Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12

AUTHORS

Scott K Powers, Marc DeCramer, Ghislaine Gayan-Ramirez, Sanford Levine

ABSTRACT

Common medical conditions that require mechanical ventilation include chronic obstructive lung disease, acute lung injury, sepsis, heart failure, drug overdose, neuromuscular disorders, and surgery. Although mechanical ventilation can be a life saving measure, prolonged mechanical ventilation can also present clinical problems. Indeed, numerous well-controlled animal studies have demonstrated that prolonged mechanical ventilation results in diaphragmatic weakness due to both atrophy and contractile dysfunction. Importantly, a recent clinical investigation has confirmed that prolonged mechanical ventilation results in atrophy of the human diaphragm. This mechanical ventilation-induced diaphragmatic weakness is important because the most frequent cause of weaning difficulty is respiratory muscle failure due to inspiratory muscle weakness and/or a decline in inspiratory muscle endurance. Therefore, developing methods to protect against mechanical ventilation-induced diaphragmatic weakness is important. More... »

PAGES

191

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/cc7095

DOI

http://dx.doi.org/10.1186/cc7095

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017687152

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19040772


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166 schema:name Department of Surgery, University of Pennsylvania School of Medicine, 19104, Philadelphia, PA, USA
167 rdf:type schema:Organization
 




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