Nitroglycerin can facilitate weaning of difficult-to-wean chronic obstructive pulmonary disease patients: a prospective interventional non-randomized study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Christina Routsi, Ioannis Stanopoulos, Epaminondas Zakynthinos, Panagiotis Politis, Vassilios Papas, Demetrios Zervakis, Spyros Zakynthinos

ABSTRACT

INTRODUCTION: Both experimental and clinical data give convincing evidence to acute cardiac dysfunction as the origin or a cofactor of weaning failure in patients with chronic obstructive pulmonary disease. Therefore, treatment targeting the cardiovascular system might help the heart to tolerate more effectively the critical period of weaning. This study aims to assess the hemodynamic, respiratory and clinical effects of nitroglycerin infusion in difficult-to-wean patients with severe chronic obstructive pulmonary disease. METHODS: Twelve difficult-to-wean (failed ≥ 3 consecutive trials) chronic obstructive pulmonary disease patients, who presented systemic arterial hypertension (systolic blood pressure ≥ 140 mmHg) during weaning failure and had systemic and pulmonary artery catheters in place, participated in this prospective, interventional, non-randomized clinical trial. Patients were studied in two consecutive days, i.e., the first day without (Control day) and the second day with (Study day) nitroglycerin continuous intravenous infusion starting at the beginning of the spontaneous breathing trial, and titrated to maintain normal systolic blood pressure. Hemodynamic, oxygenation and respiratory measurements were performed on mechanical ventilation, and during a 2-hour T-piece spontaneous breathing trial. Primary endpoint was hemodynamic and respiratory effects of nitroglycerin infusion. Secondary endpoint was spontaneous breathing trial and extubation outcome. RESULTS: Compared to mechanical ventilation, mean systemic arterial pressure, rate-pressure product, mean pulmonary arterial pressure, and pulmonary artery occlusion pressure increased [from (mean ± SD) 94 ± 14, 13708 ± 3166, 29.9 ± 4.8, and 14.8 ± 3.8 to 109 ± 20 mmHg, 19856 ± 4877 mmHg b/min, 41.6 ± 5.8 mmHg, and 23.4 ± 7.4 mmHg, respectively], and mixed venous oxygen saturation decreased (from 75.7 ± 3.5 to 69.3 ± 7.5%) during failing trials on Control day, whereas they did not change on Study day. Venous admixture increased throughout the trial on both Control day and Study day, but this increase was lower on Study day. Whereas weaning failed in all patients on Control day, nitroglycerin administration on Study day enabled a successful spontaneous breathing trial and extubation in 92% and 88% of patients, respectively. CONCLUSIONS: In this clinical setting, nitroglycerin infusion can expedite the weaning by restoring weaning-induced cardiovascular compromise. More... »

PAGES

r204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/cc9326

DOI

http://dx.doi.org/10.1186/cc9326

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037952064

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21078149


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitroglycerin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Disease, Chronic Obstructive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Gas Exchange", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiration, Artificial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventilator Weaning", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Routsi", 
        "givenName": "Christina", 
        "id": "sg:person.0636361130.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636361130.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aristotle University of Thessaloniki", 
          "id": "https://www.grid.ac/institutes/grid.4793.9", 
          "name": [
            "Respiratory Failure Unit, Aristotle University, G. Papanikolaou Hospital, Exohi, 57 010, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stanopoulos", 
        "givenName": "Ioannis", 
        "id": "sg:person.01215777453.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215777453.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zakynthinos", 
        "givenName": "Epaminondas", 
        "id": "sg:person.01247402715.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247402715.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Politis", 
        "givenName": "Panagiotis", 
        "id": "sg:person.01361127563.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361127563.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papas", 
        "givenName": "Vassilios", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zervakis", 
        "givenName": "Demetrios", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zakynthinos", 
        "givenName": "Spyros", 
        "id": "sg:person.01314166613.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314166613.94"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00256965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003383035", 
          "https://doi.org/10.1007/bf00256965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00256965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003383035", 
          "https://doi.org/10.1007/bf00256965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01704697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004258614", 
          "https://doi.org/10.1007/bf01704697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01704697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004258614", 
          "https://doi.org/10.1007/bf01704697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01704697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004258614", 
          "https://doi.org/10.1007/bf01704697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.104.3.854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004699720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1053-2498(99)00121-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004784394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.155.3.9117025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010210969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehm236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011749652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01694872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014431597", 
          "https://doi.org/10.1007/bf01694872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01694872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014431597", 
          "https://doi.org/10.1007/bf01694872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01694872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014431597", 
          "https://doi.org/10.1007/bf01694872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-005-2699-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015551214", 
          "https://doi.org/10.1007/s00134-005-2699-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-005-2699-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015551214", 
          "https://doi.org/10.1007/s00134-005-2699-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.120.6_suppl.375s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016953685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.120.6_suppl.375s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016953685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0883-9441(86)80114-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019344868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.92.1.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020739008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31819f13d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021847770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31819f13d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021847770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000250391.89780.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022081228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000250391.89780.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022081228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/00000539-199409000-00029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023231232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm197908303010901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026389756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-198808000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027728679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-198808000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027728679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.113.3.576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027966971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.162.2.9908056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030573576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.96.09061283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037419854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1513/pats.200404-032ms", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038566750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000073597.57414.a9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038570144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.158.6.9804056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039406468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.57.3.549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040478924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.119.6.1840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048267295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.119.6.1840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048267295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.150.4.7921460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048376068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrc.2005.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050077288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077520484", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0703500425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077520484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0703500425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077520484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0703500425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077520484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078691659", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1979.47.2.257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080529306"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12", 
    "datePublishedReg": "2010-12-01", 
    "description": "INTRODUCTION: Both experimental and clinical data give convincing evidence to acute cardiac dysfunction as the origin or a cofactor of weaning failure in patients with chronic obstructive pulmonary disease. Therefore, treatment targeting the cardiovascular system might help the heart to tolerate more effectively the critical period of weaning. This study aims to assess the hemodynamic, respiratory and clinical effects of nitroglycerin infusion in difficult-to-wean patients with severe chronic obstructive pulmonary disease.\nMETHODS: Twelve difficult-to-wean (failed \u2265 3 consecutive trials) chronic obstructive pulmonary disease patients, who presented systemic arterial hypertension (systolic blood pressure \u2265 140 mmHg) during weaning failure and had systemic and pulmonary artery catheters in place, participated in this prospective, interventional, non-randomized clinical trial. Patients were studied in two consecutive days, i.e., the first day without (Control day) and the second day with (Study day) nitroglycerin continuous intravenous infusion starting at the beginning of the spontaneous breathing trial, and titrated to maintain normal systolic blood pressure. Hemodynamic, oxygenation and respiratory measurements were performed on mechanical ventilation, and during a 2-hour T-piece spontaneous breathing trial. Primary endpoint was hemodynamic and respiratory effects of nitroglycerin infusion. Secondary endpoint was spontaneous breathing trial and extubation outcome.\nRESULTS: Compared to mechanical ventilation, mean systemic arterial pressure, rate-pressure product, mean pulmonary arterial pressure, and pulmonary artery occlusion pressure increased [from (mean \u00b1 SD) 94 \u00b1 14, 13708 \u00b1 3166, 29.9 \u00b1 4.8, and 14.8 \u00b1 3.8 to 109 \u00b1 20 mmHg, 19856 \u00b1 4877 mmHg b/min, 41.6 \u00b1 5.8 mmHg, and 23.4 \u00b1 7.4 mmHg, respectively], and mixed venous oxygen saturation decreased (from 75.7 \u00b1 3.5 to 69.3 \u00b1 7.5%) during failing trials on Control day, whereas they did not change on Study day. Venous admixture increased throughout the trial on both Control day and Study day, but this increase was lower on Study day. Whereas weaning failed in all patients on Control day, nitroglycerin administration on Study day enabled a successful spontaneous breathing trial and extubation in 92% and 88% of patients, respectively.\nCONCLUSIONS: In this clinical setting, nitroglycerin infusion can expedite the weaning by restoring weaning-induced cardiovascular compromise.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/cc9326", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Nitroglycerin can facilitate weaning of difficult-to-wean chronic obstructive pulmonary disease patients: a prospective interventional non-randomized study", 
    "pagination": "r204", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b4ca89fcb4a2d426c67d0329299e6628de34ee4564d3d3818454182c0cb73840"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21078149"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9801902"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/cc9326"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037952064"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/cc9326", 
      "https://app.dimensions.ai/details/publication/pub.1037952064"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fcc9326"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/cc9326'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/cc9326'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/cc9326'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/cc9326'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      70 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/cc9326 schema:about N0ecb9779748a41a38f2c13a8edc6b22a
2 N1cedc78165cb4a4bbb96e1a5cd6f21f8
3 N2fb7644825e34d9b85b4bf6364e7d349
4 N7217e4d1aca743c08d65ddebb26240ba
5 N79767dadbf4a4786bd3fe599292774b3
6 N92cf10ff1d21490ca1b49da193f9256d
7 N956c97ea81694d4f8fd9101f9e62c3ba
8 N9c08ddc2d3bf4141b241e410e09006c3
9 N9ed8baf66e01429b8042135e9302936d
10 Nc45cde1452bc45658fd5193a2841fcde
11 Nd22e798723fe48f48b40d4c9e1610b23
12 anzsrc-for:11
13 anzsrc-for:1102
14 schema:author Ncac9411ccac24ca584492283c1ce7cf4
15 schema:citation sg:pub.10.1007/bf00256965
16 sg:pub.10.1007/bf01694872
17 sg:pub.10.1007/bf01704697
18 sg:pub.10.1007/s00134-005-2699-9
19 https://app.dimensions.ai/details/publication/pub.1077520484
20 https://app.dimensions.ai/details/publication/pub.1078691659
21 https://doi.org/10.1016/j.jcrc.2005.08.007
22 https://doi.org/10.1016/s0883-9441(86)80114-9
23 https://doi.org/10.1016/s1053-2498(99)00121-7
24 https://doi.org/10.1056/nejm197908303010901
25 https://doi.org/10.1093/eurheartj/ehm236
26 https://doi.org/10.1097/00000542-198808000-00004
27 https://doi.org/10.1097/01.ccm.0000250391.89780.64
28 https://doi.org/10.1097/ccm.0b013e31819f13d0
29 https://doi.org/10.1152/jappl.1979.47.2.257
30 https://doi.org/10.1161/01.cir.0000073597.57414.a9
31 https://doi.org/10.1161/01.cir.57.3.549
32 https://doi.org/10.1164/ajrccm.150.4.7921460
33 https://doi.org/10.1164/ajrccm.155.3.9117025
34 https://doi.org/10.1164/ajrccm.158.6.9804056
35 https://doi.org/10.1164/ajrccm.162.2.9908056
36 https://doi.org/10.1177/0310057x0703500425
37 https://doi.org/10.1183/09031936.96.09061283
38 https://doi.org/10.1213/00000539-199409000-00029
39 https://doi.org/10.1378/chest.104.3.854
40 https://doi.org/10.1378/chest.113.3.576
41 https://doi.org/10.1378/chest.119.6.1840
42 https://doi.org/10.1378/chest.120.6_suppl.375s
43 https://doi.org/10.1378/chest.92.1.71
44 https://doi.org/10.1513/pats.200404-032ms
45 schema:datePublished 2010-12
46 schema:datePublishedReg 2010-12-01
47 schema:description INTRODUCTION: Both experimental and clinical data give convincing evidence to acute cardiac dysfunction as the origin or a cofactor of weaning failure in patients with chronic obstructive pulmonary disease. Therefore, treatment targeting the cardiovascular system might help the heart to tolerate more effectively the critical period of weaning. This study aims to assess the hemodynamic, respiratory and clinical effects of nitroglycerin infusion in difficult-to-wean patients with severe chronic obstructive pulmonary disease. METHODS: Twelve difficult-to-wean (failed ≥ 3 consecutive trials) chronic obstructive pulmonary disease patients, who presented systemic arterial hypertension (systolic blood pressure ≥ 140 mmHg) during weaning failure and had systemic and pulmonary artery catheters in place, participated in this prospective, interventional, non-randomized clinical trial. Patients were studied in two consecutive days, i.e., the first day without (Control day) and the second day with (Study day) nitroglycerin continuous intravenous infusion starting at the beginning of the spontaneous breathing trial, and titrated to maintain normal systolic blood pressure. Hemodynamic, oxygenation and respiratory measurements were performed on mechanical ventilation, and during a 2-hour T-piece spontaneous breathing trial. Primary endpoint was hemodynamic and respiratory effects of nitroglycerin infusion. Secondary endpoint was spontaneous breathing trial and extubation outcome. RESULTS: Compared to mechanical ventilation, mean systemic arterial pressure, rate-pressure product, mean pulmonary arterial pressure, and pulmonary artery occlusion pressure increased [from (mean ± SD) 94 ± 14, 13708 ± 3166, 29.9 ± 4.8, and 14.8 ± 3.8 to 109 ± 20 mmHg, 19856 ± 4877 mmHg b/min, 41.6 ± 5.8 mmHg, and 23.4 ± 7.4 mmHg, respectively], and mixed venous oxygen saturation decreased (from 75.7 ± 3.5 to 69.3 ± 7.5%) during failing trials on Control day, whereas they did not change on Study day. Venous admixture increased throughout the trial on both Control day and Study day, but this increase was lower on Study day. Whereas weaning failed in all patients on Control day, nitroglycerin administration on Study day enabled a successful spontaneous breathing trial and extubation in 92% and 88% of patients, respectively. CONCLUSIONS: In this clinical setting, nitroglycerin infusion can expedite the weaning by restoring weaning-induced cardiovascular compromise.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf Ndfe4b61f4e3645f58d50d32861ca542a
52 Nf37e0998be7040c4b269c00820485ef5
53 sg:journal.1117766
54 schema:name Nitroglycerin can facilitate weaning of difficult-to-wean chronic obstructive pulmonary disease patients: a prospective interventional non-randomized study
55 schema:pagination r204
56 schema:productId N6223239044a04eddb06a8a3451eb19a0
57 N7a6f36504bf34619b3abe43028039762
58 N919fbeb1b2544fc3afee8cd637f4b86e
59 Nafcdb390a94346f6b62a53679d7c8b31
60 Ndb3392036fe44e098b7b512bead1ea05
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037952064
62 https://doi.org/10.1186/cc9326
63 schema:sdDatePublished 2019-04-10T20:47
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nda235d30442c4d1a8204c22333b98dda
66 schema:url http://link.springer.com/10.1186%2Fcc9326
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N08c14978b4cf41e4a610f75fd5a9a0e7 rdf:first Nec5d50bd9a0f4b71bc090b84a4e42010
71 rdf:rest Nf9252fea706347eaa5461a27676d345f
72 N0c49969a29a842fa832346fed66219cf rdf:first sg:person.01361127563.43
73 rdf:rest N71c3f40cf1744d849c4b50fd5687d6d9
74 N0e91105a8b3d46afbfe1c652ea872637 schema:affiliation N180dfea97c604d5c9e658b9c8aed6c4a
75 schema:familyName Papas
76 schema:givenName Vassilios
77 rdf:type schema:Person
78 N0ecb9779748a41a38f2c13a8edc6b22a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Pulmonary Disease, Chronic Obstructive
80 rdf:type schema:DefinedTerm
81 N180dfea97c604d5c9e658b9c8aed6c4a schema:name Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece
82 rdf:type schema:Organization
83 N1cedc78165cb4a4bbb96e1a5cd6f21f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Humans
85 rdf:type schema:DefinedTerm
86 N2bf96d54145c4522b98f722d3c809d95 schema:name Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece
87 rdf:type schema:Organization
88 N2fb7644825e34d9b85b4bf6364e7d349 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Respiration, Artificial
90 rdf:type schema:DefinedTerm
91 N6223239044a04eddb06a8a3451eb19a0 schema:name doi
92 schema:value 10.1186/cc9326
93 rdf:type schema:PropertyValue
94 N6e52e14e59754d3d92aaab51e5a1c0bf schema:name Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece
95 rdf:type schema:Organization
96 N71c3f40cf1744d849c4b50fd5687d6d9 rdf:first N0e91105a8b3d46afbfe1c652ea872637
97 rdf:rest N08c14978b4cf41e4a610f75fd5a9a0e7
98 N7217e4d1aca743c08d65ddebb26240ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Hemodynamics
100 rdf:type schema:DefinedTerm
101 N7246a97f11f342e782973ef0a3d4c09f schema:name Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece
102 rdf:type schema:Organization
103 N79767dadbf4a4786bd3fe599292774b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Nitroglycerin
105 rdf:type schema:DefinedTerm
106 N7a6f36504bf34619b3abe43028039762 schema:name dimensions_id
107 schema:value pub.1037952064
108 rdf:type schema:PropertyValue
109 N878469ba19024e62a6a0ed56b5e05380 rdf:first sg:person.01247402715.96
110 rdf:rest N0c49969a29a842fa832346fed66219cf
111 N919fbeb1b2544fc3afee8cd637f4b86e schema:name pubmed_id
112 schema:value 21078149
113 rdf:type schema:PropertyValue
114 N92cf10ff1d21490ca1b49da193f9256d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Female
116 rdf:type schema:DefinedTerm
117 N956c97ea81694d4f8fd9101f9e62c3ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Pulmonary Gas Exchange
119 rdf:type schema:DefinedTerm
120 N9c08ddc2d3bf4141b241e410e09006c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Male
122 rdf:type schema:DefinedTerm
123 N9ed8baf66e01429b8042135e9302936d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Prospective Studies
125 rdf:type schema:DefinedTerm
126 Na82a9316e7084864bb1b0db8e79ece33 schema:name Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece
127 rdf:type schema:Organization
128 Nafcdb390a94346f6b62a53679d7c8b31 schema:name readcube_id
129 schema:value b4ca89fcb4a2d426c67d0329299e6628de34ee4564d3d3818454182c0cb73840
130 rdf:type schema:PropertyValue
131 Nc45cde1452bc45658fd5193a2841fcde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Aged
133 rdf:type schema:DefinedTerm
134 Ncac9411ccac24ca584492283c1ce7cf4 rdf:first sg:person.0636361130.65
135 rdf:rest Ne4c6a48ba3754e579f033be29a8d36ed
136 Nd22e798723fe48f48b40d4c9e1610b23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Ventilator Weaning
138 rdf:type schema:DefinedTerm
139 Nda235d30442c4d1a8204c22333b98dda schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 Ndb3392036fe44e098b7b512bead1ea05 schema:name nlm_unique_id
142 schema:value 9801902
143 rdf:type schema:PropertyValue
144 Ndfe4b61f4e3645f58d50d32861ca542a schema:volumeNumber 14
145 rdf:type schema:PublicationVolume
146 Ne4c6a48ba3754e579f033be29a8d36ed rdf:first sg:person.01215777453.70
147 rdf:rest N878469ba19024e62a6a0ed56b5e05380
148 Ne79d0ea413604d97aca18e5a2a38aec0 schema:name Critical Care Department, Medical School of Athens University, Evangelismos Hospital, 45-47 Ipslilantou Str., 106 76, Athens, Greece
149 rdf:type schema:Organization
150 Nec5d50bd9a0f4b71bc090b84a4e42010 schema:affiliation N2bf96d54145c4522b98f722d3c809d95
151 schema:familyName Zervakis
152 schema:givenName Demetrios
153 rdf:type schema:Person
154 Nf37e0998be7040c4b269c00820485ef5 schema:issueNumber 6
155 rdf:type schema:PublicationIssue
156 Nf9252fea706347eaa5461a27676d345f rdf:first sg:person.01314166613.94
157 rdf:rest rdf:nil
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
162 schema:name Cardiorespiratory Medicine and Haematology
163 rdf:type schema:DefinedTerm
164 sg:journal.1117766 schema:issn 1364-8535
165 1466-609X
166 schema:name Critical Care
167 rdf:type schema:Periodical
168 sg:person.01215777453.70 schema:affiliation https://www.grid.ac/institutes/grid.4793.9
169 schema:familyName Stanopoulos
170 schema:givenName Ioannis
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215777453.70
172 rdf:type schema:Person
173 sg:person.01247402715.96 schema:affiliation Ne79d0ea413604d97aca18e5a2a38aec0
174 schema:familyName Zakynthinos
175 schema:givenName Epaminondas
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247402715.96
177 rdf:type schema:Person
178 sg:person.01314166613.94 schema:affiliation N7246a97f11f342e782973ef0a3d4c09f
179 schema:familyName Zakynthinos
180 schema:givenName Spyros
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314166613.94
182 rdf:type schema:Person
183 sg:person.01361127563.43 schema:affiliation N6e52e14e59754d3d92aaab51e5a1c0bf
184 schema:familyName Politis
185 schema:givenName Panagiotis
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361127563.43
187 rdf:type schema:Person
188 sg:person.0636361130.65 schema:affiliation Na82a9316e7084864bb1b0db8e79ece33
189 schema:familyName Routsi
190 schema:givenName Christina
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636361130.65
192 rdf:type schema:Person
193 sg:pub.10.1007/bf00256965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003383035
194 https://doi.org/10.1007/bf00256965
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/bf01694872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014431597
197 https://doi.org/10.1007/bf01694872
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/bf01704697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004258614
200 https://doi.org/10.1007/bf01704697
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/s00134-005-2699-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015551214
203 https://doi.org/10.1007/s00134-005-2699-9
204 rdf:type schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1077520484 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1078691659 schema:CreativeWork
207 https://doi.org/10.1016/j.jcrc.2005.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050077288
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/s0883-9441(86)80114-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019344868
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s1053-2498(99)00121-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004784394
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1056/nejm197908303010901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026389756
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1093/eurheartj/ehm236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011749652
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1097/00000542-198808000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027728679
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1097/01.ccm.0000250391.89780.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022081228
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1097/ccm.0b013e31819f13d0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021847770
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1152/jappl.1979.47.2.257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080529306
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1161/01.cir.0000073597.57414.a9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038570144
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1161/01.cir.57.3.549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040478924
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1164/ajrccm.150.4.7921460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048376068
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1164/ajrccm.155.3.9117025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010210969
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1164/ajrccm.158.6.9804056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039406468
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1164/ajrccm.162.2.9908056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030573576
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1177/0310057x0703500425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077520484
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1183/09031936.96.09061283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037419854
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1213/00000539-199409000-00029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023231232
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1378/chest.104.3.854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004699720
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1378/chest.113.3.576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027966971
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1378/chest.119.6.1840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048267295
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1378/chest.120.6_suppl.375s schema:sameAs https://app.dimensions.ai/details/publication/pub.1016953685
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1378/chest.92.1.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020739008
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1513/pats.200404-032ms schema:sameAs https://app.dimensions.ai/details/publication/pub.1038566750
254 rdf:type schema:CreativeWork
255 https://www.grid.ac/institutes/grid.4793.9 schema:alternateName Aristotle University of Thessaloniki
256 schema:name Respiratory Failure Unit, Aristotle University, G. Papanikolaou Hospital, Exohi, 57 010, Thessaloniki, Greece
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...