Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-08

AUTHORS

Xavier Forceville, Bruno Laviolle, Djillali Annane, Dominique Vitoux, Gérard Bleichner, Jean-Michel Korach, Emmanuel Cantais, Hugues Georges, Jean-Louis Soubirou, Alain Combes, Eric Bellissant

ABSTRACT

INTRODUCTION: Sepsis is associated with the generation of oxygen free radicals and (lacking) decreased selenium plasma concentrations. High doses of sodium selenite might reduce inflammation by a direct pro-oxidative effect and may increase antioxidant cell capacities by selenium incorporation into selenoenzymes. We investigated the effects of a continuous administration of high doses of selenium in septic shock patients. METHODS: A prospective, multicentre, placebo-controlled, randomized, double-blind study was performed with an intention-to-treat analysis in severe septic shock patients with documented infection. Patients received, for 10 days, selenium as sodium selenite (4,000 microg on the first day, 1,000 microg/day on the nine following days) or matching placebo using continuous intravenous infusion. The primary endpoint was the time to vasopressor therapy withdrawal. The duration of mechanical ventilation, the mortality rates in the intensive care unit, at hospital discharge, and at 7, 14, 28 and 180 days and 1 year after randomization, and adverse events were recorded. RESULTS: Sixty patients were included (placebo, n = 29; selenium, n = 31). The median time to vasopressor therapy withdrawal was 7 days in both groups (95% confidence interval = 5-8 and 6-9 in the placebo and selenium groups, respectively; log-rank, P = 0.713). The median duration of mechanical ventilation was 14 days and 19 days in the placebo and selenium groups, respectively (P = 0.762). Mortality rates did not significantly differ between groups at any time point. Rates of adverse events were similar in the two groups. CONCLUSION: Continuous infusion of selenium as sodium selenite (4,000 microg on the first day, 1,000 microg/day on the nine following days) had no obvious toxicity but did not improve the clinical outcome in septic shock patients. Trial Registration = NCT00207844. More... »

PAGES

r73

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/cc5960

DOI

http://dx.doi.org/10.1186/cc5960

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033054762

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17617901


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Shock, Septic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium Selenite", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Service de R\u00e9animation Polyvalente, Centre Hospitalier de Meaux, H\u00f4pital Saint Faron, 6\u20138 rue Saint Fiacre, 77104, Meaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forceville", 
        "givenName": "Xavier", 
        "id": "sg:person.01217276447.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217276447.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "l'H\u00f4pital Pontchaillou", 
          "id": "https://www.grid.ac/institutes/grid.414271.5", 
          "name": [
            "Centre d'Investigation Clinique INSERM 0203, Unit\u00e9 de Pharmacologie Clinique, H\u00f4pital de Pontchaillou, CHU de Rennes et Universit\u00e9 de Rennes 1, 2 rue Henri le Guilloux, 35033, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laviolle", 
        "givenName": "Bruno", 
        "id": "sg:person.01346477033.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346477033.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Raymond Poincar\u00e9 University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414291.b", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Raymond Poincar\u00e9, 104 boulevard Raymond Poincar\u00e9, 92380, Garches, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Annane", 
        "givenName": "Djillali", 
        "id": "sg:person.01051603547.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051603547.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Louis", 
          "id": "https://www.grid.ac/institutes/grid.413328.f", 
          "name": [
            "Service de Biochimie A, H\u00f4pital Saint-Louis, avenue Claude Vellefaux, cedex 10, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vitoux", 
        "givenName": "Dominique", 
        "id": "sg:person.01044460635.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044460635.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Victor Dupouy", 
          "id": "https://www.grid.ac/institutes/grid.414474.6", 
          "name": [
            "Service de R\u00e9animation Polyvalente, Centre Hospitalier Victor Dupouy, 69 rue du Lieut-Col Prudhon, 95107, Argenteuil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bleichner", 
        "givenName": "G\u00e9rard", 
        "id": "sg:person.0621526767.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621526767.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Service de R\u00e9animation Polyvalente, Centre Hospitalier, 51 rue du Commandant Derrien, 95107, Argenteuil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korach", 
        "givenName": "Jean-Michel", 
        "id": "sg:person.0775505012.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775505012.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital d'Instruction des Arm\u00e9es Sainte-Anne", 
          "id": "https://www.grid.ac/institutes/grid.414039.b", 
          "name": [
            "H\u00f4pital d'Instruction des Arm\u00e9es Sainte Anne, boulevard Sainte Anne, 83800, Toulon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cantais", 
        "givenName": "Emmanuel", 
        "id": "sg:person.01272013702.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272013702.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier de Tourcoing", 
          "id": "https://www.grid.ac/institutes/grid.418052.a", 
          "name": [
            "Centre Hospitalier Gustave Dron, 135 rue du Pr\u00e9sident Coty, 59200, Tourcoing, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Georges", 
        "givenName": "Hugues", 
        "id": "sg:person.0622207653.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622207653.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Centre Hospitalier Gustave Dron, 108 boulevard Pinel, 69003, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soubirou", 
        "givenName": "Jean-Louis", 
        "id": "sg:person.0757161524.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757161524.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Service de R\u00e9animation Polyvalente, Centre Hospitalier de Meaux, H\u00f4pital Saint Faron, 6\u20138 rue Saint Fiacre, 77104, Meaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Combes", 
        "givenName": "Alain", 
        "id": "sg:person.0710520012.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710520012.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "l'H\u00f4pital Pontchaillou", 
          "id": "https://www.grid.ac/institutes/grid.414271.5", 
          "name": [
            "Centre d'Investigation Clinique INSERM 0203, Unit\u00e9 de Pharmacologie Clinique, H\u00f4pital de Pontchaillou, CHU de Rennes et Universit\u00e9 de Rennes 1, 2 rue Henri le Guilloux, 35033, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bellissant", 
        "givenName": "Eric", 
        "id": "sg:person.01115151652.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115151652.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/01.ccm.0000251124.83436.0e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006199661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000251124.83436.0e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006199661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340000757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006488484", 
          "https://doi.org/10.1007/s001340000757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clnu.2004.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009840925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-200107000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010433290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-200107000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010433290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-200107000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010433290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.24.12904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011267920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.10.4497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012935424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-9120(95)02007-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016872738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mco.0000222105.30795.7f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017609419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mco.0000222105.30795.7f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017609419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mco.0000222105.30795.7f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017609419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(98)00147-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017874465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mehy.2006.01.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018122239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc5109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018789558", 
          "https://doi.org/10.1186/cc5109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc5109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018789558", 
          "https://doi.org/10.1186/cc5109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/104063870601800108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020595748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/104063870601800108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020595748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0271-5317(00)00296-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021204175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000117317.18092.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024174028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000117317.18092.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024174028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000117317.18092.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024174028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccx.0000216581.80051.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025061786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccx.0000216581.80051.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025061786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccx.0000216581.80051.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025061786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0148607186010006545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025275639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc3753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028086901", 
          "https://doi.org/10.1186/cc3753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/biof.5520140125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029611368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.8.4924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029621390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002040050274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030055291", 
          "https://doi.org/10.1007/s002040050274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2003.08.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030123479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2003.08.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030123479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03041947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031914932", 
          "https://doi.org/10.1007/bf03041947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03041947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031914932", 
          "https://doi.org/10.1007/bf03041947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)02490-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032384467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.11.3565-3576.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035791330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-004-2522-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037002387", 
          "https://doi.org/10.1007/s00134-004-2522-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.299.6694.316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037456972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340000779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043999884", 
          "https://doi.org/10.1007/s001340000779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd003703.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045627902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2006.04.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046390149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1081/clt-100102417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047477780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3280199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047640070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3280199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047640070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00063-004-1104-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048221805", 
          "https://doi.org/10.1007/s00063-004-1104-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000129669.21649.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050179967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000129669.21649.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050179967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0985-0562(98)80022-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052162669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0985-0562(98)80022-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052162669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199809000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060173069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199809000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060173069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199809000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060173069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199909000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060174295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199909000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060174295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199909000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060174295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10915818609140736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070984953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10915818609140736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070984953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077191375", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/85.5.1293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077415631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0038-1647308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078578939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079802522", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081435019", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5694/j.1326-5377.1966.tb72571.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081435019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083154262", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/68.2.365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083304678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1201/9781420032741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1095906416"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-08", 
    "datePublishedReg": "2007-08-01", 
    "description": "INTRODUCTION: Sepsis is associated with the generation of oxygen free radicals and (lacking) decreased selenium plasma concentrations. High doses of sodium selenite might reduce inflammation by a direct pro-oxidative effect and may increase antioxidant cell capacities by selenium incorporation into selenoenzymes. We investigated the effects of a continuous administration of high doses of selenium in septic shock patients.\nMETHODS: A prospective, multicentre, placebo-controlled, randomized, double-blind study was performed with an intention-to-treat analysis in severe septic shock patients with documented infection. Patients received, for 10 days, selenium as sodium selenite (4,000 microg on the first day, 1,000 microg/day on the nine following days) or matching placebo using continuous intravenous infusion. The primary endpoint was the time to vasopressor therapy withdrawal. The duration of mechanical ventilation, the mortality rates in the intensive care unit, at hospital discharge, and at 7, 14, 28 and 180 days and 1 year after randomization, and adverse events were recorded.\nRESULTS: Sixty patients were included (placebo, n = 29; selenium, n = 31). The median time to vasopressor therapy withdrawal was 7 days in both groups (95% confidence interval = 5-8 and 6-9 in the placebo and selenium groups, respectively; log-rank, P = 0.713). The median duration of mechanical ventilation was 14 days and 19 days in the placebo and selenium groups, respectively (P = 0.762). Mortality rates did not significantly differ between groups at any time point. Rates of adverse events were similar in the two groups.\nCONCLUSION: Continuous infusion of selenium as sodium selenite (4,000 microg on the first day, 1,000 microg/day on the nine following days) had no obvious toxicity but did not improve the clinical outcome in septic shock patients. Trial Registration = NCT00207844.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/cc5960", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study", 
    "pagination": "r73", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9d7798eb18d345c86b397705dea7f7b2b0656fe9483628536c180e2ae57b0002"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17617901"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9801902"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/cc5960"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033054762"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/cc5960", 
      "https://app.dimensions.ai/details/publication/pub.1033054762"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fcc5960"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/cc5960'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/cc5960'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/cc5960'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/cc5960'


 

This table displays all metadata directly associated to this object as RDF triples.

360 TRIPLES      21 PREDICATES      89 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/cc5960 schema:about N09d5ef9bf1b84a5ea1f95ad5abe7ff9a
2 N1602fb57ab8b49289b82e669ee29641d
3 N209f0a3e08f440ada8647ccd44e6a40f
4 N20bfb91b79774218b45df7ea0e61e0b0
5 N28c330058cef43168cadd67fe518a0ec
6 N49d711dc5fe548e5b673f82a8bdc0ffc
7 N7fb3da53dcf54d51800f1218bccd8e64
8 N85937ec567e94d02a15872d3398cf38d
9 N8bb64cc0e9cb4a58b98b6cf8a54207bd
10 N90a89f3f4ed543debb55c542ac74ad96
11 Nec2aaf3de0ef4f21a2f943885dd53a67
12 Ned0b717afc274cf195adbed65614a45c
13 Nfa99239b9b77424dab331cfb15754c7a
14 Nfdf6978a959c43248ed750c2c2b3d27c
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N04c447f9a8af434693b5fad7e48e0add
18 schema:citation sg:pub.10.1007/bf03041947
19 sg:pub.10.1007/s00063-004-1104-8
20 sg:pub.10.1007/s00134-004-2522-z
21 sg:pub.10.1007/s001340000757
22 sg:pub.10.1007/s001340000779
23 sg:pub.10.1007/s002040050274
24 sg:pub.10.1186/cc3753
25 sg:pub.10.1186/cc5109
26 https://app.dimensions.ai/details/publication/pub.1077191375
27 https://app.dimensions.ai/details/publication/pub.1079802522
28 https://app.dimensions.ai/details/publication/pub.1081435019
29 https://app.dimensions.ai/details/publication/pub.1083154262
30 https://doi.org/10.1002/14651858.cd003703.pub2
31 https://doi.org/10.1002/biof.5520140125
32 https://doi.org/10.1016/0009-9120(95)02007-8
33 https://doi.org/10.1016/j.bcp.2003.08.021
34 https://doi.org/10.1016/j.clnu.2004.10.003
35 https://doi.org/10.1016/j.freeradbiomed.2006.04.031
36 https://doi.org/10.1016/j.mehy.2006.01.058
37 https://doi.org/10.1016/s0140-6736(00)02490-9
38 https://doi.org/10.1016/s0271-5317(00)00296-7
39 https://doi.org/10.1016/s0891-5849(98)00147-6
40 https://doi.org/10.1016/s0985-0562(98)80022-8
41 https://doi.org/10.1042/bj3280199
42 https://doi.org/10.1055/s-0038-1647308
43 https://doi.org/10.1073/pnas.92.10.4497
44 https://doi.org/10.1073/pnas.94.24.12904
45 https://doi.org/10.1074/jbc.274.8.4924
46 https://doi.org/10.1081/clt-100102417
47 https://doi.org/10.1093/ajcn/68.2.365
48 https://doi.org/10.1093/ajcn/85.5.1293
49 https://doi.org/10.1097/00003246-199809000-00021
50 https://doi.org/10.1097/00003246-199909000-00017
51 https://doi.org/10.1097/00003246-200107000-00002
52 https://doi.org/10.1097/01.ccm.0000117317.18092.e4
53 https://doi.org/10.1097/01.ccm.0000129669.21649.40
54 https://doi.org/10.1097/01.ccm.0000251124.83436.0e
55 https://doi.org/10.1097/01.ccx.0000216581.80051.d6
56 https://doi.org/10.1097/01.mco.0000222105.30795.7f
57 https://doi.org/10.1128/mcb.22.11.3565-3576.2002
58 https://doi.org/10.1136/bmj.299.6694.316
59 https://doi.org/10.1177/0148607186010006545
60 https://doi.org/10.1177/104063870601800108
61 https://doi.org/10.1201/9781420032741
62 https://doi.org/10.3109/10915818609140736
63 https://doi.org/10.5694/j.1326-5377.1966.tb72571.x
64 schema:datePublished 2007-08
65 schema:datePublishedReg 2007-08-01
66 schema:description INTRODUCTION: Sepsis is associated with the generation of oxygen free radicals and (lacking) decreased selenium plasma concentrations. High doses of sodium selenite might reduce inflammation by a direct pro-oxidative effect and may increase antioxidant cell capacities by selenium incorporation into selenoenzymes. We investigated the effects of a continuous administration of high doses of selenium in septic shock patients. METHODS: A prospective, multicentre, placebo-controlled, randomized, double-blind study was performed with an intention-to-treat analysis in severe septic shock patients with documented infection. Patients received, for 10 days, selenium as sodium selenite (4,000 microg on the first day, 1,000 microg/day on the nine following days) or matching placebo using continuous intravenous infusion. The primary endpoint was the time to vasopressor therapy withdrawal. The duration of mechanical ventilation, the mortality rates in the intensive care unit, at hospital discharge, and at 7, 14, 28 and 180 days and 1 year after randomization, and adverse events were recorded. RESULTS: Sixty patients were included (placebo, n = 29; selenium, n = 31). The median time to vasopressor therapy withdrawal was 7 days in both groups (95% confidence interval = 5-8 and 6-9 in the placebo and selenium groups, respectively; log-rank, P = 0.713). The median duration of mechanical ventilation was 14 days and 19 days in the placebo and selenium groups, respectively (P = 0.762). Mortality rates did not significantly differ between groups at any time point. Rates of adverse events were similar in the two groups. CONCLUSION: Continuous infusion of selenium as sodium selenite (4,000 microg on the first day, 1,000 microg/day on the nine following days) had no obvious toxicity but did not improve the clinical outcome in septic shock patients. Trial Registration = NCT00207844.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N3cb1a915b69746d5a474a11bd9add4dd
71 Nf0a92fce19cd4af9a2b2b834c3e40da2
72 sg:journal.1117766
73 schema:name Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study
74 schema:pagination r73
75 schema:productId N015ba8f16c8141d6879eea9498dbeea8
76 N357f14f0f3a24a54a5a59d6a89f51071
77 N7f8b0a6884dc4ebfb0bf6f60bc792aef
78 N947ae6559c5f4b1aacf12a44cd561bfa
79 Nbc15ab1b348949d593da3fdd42eef5c4
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033054762
81 https://doi.org/10.1186/cc5960
82 schema:sdDatePublished 2019-04-10T20:53
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nf35831eeffa54df8bf23db4d305843ac
85 schema:url http://link.springer.com/10.1186%2Fcc5960
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N015ba8f16c8141d6879eea9498dbeea8 schema:name doi
90 schema:value 10.1186/cc5960
91 rdf:type schema:PropertyValue
92 N04c447f9a8af434693b5fad7e48e0add rdf:first sg:person.01217276447.64
93 rdf:rest N8aebcc4d57fc48a9ae1f42a2cee8e4d8
94 N09d5ef9bf1b84a5ea1f95ad5abe7ff9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Treatment Outcome
96 rdf:type schema:DefinedTerm
97 N1602fb57ab8b49289b82e669ee29641d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Prospective Studies
99 rdf:type schema:DefinedTerm
100 N1918529250094f039e8a880a3b2303b1 schema:name Centre Hospitalier Gustave Dron, 108 boulevard Pinel, 69003, Lyon, France
101 rdf:type schema:Organization
102 N209f0a3e08f440ada8647ccd44e6a40f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Double-Blind Method
104 rdf:type schema:DefinedTerm
105 N20bfb91b79774218b45df7ea0e61e0b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Follow-Up Studies
107 rdf:type schema:DefinedTerm
108 N28c330058cef43168cadd67fe518a0ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Male
110 rdf:type schema:DefinedTerm
111 N345c17568f5f485c930f964455e1bfee rdf:first sg:person.0775505012.07
112 rdf:rest Ned7779ee658840a2845666a7bcc8b266
113 N357f14f0f3a24a54a5a59d6a89f51071 schema:name readcube_id
114 schema:value 9d7798eb18d345c86b397705dea7f7b2b0656fe9483628536c180e2ae57b0002
115 rdf:type schema:PropertyValue
116 N3cb1a915b69746d5a474a11bd9add4dd schema:issueNumber 4
117 rdf:type schema:PublicationIssue
118 N3f6348da67e84978876a41ddb9e1159f rdf:first sg:person.0622207653.71
119 rdf:rest Nbee5076778094f6f8323eed718e6f185
120 N4276e0347cd745dcb947e4136e86415b rdf:first sg:person.01051603547.58
121 rdf:rest N4663e542213c48648cbef2db2acef6ef
122 N4663e542213c48648cbef2db2acef6ef rdf:first sg:person.01044460635.17
123 rdf:rest N738303a3694343efa66bba6338099f01
124 N49d711dc5fe548e5b673f82a8bdc0ffc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Severity of Illness Index
126 rdf:type schema:DefinedTerm
127 N63d2c693a7004985aef3d1c0e4cb496c schema:name Service de Réanimation Polyvalente, Centre Hospitalier de Meaux, Hôpital Saint Faron, 6–8 rue Saint Fiacre, 77104, Meaux, France
128 rdf:type schema:Organization
129 N645220dde3de41609258a3e83a7b2871 rdf:first sg:person.0710520012.16
130 rdf:rest Nafa2376d3e804431950216801aec7706
131 N68fc78ce759f4708b18498743c3122ba schema:name Service de Réanimation Polyvalente, Centre Hospitalier de Meaux, Hôpital Saint Faron, 6–8 rue Saint Fiacre, 77104, Meaux, France
132 rdf:type schema:Organization
133 N70e52aedc3464a88bab4cab427fd392f schema:name Service de Réanimation Polyvalente, Centre Hospitalier, 51 rue du Commandant Derrien, 95107, Argenteuil, France
134 rdf:type schema:Organization
135 N738303a3694343efa66bba6338099f01 rdf:first sg:person.0621526767.12
136 rdf:rest N345c17568f5f485c930f964455e1bfee
137 N7f8b0a6884dc4ebfb0bf6f60bc792aef schema:name pubmed_id
138 schema:value 17617901
139 rdf:type schema:PropertyValue
140 N7fb3da53dcf54d51800f1218bccd8e64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Sodium Selenite
142 rdf:type schema:DefinedTerm
143 N85937ec567e94d02a15872d3398cf38d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Antioxidants
145 rdf:type schema:DefinedTerm
146 N8aebcc4d57fc48a9ae1f42a2cee8e4d8 rdf:first sg:person.01346477033.32
147 rdf:rest N4276e0347cd745dcb947e4136e86415b
148 N8bb64cc0e9cb4a58b98b6cf8a54207bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Infusions, Intravenous
150 rdf:type schema:DefinedTerm
151 N90a89f3f4ed543debb55c542ac74ad96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Humans
153 rdf:type schema:DefinedTerm
154 N947ae6559c5f4b1aacf12a44cd561bfa schema:name dimensions_id
155 schema:value pub.1033054762
156 rdf:type schema:PropertyValue
157 Nafa2376d3e804431950216801aec7706 rdf:first sg:person.01115151652.22
158 rdf:rest rdf:nil
159 Nbc15ab1b348949d593da3fdd42eef5c4 schema:name nlm_unique_id
160 schema:value 9801902
161 rdf:type schema:PropertyValue
162 Nbee5076778094f6f8323eed718e6f185 rdf:first sg:person.0757161524.40
163 rdf:rest N645220dde3de41609258a3e83a7b2871
164 Nec2aaf3de0ef4f21a2f943885dd53a67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Aged
166 rdf:type schema:DefinedTerm
167 Ned0b717afc274cf195adbed65614a45c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Shock, Septic
169 rdf:type schema:DefinedTerm
170 Ned7779ee658840a2845666a7bcc8b266 rdf:first sg:person.01272013702.94
171 rdf:rest N3f6348da67e84978876a41ddb9e1159f
172 Nf0a92fce19cd4af9a2b2b834c3e40da2 schema:volumeNumber 11
173 rdf:type schema:PublicationVolume
174 Nf35831eeffa54df8bf23db4d305843ac schema:name Springer Nature - SN SciGraph project
175 rdf:type schema:Organization
176 Nfa99239b9b77424dab331cfb15754c7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Dose-Response Relationship, Drug
178 rdf:type schema:DefinedTerm
179 Nfdf6978a959c43248ed750c2c2b3d27c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Female
181 rdf:type schema:DefinedTerm
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
186 schema:name Clinical Sciences
187 rdf:type schema:DefinedTerm
188 sg:journal.1117766 schema:issn 1364-8535
189 1466-609X
190 schema:name Critical Care
191 rdf:type schema:Periodical
192 sg:person.01044460635.17 schema:affiliation https://www.grid.ac/institutes/grid.413328.f
193 schema:familyName Vitoux
194 schema:givenName Dominique
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044460635.17
196 rdf:type schema:Person
197 sg:person.01051603547.58 schema:affiliation https://www.grid.ac/institutes/grid.414291.b
198 schema:familyName Annane
199 schema:givenName Djillali
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051603547.58
201 rdf:type schema:Person
202 sg:person.01115151652.22 schema:affiliation https://www.grid.ac/institutes/grid.414271.5
203 schema:familyName Bellissant
204 schema:givenName Eric
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115151652.22
206 rdf:type schema:Person
207 sg:person.01217276447.64 schema:affiliation N63d2c693a7004985aef3d1c0e4cb496c
208 schema:familyName Forceville
209 schema:givenName Xavier
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217276447.64
211 rdf:type schema:Person
212 sg:person.01272013702.94 schema:affiliation https://www.grid.ac/institutes/grid.414039.b
213 schema:familyName Cantais
214 schema:givenName Emmanuel
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272013702.94
216 rdf:type schema:Person
217 sg:person.01346477033.32 schema:affiliation https://www.grid.ac/institutes/grid.414271.5
218 schema:familyName Laviolle
219 schema:givenName Bruno
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346477033.32
221 rdf:type schema:Person
222 sg:person.0621526767.12 schema:affiliation https://www.grid.ac/institutes/grid.414474.6
223 schema:familyName Bleichner
224 schema:givenName Gérard
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621526767.12
226 rdf:type schema:Person
227 sg:person.0622207653.71 schema:affiliation https://www.grid.ac/institutes/grid.418052.a
228 schema:familyName Georges
229 schema:givenName Hugues
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622207653.71
231 rdf:type schema:Person
232 sg:person.0710520012.16 schema:affiliation N68fc78ce759f4708b18498743c3122ba
233 schema:familyName Combes
234 schema:givenName Alain
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710520012.16
236 rdf:type schema:Person
237 sg:person.0757161524.40 schema:affiliation N1918529250094f039e8a880a3b2303b1
238 schema:familyName Soubirou
239 schema:givenName Jean-Louis
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757161524.40
241 rdf:type schema:Person
242 sg:person.0775505012.07 schema:affiliation N70e52aedc3464a88bab4cab427fd392f
243 schema:familyName Korach
244 schema:givenName Jean-Michel
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775505012.07
246 rdf:type schema:Person
247 sg:pub.10.1007/bf03041947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031914932
248 https://doi.org/10.1007/bf03041947
249 rdf:type schema:CreativeWork
250 sg:pub.10.1007/s00063-004-1104-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048221805
251 https://doi.org/10.1007/s00063-004-1104-8
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/s00134-004-2522-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037002387
254 https://doi.org/10.1007/s00134-004-2522-z
255 rdf:type schema:CreativeWork
256 sg:pub.10.1007/s001340000757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006488484
257 https://doi.org/10.1007/s001340000757
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s001340000779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043999884
260 https://doi.org/10.1007/s001340000779
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s002040050274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030055291
263 https://doi.org/10.1007/s002040050274
264 rdf:type schema:CreativeWork
265 sg:pub.10.1186/cc3753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028086901
266 https://doi.org/10.1186/cc3753
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/cc5109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018789558
269 https://doi.org/10.1186/cc5109
270 rdf:type schema:CreativeWork
271 https://app.dimensions.ai/details/publication/pub.1077191375 schema:CreativeWork
272 https://app.dimensions.ai/details/publication/pub.1079802522 schema:CreativeWork
273 https://app.dimensions.ai/details/publication/pub.1081435019 schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1083154262 schema:CreativeWork
275 https://doi.org/10.1002/14651858.cd003703.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045627902
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/biof.5520140125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029611368
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/0009-9120(95)02007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016872738
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.bcp.2003.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030123479
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.clnu.2004.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009840925
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.freeradbiomed.2006.04.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046390149
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.mehy.2006.01.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018122239
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s0140-6736(00)02490-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032384467
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s0271-5317(00)00296-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021204175
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0891-5849(98)00147-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017874465
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0985-0562(98)80022-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052162669
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1042/bj3280199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047640070
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1055/s-0038-1647308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078578939
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1073/pnas.92.10.4497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012935424
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1073/pnas.94.24.12904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011267920
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1074/jbc.274.8.4924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029621390
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1081/clt-100102417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047477780
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1093/ajcn/68.2.365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083304678
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/ajcn/85.5.1293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077415631
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1097/00003246-199809000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060173069
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1097/00003246-199909000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060174295
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1097/00003246-200107000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010433290
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1097/01.ccm.0000117317.18092.e4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024174028
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1097/01.ccm.0000129669.21649.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050179967
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1097/01.ccm.0000251124.83436.0e schema:sameAs https://app.dimensions.ai/details/publication/pub.1006199661
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1097/01.ccx.0000216581.80051.d6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025061786
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1097/01.mco.0000222105.30795.7f schema:sameAs https://app.dimensions.ai/details/publication/pub.1017609419
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1128/mcb.22.11.3565-3576.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035791330
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1136/bmj.299.6694.316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037456972
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1177/0148607186010006545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025275639
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1177/104063870601800108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020595748
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1201/9781420032741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1095906416
338 rdf:type schema:CreativeWork
339 https://doi.org/10.3109/10915818609140736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070984953
340 rdf:type schema:CreativeWork
341 https://doi.org/10.5694/j.1326-5377.1966.tb72571.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081435019
342 rdf:type schema:CreativeWork
343 https://www.grid.ac/institutes/grid.413328.f schema:alternateName Hôpital Saint-Louis
344 schema:name Service de Biochimie A, Hôpital Saint-Louis, avenue Claude Vellefaux, cedex 10, Paris, France
345 rdf:type schema:Organization
346 https://www.grid.ac/institutes/grid.414039.b schema:alternateName Hôpital d'Instruction des Armées Sainte-Anne
347 schema:name Hôpital d'Instruction des Armées Sainte Anne, boulevard Sainte Anne, 83800, Toulon, France
348 rdf:type schema:Organization
349 https://www.grid.ac/institutes/grid.414271.5 schema:alternateName l'Hôpital Pontchaillou
350 schema:name Centre d'Investigation Clinique INSERM 0203, Unité de Pharmacologie Clinique, Hôpital de Pontchaillou, CHU de Rennes et Université de Rennes 1, 2 rue Henri le Guilloux, 35033, Rennes, France
351 rdf:type schema:Organization
352 https://www.grid.ac/institutes/grid.414291.b schema:alternateName Raymond Poincaré University Hospital
353 schema:name Service de Réanimation Médicale, Hôpital Raymond Poincaré, 104 boulevard Raymond Poincaré, 92380, Garches, France
354 rdf:type schema:Organization
355 https://www.grid.ac/institutes/grid.414474.6 schema:alternateName Centre Hospitalier Victor Dupouy
356 schema:name Service de Réanimation Polyvalente, Centre Hospitalier Victor Dupouy, 69 rue du Lieut-Col Prudhon, 95107, Argenteuil, France
357 rdf:type schema:Organization
358 https://www.grid.ac/institutes/grid.418052.a schema:alternateName Centre Hospitalier de Tourcoing
359 schema:name Centre Hospitalier Gustave Dron, 135 rue du Président Coty, 59200, Tourcoing, France
360 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...