Transcriptome analysis of antigenic variation in Plasmodium falciparum - var silencing is not dependent on antisense RNA View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-11

AUTHORS

Stuart A Ralph, Emmanuel Bischoff, Denise Mattei, Odile Sismeiro, Marie-Agnès Dillies, Ghislaine Guigon, Jean-Yves Coppee, Peter H David, Artur Scherf

ABSTRACT

BACKGROUND: Plasmodium falciparum, the causative agent of the most severe form of malaria, undergoes antigenic variation through successive presentation of a family of antigens on the surface of parasitized erythrocytes. These antigens, known as Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins, are subject to a mutually exclusive expression system, and are encoded by the multigene var family. The mechanism whereby inactive var genes are silenced is poorly understood. To investigate transcriptional features of this mechanism, we conducted a microarray analysis of parasites that were selected to express different var genes by adhesion to chondroitin sulfate A (CSA) or CD36. RESULTS: In addition to oligonucleotides for all predicted protein-coding genes, oligonucleotide probes specific to each known var gene of the FCR3 background were designed and added to the microarray, as well as tiled sense and antisense probes for a subset of var genes. In parasites selected for adhesion to CSA, one full-length var gene (var2csa) was strongly upregulated, as were sense RNA molecules emanating from the 3' end of a limited subset of other var genes. No global relationship between sense and antisense production of var genes was observed, but notably, some var genes had coincident high levels of both antisense and sense transcript. CONCLUSION: Mutually exclusive expression of PfEMP1 proteins results from transcriptional silencing of non-expressed var genes. The distribution of steady-state sense and antisense RNA at var loci are not consistent with a silencing mechanism based on antisense silencing of inactive var genes. Silencing of var loci is also associated with altered regulation of genes distal to var loci. More... »

PAGES

r93

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/gb-2005-6-11-r93

DOI

http://dx.doi.org/10.1186/gb-2005-6-11-r93

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002083207

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16277748


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigenic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Silencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Protozoan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium falciparum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Antisense", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Protozoan", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Walter and Eliza Hall Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "Institut Pasteur, Unit of Biology of Host-Parasite Interactions, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 2581, 25 Rue du Docteur Roux, F-75724, Paris Cedex 15, France", 
            "The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3050, Parkville, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ralph", 
        "givenName": "Stuart A", 
        "id": "sg:person.0737770610.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737770610.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Institut Pasteur, Plate-Forme 2 - Puces \u00e0 ADN, 28 Rue du Docteur Roux, F-75724, Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bischoff", 
        "givenName": "Emmanuel", 
        "id": "sg:person.01267026631.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267026631.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institut Pasteur, Unit of Biology of Host-Parasite Interactions, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 2581, 25 Rue du Docteur Roux, F-75724, Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mattei", 
        "givenName": "Denise", 
        "id": "sg:person.0701054247.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701054247.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Institut Pasteur, Plate-Forme 2 - Puces \u00e0 ADN, 28 Rue du Docteur Roux, F-75724, Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sismeiro", 
        "givenName": "Odile", 
        "id": "sg:person.01162763731.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162763731.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Institut Pasteur, Plate-Forme 2 - Puces \u00e0 ADN, 28 Rue du Docteur Roux, F-75724, Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dillies", 
        "givenName": "Marie-Agn\u00e8s", 
        "id": "sg:person.0737541137.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737541137.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Institut Pasteur, Plate-Forme 2 - Puces \u00e0 ADN, 28 Rue du Docteur Roux, F-75724, Paris Cedex 15, France", 
            "Institut Pasteur, Plate-Forme 8 - CNR/Sant\u00e9 Publique, 28 Rue du Docteur Roux, F-75724, Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guigon", 
        "givenName": "Ghislaine", 
        "id": "sg:person.01302044235.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302044235.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Institut Pasteur, Plate-Forme 2 - Puces \u00e0 ADN, 28 Rue du Docteur Roux, F-75724, Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coppee", 
        "givenName": "Jean-Yves", 
        "id": "sg:person.01256360466.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256360466.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Institut Pasteur, Unit\u00e9 d'Immunologie Mol\u00e9culaire des Parasites, 28 Rue du Docteur Roux, F-75724, Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "David", 
        "givenName": "Peter H", 
        "id": "sg:person.01114343654.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114343654.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institut Pasteur, Unit of Biology of Host-Parasite Interactions, Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 2581, 25 Rue du Docteur Roux, F-75724, Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scherf", 
        "givenName": "Artur", 
        "id": "sg:person.01075461242.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075461242.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.162349899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001842286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-3-30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002620791", 
          "https://doi.org/10.1186/1475-2875-3-30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molbiopara.2004.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002691051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.01.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003807596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(99)00193-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003840402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005029015", 
          "https://doi.org/10.1038/sj.onc.1207880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005029015", 
          "https://doi.org/10.1038/sj.onc.1207880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(02)00135-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008312122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00127-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008587641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2003-4-2-r9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009465493", 
          "https://doi.org/10.1186/gb-2003-4-2-r9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90056-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010439054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molbiopara.2003.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010855647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molbiopara.2003.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010855647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(00)00254-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011022565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2003.03378.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011175293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2003.03570.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011572487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2004.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011850489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1087025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013046147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.12.10.3114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013291254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013959549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013959549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/28660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015376219", 
          "https://doi.org/10.1038/28660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/28660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015376219", 
          "https://doi.org/10.1038/28660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m213065200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015886377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018457673", 
          "https://doi.org/10.1186/gb-2004-5-10-r80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2003.03787.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018617494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.18.5418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019831034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mib.2004.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022003966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.152321599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022256363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408883102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023292426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023978653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.20025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024495678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-01-0315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028131111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.01.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029139405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029721777", 
          "https://doi.org/10.1038/nbt808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029721777", 
          "https://doi.org/10.1038/nbt808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(99)00159-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029921259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(02)00011-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030276391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(87)90005-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030383349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(87)90005-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030383349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2005.04577.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031314561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(98)00145-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031341127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2003.03505.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032595495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4894(88)90072-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032671144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/375800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033502481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(90)90029-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035341009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(90)90029-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035341009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2002.02822.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036146865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90055-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037437291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0000005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038391481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(99)00087-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040084816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(85)90059-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041246740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(85)90059-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041246740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(01)00266-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043432403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2003-5-1-r5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045046338", 
          "https://doi.org/10.1186/gb-2003-5-1-r5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(03)00246-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045423758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.4.e15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045723576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/expr.1994.1091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046027805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.104.5.1269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047865693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0402347101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048671189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2002.03404.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049553985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2004.04145.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050504096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.7940705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051033536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1088305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062448444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1102452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062450970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.781840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082422031", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083164304", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-11", 
    "datePublishedReg": "2005-11-01", 
    "description": "BACKGROUND: Plasmodium falciparum, the causative agent of the most severe form of malaria, undergoes antigenic variation through successive presentation of a family of antigens on the surface of parasitized erythrocytes. These antigens, known as Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins, are subject to a mutually exclusive expression system, and are encoded by the multigene var family. The mechanism whereby inactive var genes are silenced is poorly understood. To investigate transcriptional features of this mechanism, we conducted a microarray analysis of parasites that were selected to express different var genes by adhesion to chondroitin sulfate A (CSA) or CD36.\nRESULTS: In addition to oligonucleotides for all predicted protein-coding genes, oligonucleotide probes specific to each known var gene of the FCR3 background were designed and added to the microarray, as well as tiled sense and antisense probes for a subset of var genes. In parasites selected for adhesion to CSA, one full-length var gene (var2csa) was strongly upregulated, as were sense RNA molecules emanating from the 3' end of a limited subset of other var genes. No global relationship between sense and antisense production of var genes was observed, but notably, some var genes had coincident high levels of both antisense and sense transcript.\nCONCLUSION: Mutually exclusive expression of PfEMP1 proteins results from transcriptional silencing of non-expressed var genes. The distribution of steady-state sense and antisense RNA at var loci are not consistent with a silencing mechanism based on antisense silencing of inactive var genes. Silencing of var loci is also associated with altered regulation of genes distal to var loci.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/gb-2005-6-11-r93", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3724512", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6724119", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3769496", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023439", 
        "issn": [
          "1474-760X", 
          "1465-6906"
        ], 
        "name": "Genome Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Transcriptome analysis of antigenic variation in Plasmodium falciparum - var silencing is not dependent on antisense RNA", 
    "pagination": "r93", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "09ebc0a579c9154299f97b9681eaa45edca94278841b11d4c9a6ea8a8345e13f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16277748"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100960660"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/gb-2005-6-11-r93"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002083207"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/gb-2005-6-11-r93", 
      "https://app.dimensions.ai/details/publication/pub.1002083207"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000509.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fgb-2005-6-11-r93"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/gb-2005-6-11-r93'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/gb-2005-6-11-r93'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/gb-2005-6-11-r93'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/gb-2005-6-11-r93'


 

This table displays all metadata directly associated to this object as RDF triples.

358 TRIPLES      21 PREDICATES      97 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/gb-2005-6-11-r93 schema:about N0decdd5e25cb4494a337d9022508b416
2 N41f3655f342b48369e70dbc2e1a892e3
3 N482c98a217284938b64f4f57a818be24
4 N6694be60c860452d8c6983af70de2365
5 Nab99fd4b407e4d74997fd1939e385084
6 Ndf6cd71bdefa4fcdb16c6a03016d0692
7 Nf0827d216a184387a0180d8b35531b92
8 Nfe61b7a21ee94c2aae1ad2f33e040785
9 anzsrc-for:06
10 anzsrc-for:0604
11 schema:author N795dce363e804eaeaff38cbc702cd391
12 schema:citation sg:pub.10.1038/28660
13 sg:pub.10.1038/nbt808
14 sg:pub.10.1038/sj.onc.1207880
15 sg:pub.10.1186/1475-2875-3-30
16 sg:pub.10.1186/gb-2003-4-2-r9
17 sg:pub.10.1186/gb-2003-5-1-r5
18 sg:pub.10.1186/gb-2004-5-10-r80
19 https://app.dimensions.ai/details/publication/pub.1082422031
20 https://app.dimensions.ai/details/publication/pub.1083164304
21 https://doi.org/10.1002/bies.20025
22 https://doi.org/10.1006/expr.1994.1091
23 https://doi.org/10.1016/0014-4894(88)90072-0
24 https://doi.org/10.1016/0092-8674(95)90055-1
25 https://doi.org/10.1016/0092-8674(95)90056-x
26 https://doi.org/10.1016/0166-6851(85)90059-3
27 https://doi.org/10.1016/0166-6851(87)90005-3
28 https://doi.org/10.1016/0166-6851(90)90029-l
29 https://doi.org/10.1016/j.cell.2005.01.036
30 https://doi.org/10.1016/j.cell.2005.01.037
31 https://doi.org/10.1016/j.gene.2004.07.004
32 https://doi.org/10.1016/j.mib.2004.06.014
33 https://doi.org/10.1016/j.molbiopara.2003.09.004
34 https://doi.org/10.1016/j.molbiopara.2004.02.007
35 https://doi.org/10.1016/s0006-291x(03)00246-8
36 https://doi.org/10.1016/s0092-8674(04)00127-8
37 https://doi.org/10.1016/s0166-6851(00)00254-1
38 https://doi.org/10.1016/s0166-6851(01)00266-3
39 https://doi.org/10.1016/s0166-6851(02)00011-7
40 https://doi.org/10.1016/s0166-6851(02)00135-4
41 https://doi.org/10.1016/s0166-6851(98)00145-5
42 https://doi.org/10.1016/s0166-6851(99)00087-0
43 https://doi.org/10.1016/s0166-6851(99)00159-0
44 https://doi.org/10.1016/s0166-6851(99)00193-0
45 https://doi.org/10.1038/sj.embor.7400466
46 https://doi.org/10.1046/j.1365-2141.2002.03404.x
47 https://doi.org/10.1046/j.1365-2958.2002.02822.x
48 https://doi.org/10.1046/j.1365-2958.2003.03378.x
49 https://doi.org/10.1046/j.1365-2958.2003.03505.x
50 https://doi.org/10.1046/j.1365-2958.2003.03570.x
51 https://doi.org/10.1046/j.1365-2958.2003.03787.x
52 https://doi.org/10.1073/pnas.0402347101
53 https://doi.org/10.1073/pnas.0408883102
54 https://doi.org/10.1073/pnas.152321599
55 https://doi.org/10.1073/pnas.162349899
56 https://doi.org/10.1074/jbc.m213065200
57 https://doi.org/10.1083/jcb.104.5.1269
58 https://doi.org/10.1084/jem.20041579
59 https://doi.org/10.1086/375800
60 https://doi.org/10.1091/mbc.12.10.3114
61 https://doi.org/10.1093/emboj/17.18.5418
62 https://doi.org/10.1093/nar/30.4.e15
63 https://doi.org/10.1111/j.1365-2958.2004.04145.x
64 https://doi.org/10.1111/j.1365-2958.2005.04577.x
65 https://doi.org/10.1126/science.1087025
66 https://doi.org/10.1126/science.1088305
67 https://doi.org/10.1126/science.1102452
68 https://doi.org/10.1126/science.781840
69 https://doi.org/10.1182/blood-2002-01-0315
70 https://doi.org/10.1261/rna.7940705
71 https://doi.org/10.1371/journal.pbio.0000005
72 schema:datePublished 2005-11
73 schema:datePublishedReg 2005-11-01
74 schema:description BACKGROUND: Plasmodium falciparum, the causative agent of the most severe form of malaria, undergoes antigenic variation through successive presentation of a family of antigens on the surface of parasitized erythrocytes. These antigens, known as Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins, are subject to a mutually exclusive expression system, and are encoded by the multigene var family. The mechanism whereby inactive var genes are silenced is poorly understood. To investigate transcriptional features of this mechanism, we conducted a microarray analysis of parasites that were selected to express different var genes by adhesion to chondroitin sulfate A (CSA) or CD36. RESULTS: In addition to oligonucleotides for all predicted protein-coding genes, oligonucleotide probes specific to each known var gene of the FCR3 background were designed and added to the microarray, as well as tiled sense and antisense probes for a subset of var genes. In parasites selected for adhesion to CSA, one full-length var gene (var2csa) was strongly upregulated, as were sense RNA molecules emanating from the 3' end of a limited subset of other var genes. No global relationship between sense and antisense production of var genes was observed, but notably, some var genes had coincident high levels of both antisense and sense transcript. CONCLUSION: Mutually exclusive expression of PfEMP1 proteins results from transcriptional silencing of non-expressed var genes. The distribution of steady-state sense and antisense RNA at var loci are not consistent with a silencing mechanism based on antisense silencing of inactive var genes. Silencing of var loci is also associated with altered regulation of genes distal to var loci.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N1f969233ea784e0bab12dd5ce42cbf26
79 N3198568c2f3347b0990c9a714d0bd958
80 sg:journal.1023439
81 schema:name Transcriptome analysis of antigenic variation in Plasmodium falciparum - var silencing is not dependent on antisense RNA
82 schema:pagination r93
83 schema:productId N0a5cb71861cc4185a140dbdb8a49b748
84 N31dde8078f374306beff3fba355aa247
85 N7ede6759319e43d485b46809391fc0a5
86 N96f224834b0843bdacdfd756a7e9a285
87 Nc199976a754849359c9246c3bd0614e9
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002083207
89 https://doi.org/10.1186/gb-2005-6-11-r93
90 schema:sdDatePublished 2019-04-11T01:59
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N903a49e5de7548849e6c082455b7a4a1
93 schema:url http://link.springer.com/10.1186%2Fgb-2005-6-11-r93
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N0a5cb71861cc4185a140dbdb8a49b748 schema:name pubmed_id
98 schema:value 16277748
99 rdf:type schema:PropertyValue
100 N0decdd5e25cb4494a337d9022508b416 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Gene Expression Regulation
102 rdf:type schema:DefinedTerm
103 N1f969233ea784e0bab12dd5ce42cbf26 schema:issueNumber 11
104 rdf:type schema:PublicationIssue
105 N25dcf853894747348938c27f67ed1281 schema:name Institut Pasteur, Unit of Biology of Host-Parasite Interactions, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2581, 25 Rue du Docteur Roux, F-75724, Paris Cedex 15, France
106 rdf:type schema:Organization
107 N3198568c2f3347b0990c9a714d0bd958 schema:volumeNumber 6
108 rdf:type schema:PublicationVolume
109 N31dde8078f374306beff3fba355aa247 schema:name doi
110 schema:value 10.1186/gb-2005-6-11-r93
111 rdf:type schema:PropertyValue
112 N41f3655f342b48369e70dbc2e1a892e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Plasmodium falciparum
114 rdf:type schema:DefinedTerm
115 N45f358aa67354735bcaf7e2b152706f9 rdf:first sg:person.01256360466.46
116 rdf:rest N681105846e4f4ee28004940edc8724b3
117 N482c98a217284938b64f4f57a818be24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Gene Silencing
119 rdf:type schema:DefinedTerm
120 N6694be60c860452d8c6983af70de2365 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name RNA, Protozoan
122 rdf:type schema:DefinedTerm
123 N681105846e4f4ee28004940edc8724b3 rdf:first sg:person.01114343654.33
124 rdf:rest Nc947ce7ab7ee41599474087bf42aec7f
125 N6c926f5660624c40b2eb6986495ca0d5 rdf:first sg:person.0701054247.71
126 rdf:rest N7d00796034a8440eb1fe25c98df379e8
127 N795dce363e804eaeaff38cbc702cd391 rdf:first sg:person.0737770610.25
128 rdf:rest Nebe762732471453998de28414ef847b7
129 N7d00796034a8440eb1fe25c98df379e8 rdf:first sg:person.01162763731.12
130 rdf:rest Nd47d3cc16cec40c993ee26bd7ce19445
131 N7ede6759319e43d485b46809391fc0a5 schema:name nlm_unique_id
132 schema:value 100960660
133 rdf:type schema:PropertyValue
134 N903a49e5de7548849e6c082455b7a4a1 schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 N96f224834b0843bdacdfd756a7e9a285 schema:name dimensions_id
137 schema:value pub.1002083207
138 rdf:type schema:PropertyValue
139 Na951cd2f57ff4da682ed9218cbb3355b rdf:first sg:person.01302044235.05
140 rdf:rest N45f358aa67354735bcaf7e2b152706f9
141 Nab99fd4b407e4d74997fd1939e385084 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Genes, Protozoan
143 rdf:type schema:DefinedTerm
144 Nc0a474acf97e491295aaa483dc85c1a4 schema:name Institut Pasteur, Unit of Biology of Host-Parasite Interactions, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2581, 25 Rue du Docteur Roux, F-75724, Paris Cedex 15, France
145 rdf:type schema:Organization
146 Nc199976a754849359c9246c3bd0614e9 schema:name readcube_id
147 schema:value 09ebc0a579c9154299f97b9681eaa45edca94278841b11d4c9a6ea8a8345e13f
148 rdf:type schema:PropertyValue
149 Nc947ce7ab7ee41599474087bf42aec7f rdf:first sg:person.01075461242.51
150 rdf:rest rdf:nil
151 Nd47d3cc16cec40c993ee26bd7ce19445 rdf:first sg:person.0737541137.92
152 rdf:rest Na951cd2f57ff4da682ed9218cbb3355b
153 Ndf6cd71bdefa4fcdb16c6a03016d0692 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name RNA, Antisense
155 rdf:type schema:DefinedTerm
156 Nebe762732471453998de28414ef847b7 rdf:first sg:person.01267026631.61
157 rdf:rest N6c926f5660624c40b2eb6986495ca0d5
158 Nf0827d216a184387a0180d8b35531b92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Antigenic Variation
160 rdf:type schema:DefinedTerm
161 Nfe61b7a21ee94c2aae1ad2f33e040785 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Animals
163 rdf:type schema:DefinedTerm
164 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
165 schema:name Biological Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
168 schema:name Genetics
169 rdf:type schema:DefinedTerm
170 sg:grant.3724512 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2005-6-11-r93
171 rdf:type schema:MonetaryGrant
172 sg:grant.3769496 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2005-6-11-r93
173 rdf:type schema:MonetaryGrant
174 sg:grant.6724119 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2005-6-11-r93
175 rdf:type schema:MonetaryGrant
176 sg:journal.1023439 schema:issn 1465-6906
177 1474-760X
178 schema:name Genome Biology
179 rdf:type schema:Periodical
180 sg:person.01075461242.51 schema:affiliation N25dcf853894747348938c27f67ed1281
181 schema:familyName Scherf
182 schema:givenName Artur
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075461242.51
184 rdf:type schema:Person
185 sg:person.01114343654.33 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
186 schema:familyName David
187 schema:givenName Peter H
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114343654.33
189 rdf:type schema:Person
190 sg:person.01162763731.12 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
191 schema:familyName Sismeiro
192 schema:givenName Odile
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162763731.12
194 rdf:type schema:Person
195 sg:person.01256360466.46 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
196 schema:familyName Coppee
197 schema:givenName Jean-Yves
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256360466.46
199 rdf:type schema:Person
200 sg:person.01267026631.61 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
201 schema:familyName Bischoff
202 schema:givenName Emmanuel
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267026631.61
204 rdf:type schema:Person
205 sg:person.01302044235.05 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
206 schema:familyName Guigon
207 schema:givenName Ghislaine
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302044235.05
209 rdf:type schema:Person
210 sg:person.0701054247.71 schema:affiliation Nc0a474acf97e491295aaa483dc85c1a4
211 schema:familyName Mattei
212 schema:givenName Denise
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701054247.71
214 rdf:type schema:Person
215 sg:person.0737541137.92 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
216 schema:familyName Dillies
217 schema:givenName Marie-Agnès
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737541137.92
219 rdf:type schema:Person
220 sg:person.0737770610.25 schema:affiliation https://www.grid.ac/institutes/grid.1042.7
221 schema:familyName Ralph
222 schema:givenName Stuart A
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737770610.25
224 rdf:type schema:Person
225 sg:pub.10.1038/28660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015376219
226 https://doi.org/10.1038/28660
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nbt808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029721777
229 https://doi.org/10.1038/nbt808
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/sj.onc.1207880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005029015
232 https://doi.org/10.1038/sj.onc.1207880
233 rdf:type schema:CreativeWork
234 sg:pub.10.1186/1475-2875-3-30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002620791
235 https://doi.org/10.1186/1475-2875-3-30
236 rdf:type schema:CreativeWork
237 sg:pub.10.1186/gb-2003-4-2-r9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009465493
238 https://doi.org/10.1186/gb-2003-4-2-r9
239 rdf:type schema:CreativeWork
240 sg:pub.10.1186/gb-2003-5-1-r5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045046338
241 https://doi.org/10.1186/gb-2003-5-1-r5
242 rdf:type schema:CreativeWork
243 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
244 https://doi.org/10.1186/gb-2004-5-10-r80
245 rdf:type schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1082422031 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1083164304 schema:CreativeWork
248 https://doi.org/10.1002/bies.20025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024495678
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1006/expr.1994.1091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046027805
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/0014-4894(88)90072-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032671144
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/0092-8674(95)90055-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037437291
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/0092-8674(95)90056-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010439054
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/0166-6851(85)90059-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041246740
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/0166-6851(87)90005-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030383349
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/0166-6851(90)90029-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1035341009
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.cell.2005.01.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003807596
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.cell.2005.01.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029139405
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.gene.2004.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011850489
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.mib.2004.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022003966
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.molbiopara.2003.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010855647
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.molbiopara.2004.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002691051
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0006-291x(03)00246-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045423758
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0092-8674(04)00127-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008587641
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s0166-6851(00)00254-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011022565
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/s0166-6851(01)00266-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043432403
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0166-6851(02)00011-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030276391
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0166-6851(02)00135-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008312122
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s0166-6851(98)00145-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031341127
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/s0166-6851(99)00087-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040084816
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/s0166-6851(99)00159-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029921259
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/s0166-6851(99)00193-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003840402
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1038/sj.embor.7400466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013959549
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1046/j.1365-2141.2002.03404.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049553985
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1046/j.1365-2958.2002.02822.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036146865
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1046/j.1365-2958.2003.03378.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011175293
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1046/j.1365-2958.2003.03505.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032595495
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1046/j.1365-2958.2003.03570.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011572487
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1046/j.1365-2958.2003.03787.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018617494
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1073/pnas.0402347101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048671189
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1073/pnas.0408883102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023292426
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1073/pnas.152321599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022256363
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1073/pnas.162349899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001842286
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1074/jbc.m213065200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015886377
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1083/jcb.104.5.1269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047865693
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1084/jem.20041579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023978653
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1086/375800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033502481
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1091/mbc.12.10.3114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013291254
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1093/emboj/17.18.5418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019831034
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1093/nar/30.4.e15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045723576
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1111/j.1365-2958.2004.04145.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050504096
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1111/j.1365-2958.2005.04577.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031314561
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1126/science.1087025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013046147
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1126/science.1088305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448444
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1126/science.1102452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062450970
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1126/science.781840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649809
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1182/blood-2002-01-0315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028131111
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1261/rna.7940705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051033536
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1371/journal.pbio.0000005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038391481
349 rdf:type schema:CreativeWork
350 https://www.grid.ac/institutes/grid.1042.7 schema:alternateName Walter and Eliza Hall Institute of Medical Research
351 schema:name Institut Pasteur, Unit of Biology of Host-Parasite Interactions, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2581, 25 Rue du Docteur Roux, F-75724, Paris Cedex 15, France
352 The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3050, Parkville, Melbourne, Victoria, Australia
353 rdf:type schema:Organization
354 https://www.grid.ac/institutes/grid.428999.7 schema:alternateName Institut Pasteur
355 schema:name Institut Pasteur, Plate-Forme 2 - Puces à ADN, 28 Rue du Docteur Roux, F-75724, Paris Cedex 15, France
356 Institut Pasteur, Plate-Forme 8 - CNR/Santé Publique, 28 Rue du Docteur Roux, F-75724, Paris Cedex 15, France
357 Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, 28 Rue du Docteur Roux, F-75724, Paris Cedex 15, France
358 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...