Clinical review: Use of helium-oxygen in critically ill patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-12-20

AUTHORS

Marc Gainnier, Jean-Marie Forel

ABSTRACT

Use of helium-oxygen (He/O2) mixtures in critically ill patients is supported by a reliable and well understood theoretical rationale and by numerous experimental observations. Breathing He/O2 can benefit critically ill patients with severe respiratory compromise mainly by reducing airway resistance in obstructive syndromes such as acute asthma and decompensated chronic obstructive pulmonary disease. However, the benefit from He/O2 in terms of respiratory mechanics diminishes rapidly with increasing oxygen concentration in the gaseous mixture. Safe use of He/O2 in the intensive care unit requires specific equipment and supervision by adequately experienced personnel. The available clinical data on inhaled He/O2 mixtures are insufficient to prove that this therapy has benefit with respect to outcome variables. For these reasons, He/O2 is not currently a standard of care in critically ill patients with acute obstructive syndromes, apart from in some, well defined situations. Its role in critically ill patients must be more precisely defined if we are to identify those patients who could benefit from this therapeutic approach. More... »

PAGES

241-241

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/cc5104

DOI

http://dx.doi.org/10.1186/cc5104

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022272520

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17210068


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