Metagenomic biomarker discovery and explanation View Full Text


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Article Info

DATE

2011-06-24

AUTHORS

Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower

ABSTRACT

This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/. More... »

PAGES

r60

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  • Journal

    TITLE

    Genome Biology

    ISSUE

    6

    VOLUME

    12

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2011-12-6-r60

    DOI

    http://dx.doi.org/10.1186/gb-2011-12-6-r60

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21702898


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