Intensive care outcomes in bone marrow transplant recipients: a population-based cohort analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-06

AUTHORS

Damon C Scales, Deva Thiruchelvam, Alexander Kiss, William J Sibbald, Donald A Redelmeier

ABSTRACT

INTRODUCTION: Intensive care unit (ICU) admission for bone marrow transplant recipients immediately following transplantation is an ominous event, yet the survival of these patients with subsequent ICU admissions is unknown. Our objective was to determine the long-term outcome of bone marrow transplant recipients admitted to an ICU during subsequent hospitalizations. METHODS: We conducted a population-based cohort analysis of all adult bone marrow transplant recipients who received subsequent ICU care in Ontario, Canada from 1 January 1992 to 31 March 2002. The primary endpoint was mortality at 1 year. RESULTS: A total of 2,653 patients received bone marrow transplantation; 504 of which received ICU care during a subsequent hospitalization. Patients receiving any major procedure during their ICU stay had higher 1-year mortality than those patients who received no ICU procedure (87% versus 44%, P < 0.0001). Death rates at 1 year were highest for those receiving mechanical ventilation (87%), pulmonary artery catheterization (91%), or hemodialysis (94%). In combination, the strongest independent predictors of death at 1 year were mechanical ventilation (odds ratio, 7.4; 95% confidence interval, 4.8 to 11.4) and hemodialysis (odds ratio, 8.7; 95% confidence interval, 2.1 to 36.7), yet no combination of procedures uniformly predicted 100% mortality. CONCLUSION: The prognosis of bone marrow transplant recipients receiving ICU care during subsequent hospitalizations is very poor but should not be considered futile. More... »

PAGES

r77

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/cc6923

DOI

http://dx.doi.org/10.1186/cc6923

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000645234

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18547422


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