Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-01-11

AUTHORS

Brian J Haas, Steven L Salzberg, Wei Zhu, Mihaela Pertea, Jonathan E Allen, Joshua Orvis, Owen White, C Robin Buell, Jennifer R Wortman

ABSTRACT

EVidenceModeler (EVM) is presented as an automated eukaryotic gene structure annotation tool that reports eukaryotic gene structures as a weighted consensus of all available evidence. EVM, when combined with the Program to Assemble Spliced Alignments (PASA), yields a comprehensive, configurable annotation system that predicts protein-coding genes and alternatively spliced isoforms. Our experiments on both rice and human genome sequences demonstrate that EVM produces automated gene structure annotation approaching the quality of manual curation. More... »

PAGES

r7

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/gb-2008-9-1-r7

DOI

http://dx.doi.org/10.1186/gb-2008-9-1-r7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029779393

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18190707


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