Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-07

AUTHORS

Sergio Kaiser, Young-Kyu Park, Jeffrey L Franklin, Richard B Halberg, Ming Yu, Walter J Jessen, Johannes Freudenberg, Xiaodi Chen, Kevin Haigis, Anil G Jegga, Sue Kong, Bhuvaneswari Sakthivel, Huan Xu, Timothy Reichling, Mohammad Azhar, Gregory P Boivin, Reade B Roberts, Anika C Bissahoyo, Fausto Gonzales, Greg C Bloom, Steven Eschrich, Scott L Carter, Jeremy E Aronow, John Kleimeyer, Michael Kleimeyer, Vivek Ramaswamy, Stephen H Settle, Braden Boone, Shawn Levy, Jonathan M Graff, Thomas Doetschman, Joanna Groden, William F Dove, David W Threadgill, Timothy J Yeatman, Robert J Coffey, Bruce J Aronow

ABSTRACT

BACKGROUND: The expression of carcino-embryonic antigen by colorectal cancer is an example of oncogenic activation of embryonic gene expression. Hypothesizing that oncogenesis-recapitulating-ontogenesis may represent a broad programmatic commitment, we compared gene expression patterns of human colorectal cancers (CRCs) and mouse colon tumor models to those of mouse colon development embryonic days 13.5-18.5. RESULTS: We report here that 39 colon tumors from four independent mouse models and 100 human CRCs encompassing all clinical stages shared a striking recapitulation of embryonic colon gene expression. Compared to normal adult colon, all mouse and human tumors over-expressed a large cluster of genes highly enriched for functional association to the control of cell cycle progression, proliferation, and migration, including those encoding MYC, AKT2, PLK1 and SPARC. Mouse tumors positive for nuclear beta-catenin shifted the shared embryonic pattern to that of early development. Human and mouse tumors differed from normal embryonic colon by their loss of expression modules enriched for tumor suppressors (EDNRB, HSPE, KIT and LSP1). Human CRC adenocarcinomas lost an additional suppressor module (IGFBP4, MAP4K1, PDGFRA, STAB1 and WNT4). Many human tumor samples also gained expression of a coordinately regulated module associated with advanced malignancy (ABCC1, FOXO3A, LIF, PIK3R1, PRNP, TNC, TIMP3 and VEGF). CONCLUSION: Cross-species, developmental, and multi-model gene expression patterning comparisons provide an integrated and versatile framework for definition of transcriptional programs associated with oncogenesis. This approach also provides a general method for identifying pattern-specific biomarkers and therapeutic targets. This delineation and categorization of developmental and non-developmental activator and suppressor gene modules can thus facilitate the formulation of sophisticated hypotheses to evaluate potential synergistic effects of targeting within- and between-modules for next-generation combinatorial therapeutics and improved mouse models. More... »

PAGES

r131

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/gb-2007-8-7-r131

DOI

http://dx.doi.org/10.1186/gb-2007-8-7-r131

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036560396

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17615082


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Developmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaiser", 
        "givenName": "Sergio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Departments of Medicine, and Cell and Developmental Biology, Vanderbilt University and Department of Veterans Affairs Medical Center, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Young-Kyu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Departments of Medicine, and Cell and Developmental Biology, Vanderbilt University and Department of Veterans Affairs Medical Center, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franklin", 
        "givenName": "Jeffrey L", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "McArdle Laboratory for Cancer Research, University of Wisconsin, 53706, Madison, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halberg", 
        "givenName": "Richard B", 
        "id": "sg:person.01356550554.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356550554.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "Department of Genetics and Lineberger Cancer Center, University of North Carolina, 27599, Chapel Hill, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Ming", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jessen", 
        "givenName": "Walter J", 
        "id": "sg:person.01237264062.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237264062.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Freudenberg", 
        "givenName": "Johannes", 
        "id": "sg:person.01370531077.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370531077.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "McArdle Laboratory for Cancer Research, University of Wisconsin, 53706, Madison, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Xiaodi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, 02129, Charlestown, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haigis", 
        "givenName": "Kevin", 
        "id": "sg:person.01174765165.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174765165.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jegga", 
        "givenName": "Anil G", 
        "id": "sg:person.01264413050.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264413050.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kong", 
        "givenName": "Sue", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakthivel", 
        "givenName": "Bhuvaneswari", 
        "id": "sg:person.01362210020.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362210020.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Huan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Ohio State University", 
          "id": "https://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Division of Human Cancer Genetics, The Ohio State University College of Medicine, 43210-2207, Columbus, Ohio, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reichling", 
        "givenName": "Timothy", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Institute for Collaborative BioResearch, University of Arizona, 85721-0036, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Azhar", 
        "givenName": "Mohammad", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cincinnati", 
          "id": "https://www.grid.ac/institutes/grid.24827.3b", 
          "name": [
            "University of Cincinnati, Department of Pathology and Laboratory Medicine, 45267, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boivin", 
        "givenName": "Gregory P", 
        "id": "sg:person.014056553757.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014056553757.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "Department of Genetics and Lineberger Cancer Center, University of North Carolina, 27599, Chapel Hill, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roberts", 
        "givenName": "Reade B", 
        "id": "sg:person.014353307367.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014353307367.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "Department of Genetics and Lineberger Cancer Center, University of North Carolina, 27599, Chapel Hill, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bissahoyo", 
        "givenName": "Anika C", 
        "id": "sg:person.01301735301.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301735301.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moffitt Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.468198.a", 
          "name": [
            "H Lee Moffitt Cancer Center and Research Institute, 33612, Tampa, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzales", 
        "givenName": "Fausto", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moffitt Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.468198.a", 
          "name": [
            "H Lee Moffitt Cancer Center and Research Institute, 33612, Tampa, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bloom", 
        "givenName": "Greg C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moffitt Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.468198.a", 
          "name": [
            "H Lee Moffitt Cancer Center and Research Institute, 33612, Tampa, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eschrich", 
        "givenName": "Steven", 
        "id": "sg:person.010462044607.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010462044607.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology (CHIP@HST), Harvard Medical School, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carter", 
        "givenName": "Scott L", 
        "id": "sg:person.01300465737.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300465737.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aronow", 
        "givenName": "Jeremy E", 
        "id": "sg:person.01160571611.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160571611.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kleimeyer", 
        "givenName": "John", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kleimeyer", 
        "givenName": "Michael", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramaswamy", 
        "givenName": "Vivek", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Departments of Medicine, and Cell and Developmental Biology, Vanderbilt University and Department of Veterans Affairs Medical Center, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Settle", 
        "givenName": "Stephen H", 
        "id": "sg:person.0606057564.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606057564.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Departments of Medicine, and Cell and Developmental Biology, Vanderbilt University and Department of Veterans Affairs Medical Center, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boone", 
        "givenName": "Braden", 
        "id": "sg:person.015243107647.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015243107647.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Departments of Medicine, and Cell and Developmental Biology, Vanderbilt University and Department of Veterans Affairs Medical Center, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levy", 
        "givenName": "Shawn", 
        "id": "sg:person.01212265075.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212265075.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "University of Texas Southwestern Medical Center at Dallas, 75390, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graff", 
        "givenName": "Jonathan M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Institute for Collaborative BioResearch, University of Arizona, 85721-0036, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Doetschman", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Ohio State University", 
          "id": "https://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Division of Human Cancer Genetics, The Ohio State University College of Medicine, 43210-2207, Columbus, Ohio, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Groden", 
        "givenName": "Joanna", 
        "id": "sg:person.0672714666.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672714666.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "McArdle Laboratory for Cancer Research, University of Wisconsin, 53706, Madison, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dove", 
        "givenName": "William F", 
        "id": "sg:person.01032227064.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032227064.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "Department of Genetics and Lineberger Cancer Center, University of North Carolina, 27599, Chapel Hill, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Threadgill", 
        "givenName": "David W", 
        "id": "sg:person.013756710137.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013756710137.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moffitt Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.468198.a", 
          "name": [
            "H Lee Moffitt Cancer Center and Research Institute, 33612, Tampa, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yeatman", 
        "givenName": "Timothy J", 
        "id": "sg:person.011105234537.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011105234537.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Departments of Medicine, and Cell and Developmental Biology, Vanderbilt University and Department of Veterans Affairs Medical Center, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coffey", 
        "givenName": "Robert J", 
        "id": "sg:person.01142442612.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142442612.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aronow", 
        "givenName": "Bruce J", 
        "id": "sg:person.01037746202.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037746202.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ygeno.2005.03.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000208740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000348123", 
          "https://doi.org/10.1038/sj.bjc.6602621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000348123", 
          "https://doi.org/10.1038/sj.bjc.6602621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001919211", 
          "https://doi.org/10.1038/sj.onc.1208387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001919211", 
          "https://doi.org/10.1038/sj.onc.1208387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/1270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002695839", 
          "https://doi.org/10.1038/1270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/1270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002695839", 
          "https://doi.org/10.1038/1270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002848303", 
          "https://doi.org/10.1038/nature05674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-4328(01)00297-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003068920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-4163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003599453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2004.018598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004698933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cbir.1996.0018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006004552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.6.2546-2559.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007377150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.20.010403.092805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007417985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007920725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.09.170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009716929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.09.170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009716929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.267103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011480346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.267103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011480346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1065718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011677173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011894036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0403338101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012092144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.9.5913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012412404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014887384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2362.2002.01004.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015005506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.02.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015877212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4020-6754-9_1893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016760737", 
          "https://doi.org/10.1007/978-1-4020-6754-9_1893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017147905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)01015-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018479938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-1437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019008259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1182504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019786385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6101(99)00038-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021152670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m307801200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022140299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022704975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-4804(03)00335-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028732995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)01014-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029474411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766632", 
          "https://doi.org/10.1038/nature03319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766632", 
          "https://doi.org/10.1038/nature03319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.suronc.2004.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030395209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000084509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033953963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000084509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033953963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035449277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5483/bmbrep.2003.36.1.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035768493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-1280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035992932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl1011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037252468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81730-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041137101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2004.041962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041216784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5382.1509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042662127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044153960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044847521", 
          "https://doi.org/10.1038/ng1481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044847521", 
          "https://doi.org/10.1038/ng1481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gene.20088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045858408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(01)00430-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046349007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2003.50094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046452312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m201493200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047248315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35001615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048926517", 
          "https://doi.org/10.1038/35001615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35001615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048926517", 
          "https://doi.org/10.1038/35001615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2536800100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050279034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2536800100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050279034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050795978", 
          "https://doi.org/10.1038/nature03626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050795978", 
          "https://doi.org/10.1038/nature03626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050795978", 
          "https://doi.org/10.1038/nature03626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050795978", 
          "https://doi.org/10.1038/nature03626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.20.010403.113126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051113440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfi313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051233619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(04)00114-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051297122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2296722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062530812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074495005", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075192342", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075279597", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076895268", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076997363", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460089501000401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082936643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460089501000401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082936643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083382568", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4018/978-1-59140-661-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1096031630"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-07", 
    "datePublishedReg": "2007-07-01", 
    "description": "BACKGROUND: The expression of carcino-embryonic antigen by colorectal cancer is an example of oncogenic activation of embryonic gene expression. Hypothesizing that oncogenesis-recapitulating-ontogenesis may represent a broad programmatic commitment, we compared gene expression patterns of human colorectal cancers (CRCs) and mouse colon tumor models to those of mouse colon development embryonic days 13.5-18.5.\nRESULTS: We report here that 39 colon tumors from four independent mouse models and 100 human CRCs encompassing all clinical stages shared a striking recapitulation of embryonic colon gene expression. Compared to normal adult colon, all mouse and human tumors over-expressed a large cluster of genes highly enriched for functional association to the control of cell cycle progression, proliferation, and migration, including those encoding MYC, AKT2, PLK1 and SPARC. Mouse tumors positive for nuclear beta-catenin shifted the shared embryonic pattern to that of early development. Human and mouse tumors differed from normal embryonic colon by their loss of expression modules enriched for tumor suppressors (EDNRB, HSPE, KIT and LSP1). Human CRC adenocarcinomas lost an additional suppressor module (IGFBP4, MAP4K1, PDGFRA, STAB1 and WNT4). Many human tumor samples also gained expression of a coordinately regulated module associated with advanced malignancy (ABCC1, FOXO3A, LIF, PIK3R1, PRNP, TNC, TIMP3 and VEGF).\nCONCLUSION: Cross-species, developmental, and multi-model gene expression patterning comparisons provide an integrated and versatile framework for definition of transcriptional programs associated with oncogenesis. This approach also provides a general method for identifying pattern-specific biomarkers and therapeutic targets. This delineation and categorization of developmental and non-developmental activator and suppressor gene modules can thus facilitate the formulation of sophisticated hypotheses to evaluate potential synergistic effects of targeting within- and between-modules for next-generation combinatorial therapeutics and improved mouse models.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/gb-2007-8-7-r131", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440210", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2473981", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2689018", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440181", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2688860", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2469659", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2684679", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634371", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2471962", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2688861", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2621217", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023439", 
        "issn": [
          "1474-760X", 
          "1465-6906"
        ], 
        "name": "Genome Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer", 
    "pagination": "r131", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ae28e48c2f31c1590cbef5f2ddc4912ecc199f3d5c6cb1ddf0bae1b588c600bd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17615082"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100960660"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/gb-2007-8-7-r131"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036560396"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/gb-2007-8-7-r131", 
      "https://app.dimensions.ai/details/publication/pub.1036560396"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fgb-2007-8-7-r131"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/gb-2007-8-7-r131'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/gb-2007-8-7-r131'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/gb-2007-8-7-r131'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/gb-2007-8-7-r131'


 

This table displays all metadata directly associated to this object as RDF triples.

601 TRIPLES      21 PREDICATES      105 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/gb-2007-8-7-r131 schema:about N028d0508db834bf5b6df9d06a5d62959
2 N16a2e34cdeb94e09ad1db4d4dd16f59d
3 N4295570e37364d75b0e4d56b2ba08281
4 N5328af91eb8f4f3eae410240a0c46119
5 N668d9f5657994ca896ea4ff427f214e3
6 N81bc710d732e49269b8f2a2a795c306a
7 Na4222a3ae32442848c7c30cf42616a0e
8 Na7fefd1b451249abb6a1dfac4a7f27a4
9 Nb4ab8df46bbe46b8a17d1eb82dcbdfec
10 Nbc1b93e93ca849ce922cac21508e28d6
11 Nc95904b96912480ebc245420cc490a73
12 Nde25c6d7bd134d3eb070f208be94395c
13 Neb6f3861adf542c88b49fac7be1ebf7d
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author N6d91ba7c43264a03bd5c1c3c08405171
17 schema:citation sg:pub.10.1007/978-1-4020-6754-9_1893
18 sg:pub.10.1038/1270
19 sg:pub.10.1038/35001615
20 sg:pub.10.1038/nature03319
21 sg:pub.10.1038/nature03626
22 sg:pub.10.1038/nature05674
23 sg:pub.10.1038/ng1481
24 sg:pub.10.1038/sj.bjc.6602621
25 sg:pub.10.1038/sj.onc.1208387
26 https://app.dimensions.ai/details/publication/pub.1074495005
27 https://app.dimensions.ai/details/publication/pub.1075192342
28 https://app.dimensions.ai/details/publication/pub.1075279597
29 https://app.dimensions.ai/details/publication/pub.1076895268
30 https://app.dimensions.ai/details/publication/pub.1076997363
31 https://app.dimensions.ai/details/publication/pub.1083382568
32 https://doi.org/10.1002/gene.20088
33 https://doi.org/10.1006/cbir.1996.0018
34 https://doi.org/10.1006/meth.2001.1262
35 https://doi.org/10.1016/j.bbrc.2005.09.170
36 https://doi.org/10.1016/j.cell.2004.08.005
37 https://doi.org/10.1016/j.suronc.2004.09.010
38 https://doi.org/10.1016/j.ygeno.2005.03.012
39 https://doi.org/10.1016/s0022-4804(03)00335-4
40 https://doi.org/10.1016/s0092-8674(00)81730-4
41 https://doi.org/10.1016/s0092-8674(02)01014-0
42 https://doi.org/10.1016/s0092-8674(02)01015-2
43 https://doi.org/10.1016/s0166-4328(01)00297-2
44 https://doi.org/10.1016/s1097-2765(01)00430-0
45 https://doi.org/10.1016/s1359-6101(99)00038-6
46 https://doi.org/10.1016/s1535-6108(04)00114-x
47 https://doi.org/10.1046/j.1365-2362.2002.01004.x
48 https://doi.org/10.1053/gast.2003.50094
49 https://doi.org/10.1053/j.gastro.2005.02.022
50 https://doi.org/10.1073/pnas.0403338101
51 https://doi.org/10.1073/pnas.2536800100
52 https://doi.org/10.1074/jbc.m201493200
53 https://doi.org/10.1074/jbc.m307801200
54 https://doi.org/10.1093/emboj/cdf649
55 https://doi.org/10.1093/nar/gkl1011
56 https://doi.org/10.1093/nar/gkm327
57 https://doi.org/10.1093/toxsci/kfi313
58 https://doi.org/10.1101/gad.1182504
59 https://doi.org/10.1101/gad.267103
60 https://doi.org/10.1126/science.1065718
61 https://doi.org/10.1126/science.2296722
62 https://doi.org/10.1126/science.281.5382.1509
63 https://doi.org/10.1128/mcb.19.9.5913
64 https://doi.org/10.1128/mcb.24.6.2546-2559.2004
65 https://doi.org/10.1136/gut.2004.041962
66 https://doi.org/10.1136/jcp.2004.018598
67 https://doi.org/10.1146/annurev.cellbio.20.010403.092805
68 https://doi.org/10.1146/annurev.cellbio.20.010403.113126
69 https://doi.org/10.1158/0008-5472.can-04-4163
70 https://doi.org/10.1158/0008-5472.can-05-0700
71 https://doi.org/10.1158/0008-5472.can-05-2448
72 https://doi.org/10.1158/0008-5472.can-06-0890
73 https://doi.org/10.1158/0008-5472.can-06-1437
74 https://doi.org/10.1158/1078-0432.ccr-04-1280
75 https://doi.org/10.1159/000084509
76 https://doi.org/10.1177/172460089501000401
77 https://doi.org/10.1242/dev.01579
78 https://doi.org/10.4018/978-1-59140-661-7
79 https://doi.org/10.5483/bmbrep.2003.36.1.110
80 schema:datePublished 2007-07
81 schema:datePublishedReg 2007-07-01
82 schema:description BACKGROUND: The expression of carcino-embryonic antigen by colorectal cancer is an example of oncogenic activation of embryonic gene expression. Hypothesizing that oncogenesis-recapitulating-ontogenesis may represent a broad programmatic commitment, we compared gene expression patterns of human colorectal cancers (CRCs) and mouse colon tumor models to those of mouse colon development embryonic days 13.5-18.5. RESULTS: We report here that 39 colon tumors from four independent mouse models and 100 human CRCs encompassing all clinical stages shared a striking recapitulation of embryonic colon gene expression. Compared to normal adult colon, all mouse and human tumors over-expressed a large cluster of genes highly enriched for functional association to the control of cell cycle progression, proliferation, and migration, including those encoding MYC, AKT2, PLK1 and SPARC. Mouse tumors positive for nuclear beta-catenin shifted the shared embryonic pattern to that of early development. Human and mouse tumors differed from normal embryonic colon by their loss of expression modules enriched for tumor suppressors (EDNRB, HSPE, KIT and LSP1). Human CRC adenocarcinomas lost an additional suppressor module (IGFBP4, MAP4K1, PDGFRA, STAB1 and WNT4). Many human tumor samples also gained expression of a coordinately regulated module associated with advanced malignancy (ABCC1, FOXO3A, LIF, PIK3R1, PRNP, TNC, TIMP3 and VEGF). CONCLUSION: Cross-species, developmental, and multi-model gene expression patterning comparisons provide an integrated and versatile framework for definition of transcriptional programs associated with oncogenesis. This approach also provides a general method for identifying pattern-specific biomarkers and therapeutic targets. This delineation and categorization of developmental and non-developmental activator and suppressor gene modules can thus facilitate the formulation of sophisticated hypotheses to evaluate potential synergistic effects of targeting within- and between-modules for next-generation combinatorial therapeutics and improved mouse models.
83 schema:genre research_article
84 schema:inLanguage en
85 schema:isAccessibleForFree true
86 schema:isPartOf N1200b80cb6ed457488101adef17dad90
87 N329e3c5d66034a10aa8706fa466538f2
88 sg:journal.1023439
89 schema:name Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
90 schema:pagination r131
91 schema:productId N0a3f5458f25740a4adeddbff629a73a0
92 N441fc110892d43509c66ce4fa6d27677
93 N9993384e4d284d3ba61c96bc16b485be
94 Nad71ab06fea84c729096d934c53aa818
95 Nf486e3f6339e4f849f6daf91bfa49be2
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036560396
97 https://doi.org/10.1186/gb-2007-8-7-r131
98 schema:sdDatePublished 2019-04-10T16:43
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher Nd818579479224a5792080240f60b9d1b
101 schema:url http://link.springer.com/10.1186%2Fgb-2007-8-7-r131
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N028d0508db834bf5b6df9d06a5d62959 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Colon
107 rdf:type schema:DefinedTerm
108 N0a3f5458f25740a4adeddbff629a73a0 schema:name doi
109 schema:value 10.1186/gb-2007-8-7-r131
110 rdf:type schema:PropertyValue
111 N0cfc70ab9240421f8430f83f01c485dc rdf:first sg:person.01370531077.81
112 rdf:rest N249caaf6f7de4868844321816e41a5c5
113 N1200b80cb6ed457488101adef17dad90 schema:issueNumber 7
114 rdf:type schema:PublicationIssue
115 N16a2e34cdeb94e09ad1db4d4dd16f59d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Gene Expression Regulation, Neoplastic
117 rdf:type schema:DefinedTerm
118 N20fa51faacac4e3eb223e71b9d1e9843 rdf:first sg:person.01237264062.23
119 rdf:rest N0cfc70ab9240421f8430f83f01c485dc
120 N249caaf6f7de4868844321816e41a5c5 rdf:first N6351f13d5bff400e8d798192cbd91fce
121 rdf:rest N4a9b22ad48954524848b4deb89022883
122 N26e0a07acfc248d9b7515233f10ec21f rdf:first Nd09c3b2620dc4e51b5bd9082e2731ea0
123 rdf:rest N20fa51faacac4e3eb223e71b9d1e9843
124 N2a9a3ce7a8a94102a61e7410ad099d66 rdf:first N56069f9f3706442eb095a1e3608af643
125 rdf:rest Naff7f0d3d31f4254b0f2e007c1dfa967
126 N2dbcee7891e54fed83810b91fb6dbc18 rdf:first N6d6353b7b7d44176a24919afe1b735ae
127 rdf:rest N4cb31411dfa74a63bdd1e366da069f78
128 N2f88d39662674d5ea9feb9ad0304a888 rdf:first N575c1ca66d1840ad98741426ef098cf8
129 rdf:rest N545d3f002e5f4a83b7016eb1bd85dd2f
130 N329e3c5d66034a10aa8706fa466538f2 schema:volumeNumber 8
131 rdf:type schema:PublicationVolume
132 N39aebfd55f624ddeb5ebf6a2b4738cc2 rdf:first sg:person.0606057564.84
133 rdf:rest N9fed7951a28342d8a770e032654e4757
134 N3a3bc645c4134e9a938592d8277946bb rdf:first sg:person.01301735301.74
135 rdf:rest N9691adffc5eb48809f76bea8f5342aa8
136 N3e97523b0560415e86adbd7062011f92 schema:affiliation https://www.grid.ac/institutes/grid.468198.a
137 schema:familyName Gonzales
138 schema:givenName Fausto
139 rdf:type schema:Person
140 N4295570e37364d75b0e4d56b2ba08281 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Wnt Proteins
142 rdf:type schema:DefinedTerm
143 N440f285068a04b9aa32ff13ba1529bda rdf:first N91ffc101ba854013aaaed97d5077f442
144 rdf:rest N838157064d8c4367a054385fa53646ea
145 N441fc110892d43509c66ce4fa6d27677 schema:name nlm_unique_id
146 schema:value 100960660
147 rdf:type schema:PropertyValue
148 N46f5b29edc114846a3a9e010d7243e08 rdf:first sg:person.01160571611.42
149 rdf:rest N5adaed0fb991406aa93b024d8286302f
150 N487a9022cc2d419e848a2c3c4ff98306 rdf:first Nd69e25fc9f4f462cba91c76444b21e91
151 rdf:rest N440f285068a04b9aa32ff13ba1529bda
152 N4a9b22ad48954524848b4deb89022883 rdf:first sg:person.01174765165.19
153 rdf:rest N8bb4425c22f34f248c47dc5dc551f57b
154 N4cb31411dfa74a63bdd1e366da069f78 rdf:first sg:person.010462044607.31
155 rdf:rest N86fb4edfab5d4a6caf891cf72df76dc3
156 N5328af91eb8f4f3eae410240a0c46119 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Oligonucleotide Array Sequence Analysis
158 rdf:type schema:DefinedTerm
159 N539b165575b64191af13c19527d6e2b2 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
160 schema:familyName Graff
161 schema:givenName Jonathan M
162 rdf:type schema:Person
163 N53b6698ce6f147f7ba34969ddcc53d79 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
164 schema:familyName Reichling
165 schema:givenName Timothy
166 rdf:type schema:Person
167 N54294b52182f4eec86163db3ed973f82 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
168 schema:familyName Azhar
169 schema:givenName Mohammad
170 rdf:type schema:Person
171 N545d3f002e5f4a83b7016eb1bd85dd2f rdf:first N53b6698ce6f147f7ba34969ddcc53d79
172 rdf:rest Ndec247755b2c4b048221dfad4f21742b
173 N56069f9f3706442eb095a1e3608af643 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
174 schema:familyName Kleimeyer
175 schema:givenName Michael
176 rdf:type schema:Person
177 N575c1ca66d1840ad98741426ef098cf8 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
178 schema:familyName Xu
179 schema:givenName Huan
180 rdf:type schema:Person
181 N5adaed0fb991406aa93b024d8286302f rdf:first Nd0a70abbfdab4511921ced7eebda1515
182 rdf:rest N2a9a3ce7a8a94102a61e7410ad099d66
183 N5d9c6e6433d04346b98e00493868c441 rdf:first sg:person.01037746202.10
184 rdf:rest rdf:nil
185 N6351f13d5bff400e8d798192cbd91fce schema:affiliation https://www.grid.ac/institutes/grid.14003.36
186 schema:familyName Chen
187 schema:givenName Xiaodi
188 rdf:type schema:Person
189 N668d9f5657994ca896ea4ff427f214e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name beta Catenin
191 rdf:type schema:DefinedTerm
192 N6d6353b7b7d44176a24919afe1b735ae schema:affiliation https://www.grid.ac/institutes/grid.468198.a
193 schema:familyName Bloom
194 schema:givenName Greg C
195 rdf:type schema:Person
196 N6d91ba7c43264a03bd5c1c3c08405171 rdf:first N8bd541ce8b6a4c00a3c3e2ed39dd952d
197 rdf:rest N487a9022cc2d419e848a2c3c4ff98306
198 N72781813ea47433d962421b39371b49c rdf:first sg:person.01032227064.83
199 rdf:rest N9bb8920bb3674a67bbd691e9a62a5ea7
200 N80af7ba819f5446f9a29c02924dd928a rdf:first sg:person.0672714666.12
201 rdf:rest N72781813ea47433d962421b39371b49c
202 N81bc710d732e49269b8f2a2a795c306a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Colonic Neoplasms
204 rdf:type schema:DefinedTerm
205 N838157064d8c4367a054385fa53646ea rdf:first sg:person.01356550554.53
206 rdf:rest N26e0a07acfc248d9b7515233f10ec21f
207 N86fb4edfab5d4a6caf891cf72df76dc3 rdf:first sg:person.01300465737.85
208 rdf:rest N46f5b29edc114846a3a9e010d7243e08
209 N8a4ccc6550e1431c8a20acdb6711e479 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
210 schema:familyName Ramaswamy
211 schema:givenName Vivek
212 rdf:type schema:Person
213 N8bb4425c22f34f248c47dc5dc551f57b rdf:first sg:person.01264413050.28
214 rdf:rest Nd6478f37590a42cba92c7601f991cf41
215 N8bd541ce8b6a4c00a3c3e2ed39dd952d schema:affiliation https://www.grid.ac/institutes/grid.239573.9
216 schema:familyName Kaiser
217 schema:givenName Sergio
218 rdf:type schema:Person
219 N91ffc101ba854013aaaed97d5077f442 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
220 schema:familyName Franklin
221 schema:givenName Jeffrey L
222 rdf:type schema:Person
223 N9691adffc5eb48809f76bea8f5342aa8 rdf:first N3e97523b0560415e86adbd7062011f92
224 rdf:rest N2dbcee7891e54fed83810b91fb6dbc18
225 N9993384e4d284d3ba61c96bc16b485be schema:name pubmed_id
226 schema:value 17615082
227 rdf:type schema:PropertyValue
228 N9bb8920bb3674a67bbd691e9a62a5ea7 rdf:first sg:person.013756710137.24
229 rdf:rest Nb96eea9bdff546a8b698e4756cdd16b4
230 N9c08c258e3ac4bea904ebe33f1fdc7fd rdf:first sg:person.01212265075.85
231 rdf:rest Nea370cfacf2f4d31a01a26eabcadccdf
232 N9fed7951a28342d8a770e032654e4757 rdf:first sg:person.015243107647.54
233 rdf:rest N9c08c258e3ac4bea904ebe33f1fdc7fd
234 Na4222a3ae32442848c7c30cf42616a0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Gene Expression Regulation, Developmental
236 rdf:type schema:DefinedTerm
237 Na4f04d40487f41768c8b0914781229b0 rdf:first sg:person.014353307367.40
238 rdf:rest N3a3bc645c4134e9a938592d8277946bb
239 Na7fefd1b451249abb6a1dfac4a7f27a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Disease Models, Animal
241 rdf:type schema:DefinedTerm
242 Nad71ab06fea84c729096d934c53aa818 schema:name dimensions_id
243 schema:value pub.1036560396
244 rdf:type schema:PropertyValue
245 Naff7f0d3d31f4254b0f2e007c1dfa967 rdf:first N8a4ccc6550e1431c8a20acdb6711e479
246 rdf:rest N39aebfd55f624ddeb5ebf6a2b4738cc2
247 Nb093c8a235c446d58ab40bbf15c63ab5 rdf:first sg:person.01142442612.76
248 rdf:rest N5d9c6e6433d04346b98e00493868c441
249 Nb4ab8df46bbe46b8a17d1eb82dcbdfec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
250 schema:name Humans
251 rdf:type schema:DefinedTerm
252 Nb96eea9bdff546a8b698e4756cdd16b4 rdf:first sg:person.011105234537.67
253 rdf:rest Nb093c8a235c446d58ab40bbf15c63ab5
254 Nbc1b93e93ca849ce922cac21508e28d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
255 schema:name Mice
256 rdf:type schema:DefinedTerm
257 Nbd832fe00414449eb7f680068b97757d rdf:first Ndfc023a1e5084c2e8786d63c6aca0fe7
258 rdf:rest N80af7ba819f5446f9a29c02924dd928a
259 Nc95904b96912480ebc245420cc490a73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
260 schema:name Transcription, Genetic
261 rdf:type schema:DefinedTerm
262 Nd09c3b2620dc4e51b5bd9082e2731ea0 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
263 schema:familyName Yu
264 schema:givenName Ming
265 rdf:type schema:Person
266 Nd0a70abbfdab4511921ced7eebda1515 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
267 schema:familyName Kleimeyer
268 schema:givenName John
269 rdf:type schema:Person
270 Nd6478f37590a42cba92c7601f991cf41 rdf:first Nfde6096506d0491aa699034c4daf8ad1
271 rdf:rest Ne97f1d6ddbee40b4be8ba331f39b552f
272 Nd69e25fc9f4f462cba91c76444b21e91 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
273 schema:familyName Park
274 schema:givenName Young-Kyu
275 rdf:type schema:Person
276 Nd818579479224a5792080240f60b9d1b schema:name Springer Nature - SN SciGraph project
277 rdf:type schema:Organization
278 Nde25c6d7bd134d3eb070f208be94395c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
279 schema:name Embryonic Development
280 rdf:type schema:DefinedTerm
281 Ndec247755b2c4b048221dfad4f21742b rdf:first N54294b52182f4eec86163db3ed973f82
282 rdf:rest Nfc183b95eee5489d85290627cb362f43
283 Ndfc023a1e5084c2e8786d63c6aca0fe7 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
284 schema:familyName Doetschman
285 schema:givenName Thomas
286 rdf:type schema:Person
287 Ne97f1d6ddbee40b4be8ba331f39b552f rdf:first sg:person.01362210020.33
288 rdf:rest N2f88d39662674d5ea9feb9ad0304a888
289 Nea370cfacf2f4d31a01a26eabcadccdf rdf:first N539b165575b64191af13c19527d6e2b2
290 rdf:rest Nbd832fe00414449eb7f680068b97757d
291 Neb6f3861adf542c88b49fac7be1ebf7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
292 schema:name Animals
293 rdf:type schema:DefinedTerm
294 Nf486e3f6339e4f849f6daf91bfa49be2 schema:name readcube_id
295 schema:value ae28e48c2f31c1590cbef5f2ddc4912ecc199f3d5c6cb1ddf0bae1b588c600bd
296 rdf:type schema:PropertyValue
297 Nfc183b95eee5489d85290627cb362f43 rdf:first sg:person.014056553757.09
298 rdf:rest Na4f04d40487f41768c8b0914781229b0
299 Nfde6096506d0491aa699034c4daf8ad1 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
300 schema:familyName Kong
301 schema:givenName Sue
302 rdf:type schema:Person
303 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
304 schema:name Biological Sciences
305 rdf:type schema:DefinedTerm
306 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
307 schema:name Genetics
308 rdf:type schema:DefinedTerm
309 sg:grant.2440181 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
310 rdf:type schema:MonetaryGrant
311 sg:grant.2440210 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
312 rdf:type schema:MonetaryGrant
313 sg:grant.2469659 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
314 rdf:type schema:MonetaryGrant
315 sg:grant.2471962 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
316 rdf:type schema:MonetaryGrant
317 sg:grant.2473981 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
318 rdf:type schema:MonetaryGrant
319 sg:grant.2621217 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
320 rdf:type schema:MonetaryGrant
321 sg:grant.2634371 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
322 rdf:type schema:MonetaryGrant
323 sg:grant.2684679 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
324 rdf:type schema:MonetaryGrant
325 sg:grant.2688860 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
326 rdf:type schema:MonetaryGrant
327 sg:grant.2688861 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
328 rdf:type schema:MonetaryGrant
329 sg:grant.2689018 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2007-8-7-r131
330 rdf:type schema:MonetaryGrant
331 sg:journal.1023439 schema:issn 1465-6906
332 1474-760X
333 schema:name Genome Biology
334 rdf:type schema:Periodical
335 sg:person.01032227064.83 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
336 schema:familyName Dove
337 schema:givenName William F
338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032227064.83
339 rdf:type schema:Person
340 sg:person.01037746202.10 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
341 schema:familyName Aronow
342 schema:givenName Bruce J
343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037746202.10
344 rdf:type schema:Person
345 sg:person.010462044607.31 schema:affiliation https://www.grid.ac/institutes/grid.468198.a
346 schema:familyName Eschrich
347 schema:givenName Steven
348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010462044607.31
349 rdf:type schema:Person
350 sg:person.011105234537.67 schema:affiliation https://www.grid.ac/institutes/grid.468198.a
351 schema:familyName Yeatman
352 schema:givenName Timothy J
353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011105234537.67
354 rdf:type schema:Person
355 sg:person.01142442612.76 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
356 schema:familyName Coffey
357 schema:givenName Robert J
358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142442612.76
359 rdf:type schema:Person
360 sg:person.01160571611.42 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
361 schema:familyName Aronow
362 schema:givenName Jeremy E
363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160571611.42
364 rdf:type schema:Person
365 sg:person.01174765165.19 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
366 schema:familyName Haigis
367 schema:givenName Kevin
368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174765165.19
369 rdf:type schema:Person
370 sg:person.01212265075.85 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
371 schema:familyName Levy
372 schema:givenName Shawn
373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212265075.85
374 rdf:type schema:Person
375 sg:person.01237264062.23 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
376 schema:familyName Jessen
377 schema:givenName Walter J
378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237264062.23
379 rdf:type schema:Person
380 sg:person.01264413050.28 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
381 schema:familyName Jegga
382 schema:givenName Anil G
383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264413050.28
384 rdf:type schema:Person
385 sg:person.01300465737.85 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
386 schema:familyName Carter
387 schema:givenName Scott L
388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300465737.85
389 rdf:type schema:Person
390 sg:person.01301735301.74 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
391 schema:familyName Bissahoyo
392 schema:givenName Anika C
393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301735301.74
394 rdf:type schema:Person
395 sg:person.01356550554.53 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
396 schema:familyName Halberg
397 schema:givenName Richard B
398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356550554.53
399 rdf:type schema:Person
400 sg:person.01362210020.33 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
401 schema:familyName Sakthivel
402 schema:givenName Bhuvaneswari
403 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362210020.33
404 rdf:type schema:Person
405 sg:person.01370531077.81 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
406 schema:familyName Freudenberg
407 schema:givenName Johannes
408 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370531077.81
409 rdf:type schema:Person
410 sg:person.013756710137.24 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
411 schema:familyName Threadgill
412 schema:givenName David W
413 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013756710137.24
414 rdf:type schema:Person
415 sg:person.014056553757.09 schema:affiliation https://www.grid.ac/institutes/grid.24827.3b
416 schema:familyName Boivin
417 schema:givenName Gregory P
418 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014056553757.09
419 rdf:type schema:Person
420 sg:person.014353307367.40 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
421 schema:familyName Roberts
422 schema:givenName Reade B
423 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014353307367.40
424 rdf:type schema:Person
425 sg:person.015243107647.54 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
426 schema:familyName Boone
427 schema:givenName Braden
428 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015243107647.54
429 rdf:type schema:Person
430 sg:person.0606057564.84 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
431 schema:familyName Settle
432 schema:givenName Stephen H
433 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606057564.84
434 rdf:type schema:Person
435 sg:person.0672714666.12 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
436 schema:familyName Groden
437 schema:givenName Joanna
438 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672714666.12
439 rdf:type schema:Person
440 sg:pub.10.1007/978-1-4020-6754-9_1893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016760737
441 https://doi.org/10.1007/978-1-4020-6754-9_1893
442 rdf:type schema:CreativeWork
443 sg:pub.10.1038/1270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002695839
444 https://doi.org/10.1038/1270
445 rdf:type schema:CreativeWork
446 sg:pub.10.1038/35001615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048926517
447 https://doi.org/10.1038/35001615
448 rdf:type schema:CreativeWork
449 sg:pub.10.1038/nature03319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766632
450 https://doi.org/10.1038/nature03319
451 rdf:type schema:CreativeWork
452 sg:pub.10.1038/nature03626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050795978
453 https://doi.org/10.1038/nature03626
454 rdf:type schema:CreativeWork
455 sg:pub.10.1038/nature05674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002848303
456 https://doi.org/10.1038/nature05674
457 rdf:type schema:CreativeWork
458 sg:pub.10.1038/ng1481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044847521
459 https://doi.org/10.1038/ng1481
460 rdf:type schema:CreativeWork
461 sg:pub.10.1038/sj.bjc.6602621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000348123
462 https://doi.org/10.1038/sj.bjc.6602621
463 rdf:type schema:CreativeWork
464 sg:pub.10.1038/sj.onc.1208387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001919211
465 https://doi.org/10.1038/sj.onc.1208387
466 rdf:type schema:CreativeWork
467 https://app.dimensions.ai/details/publication/pub.1074495005 schema:CreativeWork
468 https://app.dimensions.ai/details/publication/pub.1075192342 schema:CreativeWork
469 https://app.dimensions.ai/details/publication/pub.1075279597 schema:CreativeWork
470 https://app.dimensions.ai/details/publication/pub.1076895268 schema:CreativeWork
471 https://app.dimensions.ai/details/publication/pub.1076997363 schema:CreativeWork
472 https://app.dimensions.ai/details/publication/pub.1083382568 schema:CreativeWork
473 https://doi.org/10.1002/gene.20088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045858408
474 rdf:type schema:CreativeWork
475 https://doi.org/10.1006/cbir.1996.0018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006004552
476 rdf:type schema:CreativeWork
477 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
478 rdf:type schema:CreativeWork
479 https://doi.org/10.1016/j.bbrc.2005.09.170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009716929
480 rdf:type schema:CreativeWork
481 https://doi.org/10.1016/j.cell.2004.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011894036
482 rdf:type schema:CreativeWork
483 https://doi.org/10.1016/j.suronc.2004.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030395209
484 rdf:type schema:CreativeWork
485 https://doi.org/10.1016/j.ygeno.2005.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000208740
486 rdf:type schema:CreativeWork
487 https://doi.org/10.1016/s0022-4804(03)00335-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028732995
488 rdf:type schema:CreativeWork
489 https://doi.org/10.1016/s0092-8674(00)81730-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041137101
490 rdf:type schema:CreativeWork
491 https://doi.org/10.1016/s0092-8674(02)01014-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029474411
492 rdf:type schema:CreativeWork
493 https://doi.org/10.1016/s0092-8674(02)01015-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018479938
494 rdf:type schema:CreativeWork
495 https://doi.org/10.1016/s0166-4328(01)00297-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003068920
496 rdf:type schema:CreativeWork
497 https://doi.org/10.1016/s1097-2765(01)00430-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046349007
498 rdf:type schema:CreativeWork
499 https://doi.org/10.1016/s1359-6101(99)00038-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021152670
500 rdf:type schema:CreativeWork
501 https://doi.org/10.1016/s1535-6108(04)00114-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051297122
502 rdf:type schema:CreativeWork
503 https://doi.org/10.1046/j.1365-2362.2002.01004.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015005506
504 rdf:type schema:CreativeWork
505 https://doi.org/10.1053/gast.2003.50094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046452312
506 rdf:type schema:CreativeWork
507 https://doi.org/10.1053/j.gastro.2005.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015877212
508 rdf:type schema:CreativeWork
509 https://doi.org/10.1073/pnas.0403338101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012092144
510 rdf:type schema:CreativeWork
511 https://doi.org/10.1073/pnas.2536800100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050279034
512 rdf:type schema:CreativeWork
513 https://doi.org/10.1074/jbc.m201493200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047248315
514 rdf:type schema:CreativeWork
515 https://doi.org/10.1074/jbc.m307801200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022140299
516 rdf:type schema:CreativeWork
517 https://doi.org/10.1093/emboj/cdf649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007920725
518 rdf:type schema:CreativeWork
519 https://doi.org/10.1093/nar/gkl1011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037252468
520 rdf:type schema:CreativeWork
521 https://doi.org/10.1093/nar/gkm327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022704975
522 rdf:type schema:CreativeWork
523 https://doi.org/10.1093/toxsci/kfi313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051233619
524 rdf:type schema:CreativeWork
525 https://doi.org/10.1101/gad.1182504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019786385
526 rdf:type schema:CreativeWork
527 https://doi.org/10.1101/gad.267103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011480346
528 rdf:type schema:CreativeWork
529 https://doi.org/10.1126/science.1065718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011677173
530 rdf:type schema:CreativeWork
531 https://doi.org/10.1126/science.2296722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062530812
532 rdf:type schema:CreativeWork
533 https://doi.org/10.1126/science.281.5382.1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042662127
534 rdf:type schema:CreativeWork
535 https://doi.org/10.1128/mcb.19.9.5913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012412404
536 rdf:type schema:CreativeWork
537 https://doi.org/10.1128/mcb.24.6.2546-2559.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007377150
538 rdf:type schema:CreativeWork
539 https://doi.org/10.1136/gut.2004.041962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041216784
540 rdf:type schema:CreativeWork
541 https://doi.org/10.1136/jcp.2004.018598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004698933
542 rdf:type schema:CreativeWork
543 https://doi.org/10.1146/annurev.cellbio.20.010403.092805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007417985
544 rdf:type schema:CreativeWork
545 https://doi.org/10.1146/annurev.cellbio.20.010403.113126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051113440
546 rdf:type schema:CreativeWork
547 https://doi.org/10.1158/0008-5472.can-04-4163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003599453
548 rdf:type schema:CreativeWork
549 https://doi.org/10.1158/0008-5472.can-05-0700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035449277
550 rdf:type schema:CreativeWork
551 https://doi.org/10.1158/0008-5472.can-05-2448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017147905
552 rdf:type schema:CreativeWork
553 https://doi.org/10.1158/0008-5472.can-06-0890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014887384
554 rdf:type schema:CreativeWork
555 https://doi.org/10.1158/0008-5472.can-06-1437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019008259
556 rdf:type schema:CreativeWork
557 https://doi.org/10.1158/1078-0432.ccr-04-1280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035992932
558 rdf:type schema:CreativeWork
559 https://doi.org/10.1159/000084509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033953963
560 rdf:type schema:CreativeWork
561 https://doi.org/10.1177/172460089501000401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082936643
562 rdf:type schema:CreativeWork
563 https://doi.org/10.1242/dev.01579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044153960
564 rdf:type schema:CreativeWork
565 https://doi.org/10.4018/978-1-59140-661-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1096031630
566 rdf:type schema:CreativeWork
567 https://doi.org/10.5483/bmbrep.2003.36.1.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035768493
568 rdf:type schema:CreativeWork
569 https://www.grid.ac/institutes/grid.134563.6 schema:alternateName University of Arizona
570 schema:name Institute for Collaborative BioResearch, University of Arizona, 85721-0036, Tucson, AZ, USA
571 rdf:type schema:Organization
572 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
573 schema:name McArdle Laboratory for Cancer Research, University of Wisconsin, 53706, Madison, WI, USA
574 rdf:type schema:Organization
575 https://www.grid.ac/institutes/grid.152326.1 schema:alternateName Vanderbilt University
576 schema:name Departments of Medicine, and Cell and Developmental Biology, Vanderbilt University and Department of Veterans Affairs Medical Center, 37232, Nashville, TN, USA
577 rdf:type schema:Organization
578 https://www.grid.ac/institutes/grid.239573.9 schema:alternateName Cincinnati Children's Hospital Medical Center
579 schema:name Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA
580 rdf:type schema:Organization
581 https://www.grid.ac/institutes/grid.24827.3b schema:alternateName University of Cincinnati
582 schema:name University of Cincinnati, Department of Pathology and Laboratory Medicine, 45267, Cincinnati, OH, USA
583 rdf:type schema:Organization
584 https://www.grid.ac/institutes/grid.261331.4 schema:alternateName The Ohio State University
585 schema:name Division of Human Cancer Genetics, The Ohio State University College of Medicine, 43210-2207, Columbus, Ohio, USA
586 rdf:type schema:Organization
587 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
588 schema:name University of Texas Southwestern Medical Center at Dallas, 75390, Dallas, TX, USA
589 rdf:type schema:Organization
590 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
591 schema:name Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, 02129, Charlestown, MA, USA
592 rdf:type schema:Organization
593 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
594 schema:name Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology (CHIP@HST), Harvard Medical School, 02115, Boston, Massachusetts, USA
595 rdf:type schema:Organization
596 https://www.grid.ac/institutes/grid.410711.2 schema:alternateName University of North Carolina System
597 schema:name Department of Genetics and Lineberger Cancer Center, University of North Carolina, 27599, Chapel Hill, NC, USA
598 rdf:type schema:Organization
599 https://www.grid.ac/institutes/grid.468198.a schema:alternateName Moffitt Cancer Center
600 schema:name H Lee Moffitt Cancer Center and Research Institute, 33612, Tampa, FL, USA
601 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...