The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-11

AUTHORS

Cemalettin Bekpen, Julia P Hunn, Christoph Rohde, Iana Parvanova, Libby Guethlein, Diane M Dunn, Eva Glowalla, Maria Leptin, Jonathan C Howard

ABSTRACT

BACKGROUND: Members of the p47 (immunity-related GTPases (IRG) family) GTPases are essential, interferon-inducible resistance factors in mice that are active against a broad spectrum of important intracellular pathogens. Surprisingly, there are no reports of p47 function in humans. RESULTS: Here we show that the p47 GTPases are represented by 23 genes in the mouse, whereas humans have only a single full-length p47 GTPase and an expressed, truncated presumed pseudo-gene. The human full-length gene is orthologous to an isolated mouse p47 GTPase that carries no interferon-inducible elements in the promoter of either species and is expressed constitutively in the mature testis of both species. Thus, there is no evidence for a p47 GTPase-based resistance system in humans. Dogs have several interferon-inducible p47s, and so the primate lineage that led to humans appears to have lost an ancient function. Multiple p47 GTPases are also present in the zebrafish, but there is only a tandem p47 gene pair in pufferfish. CONCLUSION: Mice and humans must deploy their immune resources against vacuolar pathogens in radically different ways. This carries significant implications for the use of the mouse as a model of human infectious disease. The absence of the p47 resistance system in humans suggests that possession of this resistance system carries significant costs that, in the primate lineage that led to humans, are not outweighed by the benefits. The origin of the vertebrate p47 system is obscure. More... »

PAGES

r92

References to SciGraph publications

  • 1999. Ifn-γ Activated Indoleamine 2,3-Dioxygenase Activity in Human Cells is an Antiparasitic and an Antibacterial Effector Mechanism in TRYPTOPHAN, SEROTONIN, AND MELATONIN
  • 1999-01. Characterization of the mouse proteasome regulator PA28b gene in IMMUNOGENETICS
  • 1992-10. Evolution of the major histocompatibility complex: a hundred-fold amplification of MHC class I genes in the African pigmy mouse Nannomys setulosus in IMMUNOGENETICS
  • 2004-05. The GTPase-activating protein Rap1GAP uses a catalytic asparagine in NATURE
  • 2004-02. p47 GTPases: regulators of immunity to intracellular pathogens in NATURE REVIEWS IMMUNOLOGY
  • 2004-10. Antimicrobial reactive oxygen and nitrogen species: concepts and controversies in NATURE REVIEWS MICROBIOLOGY
  • 2003-09. The fitness costs to plants of resistance to pathogens in GENOME BIOLOGY
  • 2003-06. Identification of conserved regulatory elements by comparative genome analysis in BMC BIOLOGY
  • 2003-05. Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana in NATURE
  • 1998-10. Characterization and Expression of the Mx1 Gene in Wild Mouse Species in BIOCHEMICAL GENETICS
  • 2004-02. The dynamin superfamily: universal membrane tubulation and fission molecules? in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2004-12. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron in NATURE
  • 2004-12. Iron and microbial infection in NATURE REVIEWS MICROBIOLOGY
  • 2004-02. MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins in GENOME BIOLOGY
  • 2001-04. The evolution and genetics of innate immunity in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/gb-2005-6-11-r92

    DOI

    http://dx.doi.org/10.1186/gb-2005-6-11-r92

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050480030

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16277747


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