Comparative genomics of mutualistic viruses of Glyptapantelesparasitic wasps View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12-30

AUTHORS

Christopher A Desjardins, Dawn E Gundersen-Rindal, Jessica B Hostetler, Luke J Tallon, Douglas W Fadrosh, Roger W Fuester, Monica J Pedroni, Brian J Haas, Michael C Schatz, Kristine M Jones, Jonathan Crabtree, Heather Forberger, Vishvanath Nene

ABSTRACT

BackgroundPolydnaviruses, double-stranded DNA viruses with segmented genomes, have evolved as obligate endosymbionts of parasitoid wasps. Virus particles are replication deficient and produced by female wasps from proviral sequences integrated into the wasp genome. These particles are co-injected with eggs into caterpillar hosts, where viral gene expression facilitates parasitoid survival and, thereby, survival of proviral DNA. Here we characterize and compare the encapsidated viral genome sequences of bracoviruses in the family Polydnaviridae associated with Glyptapanteles gypsy moth parasitoids, along with near complete proviral sequences from which both viral genomes are derived.ResultsThe encapsidated Glyptapanteles indiensis and Glyptapanteles flavicoxis bracoviral genomes, each composed of 29 different size segments, total approximately 517 and 594 kbp, respectively. They are generated from a minimum of seven distinct loci in the wasp genome. Annotation of these sequences revealed numerous novel features for polydnaviruses, including insect-like sugar transporter genes and transposable elements. Evolutionary analyses suggest that positive selection is widespread among bracoviral genes.ConclusionsThe structure and organization of G. indiensis and G. flavicoxis bracovirus proviral segments as multiple loci containing one to many viral segments, flanked and separated by wasp gene-encoding DNA, is confirmed. Rapid evolution of bracovirus genes supports the hypothesis of bracovirus genes in an 'arms race' between bracovirus and caterpillar. Phylogenetic analyses of the bracoviral genes encoding sugar transporters provides the first robust evidence of a wasp origin for some polydnavirus genes. We hypothesize transposable elements, such as those described here, could facilitate transfer of genes between proviral segments and host DNA. More... »

PAGES

r183

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/gb-2008-9-12-r183

DOI

http://dx.doi.org/10.1186/gb-2008-9-12-r183

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043864470

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19116010


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21 schema:description BackgroundPolydnaviruses, double-stranded DNA viruses with segmented genomes, have evolved as obligate endosymbionts of parasitoid wasps. Virus particles are replication deficient and produced by female wasps from proviral sequences integrated into the wasp genome. These particles are co-injected with eggs into caterpillar hosts, where viral gene expression facilitates parasitoid survival and, thereby, survival of proviral DNA. Here we characterize and compare the encapsidated viral genome sequences of bracoviruses in the family Polydnaviridae associated with Glyptapanteles gypsy moth parasitoids, along with near complete proviral sequences from which both viral genomes are derived.ResultsThe encapsidated Glyptapanteles indiensis and Glyptapanteles flavicoxis bracoviral genomes, each composed of 29 different size segments, total approximately 517 and 594 kbp, respectively. They are generated from a minimum of seven distinct loci in the wasp genome. Annotation of these sequences revealed numerous novel features for polydnaviruses, including insect-like sugar transporter genes and transposable elements. Evolutionary analyses suggest that positive selection is widespread among bracoviral genes.ConclusionsThe structure and organization of G. indiensis and G. flavicoxis bracovirus proviral segments as multiple loci containing one to many viral segments, flanked and separated by wasp gene-encoding DNA, is confirmed. Rapid evolution of bracovirus genes supports the hypothesis of bracovirus genes in an 'arms race' between bracovirus and caterpillar. Phylogenetic analyses of the bracoviral genes encoding sugar transporters provides the first robust evidence of a wasp origin for some polydnavirus genes. We hypothesize transposable elements, such as those described here, could facilitate transfer of genes between proviral segments and host DNA.
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28 schema:keywords ConclusionsThe structure
29 DNA
30 DNA viruses
31 Glyptapanteles indiensis
32 Polydnaviridae
33 ResultsThe
34 analysis
35 annotation
36 arms race
37 bracovirus
38 bracovirus genes
39 caterpillar hosts
40 caterpillars
41 comparative genomics
42 complete proviral sequence
43 different size segments
44 distinct loci
45 eggs
46 elements
47 endosymbionts
48 evidence
49 evolution
50 evolutionary analysis
51 family Polydnaviridae
52 features
53 female wasps
54 first robust evidence
55 genes
56 genome
57 genome sequence
58 genomics
59 gypsy moth parasitoids
60 host
61 host DNA
62 hypothesis
63 kbp
64 loci
65 minimum
66 moth parasitoids
67 multiple loci
68 mutualistic viruses
69 novel features
70 numerous novel features
71 obligate endosymbionts
72 organization
73 origin
74 parasitoid survival
75 parasitoid wasps
76 parasitoids
77 particles
78 phylogenetic analysis
79 polydnavirus
80 polydnavirus genes
81 positive selection
82 proviral DNA
83 proviral segments
84 proviral sequences
85 race
86 rapid evolution
87 replication
88 robust evidence
89 segmented genome
90 segments
91 selection
92 sequence
93 size segments
94 structure
95 sugar transporter genes
96 sugar transporters
97 survival
98 transfer
99 transfer of genes
100 transporter gene
101 transporters
102 transposable elements
103 viral genome
104 viral genome sequences
105 viral segments
106 virus
107 virus particles
108 wasp genome
109 wasps
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