Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-08-07

AUTHORS

Mette M Berger, Ludivine Soguel, Alan Shenkin, Jean-Pierre Revelly, Christophe Pinget, Malcolm Baines, René L Chioléro

ABSTRACT

IntroductionOxidative stress is involved in the development of secondary tissue damage and organ failure. Micronutrients contributing to the antioxidant (AOX) defense exhibit low plasma levels during critical illness. The aim of this study was to investigate the impact of early AOX micronutrients on clinical outcome in intensive care unit (ICU) patients with conditions characterized by oxidative stress.MethodsWe conducted a prospective, randomized, double-blind, placebo-controlled, single-center trial in patients admitted to a university hospital ICU with organ failure after complicated cardiac surgery, major trauma, or subarachnoid hemorrhage. Stratification by diagnosis was performed before randomization. The intervention was intravenous supplements for 5 days (selenium 270 μg, zinc 30 mg, vitamin C 1.1 g, and vitamin B1 100 mg) with a double-loading dose on days 1 and 2 or placebo.ResultsTwo hundred patients were included (102 AOX and 98 placebo). While age and gender did not differ, brain injury was more severe in the AOX trauma group (P = 0.019). Organ function endpoints did not differ: incidence of acute kidney failure and sequential organ failure assessment score decrease were similar (-3.2 ± 3.2 versus -4.2 ± 2.3 over the course of 5 days). Plasma concentrations of selenium, zinc, and glutathione peroxidase, low on admission, increased significantly to within normal values in the AOX group. C-reactive protein decreased faster in the AOX group (P = 0.039). Infectious complications did not differ. Length of hospital stay did not differ (16.5 versus 20 days), being shorter only in surviving AOX trauma patients (-10 days; P = 0.045).ConclusionThe AOX intervention did not reduce early organ dysfunction but significantly reduced the inflammatory response in cardiac surgery and trauma patients, which may prove beneficial in conditions with an intense inflammation.Trials RegistrationClinical Trials.gov RCT Register: NCT00515736. More... »

PAGES

r101

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/cc6981

DOI

http://dx.doi.org/10.1186/cc6981

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031287201

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18687132


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiac Surgical Procedures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebrovascular Trauma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Critical Illness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiple Organ Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Subarachnoid Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Intensive Care Medicine & Burns Centre, University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.414250.6", 
          "name": [
            "Department of Intensive Care Medicine & Burns Centre, University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Mette M", 
        "id": "sg:person.01160620574.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160620574.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Intensive Care Medicine & Burns Centre, University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.414250.6", 
          "name": [
            "Department of Intensive Care Medicine & Burns Centre, University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soguel", 
        "givenName": "Ludivine", 
        "id": "sg:person.01040276437.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040276437.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Chemistry, Royal Liverpool University Hospital and University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Clinical Chemistry, Royal Liverpool University Hospital and University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shenkin", 
        "givenName": "Alan", 
        "id": "sg:person.01027621315.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027621315.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Intensive Care Medicine & Burns Centre, University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.414250.6", 
          "name": [
            "Department of Intensive Care Medicine & Burns Centre, University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Revelly", 
        "givenName": "Jean-Pierre", 
        "id": "sg:person.0725460421.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725460421.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Health Technology Assessment Unit, CHUV, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.414250.6", 
          "name": [
            "Health Technology Assessment Unit, CHUV, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinget", 
        "givenName": "Christophe", 
        "id": "sg:person.01316677331.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316677331.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Chemistry, Royal Liverpool University Hospital and University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Clinical Chemistry, Royal Liverpool University Hospital and University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baines", 
        "givenName": "Malcolm", 
        "id": "sg:person.0707243464.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707243464.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Intensive Care Medicine & Burns Centre, University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.414250.6", 
          "name": [
            "Department of Intensive Care Medicine & Burns Centre, University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiol\u00e9ro", 
        "givenName": "Ren\u00e9 L", 
        "id": "sg:person.01121362247.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121362247.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/cc5960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033054762", 
          "https://doi.org/10.1186/cc5960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-004-2551-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037127110", 
          "https://doi.org/10.1007/s00134-004-2551-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc5713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042075619", 
          "https://doi.org/10.1186/cc5713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00262893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036613623", 
          "https://doi.org/10.1007/bf00262893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-004-2522-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037002387", 
          "https://doi.org/10.1007/s00134-004-2522-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-004-2528-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008878297", 
          "https://doi.org/10.1007/s00134-004-2528-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc5068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022732717", 
          "https://doi.org/10.1186/cc5068"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-08-07", 
    "datePublishedReg": "2008-08-07", 
    "description": "IntroductionOxidative stress is involved in the development of secondary tissue damage and organ failure. Micronutrients contributing to the antioxidant (AOX) defense exhibit low plasma levels during critical illness. The aim of this study was to investigate the impact of early AOX micronutrients on clinical outcome in intensive care unit (ICU) patients with conditions characterized by oxidative stress.MethodsWe conducted a prospective, randomized, double-blind, placebo-controlled, single-center trial in patients admitted to a university hospital ICU with organ failure after complicated cardiac surgery, major trauma, or subarachnoid hemorrhage. Stratification by diagnosis was performed before randomization. The intervention was intravenous supplements for 5 days (selenium 270 \u03bcg, zinc 30 mg, vitamin C 1.1 g, and vitamin B1 100 mg) with a double-loading dose on days 1 and 2 or placebo.ResultsTwo hundred patients were included (102 AOX and 98 placebo). While age and gender did not differ, brain injury was more severe in the AOX trauma group (P = 0.019). Organ function endpoints did not differ: incidence of acute kidney failure and sequential organ failure assessment score decrease were similar (-3.2 \u00b1 3.2 versus -4.2 \u00b1 2.3 over the course of 5 days). Plasma concentrations of selenium, zinc, and glutathione peroxidase, low on admission, increased significantly to within normal values in the AOX group. C-reactive protein decreased faster in the AOX group (P = 0.039). Infectious complications did not differ. Length of hospital stay did not differ (16.5 versus 20 days), being shorter only in surviving AOX trauma patients (-10 days; P = 0.045).ConclusionThe AOX intervention did not reduce early organ dysfunction but significantly reduced the inflammatory response in cardiac surgery and trauma patients, which may prove beneficial in conditions with an intense inflammation.Trials RegistrationClinical Trials.gov RCT Register: NCT00515736.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/cc6981", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "keywords": [
      "cardiac surgery", 
      "trauma patients", 
      "organ failure", 
      "major trauma", 
      "AOX group", 
      "intensive care unit patients", 
      "double loading dose", 
      "ResultsTwo hundred patients", 
      "early organ dysfunction", 
      "secondary tissue damage", 
      "single-center trial", 
      "acute kidney failure", 
      "care unit patients", 
      "university hospital ICU", 
      "C-reactive protein", 
      "complicated cardiac surgery", 
      "low plasma levels", 
      "IntroductionOxidative stress", 
      "infectious complications", 
      "hospital stay", 
      "critical illness", 
      "unit patients", 
      "intravenous supplements", 
      "hundred patients", 
      "organ dysfunction", 
      "clinical outcomes", 
      "hemorrhage patients", 
      "intense inflammation", 
      "clinical evolution", 
      "kidney failure", 
      "plasma levels", 
      "hospital ICU", 
      "brain injury", 
      "inflammatory response", 
      "trauma group", 
      "plasma concentrations", 
      "score decrease", 
      "antioxidant supplements", 
      "patients", 
      "function endpoints", 
      "day 1", 
      "organ function", 
      "tissue damage", 
      "normal values", 
      "surgery", 
      "glutathione peroxidase", 
      "oxidative stress", 
      "trauma", 
      "intervention", 
      "failure", 
      "group", 
      "supplements", 
      "placebo", 
      "ICU", 
      "hemorrhage", 
      "complications", 
      "inflammation", 
      "admission", 
      "stay", 
      "dysfunction", 
      "injury", 
      "illness", 
      "MethodsWe", 
      "incidence", 
      "diagnosis", 
      "dose", 
      "trials", 
      "endpoint", 
      "micronutrients", 
      "outcomes", 
      "age", 
      "randomization", 
      "Register", 
      "days", 
      "gender", 
      "aim", 
      "stratification", 
      "damage", 
      "response", 
      "stress", 
      "levels", 
      "peroxidase", 
      "decrease", 
      "protein", 
      "study", 
      "concentration", 
      "selenium", 
      "function", 
      "development", 
      "conditions", 
      "impact", 
      "zinc", 
      "length", 
      "values", 
      "influence", 
      "evolution"
    ], 
    "name": "Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients", 
    "pagination": "r101", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031287201"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/cc6981"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18687132"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/cc6981", 
      "https://app.dimensions.ai/details/publication/pub.1031287201"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_457.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/cc6981"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/cc6981'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/cc6981'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/cc6981'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/cc6981'


 

This table displays all metadata directly associated to this object as RDF triples.

300 TRIPLES      21 PREDICATES      145 URIs      130 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/cc6981 schema:about N0b54642c50244cd3bb732401440cb2b6
2 N14b40617a73c4c7f906df1c9adce7861
3 N193009110ab04c9d80634ba205e41a75
4 N21d43d425cda4df4a65bf27687a5609c
5 N2cc5a66a036947988ecb77418c202b1a
6 N4b0b8b543fe947b1a30efaa0ba207c38
7 N63fb9b5e2fea4873be86c468972ae07c
8 N6e067382094c4269b608cb416009474d
9 N704761bc93a44c2797ed8d18106564e5
10 N7437a49eac1546f3b1fe3aefc930b5b2
11 N7ab13b0c66044fc9b2223ca1d36e065c
12 N7acf379d6a1e4cd49d0880e5f9a41bcd
13 Nd57e8c5f40ff4a6a9768f992e621e95e
14 Nebab7caf00bd42f2ac77e3becc1800f6
15 Ned5dc0c17af149bf8465debdc662e3b4
16 Nf2c353ca3912469db93f643048956364
17 Nfa1fad37d6414ab8a0f5797552cd77f7
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Nb06e9ed2966844959aa19aad9a137371
21 schema:citation sg:pub.10.1007/bf00262893
22 sg:pub.10.1007/s00134-004-2522-z
23 sg:pub.10.1007/s00134-004-2528-6
24 sg:pub.10.1007/s00134-004-2551-7
25 sg:pub.10.1186/cc5068
26 sg:pub.10.1186/cc5713
27 sg:pub.10.1186/cc5960
28 schema:datePublished 2008-08-07
29 schema:datePublishedReg 2008-08-07
30 schema:description IntroductionOxidative stress is involved in the development of secondary tissue damage and organ failure. Micronutrients contributing to the antioxidant (AOX) defense exhibit low plasma levels during critical illness. The aim of this study was to investigate the impact of early AOX micronutrients on clinical outcome in intensive care unit (ICU) patients with conditions characterized by oxidative stress.MethodsWe conducted a prospective, randomized, double-blind, placebo-controlled, single-center trial in patients admitted to a university hospital ICU with organ failure after complicated cardiac surgery, major trauma, or subarachnoid hemorrhage. Stratification by diagnosis was performed before randomization. The intervention was intravenous supplements for 5 days (selenium 270 μg, zinc 30 mg, vitamin C 1.1 g, and vitamin B1 100 mg) with a double-loading dose on days 1 and 2 or placebo.ResultsTwo hundred patients were included (102 AOX and 98 placebo). While age and gender did not differ, brain injury was more severe in the AOX trauma group (P = 0.019). Organ function endpoints did not differ: incidence of acute kidney failure and sequential organ failure assessment score decrease were similar (-3.2 ± 3.2 versus -4.2 ± 2.3 over the course of 5 days). Plasma concentrations of selenium, zinc, and glutathione peroxidase, low on admission, increased significantly to within normal values in the AOX group. C-reactive protein decreased faster in the AOX group (P = 0.039). Infectious complications did not differ. Length of hospital stay did not differ (16.5 versus 20 days), being shorter only in surviving AOX trauma patients (-10 days; P = 0.045).ConclusionThe AOX intervention did not reduce early organ dysfunction but significantly reduced the inflammatory response in cardiac surgery and trauma patients, which may prove beneficial in conditions with an intense inflammation.Trials RegistrationClinical Trials.gov RCT Register: NCT00515736.
31 schema:genre article
32 schema:isAccessibleForFree true
33 schema:isPartOf N565f6f70264747b3928c435ce0d76661
34 Nfa57fd7aa2f642a586e021da8efe42b0
35 sg:journal.1117766
36 schema:keywords AOX group
37 C-reactive protein
38 ICU
39 IntroductionOxidative stress
40 MethodsWe
41 Register
42 ResultsTwo hundred patients
43 acute kidney failure
44 admission
45 age
46 aim
47 antioxidant supplements
48 brain injury
49 cardiac surgery
50 care unit patients
51 clinical evolution
52 clinical outcomes
53 complicated cardiac surgery
54 complications
55 concentration
56 conditions
57 critical illness
58 damage
59 day 1
60 days
61 decrease
62 development
63 diagnosis
64 dose
65 double loading dose
66 dysfunction
67 early organ dysfunction
68 endpoint
69 evolution
70 failure
71 function
72 function endpoints
73 gender
74 glutathione peroxidase
75 group
76 hemorrhage
77 hemorrhage patients
78 hospital ICU
79 hospital stay
80 hundred patients
81 illness
82 impact
83 incidence
84 infectious complications
85 inflammation
86 inflammatory response
87 influence
88 injury
89 intense inflammation
90 intensive care unit patients
91 intervention
92 intravenous supplements
93 kidney failure
94 length
95 levels
96 low plasma levels
97 major trauma
98 micronutrients
99 normal values
100 organ dysfunction
101 organ failure
102 organ function
103 outcomes
104 oxidative stress
105 patients
106 peroxidase
107 placebo
108 plasma concentrations
109 plasma levels
110 protein
111 randomization
112 response
113 score decrease
114 secondary tissue damage
115 selenium
116 single-center trial
117 stay
118 stratification
119 stress
120 study
121 supplements
122 surgery
123 tissue damage
124 trauma
125 trauma group
126 trauma patients
127 trials
128 unit patients
129 university hospital ICU
130 values
131 zinc
132 schema:name Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients
133 schema:pagination r101
134 schema:productId N415496bd11ba45dcba566102ec400549
135 Nacc5fb9396854a49b3630fe21d352027
136 Nf1f2dbadc00a4c28b7b064299b5c7abd
137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031287201
138 https://doi.org/10.1186/cc6981
139 schema:sdDatePublished 2022-12-01T06:26
140 schema:sdLicense https://scigraph.springernature.com/explorer/license/
141 schema:sdPublisher Nec4a836277194086869ec728111c8c16
142 schema:url https://doi.org/10.1186/cc6981
143 sgo:license sg:explorer/license/
144 sgo:sdDataset articles
145 rdf:type schema:ScholarlyArticle
146 N0b54642c50244cd3bb732401440cb2b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Aged, 80 and over
148 rdf:type schema:DefinedTerm
149 N14b40617a73c4c7f906df1c9adce7861 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Adult
151 rdf:type schema:DefinedTerm
152 N166bdab0c8ec47d1884b12200cff7cf4 rdf:first sg:person.01121362247.08
153 rdf:rest rdf:nil
154 N193009110ab04c9d80634ba205e41a75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 N1e8f87b1b42243f48d938f22fa12edb9 rdf:first sg:person.01040276437.15
158 rdf:rest Nb312cc5ca23a4814af1ae8604eac3ddf
159 N21d43d425cda4df4a65bf27687a5609c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Antioxidants
161 rdf:type schema:DefinedTerm
162 N2cc5a66a036947988ecb77418c202b1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Female
164 rdf:type schema:DefinedTerm
165 N415496bd11ba45dcba566102ec400549 schema:name pubmed_id
166 schema:value 18687132
167 rdf:type schema:PropertyValue
168 N4b0b8b543fe947b1a30efaa0ba207c38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Young Adult
170 rdf:type schema:DefinedTerm
171 N565f6f70264747b3928c435ce0d76661 schema:volumeNumber 12
172 rdf:type schema:PublicationVolume
173 N63fb9b5e2fea4873be86c468972ae07c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Middle Aged
175 rdf:type schema:DefinedTerm
176 N6e067382094c4269b608cb416009474d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Male
178 rdf:type schema:DefinedTerm
179 N704761bc93a44c2797ed8d18106564e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Time Factors
181 rdf:type schema:DefinedTerm
182 N7437a49eac1546f3b1fe3aefc930b5b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Prospective Studies
184 rdf:type schema:DefinedTerm
185 N7ab13b0c66044fc9b2223ca1d36e065c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Subarachnoid Hemorrhage
187 rdf:type schema:DefinedTerm
188 N7acf379d6a1e4cd49d0880e5f9a41bcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Multiple Organ Failure
190 rdf:type schema:DefinedTerm
191 N80debddab5cf4287a67d7a8fe71966b1 rdf:first sg:person.01316677331.51
192 rdf:rest Nfcbf28aff03b41a5829b58ef1e148197
193 N94ba02428b954308a91c1638b0cb5168 rdf:first sg:person.0725460421.52
194 rdf:rest N80debddab5cf4287a67d7a8fe71966b1
195 Nacc5fb9396854a49b3630fe21d352027 schema:name dimensions_id
196 schema:value pub.1031287201
197 rdf:type schema:PropertyValue
198 Nb06e9ed2966844959aa19aad9a137371 rdf:first sg:person.01160620574.24
199 rdf:rest N1e8f87b1b42243f48d938f22fa12edb9
200 Nb312cc5ca23a4814af1ae8604eac3ddf rdf:first sg:person.01027621315.74
201 rdf:rest N94ba02428b954308a91c1638b0cb5168
202 Nd57e8c5f40ff4a6a9768f992e621e95e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Cardiac Surgical Procedures
204 rdf:type schema:DefinedTerm
205 Nebab7caf00bd42f2ac77e3becc1800f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Aged
207 rdf:type schema:DefinedTerm
208 Nec4a836277194086869ec728111c8c16 schema:name Springer Nature - SN SciGraph project
209 rdf:type schema:Organization
210 Ned5dc0c17af149bf8465debdc662e3b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Cerebrovascular Trauma
212 rdf:type schema:DefinedTerm
213 Nf1f2dbadc00a4c28b7b064299b5c7abd schema:name doi
214 schema:value 10.1186/cc6981
215 rdf:type schema:PropertyValue
216 Nf2c353ca3912469db93f643048956364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Double-Blind Method
218 rdf:type schema:DefinedTerm
219 Nfa1fad37d6414ab8a0f5797552cd77f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Critical Illness
221 rdf:type schema:DefinedTerm
222 Nfa57fd7aa2f642a586e021da8efe42b0 schema:issueNumber 4
223 rdf:type schema:PublicationIssue
224 Nfcbf28aff03b41a5829b58ef1e148197 rdf:first sg:person.0707243464.87
225 rdf:rest N166bdab0c8ec47d1884b12200cff7cf4
226 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
227 schema:name Medical and Health Sciences
228 rdf:type schema:DefinedTerm
229 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
230 schema:name Clinical Sciences
231 rdf:type schema:DefinedTerm
232 sg:journal.1117766 schema:issn 1364-8535
233 1466-609X
234 schema:name Critical Care
235 schema:publisher Springer Nature
236 rdf:type schema:Periodical
237 sg:person.01027621315.74 schema:affiliation grid-institutes:grid.10025.36
238 schema:familyName Shenkin
239 schema:givenName Alan
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027621315.74
241 rdf:type schema:Person
242 sg:person.01040276437.15 schema:affiliation grid-institutes:grid.414250.6
243 schema:familyName Soguel
244 schema:givenName Ludivine
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040276437.15
246 rdf:type schema:Person
247 sg:person.01121362247.08 schema:affiliation grid-institutes:grid.414250.6
248 schema:familyName Chioléro
249 schema:givenName René L
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121362247.08
251 rdf:type schema:Person
252 sg:person.01160620574.24 schema:affiliation grid-institutes:grid.414250.6
253 schema:familyName Berger
254 schema:givenName Mette M
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160620574.24
256 rdf:type schema:Person
257 sg:person.01316677331.51 schema:affiliation grid-institutes:grid.414250.6
258 schema:familyName Pinget
259 schema:givenName Christophe
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316677331.51
261 rdf:type schema:Person
262 sg:person.0707243464.87 schema:affiliation grid-institutes:grid.10025.36
263 schema:familyName Baines
264 schema:givenName Malcolm
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707243464.87
266 rdf:type schema:Person
267 sg:person.0725460421.52 schema:affiliation grid-institutes:grid.414250.6
268 schema:familyName Revelly
269 schema:givenName Jean-Pierre
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725460421.52
271 rdf:type schema:Person
272 sg:pub.10.1007/bf00262893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036613623
273 https://doi.org/10.1007/bf00262893
274 rdf:type schema:CreativeWork
275 sg:pub.10.1007/s00134-004-2522-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037002387
276 https://doi.org/10.1007/s00134-004-2522-z
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/s00134-004-2528-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008878297
279 https://doi.org/10.1007/s00134-004-2528-6
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s00134-004-2551-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037127110
282 https://doi.org/10.1007/s00134-004-2551-7
283 rdf:type schema:CreativeWork
284 sg:pub.10.1186/cc5068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022732717
285 https://doi.org/10.1186/cc5068
286 rdf:type schema:CreativeWork
287 sg:pub.10.1186/cc5713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042075619
288 https://doi.org/10.1186/cc5713
289 rdf:type schema:CreativeWork
290 sg:pub.10.1186/cc5960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033054762
291 https://doi.org/10.1186/cc5960
292 rdf:type schema:CreativeWork
293 grid-institutes:grid.10025.36 schema:alternateName Department of Clinical Chemistry, Royal Liverpool University Hospital and University of Liverpool, Liverpool, UK
294 schema:name Department of Clinical Chemistry, Royal Liverpool University Hospital and University of Liverpool, Liverpool, UK
295 rdf:type schema:Organization
296 grid-institutes:grid.414250.6 schema:alternateName Department of Intensive Care Medicine & Burns Centre, University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland
297 Health Technology Assessment Unit, CHUV, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland
298 schema:name Department of Intensive Care Medicine & Burns Centre, University Hospital (Centre Hospitalier Universitaire Vaudois, CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland
299 Health Technology Assessment Unit, CHUV, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland
300 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...