Enrichment of sequencing targets from the human genome by solution hybridization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10

AUTHORS

Ryan Tewhey, Masakazu Nakano, Xiaoyun Wang, Carlos Pabón-Peña, Barbara Novak, Angelica Giuffre, Eric Lin, Scott Happe, Doug N Roberts, Emily M LeProust, Eric J Topol, Olivier Harismendy, Kelly A Frazer

ABSTRACT

To exploit fully the potential of current sequencing technologies for population-based studies, one must enrich for loci from the human genome. Here we evaluate the hybridization-based approach by using oligonucleotide capture probes in solution to enrich for approximately 3.9 Mb of sequence target. We demonstrate that the tiling probe frequency is important for generating sequence data with high uniform coverage of targets. We obtained 93% sensitivity to detect SNPs, with a calling accuracy greater than 99%. More... »

PAGES

r116

References to SciGraph publications

  • 2008-09. Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers in HUMAN GENETICS
  • 2009-04. Human genetic variation and its contribution to complex traits in NATURE REVIEWS GENETICS
  • 1995-05. Apolipoprotein E and Alzheimer's in NATURE
  • 2008-04-17. The complete genome of an individual by massively parallel DNA sequencing in NATURE
  • 2007-05. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 in NATURE GENETICS
  • 2000-11. Genetic pathways that regulate ageing in model organisms in NATURE
  • 2008-02. Newly identified loci that influence lipid concentrations and risk of coronary artery disease in NATURE GENETICS
  • 2008-11. Sequence variant on 8q24 confers susceptibility to urinary bladder cancer in NATURE GENETICS
  • 2009-02. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing in NATURE BIOTECHNOLOGY
  • 2008-10-23. Comprehensive genomic characterization defines human glioblastoma genes and core pathways in NATURE
  • 2008-12. A large genome center's improvements to the Illumina sequencing system in NATURE METHODS
  • 2007-11. Direct selection of human genomic loci by microarray hybridization in NATURE METHODS
  • 2008-08. Puzzles, promises and a cure for ageing in NATURE
  • 2008-10-23. Somatic mutations affect key pathways in lung adenocarcinoma in NATURE
  • 2009-09-10. Targeted capture and massively parallel sequencing of 12 human exomes in NATURE
  • 2007-05. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 in NATURE GENETICS
  • 2007-06-28. Genome-wide association study identifies novel breast cancer susceptibility loci in NATURE
  • 2007-11. Microarray-based genomic selection for high-throughput resequencing in NATURE METHODS
  • 2007-12. Genome-wide in situ exon capture for selective resequencing in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2009-10-10-r116

    DOI

    http://dx.doi.org/10.1186/gb-2009-10-10-r116

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002355063

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19835619


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