Isochores Merit the Prefix 'Iso' View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-10

AUTHORS

Wentian Li, Pedro Bernaola-Galvan, Pedro Carpena, Jose L Oliver

ABSTRACT

The isochore concept in human genome sequence was challenged in an analysis by the International Human Genome Sequencing Consortium (IHGSC). We argue here that a statement in IGHSC analysis concerning the existence of isochore is incorrect, because it had applied an inappropriate statistical test. To test the existence of isochores should be equivalent to a test of homogeneity of windowed GC%. The statistical test applied in the IHGSC's analysis, the binomial test, is however a test of a sequence being random on the base level. For testing the existence of isochore, or homogeneity in GC%, we propose to use another statistical test: the analysis of variance (ANOVA). It can be shown that DNA sequences that are rejected by binomial test may not be rejected by the ANOVA test. More... »

PAGES

preprint0009.1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/gb-2002-3-11-preprint0009

DOI

http://dx.doi.org/10.1186/gb-2002-3-11-preprint0009

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051892070


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