Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-02-13

AUTHORS

Lakshminarayan M Iyer, Eugene V Koonin, L Aravind

ABSTRACT

BackgroundViral DNA-binding proteins have served as good models to study the biochemistry of transcription regulation and chromatin dynamics. Computational analysis of viral DNA-binding regulatory proteins and identification of their previously undetected homologs encoded by cellular genomes might lead to a better understanding of their function and evolution in both viral and cellular systems.ResultsThe phyletic range and the conserved DNA-binding domains of the viral regulatory proteins of the poxvirus D6R/N1R and baculoviral Bro protein families have not been previously defined. Using computational analysis, we show that the amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain is suggested to be homologous to the fungal DNA-binding APSES domain. We provide evidence for the KilA-N and APSES domains sharing a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease. The amino-terminal module of the Bro proteins is another, distinct DNA-binding domain (the Bro-N domain) that is present in proteins whose domain architectures parallel those of the KilA-N domain-containing proteins. A detailed analysis of the KilA-N and Bro-N domains and the associated domains points to extensive domain shuffling and lineage-specific gene family expansion within DNA virus genomes.ConclusionsWe define a large class of novel viral DNA-binding proteins and their cellular homologs and identify their domain architectures. On the basis of phyletic pattern analysis we present evidence for a probable viral origin of the fungus-specific cell-cycle regulatory transcription factors containing the APSES DNA-binding domain. We also demonstrate the extensive role of lineage-specific gene expansion and domain shuffling, within a limited set of approximately 24 domains, in the generation of the diversity of virus-specific regulatory proteins. More... »

PAGES

research0012.1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/gb-2002-3-3-research0012

DOI

http://dx.doi.org/10.1186/gb-2002-3-3-research0012

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011560169

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11897024


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Baculoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Computational Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Conserved Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Viruses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fungal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Regulator", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Poxviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Regulatory and Accessory Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.419234.9", 
          "name": [
            "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iyer", 
        "givenName": "Lakshminarayan M", 
        "id": "sg:person.012162224357.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.419234.9", 
          "name": [
            "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koonin", 
        "givenName": "Eugene V", 
        "id": "sg:person.01017015051.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017015051.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.419234.9", 
          "name": [
            "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aravind", 
        "givenName": "L", 
        "id": "sg:person.01106662166.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/298447a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002302727", 
          "https://doi.org/10.1038/298447a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02101285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045563541", 
          "https://doi.org/10.1007/bf02101285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/367754a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049777638", 
          "https://doi.org/10.1038/367754a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb0697-468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044345312", 
          "https://doi.org/10.1038/nsb0697-468"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-02-13", 
    "datePublishedReg": "2002-02-13", 
    "description": "BackgroundViral DNA-binding proteins have served as good models to study the biochemistry of transcription regulation and chromatin dynamics. Computational analysis of viral DNA-binding regulatory proteins and identification of their previously undetected homologs encoded by cellular genomes might lead to a better understanding of their function and evolution in both viral and cellular systems.ResultsThe phyletic range and the conserved DNA-binding domains of the viral regulatory proteins of the poxvirus D6R/N1R and baculoviral Bro protein families have not been previously defined. Using computational analysis, we show that the amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain is suggested to be homologous to the fungal DNA-binding APSES domain. We provide evidence for the KilA-N and APSES domains sharing a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease. The amino-terminal module of the Bro proteins is another, distinct DNA-binding domain (the Bro-N domain) that is present in proteins whose domain architectures parallel those of the KilA-N domain-containing proteins. A detailed analysis of the KilA-N and Bro-N domains and the associated domains points to extensive domain shuffling and lineage-specific gene family expansion within DNA virus genomes.ConclusionsWe define a large class of novel viral DNA-binding proteins and their cellular homologs and identify their domain architectures. On the basis of phyletic pattern analysis we present evidence for a probable viral origin of the fungus-specific cell-cycle regulatory transcription factors containing the APSES DNA-binding domain. We also demonstrate the extensive role of lineage-specific gene expansion and domain shuffling, within a limited set of approximately 24 domains, in the generation of the diversity of virus-specific regulatory proteins.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/gb-2002-3-3-research0012", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2726029", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2720255", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023439", 
        "issn": [
          "1474-760X", 
          "1465-6906"
        ], 
        "name": "Genome Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "keywords": [
      "DNA-binding domain", 
      "DNA-binding proteins", 
      "amino-terminal module", 
      "regulatory proteins", 
      "APSES domain", 
      "transcription factors", 
      "lineage-specific gene family expansions", 
      "cell-cycle regulatory transcription factors", 
      "DNA-binding regulatory proteins", 
      "distinct DNA-binding domains", 
      "lineage-specific gene expansion", 
      "viral DNA-binding protein", 
      "DNA viruses", 
      "extensive domain shuffling", 
      "gene family expansion", 
      "phyletic pattern analysis", 
      "APSES transcription factor", 
      "domain-containing proteins", 
      "eukaryotic DNA viruses", 
      "DNA virus genomes", 
      "regulatory transcription factors", 
      "amino-terminal domain", 
      "viral regulatory proteins", 
      "family expansion", 
      "chromatin dynamics", 
      "domain shuffling", 
      "transcription regulation", 
      "gene expansion", 
      "tRNA endonuclease", 
      "cellular homolog", 
      "domain architecture", 
      "BRO proteins", 
      "transcription regulators", 
      "protein family", 
      "common fold", 
      "cellular genome", 
      "computational analysis", 
      "virus genome", 
      "protein", 
      "homolog", 
      "genome", 
      "kilA", 
      "viral origin", 
      "extensive role", 
      "extensive domain", 
      "shuffling", 
      "cellular systems", 
      "domain", 
      "nuclease", 
      "N1R", 
      "endonuclease", 
      "regulator", 
      "probable viral origin", 
      "diversity", 
      "regulation", 
      "better understanding", 
      "virus", 
      "biochemistry", 
      "pattern analysis", 
      "limited set", 
      "origin", 
      "family", 
      "best model", 
      "wide range", 
      "folds", 
      "identification", 
      "evolution", 
      "detailed analysis", 
      "domain points", 
      "analysis", 
      "evidence", 
      "role", 
      "expansion", 
      "factors", 
      "function", 
      "understanding", 
      "dynamics", 
      "module", 
      "basis", 
      "range", 
      "generation", 
      "novel", 
      "class", 
      "implications", 
      "large class", 
      "architecture", 
      "ConclusionsWe", 
      "set", 
      "system", 
      "model", 
      "point"
    ], 
    "name": "Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors", 
    "pagination": "research0012.1", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011560169"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/gb-2002-3-3-research0012"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11897024"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/gb-2002-3-3-research0012", 
      "https://app.dimensions.ai/details/publication/pub.1011560169"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_350.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/gb-2002-3-3-research0012"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/gb-2002-3-3-research0012'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/gb-2002-3-3-research0012'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/gb-2002-3-3-research0012'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/gb-2002-3-3-research0012'


 

This table displays all metadata directly associated to this object as RDF triples.

251 TRIPLES      22 PREDICATES      137 URIs      124 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/gb-2002-3-3-research0012 schema:about N04d4def43fa64bccb5a07194c804b80d
2 N073148ee6fa440c3b622aa083d239c92
3 N28bcfd8e18a14156a259e4e009b00df3
4 N3b917f4f77444b3a98210692d18c0b5d
5 N5d33d13802ac4796b324e6b3ea660831
6 N5e3388c6786345c08fa863abd7057d0d
7 N848f0e6ea08640c19a84c44da2f20caa
8 Nac2384eaecab4b3b9791946b30f75b50
9 Nc04923383c1a405eab53c0af5deb479b
10 Nc4f122e159934d44bd2e3cc5c488f9d0
11 Nc59a768e803c4053bc06f6424d722b78
12 Nd3a50c8d4ac848beb6899c66bf8acb75
13 Nf921e86b112f40f98cbfde20fa4bb57a
14 Nf95f5812477748adbb715c2771fe7294
15 Nfc69614b2d44434397c742636bc47dfd
16 anzsrc-for:06
17 anzsrc-for:0601
18 anzsrc-for:0604
19 schema:author Nb4a5907ba5de4f9a9ac82e1ea827429d
20 schema:citation sg:pub.10.1007/bf02101285
21 sg:pub.10.1038/298447a0
22 sg:pub.10.1038/367754a0
23 sg:pub.10.1038/nsb0697-468
24 schema:datePublished 2002-02-13
25 schema:datePublishedReg 2002-02-13
26 schema:description BackgroundViral DNA-binding proteins have served as good models to study the biochemistry of transcription regulation and chromatin dynamics. Computational analysis of viral DNA-binding regulatory proteins and identification of their previously undetected homologs encoded by cellular genomes might lead to a better understanding of their function and evolution in both viral and cellular systems.ResultsThe phyletic range and the conserved DNA-binding domains of the viral regulatory proteins of the poxvirus D6R/N1R and baculoviral Bro protein families have not been previously defined. Using computational analysis, we show that the amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain is suggested to be homologous to the fungal DNA-binding APSES domain. We provide evidence for the KilA-N and APSES domains sharing a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease. The amino-terminal module of the Bro proteins is another, distinct DNA-binding domain (the Bro-N domain) that is present in proteins whose domain architectures parallel those of the KilA-N domain-containing proteins. A detailed analysis of the KilA-N and Bro-N domains and the associated domains points to extensive domain shuffling and lineage-specific gene family expansion within DNA virus genomes.ConclusionsWe define a large class of novel viral DNA-binding proteins and their cellular homologs and identify their domain architectures. On the basis of phyletic pattern analysis we present evidence for a probable viral origin of the fungus-specific cell-cycle regulatory transcription factors containing the APSES DNA-binding domain. We also demonstrate the extensive role of lineage-specific gene expansion and domain shuffling, within a limited set of approximately 24 domains, in the generation of the diversity of virus-specific regulatory proteins.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree true
30 schema:isPartOf Nc80c5ca92a7548d087a46c90db43934c
31 Nf325f6a58d404b1398ab8c075639485f
32 sg:journal.1023439
33 schema:keywords APSES domain
34 APSES transcription factor
35 BRO proteins
36 ConclusionsWe
37 DNA virus genomes
38 DNA viruses
39 DNA-binding domain
40 DNA-binding proteins
41 DNA-binding regulatory proteins
42 N1R
43 amino-terminal domain
44 amino-terminal module
45 analysis
46 architecture
47 basis
48 best model
49 better understanding
50 biochemistry
51 cell-cycle regulatory transcription factors
52 cellular genome
53 cellular homolog
54 cellular systems
55 chromatin dynamics
56 class
57 common fold
58 computational analysis
59 detailed analysis
60 distinct DNA-binding domains
61 diversity
62 domain
63 domain architecture
64 domain points
65 domain shuffling
66 domain-containing proteins
67 dynamics
68 endonuclease
69 eukaryotic DNA viruses
70 evidence
71 evolution
72 expansion
73 extensive domain
74 extensive domain shuffling
75 extensive role
76 factors
77 family
78 family expansion
79 folds
80 function
81 gene expansion
82 gene family expansion
83 generation
84 genome
85 homolog
86 identification
87 implications
88 kilA
89 large class
90 limited set
91 lineage-specific gene expansion
92 lineage-specific gene family expansions
93 model
94 module
95 novel
96 nuclease
97 origin
98 pattern analysis
99 phyletic pattern analysis
100 point
101 probable viral origin
102 protein
103 protein family
104 range
105 regulation
106 regulator
107 regulatory proteins
108 regulatory transcription factors
109 role
110 set
111 shuffling
112 system
113 tRNA endonuclease
114 transcription factors
115 transcription regulation
116 transcription regulators
117 understanding
118 viral DNA-binding protein
119 viral origin
120 viral regulatory proteins
121 virus
122 virus genome
123 wide range
124 schema:name Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors
125 schema:pagination research0012.1
126 schema:productId N428d30f42c7a48db97b67791cfd41e32
127 N50ab290e6d5446a69448d5527e984434
128 Nea4eeeb4605c4dc09f9dc09f37c5d5fb
129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011560169
130 https://doi.org/10.1186/gb-2002-3-3-research0012
131 schema:sdDatePublished 2022-05-20T07:22
132 schema:sdLicense https://scigraph.springernature.com/explorer/license/
133 schema:sdPublisher N50755b580b734070849933e2dde00d1d
134 schema:url https://doi.org/10.1186/gb-2002-3-3-research0012
135 sgo:license sg:explorer/license/
136 sgo:sdDataset articles
137 rdf:type schema:ScholarlyArticle
138 N04d4def43fa64bccb5a07194c804b80d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Computational Biology
140 rdf:type schema:DefinedTerm
141 N073148ee6fa440c3b622aa083d239c92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Sequence Homology, Amino Acid
143 rdf:type schema:DefinedTerm
144 N28bcfd8e18a14156a259e4e009b00df3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Evolution, Molecular
146 rdf:type schema:DefinedTerm
147 N2ed9bcbc2d3243318af3009c6d2f4471 rdf:first sg:person.01106662166.38
148 rdf:rest rdf:nil
149 N3b917f4f77444b3a98210692d18c0b5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name DNA-Binding Proteins
151 rdf:type schema:DefinedTerm
152 N428d30f42c7a48db97b67791cfd41e32 schema:name pubmed_id
153 schema:value 11897024
154 rdf:type schema:PropertyValue
155 N50755b580b734070849933e2dde00d1d schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 N50ab290e6d5446a69448d5527e984434 schema:name dimensions_id
158 schema:value pub.1011560169
159 rdf:type schema:PropertyValue
160 N5d33d13802ac4796b324e6b3ea660831 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Genes, Regulator
162 rdf:type schema:DefinedTerm
163 N5e3388c6786345c08fa863abd7057d0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Fungal Proteins
165 rdf:type schema:DefinedTerm
166 N848f0e6ea08640c19a84c44da2f20caa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Conserved Sequence
168 rdf:type schema:DefinedTerm
169 Nac2384eaecab4b3b9791946b30f75b50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Baculoviridae
171 rdf:type schema:DefinedTerm
172 Nb4a5907ba5de4f9a9ac82e1ea827429d rdf:first sg:person.012162224357.20
173 rdf:rest Nd0e1d061b8e34968b37e4d75a4bc5acb
174 Nc04923383c1a405eab53c0af5deb479b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name DNA Viruses
176 rdf:type schema:DefinedTerm
177 Nc4f122e159934d44bd2e3cc5c488f9d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Viral Proteins
179 rdf:type schema:DefinedTerm
180 Nc59a768e803c4053bc06f6424d722b78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Viral Regulatory and Accessory Proteins
182 rdf:type schema:DefinedTerm
183 Nc80c5ca92a7548d087a46c90db43934c schema:volumeNumber 3
184 rdf:type schema:PublicationVolume
185 Nd0e1d061b8e34968b37e4d75a4bc5acb rdf:first sg:person.01017015051.78
186 rdf:rest N2ed9bcbc2d3243318af3009c6d2f4471
187 Nd3a50c8d4ac848beb6899c66bf8acb75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Protein Structure, Tertiary
189 rdf:type schema:DefinedTerm
190 Nea4eeeb4605c4dc09f9dc09f37c5d5fb schema:name doi
191 schema:value 10.1186/gb-2002-3-3-research0012
192 rdf:type schema:PropertyValue
193 Nf325f6a58d404b1398ab8c075639485f schema:issueNumber 3
194 rdf:type schema:PublicationIssue
195 Nf921e86b112f40f98cbfde20fa4bb57a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Transcription Factors
197 rdf:type schema:DefinedTerm
198 Nf95f5812477748adbb715c2771fe7294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Amino Acid Sequence
200 rdf:type schema:DefinedTerm
201 Nfc69614b2d44434397c742636bc47dfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Poxviridae
203 rdf:type schema:DefinedTerm
204 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
205 schema:name Biological Sciences
206 rdf:type schema:DefinedTerm
207 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
208 schema:name Biochemistry and Cell Biology
209 rdf:type schema:DefinedTerm
210 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
211 schema:name Genetics
212 rdf:type schema:DefinedTerm
213 sg:grant.2720255 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2002-3-3-research0012
214 rdf:type schema:MonetaryGrant
215 sg:grant.2726029 http://pending.schema.org/fundedItem sg:pub.10.1186/gb-2002-3-3-research0012
216 rdf:type schema:MonetaryGrant
217 sg:journal.1023439 schema:issn 1465-6906
218 1474-760X
219 schema:name Genome Biology
220 schema:publisher Springer Nature
221 rdf:type schema:Periodical
222 sg:person.01017015051.78 schema:affiliation grid-institutes:grid.419234.9
223 schema:familyName Koonin
224 schema:givenName Eugene V
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017015051.78
226 rdf:type schema:Person
227 sg:person.01106662166.38 schema:affiliation grid-institutes:grid.419234.9
228 schema:familyName Aravind
229 schema:givenName L
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38
231 rdf:type schema:Person
232 sg:person.012162224357.20 schema:affiliation grid-institutes:grid.419234.9
233 schema:familyName Iyer
234 schema:givenName Lakshminarayan M
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20
236 rdf:type schema:Person
237 sg:pub.10.1007/bf02101285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045563541
238 https://doi.org/10.1007/bf02101285
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/298447a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002302727
241 https://doi.org/10.1038/298447a0
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/367754a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049777638
244 https://doi.org/10.1038/367754a0
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nsb0697-468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044345312
247 https://doi.org/10.1038/nsb0697-468
248 rdf:type schema:CreativeWork
249 grid-institutes:grid.419234.9 schema:alternateName National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA
250 schema:name National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA
251 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...