Metagenomics for studying unculturable microorganisms: cutting the Gordian knot View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-08-01

AUTHORS

Patrick D Schloss, Jo Handelsman

ABSTRACT

More than 99% of prokaryotes in the environment cannot be cultured in the laboratory, a phenomenon that limits our understanding of microbial physiology, genetics, and community ecology. One way around this problem is metagenomics, the culture-independent cloning and analysis of microbial DNA extracted directly from an environmental sample. Recent advances in shotgun sequencing and computational methods for genome assembly have advanced the field of metagenomics to provide glimpses into the life of uncultured microorganisms. More... »

PAGES

229

References to SciGraph publications

  • 2004-02-01. Community structure and metabolism through reconstruction of microbial genomes from the environment in NATURE
  • 2005-03-29. The microbial selenoproteome of the Sargasso Sea in GENOME BIOLOGY
  • 2005-06. Metagenomics or Megagenomics? in NATURE REVIEWS MICROBIOLOGY
  • 2005-05-10. Microbial community genomics in the ocean in NATURE REVIEWS MICROBIOLOGY
  • 2005-06. Community genomics in microbial ecology and evolution in NATURE REVIEWS MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2005-6-8-229

    DOI

    http://dx.doi.org/10.1186/gb-2005-6-8-229

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029667488

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16086859


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