Identification of transcripts with enriched expression in the developing and adult pancreas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-10

AUTHORS

Brad G Hoffman, Bogard Zavaglia, Joy Witzsche, Teresa Ruiz de Algara, Mike Beach, Pamela A Hoodless, Steven JM Jones, Marco A Marra, Cheryl D Helgason

ABSTRACT

BACKGROUND: Despite recent advances, the transcriptional hierarchy driving pancreas organogenesis remains largely unknown, in part due to the paucity of comprehensive analyses. To address this deficit we generated ten SAGE libraries from the developing murine pancreas spanning Theiler stages 17-26, making use of available Pdx1 enhanced green fluorescent protein (EGFP) and Neurog3 EGFP reporter strains, as well as tissue from adult islets and ducts. RESULTS: We used a specificity metric to identify 2,536 tags with pancreas-enriched expression compared to 195 other mouse SAGE libraries. We subsequently grouped co-expressed transcripts with differential expression during pancreas development using K-means clustering. We validated the clusters first using quantitative real time PCR and then by analyzing the Theiler stage 22 pancreas in situ hybridization staining patterns of over 600 of the identified genes using the GenePaint database. These were then categorized into one of the five expression domains within the developing pancreas. Based on these results we identified a cascade of transcriptional regulators expressed in the endocrine pancreas lineage and, from this, we developed a predictive regulatory network describing beta-cell development. CONCLUSION: Taken together, this work provides evidence that the SAGE libraries generated here are a valuable resource for continuing to elucidate the molecular mechanisms regulating pancreas development. Furthermore, our studies provide a comprehensive analysis of pancreas development, and insights into the regulatory networks driving this process are revealed. More... »

PAGES

r99

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/gb-2008-9-6-r99

DOI

http://dx.doi.org/10.1186/gb-2008-9-6-r99

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022099064

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18554416


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Green Fluorescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreas", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoffman", 
        "givenName": "Brad G", 
        "id": "sg:person.01203071557.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203071557.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zavaglia", 
        "givenName": "Bogard", 
        "id": "sg:person.01214545203.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214545203.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Witzsche", 
        "givenName": "Joy", 
        "id": "sg:person.011634111353.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011634111353.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruiz de Algara", 
        "givenName": "Teresa", 
        "id": "sg:person.0624504670.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624504670.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beach", 
        "givenName": "Mike", 
        "id": "sg:person.01072504257.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072504257.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Terry Fox Laboratory, C Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada", 
            "Department of Medical Genetics, Faculty of Medicine, University of British Columbia, University Boulevard, V6T 1Z3, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoodless", 
        "givenName": "Pamela A", 
        "id": "sg:person.01334177323.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334177323.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Medical Genetics, Faculty of Medicine, University of British Columbia, University Boulevard, V6T 1Z3, Vancouver, BC, Canada", 
            "Micheal Smith Genome Sciences Centre, BC Cancer Agency, West 7th Ave, V5Z 4S6, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Steven JM", 
        "id": "sg:person.011076371162.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Medical Genetics, Faculty of Medicine, University of British Columbia, University Boulevard, V6T 1Z3, Vancouver, BC, Canada", 
            "Micheal Smith Genome Sciences Centre, BC Cancer Agency, West 7th Ave, V5Z 4S6, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marra", 
        "givenName": "Marco A", 
        "id": "sg:person.01150455763.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada", 
            "Department of Surgery, Faculty of Medicine, University of British Columbia, West 10th Avenue, V5Z 4E3, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Helgason", 
        "givenName": "Cheryl D", 
        "id": "sg:person.01072777374.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072777374.53"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2337/diabetes.49.2.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000716550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2003-4-10-r70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001293245", 
          "https://doi.org/10.1186/gb-2003-4-10-r70"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/10.6.617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001674026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.10.3488-3496.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002530960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.02358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004293237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408122102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004355237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1064344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004467358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81815-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006236529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00825-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006904538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008629405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-8-127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008753143", 
          "https://doi.org/10.1186/1471-2164-8-127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gki475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009967407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00304-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010946811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011628190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0030178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012018598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012406364", 
          "https://doi.org/10.1038/ng1532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012406364", 
          "https://doi.org/10.1038/ng1532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-1-r6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016160695", 
          "https://doi.org/10.1186/gb-2007-8-1-r6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0509455102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017640657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.4.1607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019671575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m213196200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019991857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.7.1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020800949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021865708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkj075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022340368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022656805", 
          "https://doi.org/10.1038/nrg841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022656805", 
          "https://doi.org/10.1038/nrg841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2003.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023987484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025435658", 
          "https://doi.org/10.1038/nrg1726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025435658", 
          "https://doi.org/10.1038/nrg1726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkh029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gki145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025682496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026975094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m314115200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027632058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.7.2757-2766.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028751081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2007.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029666504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.9.e45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030834024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2005-6-4-r33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032005646", 
          "https://doi.org/10.1186/gb-2005-6-4-r33"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/23716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032685574", 
          "https://doi.org/10.1038/23716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/23716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032685574", 
          "https://doi.org/10.1038/23716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.12.11.1705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034811466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2004-5-7-r51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036919417", 
          "https://doi.org/10.1186/gb-2004-5-7-r51"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/71657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038546983", 
          "https://doi.org/10.1038/71657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/71657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038546983", 
          "https://doi.org/10.1038/71657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygeno.2006.03.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038813539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2005.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038836676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.8.3.186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038920266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m101330200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038926769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(99)00033-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039134392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.5.2665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039380829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-004-1368-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039838151", 
          "https://doi.org/10.1007/s00125-004-1368-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-004-1368-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039838151", 
          "https://doi.org/10.1007/s00125-004-1368-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0925-4773(00)00317-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041009207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-0436.2001.680408.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041142130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041398021", 
          "https://doi.org/10.1038/ng959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041398021", 
          "https://doi.org/10.1038/ng959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470062128.ch2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041455612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0020247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044722980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db07-1362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045097906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1534-5807(03)00035-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045407027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-7-116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046354959", 
          "https://doi.org/10.1186/1471-2105-7-116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.12.4445-4454.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046764530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047917847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.9.5366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048425576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.5488207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048766691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.52.7.1604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050721057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2003.12.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050832662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.10460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051341696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygeno.2004.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051846375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.10.5679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052828080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.286.5439.455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062566964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2004-1175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2004-1576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2005-0910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.141.6.7567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064283770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.47.12.1817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070743739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.19-23-10348.1999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074555053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074607259", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075039876", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/03342mt01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075245738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.7.10.986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083159139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083160574", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780471650126.dob0560.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090239289"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-10", 
    "datePublishedReg": "2008-10-01", 
    "description": "BACKGROUND: Despite recent advances, the transcriptional hierarchy driving pancreas organogenesis remains largely unknown, in part due to the paucity of comprehensive analyses. To address this deficit we generated ten SAGE libraries from the developing murine pancreas spanning Theiler stages 17-26, making use of available Pdx1 enhanced green fluorescent protein (EGFP) and Neurog3 EGFP reporter strains, as well as tissue from adult islets and ducts.\nRESULTS: We used a specificity metric to identify 2,536 tags with pancreas-enriched expression compared to 195 other mouse SAGE libraries. We subsequently grouped co-expressed transcripts with differential expression during pancreas development using K-means clustering. We validated the clusters first using quantitative real time PCR and then by analyzing the Theiler stage 22 pancreas in situ hybridization staining patterns of over 600 of the identified genes using the GenePaint database. These were then categorized into one of the five expression domains within the developing pancreas. Based on these results we identified a cascade of transcriptional regulators expressed in the endocrine pancreas lineage and, from this, we developed a predictive regulatory network describing beta-cell development.\nCONCLUSION: Taken together, this work provides evidence that the SAGE libraries generated here are a valuable resource for continuing to elucidate the molecular mechanisms regulating pancreas development. Furthermore, our studies provide a comprehensive analysis of pancreas development, and insights into the regulatory networks driving this process are revealed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/gb-2008-9-6-r99", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1023439", 
        "issn": [
          "1474-760X", 
          "1465-6906"
        ], 
        "name": "Genome Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Identification of transcripts with enriched expression in the developing and adult pancreas", 
    "pagination": "r99", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "69491890cdb52b7896d619da38655fd8b4996e37eaedd90d1d9a23c39e85afbf"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18554416"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100960660"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/gb-2008-9-6-r99"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022099064"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/gb-2008-9-6-r99", 
      "https://app.dimensions.ai/details/publication/pub.1022099064"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fgb-2008-9-6-r99"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/gb-2008-9-6-r99'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/gb-2008-9-6-r99'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/gb-2008-9-6-r99'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/gb-2008-9-6-r99'


 

This table displays all metadata directly associated to this object as RDF triples.

409 TRIPLES      21 PREDICATES      112 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/gb-2008-9-6-r99 schema:about N37a6af4950644fbcb69b6d58727414b6
2 N386ee0f5250a42358908c5da6fec27af
3 Naaa60e67d5594aed85a376c2cbbd906c
4 Nafa6a580a71d47f39a53bbfa6876a5c9
5 Nc2b71882e4ff4e9db8f466e1563ab2a6
6 Nc965d847f9bc4dc2a86229e5ddc5ef39
7 Nccff18f9796b4bd5a0d35f746410dd03
8 Nd0941e418c5b4b7cb767772368ee0485
9 anzsrc-for:06
10 anzsrc-for:0604
11 schema:author N3a3bf064f1d1412e8d6b6162983ba026
12 schema:citation sg:pub.10.1007/s00125-004-1368-9
13 sg:pub.10.1038/23716
14 sg:pub.10.1038/71657
15 sg:pub.10.1038/ng1532
16 sg:pub.10.1038/ng959
17 sg:pub.10.1038/nrg1726
18 sg:pub.10.1038/nrg841
19 sg:pub.10.1186/1471-2105-7-116
20 sg:pub.10.1186/1471-2164-8-127
21 sg:pub.10.1186/gb-2003-4-10-r70
22 sg:pub.10.1186/gb-2004-5-7-r51
23 sg:pub.10.1186/gb-2005-6-4-r33
24 sg:pub.10.1186/gb-2007-8-1-r6
25 https://app.dimensions.ai/details/publication/pub.1074607259
26 https://app.dimensions.ai/details/publication/pub.1075039876
27 https://app.dimensions.ai/details/publication/pub.1083160574
28 https://doi.org/10.1002/9780470062128.ch2
29 https://doi.org/10.1002/9780471650126.dob0560.pub2
30 https://doi.org/10.1002/dmrr.331
31 https://doi.org/10.1002/dmrr.364
32 https://doi.org/10.1002/dvdy.10460
33 https://doi.org/10.1016/j.biocel.2003.08.010
34 https://doi.org/10.1016/j.devcel.2007.06.001
35 https://doi.org/10.1016/j.ydbio.2003.12.016
36 https://doi.org/10.1016/j.ydbio.2005.04.023
37 https://doi.org/10.1016/j.ygeno.2004.06.014
38 https://doi.org/10.1016/j.ygeno.2006.03.022
39 https://doi.org/10.1016/s0092-8674(00)81815-2
40 https://doi.org/10.1016/s0092-8674(02)00825-5
41 https://doi.org/10.1016/s0092-8674(04)00304-6
42 https://doi.org/10.1016/s0925-4773(00)00317-8
43 https://doi.org/10.1016/s0955-0674(99)00033-2
44 https://doi.org/10.1016/s1534-5807(03)00035-2
45 https://doi.org/10.1046/j.1432-0436.2001.680408.x
46 https://doi.org/10.1073/pnas.0408122102
47 https://doi.org/10.1073/pnas.0509455102
48 https://doi.org/10.1073/pnas.97.4.1607
49 https://doi.org/10.1074/jbc.273.9.5366
50 https://doi.org/10.1074/jbc.274.5.2665
51 https://doi.org/10.1074/jbc.m101330200
52 https://doi.org/10.1074/jbc.m213196200
53 https://doi.org/10.1074/jbc.m314115200
54 https://doi.org/10.1093/hmg/10.6.617
55 https://doi.org/10.1093/nar/29.9.e45
56 https://doi.org/10.1093/nar/gkh029
57 https://doi.org/10.1093/nar/gki145
58 https://doi.org/10.1093/nar/gki475
59 https://doi.org/10.1093/nar/gkj075
60 https://doi.org/10.1101/gad.12.11.1705
61 https://doi.org/10.1101/gr.5488207
62 https://doi.org/10.1101/gr.7.10.986
63 https://doi.org/10.1101/gr.8.3.186
64 https://doi.org/10.1126/science.1064344
65 https://doi.org/10.1126/science.286.5439.455
66 https://doi.org/10.1128/mcb.17.10.5679
67 https://doi.org/10.1128/mcb.20.12.4445-4454.2000
68 https://doi.org/10.1128/mcb.22.10.3488-3496.2002
69 https://doi.org/10.1128/mcb.24.7.2757-2766.2004
70 https://doi.org/10.1210/en.2004-1175
71 https://doi.org/10.1210/en.2004-1576
72 https://doi.org/10.1210/en.2005-0910
73 https://doi.org/10.1210/endo.141.6.7567
74 https://doi.org/10.1242/dev.00921
75 https://doi.org/10.1242/dev.00960
76 https://doi.org/10.1242/dev.01256
77 https://doi.org/10.1242/dev.02358
78 https://doi.org/10.1371/journal.pbio.0020247
79 https://doi.org/10.1371/journal.pgen.0030178
80 https://doi.org/10.1523/jneurosci.19-23-10348.1999
81 https://doi.org/10.2144/03342mt01
82 https://doi.org/10.2337/db07-1362
83 https://doi.org/10.2337/diabetes.47.12.1817
84 https://doi.org/10.2337/diabetes.49.2.163
85 https://doi.org/10.2337/diabetes.51.7.1997
86 https://doi.org/10.2337/diabetes.52.7.1604
87 schema:datePublished 2008-10
88 schema:datePublishedReg 2008-10-01
89 schema:description BACKGROUND: Despite recent advances, the transcriptional hierarchy driving pancreas organogenesis remains largely unknown, in part due to the paucity of comprehensive analyses. To address this deficit we generated ten SAGE libraries from the developing murine pancreas spanning Theiler stages 17-26, making use of available Pdx1 enhanced green fluorescent protein (EGFP) and Neurog3 EGFP reporter strains, as well as tissue from adult islets and ducts. RESULTS: We used a specificity metric to identify 2,536 tags with pancreas-enriched expression compared to 195 other mouse SAGE libraries. We subsequently grouped co-expressed transcripts with differential expression during pancreas development using K-means clustering. We validated the clusters first using quantitative real time PCR and then by analyzing the Theiler stage 22 pancreas in situ hybridization staining patterns of over 600 of the identified genes using the GenePaint database. These were then categorized into one of the five expression domains within the developing pancreas. Based on these results we identified a cascade of transcriptional regulators expressed in the endocrine pancreas lineage and, from this, we developed a predictive regulatory network describing beta-cell development. CONCLUSION: Taken together, this work provides evidence that the SAGE libraries generated here are a valuable resource for continuing to elucidate the molecular mechanisms regulating pancreas development. Furthermore, our studies provide a comprehensive analysis of pancreas development, and insights into the regulatory networks driving this process are revealed.
90 schema:genre research_article
91 schema:inLanguage en
92 schema:isAccessibleForFree true
93 schema:isPartOf N374d173fec614df684fe41c3cb526d1f
94 Nb08fc50c6ef1461684482a523244c65d
95 sg:journal.1023439
96 schema:name Identification of transcripts with enriched expression in the developing and adult pancreas
97 schema:pagination r99
98 schema:productId N297285c71f3b45b99888b34167a08cb0
99 N63b43f9429d14a9fbd3e198f41e16c5f
100 N69d3b8bde6e84f6ab751508f316cd1e6
101 N6eb1dd3c992c4c8db0ba2c11efe6d6e7
102 Nedcde71568df4a139e3233c4b3cdeba5
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022099064
104 https://doi.org/10.1186/gb-2008-9-6-r99
105 schema:sdDatePublished 2019-04-10T15:51
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher N75da9f401690434e8d6458fb21aebdc7
108 schema:url http://link.springer.com/10.1186%2Fgb-2008-9-6-r99
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N0c6f06f6be3c45839353ad2193b3a5db rdf:first sg:person.01334177323.24
113 rdf:rest N633e962603db428ab8080acea9dca066
114 N0e52ab78a9d8484eabef28a4b4e75083 schema:name Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada
115 rdf:type schema:Organization
116 N297285c71f3b45b99888b34167a08cb0 schema:name dimensions_id
117 schema:value pub.1022099064
118 rdf:type schema:PropertyValue
119 N374d173fec614df684fe41c3cb526d1f schema:volumeNumber 9
120 rdf:type schema:PublicationVolume
121 N37a6af4950644fbcb69b6d58727414b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Female
123 rdf:type schema:DefinedTerm
124 N386ee0f5250a42358908c5da6fec27af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Green Fluorescent Proteins
126 rdf:type schema:DefinedTerm
127 N39e65a74bc3a4c898e6e115834aa4225 schema:name Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada
128 rdf:type schema:Organization
129 N3a3bf064f1d1412e8d6b6162983ba026 rdf:first sg:person.01203071557.28
130 rdf:rest N3d8281d51d72484c822cc2a8179ad7c5
131 N3d8281d51d72484c822cc2a8179ad7c5 rdf:first sg:person.01214545203.18
132 rdf:rest Ne54a14516b5f4fc69a484975c6567fba
133 N62d28b49ee464c0e90571b1795f2ac97 rdf:first sg:person.0624504670.34
134 rdf:rest Nb0f864d810474ae4b93823be8a77345a
135 N633e962603db428ab8080acea9dca066 rdf:first sg:person.011076371162.80
136 rdf:rest Nd13550c1a5af4abbab80fdc239973078
137 N63b43f9429d14a9fbd3e198f41e16c5f schema:name pubmed_id
138 schema:value 18554416
139 rdf:type schema:PropertyValue
140 N6748cf0188e544569cef6f57082f18cc schema:name Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada
141 rdf:type schema:Organization
142 N69d3b8bde6e84f6ab751508f316cd1e6 schema:name doi
143 schema:value 10.1186/gb-2008-9-6-r99
144 rdf:type schema:PropertyValue
145 N6eb1dd3c992c4c8db0ba2c11efe6d6e7 schema:name readcube_id
146 schema:value 69491890cdb52b7896d619da38655fd8b4996e37eaedd90d1d9a23c39e85afbf
147 rdf:type schema:PropertyValue
148 N75da9f401690434e8d6458fb21aebdc7 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N89c5ffef9269492280cba7f65ec278c4 rdf:first sg:person.01072777374.53
151 rdf:rest rdf:nil
152 N902f72218a72420cb1686622a29eabb7 schema:name Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada
153 rdf:type schema:Organization
154 Naaa60e67d5594aed85a376c2cbbd906c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Organogenesis
156 rdf:type schema:DefinedTerm
157 Nafa6a580a71d47f39a53bbfa6876a5c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Animals
159 rdf:type schema:DefinedTerm
160 Nb08fc50c6ef1461684482a523244c65d schema:issueNumber 6
161 rdf:type schema:PublicationIssue
162 Nb0f864d810474ae4b93823be8a77345a rdf:first sg:person.01072504257.27
163 rdf:rest N0c6f06f6be3c45839353ad2193b3a5db
164 Nc2b71882e4ff4e9db8f466e1563ab2a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Male
166 rdf:type schema:DefinedTerm
167 Nc965d847f9bc4dc2a86229e5ddc5ef39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Pancreas
169 rdf:type schema:DefinedTerm
170 Nccff18f9796b4bd5a0d35f746410dd03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Gene Expression Profiling
172 rdf:type schema:DefinedTerm
173 Ncdf88eb86453467494cac53ae3fcf449 schema:name Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada
174 rdf:type schema:Organization
175 Nd0941e418c5b4b7cb767772368ee0485 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Mice
177 rdf:type schema:DefinedTerm
178 Nd13550c1a5af4abbab80fdc239973078 rdf:first sg:person.01150455763.02
179 rdf:rest N89c5ffef9269492280cba7f65ec278c4
180 Ne54a14516b5f4fc69a484975c6567fba rdf:first sg:person.011634111353.16
181 rdf:rest N62d28b49ee464c0e90571b1795f2ac97
182 Nedcde71568df4a139e3233c4b3cdeba5 schema:name nlm_unique_id
183 schema:value 100960660
184 rdf:type schema:PropertyValue
185 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
186 schema:name Biological Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
189 schema:name Genetics
190 rdf:type schema:DefinedTerm
191 sg:journal.1023439 schema:issn 1465-6906
192 1474-760X
193 schema:name Genome Biology
194 rdf:type schema:Periodical
195 sg:person.01072504257.27 schema:affiliation N902f72218a72420cb1686622a29eabb7
196 schema:familyName Beach
197 schema:givenName Mike
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072504257.27
199 rdf:type schema:Person
200 sg:person.01072777374.53 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
201 schema:familyName Helgason
202 schema:givenName Cheryl D
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072777374.53
204 rdf:type schema:Person
205 sg:person.011076371162.80 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
206 schema:familyName Jones
207 schema:givenName Steven JM
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80
209 rdf:type schema:Person
210 sg:person.01150455763.02 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
211 schema:familyName Marra
212 schema:givenName Marco A
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02
214 rdf:type schema:Person
215 sg:person.011634111353.16 schema:affiliation N39e65a74bc3a4c898e6e115834aa4225
216 schema:familyName Witzsche
217 schema:givenName Joy
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011634111353.16
219 rdf:type schema:Person
220 sg:person.01203071557.28 schema:affiliation N0e52ab78a9d8484eabef28a4b4e75083
221 schema:familyName Hoffman
222 schema:givenName Brad G
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203071557.28
224 rdf:type schema:Person
225 sg:person.01214545203.18 schema:affiliation N6748cf0188e544569cef6f57082f18cc
226 schema:familyName Zavaglia
227 schema:givenName Bogard
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214545203.18
229 rdf:type schema:Person
230 sg:person.01334177323.24 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
231 schema:familyName Hoodless
232 schema:givenName Pamela A
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334177323.24
234 rdf:type schema:Person
235 sg:person.0624504670.34 schema:affiliation Ncdf88eb86453467494cac53ae3fcf449
236 schema:familyName Ruiz de Algara
237 schema:givenName Teresa
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624504670.34
239 rdf:type schema:Person
240 sg:pub.10.1007/s00125-004-1368-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039838151
241 https://doi.org/10.1007/s00125-004-1368-9
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/23716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032685574
244 https://doi.org/10.1038/23716
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/71657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038546983
247 https://doi.org/10.1038/71657
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/ng1532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012406364
250 https://doi.org/10.1038/ng1532
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/ng959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041398021
253 https://doi.org/10.1038/ng959
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nrg1726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025435658
256 https://doi.org/10.1038/nrg1726
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nrg841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022656805
259 https://doi.org/10.1038/nrg841
260 rdf:type schema:CreativeWork
261 sg:pub.10.1186/1471-2105-7-116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046354959
262 https://doi.org/10.1186/1471-2105-7-116
263 rdf:type schema:CreativeWork
264 sg:pub.10.1186/1471-2164-8-127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008753143
265 https://doi.org/10.1186/1471-2164-8-127
266 rdf:type schema:CreativeWork
267 sg:pub.10.1186/gb-2003-4-10-r70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001293245
268 https://doi.org/10.1186/gb-2003-4-10-r70
269 rdf:type schema:CreativeWork
270 sg:pub.10.1186/gb-2004-5-7-r51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036919417
271 https://doi.org/10.1186/gb-2004-5-7-r51
272 rdf:type schema:CreativeWork
273 sg:pub.10.1186/gb-2005-6-4-r33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032005646
274 https://doi.org/10.1186/gb-2005-6-4-r33
275 rdf:type schema:CreativeWork
276 sg:pub.10.1186/gb-2007-8-1-r6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016160695
277 https://doi.org/10.1186/gb-2007-8-1-r6
278 rdf:type schema:CreativeWork
279 https://app.dimensions.ai/details/publication/pub.1074607259 schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1075039876 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1083160574 schema:CreativeWork
282 https://doi.org/10.1002/9780470062128.ch2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041455612
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/9780471650126.dob0560.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090239289
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/dmrr.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026975094
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1002/dmrr.364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008629405
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1002/dvdy.10460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051341696
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.biocel.2003.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023987484
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.devcel.2007.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029666504
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.ydbio.2003.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050832662
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.ydbio.2005.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038836676
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.ygeno.2004.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051846375
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.ygeno.2006.03.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038813539
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/s0092-8674(00)81815-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006236529
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/s0092-8674(02)00825-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006904538
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/s0092-8674(04)00304-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010946811
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s0925-4773(00)00317-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041009207
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s0955-0674(99)00033-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039134392
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s1534-5807(03)00035-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045407027
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1046/j.1432-0436.2001.680408.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041142130
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1073/pnas.0408122102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004355237
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1073/pnas.0509455102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017640657
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1073/pnas.97.4.1607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019671575
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1074/jbc.273.9.5366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048425576
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1074/jbc.274.5.2665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039380829
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1074/jbc.m101330200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038926769
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1074/jbc.m213196200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019991857
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1074/jbc.m314115200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027632058
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/hmg/10.6.617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001674026
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/nar/29.9.e45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030834024
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/nar/gkh029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573499
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/nar/gki145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025682496
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1093/nar/gki475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009967407
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1093/nar/gkj075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022340368
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1101/gad.12.11.1705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034811466
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1101/gr.5488207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048766691
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1101/gr.7.10.986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083159139
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1101/gr.8.3.186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038920266
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1126/science.1064344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004467358
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1126/science.286.5439.455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062566964
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1128/mcb.17.10.5679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052828080
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1128/mcb.20.12.4445-4454.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046764530
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1128/mcb.22.10.3488-3496.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002530960
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1128/mcb.24.7.2757-2766.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028751081
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1210/en.2004-1175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247100
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1210/en.2004-1576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247248
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1210/en.2005-0910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247624
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1210/endo.141.6.7567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064283770
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1242/dev.00921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047917847
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1242/dev.00960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021865708
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1242/dev.01256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011628190
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1242/dev.02358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004293237
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1371/journal.pbio.0020247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044722980
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1371/journal.pgen.0030178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012018598
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1523/jneurosci.19-23-10348.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074555053
387 rdf:type schema:CreativeWork
388 https://doi.org/10.2144/03342mt01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075245738
389 rdf:type schema:CreativeWork
390 https://doi.org/10.2337/db07-1362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045097906
391 rdf:type schema:CreativeWork
392 https://doi.org/10.2337/diabetes.47.12.1817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070743739
393 rdf:type schema:CreativeWork
394 https://doi.org/10.2337/diabetes.49.2.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000716550
395 rdf:type schema:CreativeWork
396 https://doi.org/10.2337/diabetes.51.7.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020800949
397 rdf:type schema:CreativeWork
398 https://doi.org/10.2337/diabetes.52.7.1604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050721057
399 rdf:type schema:CreativeWork
400 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
401 schema:name Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada
402 Department of Medical Genetics, Faculty of Medicine, University of British Columbia, University Boulevard, V6T 1Z3, Vancouver, BC, Canada
403 Department of Surgery, Faculty of Medicine, University of British Columbia, West 10th Avenue, V5Z 4E3, Vancouver, BC, Canada
404 Terry Fox Laboratory, C Cancer Research Center, West 10th Ave, V5Z 1L3, Vancouver, BC, Canada
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
407 schema:name Department of Medical Genetics, Faculty of Medicine, University of British Columbia, University Boulevard, V6T 1Z3, Vancouver, BC, Canada
408 Micheal Smith Genome Sciences Centre, BC Cancer Agency, West 7th Ave, V5Z 4S6, Vancouver, BC, Canada
409 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...