A novel and universal method for microRNA RT-qPCR data normalization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-06

AUTHORS

Pieter Mestdagh, Pieter Van Vlierberghe, An De Weer, Daniel Muth, Frank Westermann, Frank Speleman, Jo Vandesompele

ABSTRACT

Gene expression analysis of microRNA molecules is becoming increasingly important. In this study we assess the use of the mean expression value of all expressed microRNAs in a given sample as a normalization factor for microRNA real-time quantitative PCR data and compare its performance to the currently adopted approach. We demonstrate that the mean expression value outperforms the current normalization strategy in terms of better reduction of technical variation and more accurate appreciation of biological changes. More... »

PAGES

r64

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2009-10-6-r64

    DOI

    http://dx.doi.org/10.1186/gb-2009-10-6-r64

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044394180

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19531210


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    N-Triples is a line-based linked data format ideal for batch operations.

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    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/gb-2009-10-6-r64'

    RDF/XML is a standard XML format for linked data.

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