Ultrafast and memory-efficient alignment of short DNA sequences to the human genome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-03

AUTHORS

Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg

ABSTRACT

Bowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU hour with a memory footprint of approximately 1.3 gigabytes. Bowtie extends previous Burrows-Wheeler techniques with a novel quality-aware backtracking algorithm that permits mismatches. Multiple processor cores can be used simultaneously to achieve even greater alignment speeds. Bowtie is open source (http://bowtie.cbcb.umd.edu). More... »

PAGES

r25

Journal

TITLE

Genome Biology

ISSUE

3

VOLUME

10

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2009-10-3-r25

    DOI

    http://dx.doi.org/10.1186/gb-2009-10-3-r25

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049583368

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19261174


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