Integrating sequence, evolution and functional genomics in regulatory genomics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-01-30

AUTHORS

Martin Vingron, Alvis Brazma, Richard Coulson, Jacques van Helden, Thomas Manke, Kimmo Palin, Olivier Sand, Esko Ukkonen

ABSTRACT

With genome analysis expanding from the study of genes to the study of gene regulation, 'regulatory genomics' utilizes sequence information, evolution and functional genomics measurements to unravel how regulatory information is encoded in the genome.

PAGES

202-202

References to SciGraph publications

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  • 1998-10. Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation in NATURE BIOTECHNOLOGY
  • 2004-10-28. PhyME: A probabilistic algorithm for finding motifs in sets of orthologous sequences in BMC BIOINFORMATICS
  • 2005-02-27. Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals in NATURE
  • 2006-11-05. In vivo enhancer analysis of human conserved non-coding sequences in NATURE
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  • 2008-09-18. Using RSAT to scan genome sequences for transcription factor binding sites and cis-regulatory modules in NATURE PROTOCOLS
  • 2001-01. Experimental data of a single promoter can be used for in silico detection of genes with related regulation in the absence of sequence similarity in MAMMALIAN GENOME
  • 2002-10-24. Computational detection of genomic cis-regulatory modules applied to body patterning in the early Drosophila embryo in BMC BIOINFORMATICS
  • 1999-07. Systematic determination of genetic network architecture in NATURE GENETICS
  • 2007-06. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project in NATURE
  • 2000-10. Human-mouse genome comparisons to locate regulatory sites in NATURE GENETICS
  • 2005-01-01. Assessing computational tools for the discovery of transcription factor binding sites in NATURE BIOTECHNOLOGY
  • 2008-03-02. Systematic identification of mammalian regulatory motifs' target genes and functions in NATURE METHODS
  • 2008-01-23. Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution in BMC BIOINFORMATICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2009-10-1-202

    DOI

    http://dx.doi.org/10.1186/gb-2009-10-1-202

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026554987

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19226437


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