012-13-12-r113", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438833", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435780", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2479507", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023439", 
        "issn": [
          "1474-760X", 
          "1465-6906"
        ], 
        "name": "Genome Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data", 
    "pagination": "r113", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4cfce13e923a3ab6a2cfdafdc3eaaa0c5f9ff39f0d84ab042e9ca750aac528b2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23232254"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100960660"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/gb-2012-13-12-r113"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016157732"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/gb-2012-13-12-r113", 
      "https://app.dimensions.ai/details/publication/pub.1016157732"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fgb-2012-13-12-r113"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/gb-2012-13-12-r113'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/gb-2012-13-12-r113'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/gb-2012-13-12-r113'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/gb-2012-13-12-r113'


 

This table displays all metadata directly associated to this object as RDF triples.

344 TRIPLES      21 PREDICATES      68 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/gb-2012-13-12-r113 schema:about N03ed66778c1b4c559affd23f36efd1fe
2 N2b7d69ab5ad2450c99a82ace81c797aa
3 N4b7d80e257e24d4fbc7f04d46d09cea9
4 N4f4f996339a547928fd57688c22bf1c6
5 N6f87a1080bc24fe08ad919775104808e
6 N95a2a5b760e140abb99cb60a54c4062f
7 Nd787eafaf9e94d5991b1b14fa7112028
8 Ndff3bfef0cb54d32a725d846cd166872
9 anzsrc-for:11
10 anzsrc-for:1112
11 schema:author N9e3a9e19bdd24cbead3b98529c59c236
12 schema:citation sg:pub.10.1038/nature02118
13 sg:pub.10.1038/nature07385
14 sg:pub.10.1038/nature10166
15 sg:pub.10.1038/nature10725
16 sg:pub.10.1038/nature10733
17 sg:pub.10.1038/ng.1102
18 sg:pub.10.1038/ng.2287
19 sg:pub.10.1038/nmeth.1628
20 sg:pub.10.1038/sj.leu.2400889
21 sg:pub.10.1186/1471-2164-11-244
22 sg:pub.10.1186/1480-9222-13-3
23 sg:pub.10.1186/gb-2011-12-2-r18
24 sg:pub.10.1203/00006450-200209000-00012
25 https://app.dimensions.ai/details/publication/pub.1074520988
26 https://app.dimensions.ai/details/publication/pub.1075271936
27 https://app.dimensions.ai/details/publication/pub.1076998666
28 https://doi.org/10.1001/jama.2012.228
29 https://doi.org/10.1006/bcmd.2000.0332
30 https://doi.org/10.1016/j.mad.2007.11.006
31 https://doi.org/10.1016/s0140-6736(03)12681-5
32 https://doi.org/10.1016/s0959-8049(97)00062-2
33 https://doi.org/10.1080/07357900701208683
34 https://doi.org/10.1093/bioinformatics/17.10.977
35 https://doi.org/10.1093/bioinformatics/btr032
36 https://doi.org/10.1093/hmg/6.6.921
37 https://doi.org/10.1093/nar/30.10.e47
38 https://doi.org/10.1111/j.1349-7006.1992.tb00081.x
39 https://doi.org/10.1182/blood-2002-12-3817
40 https://doi.org/10.1200/jco.2004.03.043
41 https://doi.org/10.1210/jc.2007-1840
42 https://doi.org/10.2144/000112761
43 schema:datePublished 2012-12
44 schema:datePublishedReg 2012-12-01
45 schema:description BACKGROUND: Telomeres are the protective arrays of tandem TTAGGG sequence and associated proteins at the termini of chromosomes. Telomeres shorten at each cell division due to the end-replication problem and are maintained above a critical threshold in malignant cancer cells to prevent cellular senescence or apoptosis. With the recent advances in massive parallel sequencing, assessing telomere content in the context of other cancer genomic aberrations becomes an attractive possibility. We present the first comprehensive analysis of telomeric DNA content change in tumors using whole-genome sequencing data from 235 pediatric cancers. RESULTS: To measure telomeric DNA content, we counted telomeric reads containing TTAGGGx4 or CCCTAAx4 and normalized to the average genomic coverage. Changes in telomeric DNA content in tumor genomes were clustered using a Bayesian Information Criterion to determine loss, no change, or gain. Using this approach, we found that the pattern of telomeric DNA alteration varies dramatically across the landscape of pediatric malignancies: telomere gain was found in 32% of solid tumors, 4% of brain tumors and 0% of hematopoietic malignancies. The results were validated by three independent experimental approaches and reveal significant association of telomere gain with the frequency of somatic sequence mutations and structural variations. CONCLUSIONS: Telomere DNA content measurement using whole-genome sequencing data is a reliable approach that can generate useful insights into the landscape of the cancer genome. Measuring the change in telomeric DNA during malignant progression is likely to be a useful metric when considering telomeres in the context of the whole genome.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree true
49 schema:isPartOf N2325bbbe44b74f14afd748f850001f79
50 N8a80bbb92efe46058aca1b3366302d21
51 sg:journal.1023439
52 schema:name Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data
53 schema:pagination r113
54 schema:productId N06bf3889a41543a1be92b0fe4e471f1e
55 N81da584c1a58450283f870213d8e0e3a
56 N9db77c9ecf4d47fba83e3b15c7556706
57 Nba7bc36eefe34f82a90f5a1450da6b75
58 Nbbeae8d7de33469d9b2a16b445ee47c8
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016157732
60 https://doi.org/10.1186/gb-2012-13-12-r113
61 schema:sdDatePublished 2019-04-10T17:31
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N26bce173613e44108fa2b7d407f03818
64 schema:url http://link.springer.com/10.1186%2Fgb-2012-13-12-r113
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N03ed66778c1b4c559affd23f36efd1fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name DNA, Neoplasm
70 rdf:type schema:DefinedTerm
71 N06bf3889a41543a1be92b0fe4e471f1e schema:name readcube_id
72 schema:value 4cfce13e923a3ab6a2cfdafdc3eaaa0c5f9ff39f0d84ab042e9ca750aac528b2
73 rdf:type schema:PropertyValue
74 N203e60d9f4324428955e0ee182cfe8ac rdf:first sg:person.01125315303.25
75 rdf:rest Ne3bf9ffb21ca4e78a5aad625bafd171e
76 N2325bbbe44b74f14afd748f850001f79 schema:issueNumber 12
77 rdf:type schema:PublicationIssue
78 N26bce173613e44108fa2b7d407f03818 schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 N2b7d69ab5ad2450c99a82ace81c797aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Neoplasms
82 rdf:type schema:DefinedTerm
83 N2c55b77f247646e08036ae3fab74d5b6 rdf:first sg:person.0711416333.21
84 rdf:rest Nf912b09175b24abca285803e97d58fd5
85 N45646e47254d4ff28082a9bf84c26a6f rdf:first sg:person.0776022700.87
86 rdf:rest Na5c58fc2fe9e48df9ed1be43410bb182
87 N470fbfc91971417b96bf04bb57e5858b rdf:first sg:person.01023627236.33
88 rdf:rest Nb465c7bedbb64ab49b5381941f257d75
89 N4b7d80e257e24d4fbc7f04d46d09cea9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Adult
91 rdf:type schema:DefinedTerm
92 N4ca90423e64c44afb070c0983de14915 rdf:first Nadb1bc8e1c754906b45f9dbb018f7b1a
93 rdf:rest rdf:nil
94 N4d4f4f080acb4c40a6e4a0a8d4e4fea2 rdf:first sg:person.0723007550.69
95 rdf:rest N470fbfc91971417b96bf04bb57e5858b
96 N4f4f996339a547928fd57688c22bf1c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Telomere
98 rdf:type schema:DefinedTerm
99 N6f87a1080bc24fe08ad919775104808e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Genomics
101 rdf:type schema:DefinedTerm
102 N7af7eea74bd04b6e87dad6e065075da3 rdf:first sg:person.01024145163.14
103 rdf:rest Nd302c38aaf6344a5aa2ae926e1ab60c5
104 N81da584c1a58450283f870213d8e0e3a schema:name dimensions_id
105 schema:value pub.1016157732
106 rdf:type schema:PropertyValue
107 N8a80bbb92efe46058aca1b3366302d21 schema:volumeNumber 13
108 rdf:type schema:PublicationVolume
109 N95a2a5b760e140abb99cb60a54c4062f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Sequence Analysis, DNA
111 rdf:type schema:DefinedTerm
112 N99d7748fe9db4381927bda80915c63ea rdf:first sg:person.011122030077.73
113 rdf:rest N4d4f4f080acb4c40a6e4a0a8d4e4fea2
114 N9db77c9ecf4d47fba83e3b15c7556706 schema:name nlm_unique_id
115 schema:value 100960660
116 rdf:type schema:PropertyValue
117 N9e3a9e19bdd24cbead3b98529c59c236 rdf:first sg:person.01272305533.58
118 rdf:rest Na3a74b1c8d2849bc97626f14bced3059
119 N9f4475a81b3a4b2c8567d146abbb427e rdf:first sg:person.07621361737.09
120 rdf:rest Nb72b2b4f672d44f79293ffd4b31cd088
121 Na3a74b1c8d2849bc97626f14bced3059 rdf:first sg:person.015526027337.83
122 rdf:rest Na5c326207b6040a1bc60b19c2521158f
123 Na5c326207b6040a1bc60b19c2521158f rdf:first sg:person.0621024167.17
124 rdf:rest N9f4475a81b3a4b2c8567d146abbb427e
125 Na5c58fc2fe9e48df9ed1be43410bb182 rdf:first sg:person.011367065707.90
126 rdf:rest N4ca90423e64c44afb070c0983de14915
127 Nadb1bc8e1c754906b45f9dbb018f7b1a schema:familyName Pediatric Cancer Genome Project
128 rdf:type schema:Person
129 Nb465c7bedbb64ab49b5381941f257d75 rdf:first sg:person.013076541047.38
130 rdf:rest Neb004da7b0584d82a2b824207d8978e2
131 Nb72b2b4f672d44f79293ffd4b31cd088 rdf:first sg:person.01307135342.00
132 rdf:rest N203e60d9f4324428955e0ee182cfe8ac
133 Nba7bc36eefe34f82a90f5a1450da6b75 schema:name doi
134 schema:value 10.1186/gb-2012-13-12-r113
135 rdf:type schema:PropertyValue
136 Nbbeae8d7de33469d9b2a16b445ee47c8 schema:name pubmed_id
137 schema:value 23232254
138 rdf:type schema:PropertyValue
139 Nd302c38aaf6344a5aa2ae926e1ab60c5 rdf:first sg:person.011551276412.71
140 rdf:rest N2c55b77f247646e08036ae3fab74d5b6
141 Nd787eafaf9e94d5991b1b14fa7112028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Humans
143 rdf:type schema:DefinedTerm
144 Ndff3bfef0cb54d32a725d846cd166872 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Child
146 rdf:type schema:DefinedTerm
147 Ne3bf9ffb21ca4e78a5aad625bafd171e rdf:first sg:person.0721607077.65
148 rdf:rest N99d7748fe9db4381927bda80915c63ea
149 Neb004da7b0584d82a2b824207d8978e2 rdf:first sg:person.0671073025.86
150 rdf:rest N7af7eea74bd04b6e87dad6e065075da3
151 Nf912b09175b24abca285803e97d58fd5 rdf:first sg:person.0711352500.88
152 rdf:rest N45646e47254d4ff28082a9bf84c26a6f
153 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
154 schema:name Medical and Health Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
157 schema:name Oncology and Carcinogenesis
158 rdf:type schema:DefinedTerm
159 sg:grant.2435780 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2012-13-12-r113
160 rdf:type schema:MonetaryGrant
161 sg:grant.2438833 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2012-13-12-r113
162 rdf:type schema:MonetaryGrant
163 sg:grant.2479507 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2012-13-12-r113
164 rdf:type schema:MonetaryGrant
165 sg:journal.1023439 schema:issn 1465-6906
166 1474-760X
167 schema:name Genome Biology
168 rdf:type schema:Periodical
169 sg:person.01023627236.33 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
170 schema:familyName Mardis
171 schema:givenName Elaine R
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023627236.33
173 rdf:type schema:Person
174 sg:person.01024145163.14 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
175 schema:familyName Gilbertson
176 schema:givenName Richard
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024145163.14
178 rdf:type schema:Person
179 sg:person.011122030077.73 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
180 schema:familyName Cheung
181 schema:givenName Nai-Kong
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011122030077.73
183 rdf:type schema:Person
184 sg:person.01125315303.25 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
185 schema:familyName Wu
186 schema:givenName Gang
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125315303.25
188 rdf:type schema:Person
189 sg:person.011367065707.90 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
190 schema:familyName Zhang
191 schema:givenName Jinghui
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011367065707.90
193 rdf:type schema:Person
194 sg:person.011551276412.71 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
195 schema:familyName Baker
196 schema:givenName Suzanne J
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011551276412.71
198 rdf:type schema:Person
199 sg:person.01272305533.58 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
200 schema:familyName Parker
201 schema:givenName Matthew
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272305533.58
203 rdf:type schema:Person
204 sg:person.01307135342.00 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
205 schema:familyName Rusch
206 schema:givenName Michael
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307135342.00
208 rdf:type schema:Person
209 sg:person.013076541047.38 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
210 schema:familyName Wilson
211 schema:givenName Richard K
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013076541047.38
213 rdf:type schema:Person
214 sg:person.015526027337.83 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
215 schema:familyName Chen
216 schema:givenName Xiang
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015526027337.83
218 rdf:type schema:Person
219 sg:person.0621024167.17 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
220 schema:familyName Bahrami
221 schema:givenName Armita
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621024167.17
223 rdf:type schema:Person
224 sg:person.0671073025.86 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
225 schema:familyName Mullighan
226 schema:givenName Charles
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671073025.86
228 rdf:type schema:Person
229 sg:person.0711352500.88 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
230 schema:familyName Ellison
231 schema:givenName David W
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711352500.88
233 rdf:type schema:Person
234 sg:person.0711416333.21 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
235 schema:familyName Zambetti
236 schema:givenName Gerard
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711416333.21
238 rdf:type schema:Person
239 sg:person.0721607077.65 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
240 schema:familyName Easton
241 schema:givenName John
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721607077.65
243 rdf:type schema:Person
244 sg:person.0723007550.69 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
245 schema:familyName Dyer
246 schema:givenName Michael
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723007550.69
248 rdf:type schema:Person
249 sg:person.07621361737.09 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
250 schema:familyName Dalton
251 schema:givenName James
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07621361737.09
253 rdf:type schema:Person
254 sg:person.0776022700.87 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
255 schema:familyName Downing
256 schema:givenName James R
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776022700.87
258 rdf:type schema:Person
259 sg:pub.10.1038/nature02118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014616827
260 https://doi.org/10.1038/nature02118
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nature07385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039570773
263 https://doi.org/10.1038/nature07385
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nature10166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736346
266 https://doi.org/10.1038/nature10166
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nature10725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006487337
269 https://doi.org/10.1038/nature10725
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nature10733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006780793
272 https://doi.org/10.1038/nature10733
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/ng.1102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048296872
275 https://doi.org/10.1038/ng.1102
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/ng.2287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053062388
278 https://doi.org/10.1038/ng.2287
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nmeth.1628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004171938
281 https://doi.org/10.1038/nmeth.1628
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/sj.leu.2400889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045293622
284 https://doi.org/10.1038/sj.leu.2400889
285 rdf:type schema:CreativeWork
286 sg:pub.10.1186/1471-2164-11-244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000146260
287 https://doi.org/10.1186/1471-2164-11-244
288 rdf:type schema:CreativeWork
289 sg:pub.10.1186/1480-9222-13-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015434742
290 https://doi.org/10.1186/1480-9222-13-3
291 rdf:type schema:CreativeWork
292 sg:pub.10.1186/gb-2011-12-2-r18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000268052
293 https://doi.org/10.1186/gb-2011-12-2-r18
294 rdf:type schema:CreativeWork
295 sg:pub.10.1203/00006450-200209000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018346654
296 https://doi.org/10.1203/00006450-200209000-00012
297 rdf:type schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1074520988 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1075271936 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1076998666 schema:CreativeWork
301 https://doi.org/10.1001/jama.2012.228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003051075
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1006/bcmd.2000.0332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017820360
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.mad.2007.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015725592
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s0140-6736(03)12681-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049829647
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/s0959-8049(97)00062-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001394077
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1080/07357900701208683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039488431
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/bioinformatics/17.10.977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029038829
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/bioinformatics/btr032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017115352
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1093/hmg/6.6.921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038411164
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1093/nar/30.10.e47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001970199
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1111/j.1349-7006.1992.tb00081.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040601010
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1182/blood-2002-12-3817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024017913
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1200/jco.2004.03.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051418678
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1210/jc.2007-1840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064290237
328 rdf:type schema:CreativeWork
329 https://doi.org/10.2144/000112761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069095771
330 rdf:type schema:CreativeWork
331 https://www.grid.ac/institutes/grid.240871.8 schema:alternateName St. Jude Children's Research Hospital
332 schema:name Department of Biochemistry, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA
333 Department of Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA
334 Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA
335 Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA
336 The Pediatric Cancer Genome Project, St Jude Children's Research Hospital, 262 Danny Thomas Place, 38105, Memphis, TN, USA
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
339 schema:name Department of Genetics, Washington University, 4444 Forest Park Ave, 63108, St Louis, Missouri, USA
340 The Genome Center at Washington University, Washington University, 4444 Forest Park Ave, 63108, St Louis, Missouri, USA
341 rdf:type schema:Organization
342 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
343 schema:name Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA
344 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...