Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-10-13

AUTHORS

Maria Francesca Cardone, Alicia Alonso, Michele Pazienza, Mario Ventura, Gabriella Montemurro, Lucia Carbone, Pieter J de Jong, Roscoe Stanyon, Pietro D'Addabbo, Nicoletta Archidiacono, Xinwei She, Evan E Eichler, Peter E Warburton, Mariano Rocchi

ABSTRACT

BACKGROUND: Evolutionary centromere repositioning and human analphoid neocentromeres occurring in clinical cases are, very likely, two stages of the same phenomenon whose properties still remain substantially obscure. Chromosome 13 is the chromosome with the highest number of neocentromeres. We reconstructed the mammalian evolutionary history of this chromosome and characterized two human neocentromeres at 13q21, in search of information that could improve our understanding of the relationship between evolutionarily new centromeres, inactivated centromeres, and clinical neocentromeres. RESULTS: Chromosome 13 evolution was studied, using FISH experiments, across several diverse superordinal phylogenetic clades spanning >100 million years of evolution. The analysis revealed exceptional conservation among primates (hominoids, Old World monkeys, and New World monkeys), Carnivora (cat), Perissodactyla (horse), and Cetartiodactyla (pig). In contrast, the centromeres in both Old World monkeys and pig have apparently repositioned independently to a central location (13q21). We compared these results to the positions of two human 13q21 neocentromeres using chromatin immunoprecipitation and genomic microarrays. CONCLUSION: We show that a gene-desert region at 13q21 of approximately 3.9 Mb in size possesses an inherent potential to form evolutionarily new centromeres over, at least, approximately 95 million years of mammalian evolution. The striking absence of genes may represent an important property, making the region tolerant to the extensive pericentromeric reshuffling during subsequent evolution. Comparison of the pericentromeric organization of chromosome 13 in four Old World monkey species revealed many differences in sequence organization. The region contains clusters of duplicons showing peculiar features. More... »

PAGES

r91-r91

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/gb-2006-7-10-r91

DOI

http://dx.doi.org/10.1186/gb-2006-7-10-r91

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039523986

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17040560


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0603", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Evolutionary Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Centromere", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cercopithecidae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Elephants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Duplication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Markers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hominidae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Horses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Swine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Microbiology, University of Bari, Bari, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Department of Genetics and Microbiology, University of Bari, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cardone", 
        "givenName": "Maria Francesca", 
        "id": "sg:person.01314575046.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314575046.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA", 
          "id": "http://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alonso", 
        "givenName": "Alicia", 
        "id": "sg:person.0664540260.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664540260.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Microbiology, University of Bari, Bari, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Department of Genetics and Microbiology, University of Bari, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pazienza", 
        "givenName": "Michele", 
        "id": "sg:person.01255674154.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255674154.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Microbiology, University of Bari, Bari, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Department of Genetics and Microbiology, University of Bari, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ventura", 
        "givenName": "Mario", 
        "id": "sg:person.0615524234.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615524234.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Microbiology, University of Bari, Bari, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Department of Genetics and Microbiology, University of Bari, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Montemurro", 
        "givenName": "Gabriella", 
        "id": "sg:person.01107311527.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107311527.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Microbiology, University of Bari, Bari, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Department of Genetics and Microbiology, University of Bari, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carbone", 
        "givenName": "Lucia", 
        "id": "sg:person.01042246367.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042246367.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Hospital Oakland Research Institute, Oakland, California 94609, USA", 
          "id": "http://www.grid.ac/institutes/grid.414016.6", 
          "name": [
            "Children's Hospital Oakland Research Institute, Oakland, California 94609, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Jong", 
        "givenName": "Pieter J", 
        "id": "sg:person.014644352072.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014644352072.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Biology and Genetics 'Leo Pardi', University of Florence, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Animal Biology and Genetics 'Leo Pardi', University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stanyon", 
        "givenName": "Roscoe", 
        "id": "sg:person.01171025130.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171025130.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Microbiology, University of Bari, Bari, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Department of Genetics and Microbiology, University of Bari, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D'Addabbo", 
        "givenName": "Pietro", 
        "id": "sg:person.01317561617.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317561617.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Microbiology, University of Bari, Bari, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Department of Genetics and Microbiology, University of Bari, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Archidiacono", 
        "givenName": "Nicoletta", 
        "id": "sg:person.056410501.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.056410501.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "She", 
        "givenName": "Xinwei", 
        "id": "sg:person.0746501360.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746501360.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eichler", 
        "givenName": "Evan E", 
        "id": "sg:person.0705101106.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705101106.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA", 
          "id": "http://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Warburton", 
        "givenName": "Peter E", 
        "id": "sg:person.0636762132.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636762132.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Microbiology, University of Bari, Bari, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Department of Genetics and Microbiology, University of Bari, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rocchi", 
        "givenName": "Mariano", 
        "id": "sg:person.01021645746.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021645746.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35057157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012003820", 
          "https://doi.org/10.1038/35057157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:chro.0000009294.18760.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031181282", 
          "https://doi.org/10.1023/b:chro.0000009294.18760.e4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025178904", 
          "https://doi.org/10.1038/nature02806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020088834", 
          "https://doi.org/10.1038/31927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35054550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034389621", 
          "https://doi.org/10.1038/35054550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:chro.0000036585.44138.4b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010530950", 
          "https://doi.org/10.1023/b:chro.0000036585.44138.4b"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1009233327176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040068901", 
          "https://doi.org/10.1023/a:1009233327176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006367901", 
          "https://doi.org/10.1038/nature03154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043347347", 
          "https://doi.org/10.1038/nature02379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043529277", 
          "https://doi.org/10.1038/ng1289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-002-0205-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030251976", 
          "https://doi.org/10.1007/s00412-002-0205-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0697-144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001740705", 
          "https://doi.org/10.1038/ng0697-144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01731581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023239976", 
          "https://doi.org/10.1007/bf01731581"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-10-13", 
    "datePublishedReg": "2006-10-13", 
    "description": "BACKGROUND: Evolutionary centromere repositioning and human analphoid neocentromeres occurring in clinical cases are, very likely, two stages of the same phenomenon whose properties still remain substantially obscure. Chromosome 13 is the chromosome with the highest number of neocentromeres. We reconstructed the mammalian evolutionary history of this chromosome and characterized two human neocentromeres at 13q21, in search of information that could improve our understanding of the relationship between evolutionarily new centromeres, inactivated centromeres, and clinical neocentromeres.\nRESULTS: Chromosome 13 evolution was studied, using FISH experiments, across several diverse superordinal phylogenetic clades spanning >100 million years of evolution. The analysis revealed exceptional conservation among primates (hominoids, Old World monkeys, and New World monkeys), Carnivora (cat), Perissodactyla (horse), and Cetartiodactyla (pig). In contrast, the centromeres in both Old World monkeys and pig have apparently repositioned independently to a central location (13q21). We compared these results to the positions of two human 13q21 neocentromeres using chromatin immunoprecipitation and genomic microarrays.\nCONCLUSION: We show that a gene-desert region at 13q21 of approximately 3.9 Mb in size possesses an inherent potential to form evolutionarily new centromeres over, at least, approximately 95 million years of mammalian evolution. The striking absence of genes may represent an important property, making the region tolerant to the extensive pericentromeric reshuffling during subsequent evolution. Comparison of the pericentromeric organization of chromosome 13 in four Old World monkey species revealed many differences in sequence organization. The region contains clusters of duplicons showing peculiar features.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/gb-2006-7-10-r91", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2516015", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2516572", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3751666", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023439", 
        "issn": [
          "1474-760X", 
          "1465-6906"
        ], 
        "name": "Genome Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "new centromeres", 
      "Old World monkeys", 
      "Evolutionary centromere repositioning", 
      "mammalian evolutionary history", 
      "gene-desert region", 
      "chromosome 13", 
      "World monkeys", 
      "clinical neocentromeres", 
      "Old World monkey species", 
      "centromere repositioning", 
      "centromere formation", 
      "years of evolution", 
      "human neocentromeres", 
      "mammalian evolution", 
      "evolutionary history", 
      "FISH experiments", 
      "phylogenetic clades", 
      "chromatin immunoprecipitation", 
      "neocentromeres", 
      "sequence organization", 
      "genomic microarrays", 
      "centromeres", 
      "exceptional conservation", 
      "chromosomes", 
      "monkey species", 
      "chromosome 13q21", 
      "Cetartiodactyla", 
      "duplicons", 
      "clade", 
      "evolution", 
      "Perissodactyla", 
      "Carnivora", 
      "subsequent evolution", 
      "immunoprecipitation", 
      "genes", 
      "higher number", 
      "microarrays", 
      "species", 
      "striking absence", 
      "reshuffling", 
      "conservation", 
      "inherent potential", 
      "region", 
      "MB", 
      "domain", 
      "primates", 
      "peculiar features", 
      "absence", 
      "same phenomenon", 
      "clusters", 
      "contrast", 
      "organization", 
      "understanding", 
      "formation", 
      "stage", 
      "pigs", 
      "potential", 
      "monkeys", 
      "analysis", 
      "location", 
      "number", 
      "size", 
      "repositioning", 
      "experiments", 
      "relationship", 
      "differences", 
      "central location", 
      "position", 
      "features", 
      "results", 
      "years", 
      "comparison", 
      "information", 
      "properties", 
      "search", 
      "history", 
      "phenomenon", 
      "important properties", 
      "clinical cases", 
      "cases", 
      "search of information", 
      "human analphoid neocentromeres", 
      "analphoid neocentromeres", 
      "Chromosome 13 evolution", 
      "diverse superordinal phylogenetic clades", 
      "superordinal phylogenetic clades", 
      "extensive pericentromeric reshuffling", 
      "pericentromeric reshuffling", 
      "pericentromeric organization", 
      "World monkey species", 
      "clusters of duplicons", 
      "Independent centromere formation", 
      "gene-free domain"
    ], 
    "name": "Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs", 
    "pagination": "r91-r91", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039523986"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/gb-2006-7-10-r91"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17040560"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/gb-2006-7-10-r91", 
      "https://app.dimensions.ai/details/publication/pub.1039523986"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_428.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/gb-2006-7-10-r91"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/gb-2006-7-10-r91'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/gb-2006-7-10-r91'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/gb-2006-7-10-r91'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/gb-2006-7-10-r91'


 

This table displays all metadata directly associated to this object as RDF triples.

380 TRIPLES      22 PREDICATES      148 URIs      126 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/gb-2006-7-10-r91 schema:about N0569e9966b7b4067a751883bfb3b0534
2 N175542d626f24f39802266a18989a0a6
3 N41bd5335f1b94f3786999f38e7a0c16d
4 N5e710f22faf942779089e51cd52a9947
5 N5e8bd7d8334540b68ffb6faacf15204a
6 N6590e970be074c72910d161c8b34e675
7 N82d372b4ef7c4383901852cd6cab7dbb
8 N93943fdec4534da69c666b47c7fb5dbe
9 N94c7517a7154423a9e135646f5575fe1
10 N999063d4c88b4005a70eb555bbec5924
11 Na347e012133e47cd90633dcbbc4afad0
12 Nc6323578e9cd4f3ba06f2d1452da601d
13 Nf357f503a4984de799919d3cacfd6c82
14 Nf67ebabb13f141688a0e706f47844fa9
15 Nf90f6259f3d24afea8a4caccd7cc01ed
16 anzsrc-for:06
17 anzsrc-for:0603
18 anzsrc-for:0604
19 schema:author N01053b8cc5bb47a4a9cf3656c27db648
20 schema:citation sg:pub.10.1007/bf01731581
21 sg:pub.10.1007/s00412-002-0205-5
22 sg:pub.10.1023/a:1009233327176
23 sg:pub.10.1023/b:chro.0000009294.18760.e4
24 sg:pub.10.1023/b:chro.0000036585.44138.4b
25 sg:pub.10.1038/31927
26 sg:pub.10.1038/35054550
27 sg:pub.10.1038/35057157
28 sg:pub.10.1038/nature02379
29 sg:pub.10.1038/nature02806
30 sg:pub.10.1038/nature03154
31 sg:pub.10.1038/ng0697-144
32 sg:pub.10.1038/ng1289
33 schema:datePublished 2006-10-13
34 schema:datePublishedReg 2006-10-13
35 schema:description BACKGROUND: Evolutionary centromere repositioning and human analphoid neocentromeres occurring in clinical cases are, very likely, two stages of the same phenomenon whose properties still remain substantially obscure. Chromosome 13 is the chromosome with the highest number of neocentromeres. We reconstructed the mammalian evolutionary history of this chromosome and characterized two human neocentromeres at 13q21, in search of information that could improve our understanding of the relationship between evolutionarily new centromeres, inactivated centromeres, and clinical neocentromeres. RESULTS: Chromosome 13 evolution was studied, using FISH experiments, across several diverse superordinal phylogenetic clades spanning >100 million years of evolution. The analysis revealed exceptional conservation among primates (hominoids, Old World monkeys, and New World monkeys), Carnivora (cat), Perissodactyla (horse), and Cetartiodactyla (pig). In contrast, the centromeres in both Old World monkeys and pig have apparently repositioned independently to a central location (13q21). We compared these results to the positions of two human 13q21 neocentromeres using chromatin immunoprecipitation and genomic microarrays. CONCLUSION: We show that a gene-desert region at 13q21 of approximately 3.9 Mb in size possesses an inherent potential to form evolutionarily new centromeres over, at least, approximately 95 million years of mammalian evolution. The striking absence of genes may represent an important property, making the region tolerant to the extensive pericentromeric reshuffling during subsequent evolution. Comparison of the pericentromeric organization of chromosome 13 in four Old World monkey species revealed many differences in sequence organization. The region contains clusters of duplicons showing peculiar features.
36 schema:genre article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N04bd87edc3cf4040a51678a0dca5b687
40 Neadac110bcf541a18bcf7c135f2821e0
41 sg:journal.1023439
42 schema:keywords Carnivora
43 Cetartiodactyla
44 Chromosome 13 evolution
45 Evolutionary centromere repositioning
46 FISH experiments
47 Independent centromere formation
48 MB
49 Old World monkey species
50 Old World monkeys
51 Perissodactyla
52 World monkey species
53 World monkeys
54 absence
55 analphoid neocentromeres
56 analysis
57 cases
58 central location
59 centromere formation
60 centromere repositioning
61 centromeres
62 chromatin immunoprecipitation
63 chromosome 13
64 chromosome 13q21
65 chromosomes
66 clade
67 clinical cases
68 clinical neocentromeres
69 clusters
70 clusters of duplicons
71 comparison
72 conservation
73 contrast
74 differences
75 diverse superordinal phylogenetic clades
76 domain
77 duplicons
78 evolution
79 evolutionary history
80 exceptional conservation
81 experiments
82 extensive pericentromeric reshuffling
83 features
84 formation
85 gene-desert region
86 gene-free domain
87 genes
88 genomic microarrays
89 higher number
90 history
91 human analphoid neocentromeres
92 human neocentromeres
93 immunoprecipitation
94 important properties
95 information
96 inherent potential
97 location
98 mammalian evolution
99 mammalian evolutionary history
100 microarrays
101 monkey species
102 monkeys
103 neocentromeres
104 new centromeres
105 number
106 organization
107 peculiar features
108 pericentromeric organization
109 pericentromeric reshuffling
110 phenomenon
111 phylogenetic clades
112 pigs
113 position
114 potential
115 primates
116 properties
117 region
118 relationship
119 repositioning
120 reshuffling
121 results
122 same phenomenon
123 search
124 search of information
125 sequence organization
126 size
127 species
128 stage
129 striking absence
130 subsequent evolution
131 superordinal phylogenetic clades
132 understanding
133 years
134 years of evolution
135 schema:name Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs
136 schema:pagination r91-r91
137 schema:productId N6b208a1be0034c9aa9da75a240e64fd3
138 N9b464d0d0ad645dea9a939d11bb52881
139 Nf778e703edda452ba6ed27f26cda96b6
140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039523986
141 https://doi.org/10.1186/gb-2006-7-10-r91
142 schema:sdDatePublished 2022-01-01T18:16
143 schema:sdLicense https://scigraph.springernature.com/explorer/license/
144 schema:sdPublisher Nc32795253573425d9a342479ad9e0dca
145 schema:url https://doi.org/10.1186/gb-2006-7-10-r91
146 sgo:license sg:explorer/license/
147 sgo:sdDataset articles
148 rdf:type schema:ScholarlyArticle
149 N01053b8cc5bb47a4a9cf3656c27db648 rdf:first sg:person.01314575046.31
150 rdf:rest N5ff8517f5c8f46d49422c2ee00ccd565
151 N04bd87edc3cf4040a51678a0dca5b687 schema:issueNumber 10
152 rdf:type schema:PublicationIssue
153 N0569e9966b7b4067a751883bfb3b0534 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Chromosome Mapping
155 rdf:type schema:DefinedTerm
156 N175542d626f24f39802266a18989a0a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Evolution, Molecular
158 rdf:type schema:DefinedTerm
159 N22a52fec54b843d3b195592a26090c2b rdf:first sg:person.056410501.58
160 rdf:rest Nc89a3e3a0dda4e10bb81b3af3e696aba
161 N22bc26f03aa6414f91e1628fd4e985a1 rdf:first sg:person.01171025130.24
162 rdf:rest N7575ff6adeab4c62b7fadd52eab6f08d
163 N2f43056c9dab43aea953b2e9b6e57c67 rdf:first sg:person.0615524234.10
164 rdf:rest N92cb584338414ba09176059e02734351
165 N36ffaf84b59344bc92cbc68017e96595 rdf:first sg:person.01255674154.93
166 rdf:rest N2f43056c9dab43aea953b2e9b6e57c67
167 N41bd5335f1b94f3786999f38e7a0c16d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name In Situ Hybridization, Fluorescence
169 rdf:type schema:DefinedTerm
170 N5e710f22faf942779089e51cd52a9947 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Horses
172 rdf:type schema:DefinedTerm
173 N5e8bd7d8334540b68ffb6faacf15204a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Cercopithecidae
175 rdf:type schema:DefinedTerm
176 N5f93370fe1bf45e58e75999800d3785d rdf:first sg:person.01021645746.17
177 rdf:rest rdf:nil
178 N5ff8517f5c8f46d49422c2ee00ccd565 rdf:first sg:person.0664540260.51
179 rdf:rest N36ffaf84b59344bc92cbc68017e96595
180 N6590e970be074c72910d161c8b34e675 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Centromere
182 rdf:type schema:DefinedTerm
183 N6b208a1be0034c9aa9da75a240e64fd3 schema:name pubmed_id
184 schema:value 17040560
185 rdf:type schema:PropertyValue
186 N7575ff6adeab4c62b7fadd52eab6f08d rdf:first sg:person.01317561617.87
187 rdf:rest N22a52fec54b843d3b195592a26090c2b
188 N82d372b4ef7c4383901852cd6cab7dbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Genetic Markers
190 rdf:type schema:DefinedTerm
191 N92cb584338414ba09176059e02734351 rdf:first sg:person.01107311527.39
192 rdf:rest Ncca6b697ad8347658b2b00cb610d341d
193 N93943fdec4534da69c666b47c7fb5dbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Gene Duplication
195 rdf:type schema:DefinedTerm
196 N94c7517a7154423a9e135646f5575fe1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Swine
198 rdf:type schema:DefinedTerm
199 N999063d4c88b4005a70eb555bbec5924 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Hominidae
201 rdf:type schema:DefinedTerm
202 N9b464d0d0ad645dea9a939d11bb52881 schema:name doi
203 schema:value 10.1186/gb-2006-7-10-r91
204 rdf:type schema:PropertyValue
205 Na347e012133e47cd90633dcbbc4afad0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Humans
207 rdf:type schema:DefinedTerm
208 Na560987ae6d64d9e8c44ffcebd05cefe rdf:first sg:person.0636762132.78
209 rdf:rest N5f93370fe1bf45e58e75999800d3785d
210 Nc32795253573425d9a342479ad9e0dca schema:name Springer Nature - SN SciGraph project
211 rdf:type schema:Organization
212 Nc6323578e9cd4f3ba06f2d1452da601d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Elephants
214 rdf:type schema:DefinedTerm
215 Nc89a3e3a0dda4e10bb81b3af3e696aba rdf:first sg:person.0746501360.35
216 rdf:rest Nf5581d1991914794a088c012d3163061
217 Ncca6b697ad8347658b2b00cb610d341d rdf:first sg:person.01042246367.28
218 rdf:rest Ne1d0e37a8bea4628a36058455b8502cf
219 Ne1d0e37a8bea4628a36058455b8502cf rdf:first sg:person.014644352072.19
220 rdf:rest N22bc26f03aa6414f91e1628fd4e985a1
221 Neadac110bcf541a18bcf7c135f2821e0 schema:volumeNumber 7
222 rdf:type schema:PublicationVolume
223 Nf357f503a4984de799919d3cacfd6c82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Chromatin
225 rdf:type schema:DefinedTerm
226 Nf5581d1991914794a088c012d3163061 rdf:first sg:person.0705101106.89
227 rdf:rest Na560987ae6d64d9e8c44ffcebd05cefe
228 Nf67ebabb13f141688a0e706f47844fa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Oligonucleotide Array Sequence Analysis
230 rdf:type schema:DefinedTerm
231 Nf778e703edda452ba6ed27f26cda96b6 schema:name dimensions_id
232 schema:value pub.1039523986
233 rdf:type schema:PropertyValue
234 Nf90f6259f3d24afea8a4caccd7cc01ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Animals
236 rdf:type schema:DefinedTerm
237 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
238 schema:name Biological Sciences
239 rdf:type schema:DefinedTerm
240 anzsrc-for:0603 schema:inDefinedTermSet anzsrc-for:
241 schema:name Evolutionary Biology
242 rdf:type schema:DefinedTerm
243 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
244 schema:name Genetics
245 rdf:type schema:DefinedTerm
246 sg:grant.2516015 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2006-7-10-r91
247 rdf:type schema:MonetaryGrant
248 sg:grant.2516572 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2006-7-10-r91
249 rdf:type schema:MonetaryGrant
250 sg:grant.3751666 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2006-7-10-r91
251 rdf:type schema:MonetaryGrant
252 sg:journal.1023439 schema:issn 1465-6906
253 1474-760X
254 schema:name Genome Biology
255 schema:publisher Springer Nature
256 rdf:type schema:Periodical
257 sg:person.01021645746.17 schema:affiliation grid-institutes:grid.7644.1
258 schema:familyName Rocchi
259 schema:givenName Mariano
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021645746.17
261 rdf:type schema:Person
262 sg:person.01042246367.28 schema:affiliation grid-institutes:grid.7644.1
263 schema:familyName Carbone
264 schema:givenName Lucia
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042246367.28
266 rdf:type schema:Person
267 sg:person.01107311527.39 schema:affiliation grid-institutes:grid.7644.1
268 schema:familyName Montemurro
269 schema:givenName Gabriella
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107311527.39
271 rdf:type schema:Person
272 sg:person.01171025130.24 schema:affiliation grid-institutes:grid.8404.8
273 schema:familyName Stanyon
274 schema:givenName Roscoe
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171025130.24
276 rdf:type schema:Person
277 sg:person.01255674154.93 schema:affiliation grid-institutes:grid.7644.1
278 schema:familyName Pazienza
279 schema:givenName Michele
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255674154.93
281 rdf:type schema:Person
282 sg:person.01314575046.31 schema:affiliation grid-institutes:grid.7644.1
283 schema:familyName Cardone
284 schema:givenName Maria Francesca
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314575046.31
286 rdf:type schema:Person
287 sg:person.01317561617.87 schema:affiliation grid-institutes:grid.7644.1
288 schema:familyName D'Addabbo
289 schema:givenName Pietro
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317561617.87
291 rdf:type schema:Person
292 sg:person.014644352072.19 schema:affiliation grid-institutes:grid.414016.6
293 schema:familyName de Jong
294 schema:givenName Pieter J
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014644352072.19
296 rdf:type schema:Person
297 sg:person.056410501.58 schema:affiliation grid-institutes:grid.7644.1
298 schema:familyName Archidiacono
299 schema:givenName Nicoletta
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.056410501.58
301 rdf:type schema:Person
302 sg:person.0615524234.10 schema:affiliation grid-institutes:grid.7644.1
303 schema:familyName Ventura
304 schema:givenName Mario
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615524234.10
306 rdf:type schema:Person
307 sg:person.0636762132.78 schema:affiliation grid-institutes:grid.59734.3c
308 schema:familyName Warburton
309 schema:givenName Peter E
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636762132.78
311 rdf:type schema:Person
312 sg:person.0664540260.51 schema:affiliation grid-institutes:grid.59734.3c
313 schema:familyName Alonso
314 schema:givenName Alicia
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664540260.51
316 rdf:type schema:Person
317 sg:person.0705101106.89 schema:affiliation grid-institutes:grid.34477.33
318 schema:familyName Eichler
319 schema:givenName Evan E
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705101106.89
321 rdf:type schema:Person
322 sg:person.0746501360.35 schema:affiliation grid-institutes:grid.34477.33
323 schema:familyName She
324 schema:givenName Xinwei
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746501360.35
326 rdf:type schema:Person
327 sg:pub.10.1007/bf01731581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023239976
328 https://doi.org/10.1007/bf01731581
329 rdf:type schema:CreativeWork
330 sg:pub.10.1007/s00412-002-0205-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030251976
331 https://doi.org/10.1007/s00412-002-0205-5
332 rdf:type schema:CreativeWork
333 sg:pub.10.1023/a:1009233327176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040068901
334 https://doi.org/10.1023/a:1009233327176
335 rdf:type schema:CreativeWork
336 sg:pub.10.1023/b:chro.0000009294.18760.e4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031181282
337 https://doi.org/10.1023/b:chro.0000009294.18760.e4
338 rdf:type schema:CreativeWork
339 sg:pub.10.1023/b:chro.0000036585.44138.4b schema:sameAs https://app.dimensions.ai/details/publication/pub.1010530950
340 https://doi.org/10.1023/b:chro.0000036585.44138.4b
341 rdf:type schema:CreativeWork
342 sg:pub.10.1038/31927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020088834
343 https://doi.org/10.1038/31927
344 rdf:type schema:CreativeWork
345 sg:pub.10.1038/35054550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034389621
346 https://doi.org/10.1038/35054550
347 rdf:type schema:CreativeWork
348 sg:pub.10.1038/35057157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012003820
349 https://doi.org/10.1038/35057157
350 rdf:type schema:CreativeWork
351 sg:pub.10.1038/nature02379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043347347
352 https://doi.org/10.1038/nature02379
353 rdf:type schema:CreativeWork
354 sg:pub.10.1038/nature02806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025178904
355 https://doi.org/10.1038/nature02806
356 rdf:type schema:CreativeWork
357 sg:pub.10.1038/nature03154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006367901
358 https://doi.org/10.1038/nature03154
359 rdf:type schema:CreativeWork
360 sg:pub.10.1038/ng0697-144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001740705
361 https://doi.org/10.1038/ng0697-144
362 rdf:type schema:CreativeWork
363 sg:pub.10.1038/ng1289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043529277
364 https://doi.org/10.1038/ng1289
365 rdf:type schema:CreativeWork
366 grid-institutes:grid.34477.33 schema:alternateName Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA
367 schema:name Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA
368 rdf:type schema:Organization
369 grid-institutes:grid.414016.6 schema:alternateName Children's Hospital Oakland Research Institute, Oakland, California 94609, USA
370 schema:name Children's Hospital Oakland Research Institute, Oakland, California 94609, USA
371 rdf:type schema:Organization
372 grid-institutes:grid.59734.3c schema:alternateName Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
373 schema:name Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
374 rdf:type schema:Organization
375 grid-institutes:grid.7644.1 schema:alternateName Department of Genetics and Microbiology, University of Bari, Bari, Italy
376 schema:name Department of Genetics and Microbiology, University of Bari, Bari, Italy
377 rdf:type schema:Organization
378 grid-institutes:grid.8404.8 schema:alternateName Department of Animal Biology and Genetics 'Leo Pardi', University of Florence, Florence, Italy
379 schema:name Department of Animal Biology and Genetics 'Leo Pardi', University of Florence, Florence, Italy
380 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...