Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-02

AUTHORS

Koenraad H Vandewoude, Stijn I Blot, Pieter Depuydt, Dominique Benoit, Werner Temmerman, Francis Colardyn, Dirk Vogelaers

ABSTRACT

INTRODUCTION: The diagnosis of invasive pulmonary aspergillosis, according to the criteria as defined by the European Organisation for the Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG), is difficult to establish in critically ill patients. The aim of this study is to address the clinical significance of isolation of Aspergillus spp. from lower respiratory tract samples in critically ill patients on the basis of medical and radiological files using an adapted diagnostic algorithm to discriminate proven and probable invasive pulmonary aspergillosis from Aspergillus colonisation. METHODS: Using a historical cohort (January 1997 to December 2003), all critically ill patients with respiratory tract samples positive for Aspergillus were studied. In comparison to the EORTC/MSG criteria, a different appreciation was given to radiological features and microbiological data, including semiquantitative cultures and direct microscopic examination of broncho-alveolar lavage samples. RESULTS: Over a 7 year period, 172 patients were identified with a positive culture. Of these, 83 patients were classified as invasive aspergillosis. In 50 of these patients (60%), no high risk predisposing conditions (neutropenia, hematologic cancer and stem cell or bone marrow transplantation) were found. Typical radiological imaging (halo and air-crescent sign) occurred in only 5% of patients. In 26 patients, histological examination either by ante-mortem lung biopsy (n = 10) or necropsy (n = 16) was performed, allowing a rough estimation of the predictive value of the diagnostic algorithm. In all patients with histology, all cases of clinical probable pulmonary aspergillosis were confirmed (n = 17). Conversely, all cases classified as colonisation had negative histology (n = 9). CONCLUSION: A respiratory tract sample positive for Aspergillus spp. in the critically ill should always prompt further diagnostic assessment, even in the absence of the typical hematological and immunological host risk factors. In a minority of patients, the value of the clinical diagnostic algorithm was confirmed by histological findings, supporting its predictive value. The proposed diagnostic algorithm needs prospective validation. More... »

PAGES

r31

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/cc4823

DOI

http://dx.doi.org/10.1186/cc4823

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013845147

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16507158


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspergillosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspergillus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Critical Illness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Diseases, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University College Ghent", 
          "id": "https://www.grid.ac/institutes/grid.412437.7", 
          "name": [
            "Department of Intensive Care, Ghent University Hospital, Ghent, Belgium", 
            "Hogeschool Gent, Health Care Department \"Vesalius\", Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vandewoude", 
        "givenName": "Koenraad H", 
        "id": "sg:person.01301312561.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301312561.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Ghent", 
          "id": "https://www.grid.ac/institutes/grid.412437.7", 
          "name": [
            "Department of Intensive Care, Ghent University Hospital, Ghent, Belgium", 
            "Hogeschool Gent, Health Care Department \"Vesalius\", Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blot", 
        "givenName": "Stijn I", 
        "id": "sg:person.01052110704.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052110704.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410566.0", 
          "name": [
            "Department of Intensive Care, Ghent University Hospital, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Depuydt", 
        "givenName": "Pieter", 
        "id": "sg:person.01255004115.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255004115.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410566.0", 
          "name": [
            "Department of Intensive Care, Ghent University Hospital, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benoit", 
        "givenName": "Dominique", 
        "id": "sg:person.01225564344.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225564344.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410566.0", 
          "name": [
            "Department of Intensive Care, Ghent University Hospital, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Temmerman", 
        "givenName": "Werner", 
        "id": "sg:person.01053517756.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053517756.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410566.0", 
          "name": [
            "Department of Intensive Care, Ghent University Hospital, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colardyn", 
        "givenName": "Francis", 
        "id": "sg:person.012411215117.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012411215117.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410566.0", 
          "name": [
            "Department for Infectious Diseases, Ghent University Hospital, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vogelaers", 
        "givenName": "Dirk", 
        "id": "sg:person.01016616645.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016616645.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)14904-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000664944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2044.2001.01841.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001225221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(81)90208-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003112115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/323900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003663038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.288.7.862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003730654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00013542-199307000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004067323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00013542-199307000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004067323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00013542-199307000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004067323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1979.03290340021019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005395534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(86)90259-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005459055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-002-0699-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006067878", 
          "https://doi.org/10.1007/s10096-002-0699-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhin.2004.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006564620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/323335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010225317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.112.2.541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010413914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-003-0970-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010959160", 
          "https://doi.org/10.1007/s10096-003-0970-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-003-0970-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010959160", 
          "https://doi.org/10.1007/s10096-003-0970-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc3488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013113022", 
          "https://doi.org/10.1186/cc3488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc3488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013113022", 
          "https://doi.org/10.1186/cc3488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200401-093oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014608330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/clinids/27.5.1138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018702681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340000768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022602753", 
          "https://doi.org/10.1007/s001340000768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01709544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023497361", 
          "https://doi.org/10.1007/bf01709544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01709544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023497361", 
          "https://doi.org/10.1007/bf01709544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-8278(91)90900-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025931466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.87.5.691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025946286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.43.5.2075-2079.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027386042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/432470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027995690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/432470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027995690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(84)90853-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029490847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/joc.2003.15.1.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029717711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.6.1604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030795050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0954-6111(06)80062-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033348172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-0691.1998.tb00656.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034062083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.123.4.1208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035847095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.123.4.1208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035847095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.154.2.8756836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039061167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198510000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039110630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198510000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039110630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-003-1648-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040261622", 
          "https://doi.org/10.1007/s00134-003-1648-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.46.1.15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043207132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.46.1.15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043207132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/513943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044120619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-003-1778-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045947012", 
          "https://doi.org/10.1007/s00134-003-1778-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/acb.2004.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050460684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.98.12030705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052301972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000186651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052306678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9343(97)89455-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052375578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.241.8.803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054137926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/517672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058791252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/clinids/8.3.357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059475796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-77-3-383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073730196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-90-1-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073736513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiology.157.3.3864189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080000584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082316492", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.1.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083031473"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-02", 
    "datePublishedReg": "2006-02-01", 
    "description": "INTRODUCTION: The diagnosis of invasive pulmonary aspergillosis, according to the criteria as defined by the European Organisation for the Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG), is difficult to establish in critically ill patients. The aim of this study is to address the clinical significance of isolation of Aspergillus spp. from lower respiratory tract samples in critically ill patients on the basis of medical and radiological files using an adapted diagnostic algorithm to discriminate proven and probable invasive pulmonary aspergillosis from Aspergillus colonisation.\nMETHODS: Using a historical cohort (January 1997 to December 2003), all critically ill patients with respiratory tract samples positive for Aspergillus were studied. In comparison to the EORTC/MSG criteria, a different appreciation was given to radiological features and microbiological data, including semiquantitative cultures and direct microscopic examination of broncho-alveolar lavage samples.\nRESULTS: Over a 7 year period, 172 patients were identified with a positive culture. Of these, 83 patients were classified as invasive aspergillosis. In 50 of these patients (60%), no high risk predisposing conditions (neutropenia, hematologic cancer and stem cell or bone marrow transplantation) were found. Typical radiological imaging (halo and air-crescent sign) occurred in only 5% of patients. In 26 patients, histological examination either by ante-mortem lung biopsy (n = 10) or necropsy (n = 16) was performed, allowing a rough estimation of the predictive value of the diagnostic algorithm. In all patients with histology, all cases of clinical probable pulmonary aspergillosis were confirmed (n = 17). Conversely, all cases classified as colonisation had negative histology (n = 9).\nCONCLUSION: A respiratory tract sample positive for Aspergillus spp. in the critically ill should always prompt further diagnostic assessment, even in the absence of the typical hematological and immunological host risk factors. In a minority of patients, the value of the clinical diagnostic algorithm was confirmed by histological findings, supporting its predictive value. The proposed diagnostic algorithm needs prospective validation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/cc4823", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients", 
    "pagination": "r31", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "41f4a0125ede7c0aac8557009b3cda30b67fe7c5b4650e56c67c2d57f30f908c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16507158"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9801902"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/cc4823"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013845147"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/cc4823", 
      "https://app.dimensions.ai/details/publication/pub.1013845147"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fcc4823"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/cc4823'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/cc4823'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/cc4823'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/cc4823'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      21 PREDICATES      87 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/cc4823 schema:about N07a25f57b1234160af0da9f0831e27c9
2 N0c693a9e6809495f90f47be7098e4e05
3 N2f580b60e5554a9eaaede24b64efb50f
4 N3f8fae9bd7944b13a10b206d24675184
5 N5eff933dc738478199d602f6efd1ac1b
6 N82eb0a1c0f32483c958c9076b1f4c7d5
7 Nbebd8262ab1a4b9da3fabe06fe3a46a1
8 Ndc9cd8ae01db40a182e8e6c5a59f67d0
9 Ne54e3ace4a5848049e140b2e8112431d
10 Ne741c73a98184b1489e7daad9b363eed
11 Neb9cce98d8864a65b9e5e6a507592662
12 Nec1ebd7cc4c94b6ead2515da42484b0b
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author N97aed7afe4b046ab87d0f98007266698
16 schema:citation sg:pub.10.1007/bf01709544
17 sg:pub.10.1007/s00134-003-1648-8
18 sg:pub.10.1007/s00134-003-1778-z
19 sg:pub.10.1007/s001340000768
20 sg:pub.10.1007/s10096-002-0699-z
21 sg:pub.10.1007/s10096-003-0970-y
22 sg:pub.10.1186/cc3488
23 https://app.dimensions.ai/details/publication/pub.1082316492
24 https://doi.org/10.1001/jama.1979.03290340021019
25 https://doi.org/10.1001/jama.241.8.803
26 https://doi.org/10.1001/jama.288.7.862
27 https://doi.org/10.1016/0002-9343(81)90208-4
28 https://doi.org/10.1016/0002-9343(84)90853-2
29 https://doi.org/10.1016/0002-9343(86)90259-7
30 https://doi.org/10.1016/0168-8278(91)90900-v
31 https://doi.org/10.1016/j.jhin.2004.01.006
32 https://doi.org/10.1016/s0002-9343(97)89455-7
33 https://doi.org/10.1016/s0140-6736(03)14904-5
34 https://doi.org/10.1016/s0954-6111(06)80062-4
35 https://doi.org/10.1046/j.1365-2044.2001.01841.x
36 https://doi.org/10.1086/323335
37 https://doi.org/10.1086/323900
38 https://doi.org/10.1086/432470
39 https://doi.org/10.1086/513943
40 https://doi.org/10.1086/517672
41 https://doi.org/10.1093/clinids/27.5.1138
42 https://doi.org/10.1093/clinids/8.3.357
43 https://doi.org/10.1097/00003246-198510000-00009
44 https://doi.org/10.1097/00013542-199307000-00009
45 https://doi.org/10.1111/j.1469-0691.1998.tb00656.x
46 https://doi.org/10.1128/jcm.43.5.2075-2079.2005
47 https://doi.org/10.1136/thx.46.1.15
48 https://doi.org/10.1148/radiology.157.3.3864189
49 https://doi.org/10.1159/000186651
50 https://doi.org/10.1164/ajrccm.154.2.8756836
51 https://doi.org/10.1164/rccm.200401-093oc
52 https://doi.org/10.1179/acb.2004.037
53 https://doi.org/10.1179/joc.2003.15.1.71
54 https://doi.org/10.1182/blood.v97.6.1604
55 https://doi.org/10.1183/09031936.98.12030705
56 https://doi.org/10.1200/jco.1997.15.1.139
57 https://doi.org/10.1378/chest.112.2.541
58 https://doi.org/10.1378/chest.123.4.1208
59 https://doi.org/10.1378/chest.87.5.691
60 https://doi.org/10.7326/0003-4819-77-3-383
61 https://doi.org/10.7326/0003-4819-90-1-4
62 schema:datePublished 2006-02
63 schema:datePublishedReg 2006-02-01
64 schema:description INTRODUCTION: The diagnosis of invasive pulmonary aspergillosis, according to the criteria as defined by the European Organisation for the Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG), is difficult to establish in critically ill patients. The aim of this study is to address the clinical significance of isolation of Aspergillus spp. from lower respiratory tract samples in critically ill patients on the basis of medical and radiological files using an adapted diagnostic algorithm to discriminate proven and probable invasive pulmonary aspergillosis from Aspergillus colonisation. METHODS: Using a historical cohort (January 1997 to December 2003), all critically ill patients with respiratory tract samples positive for Aspergillus were studied. In comparison to the EORTC/MSG criteria, a different appreciation was given to radiological features and microbiological data, including semiquantitative cultures and direct microscopic examination of broncho-alveolar lavage samples. RESULTS: Over a 7 year period, 172 patients were identified with a positive culture. Of these, 83 patients were classified as invasive aspergillosis. In 50 of these patients (60%), no high risk predisposing conditions (neutropenia, hematologic cancer and stem cell or bone marrow transplantation) were found. Typical radiological imaging (halo and air-crescent sign) occurred in only 5% of patients. In 26 patients, histological examination either by ante-mortem lung biopsy (n = 10) or necropsy (n = 16) was performed, allowing a rough estimation of the predictive value of the diagnostic algorithm. In all patients with histology, all cases of clinical probable pulmonary aspergillosis were confirmed (n = 17). Conversely, all cases classified as colonisation had negative histology (n = 9). CONCLUSION: A respiratory tract sample positive for Aspergillus spp. in the critically ill should always prompt further diagnostic assessment, even in the absence of the typical hematological and immunological host risk factors. In a minority of patients, the value of the clinical diagnostic algorithm was confirmed by histological findings, supporting its predictive value. The proposed diagnostic algorithm needs prospective validation.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree true
68 schema:isPartOf N6594279f046745dbb6c4d89a7ef6b35d
69 Ne2f89b4190ee4dbd94673496c408e136
70 sg:journal.1117766
71 schema:name Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients
72 schema:pagination r31
73 schema:productId N208fa0412e59458f9cdcae2cf49d43a7
74 N2b65d2875e194368969a05ead4c390a2
75 N87dcf073f11c4dd78fbba7dd40633b7e
76 N8a9f56c428bd4d7799f1075460f25af8
77 Nd3ef84e5361a46a19425d61ead94e010
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013845147
79 https://doi.org/10.1186/cc4823
80 schema:sdDatePublished 2019-04-10T22:31
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher Nba36408a78ff497da62f2247c3fde0e1
83 schema:url http://link.springer.com/10.1186%2Fcc4823
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N05476769a85d4b3182baccab48ac33c0 rdf:first sg:person.01016616645.83
88 rdf:rest rdf:nil
89 N07a25f57b1234160af0da9f0831e27c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Aspergillus
91 rdf:type schema:DefinedTerm
92 N0c693a9e6809495f90f47be7098e4e05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Critical Illness
94 rdf:type schema:DefinedTerm
95 N208fa0412e59458f9cdcae2cf49d43a7 schema:name doi
96 schema:value 10.1186/cc4823
97 rdf:type schema:PropertyValue
98 N2169a37e4d634ee39dfbce7241d97fda rdf:first sg:person.01053517756.59
99 rdf:rest N797ebaf89bb6464c8c79f3097d9cf4f1
100 N2b65d2875e194368969a05ead4c390a2 schema:name dimensions_id
101 schema:value pub.1013845147
102 rdf:type schema:PropertyValue
103 N2f580b60e5554a9eaaede24b64efb50f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Retrospective Studies
105 rdf:type schema:DefinedTerm
106 N378fc43e85394f1aa8d7de54f0d17654 rdf:first sg:person.01255004115.94
107 rdf:rest Neb23348ad9d04632a1d4e9cf4db30669
108 N3f8fae9bd7944b13a10b206d24675184 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Respiratory System
110 rdf:type schema:DefinedTerm
111 N5eff933dc738478199d602f6efd1ac1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Cohort Studies
113 rdf:type schema:DefinedTerm
114 N6594279f046745dbb6c4d89a7ef6b35d schema:issueNumber 1
115 rdf:type schema:PublicationIssue
116 N797ebaf89bb6464c8c79f3097d9cf4f1 rdf:first sg:person.012411215117.40
117 rdf:rest N05476769a85d4b3182baccab48ac33c0
118 N82eb0a1c0f32483c958c9076b1f4c7d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Humans
120 rdf:type schema:DefinedTerm
121 N87dcf073f11c4dd78fbba7dd40633b7e schema:name readcube_id
122 schema:value 41f4a0125ede7c0aac8557009b3cda30b67fe7c5b4650e56c67c2d57f30f908c
123 rdf:type schema:PropertyValue
124 N8a9f56c428bd4d7799f1075460f25af8 schema:name nlm_unique_id
125 schema:value 9801902
126 rdf:type schema:PropertyValue
127 N91e4ac0df46049559f53f947058a3e27 rdf:first sg:person.01052110704.48
128 rdf:rest N378fc43e85394f1aa8d7de54f0d17654
129 N97aed7afe4b046ab87d0f98007266698 rdf:first sg:person.01301312561.02
130 rdf:rest N91e4ac0df46049559f53f947058a3e27
131 Nba36408a78ff497da62f2247c3fde0e1 schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 Nbebd8262ab1a4b9da3fabe06fe3a46a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Survival Analysis
135 rdf:type schema:DefinedTerm
136 Nd3ef84e5361a46a19425d61ead94e010 schema:name pubmed_id
137 schema:value 16507158
138 rdf:type schema:PropertyValue
139 Ndc9cd8ae01db40a182e8e6c5a59f67d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Prospective Studies
141 rdf:type schema:DefinedTerm
142 Ne2f89b4190ee4dbd94673496c408e136 schema:volumeNumber 10
143 rdf:type schema:PublicationVolume
144 Ne54e3ace4a5848049e140b2e8112431d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Lung Diseases, Fungal
146 rdf:type schema:DefinedTerm
147 Ne741c73a98184b1489e7daad9b363eed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Aged
149 rdf:type schema:DefinedTerm
150 Neb23348ad9d04632a1d4e9cf4db30669 rdf:first sg:person.01225564344.52
151 rdf:rest N2169a37e4d634ee39dfbce7241d97fda
152 Neb9cce98d8864a65b9e5e6a507592662 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Middle Aged
154 rdf:type schema:DefinedTerm
155 Nec1ebd7cc4c94b6ead2515da42484b0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Aspergillosis
157 rdf:type schema:DefinedTerm
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
162 schema:name Clinical Sciences
163 rdf:type schema:DefinedTerm
164 sg:journal.1117766 schema:issn 1364-8535
165 1466-609X
166 schema:name Critical Care
167 rdf:type schema:Periodical
168 sg:person.01016616645.83 schema:affiliation https://www.grid.ac/institutes/grid.410566.0
169 schema:familyName Vogelaers
170 schema:givenName Dirk
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016616645.83
172 rdf:type schema:Person
173 sg:person.01052110704.48 schema:affiliation https://www.grid.ac/institutes/grid.412437.7
174 schema:familyName Blot
175 schema:givenName Stijn I
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052110704.48
177 rdf:type schema:Person
178 sg:person.01053517756.59 schema:affiliation https://www.grid.ac/institutes/grid.410566.0
179 schema:familyName Temmerman
180 schema:givenName Werner
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053517756.59
182 rdf:type schema:Person
183 sg:person.01225564344.52 schema:affiliation https://www.grid.ac/institutes/grid.410566.0
184 schema:familyName Benoit
185 schema:givenName Dominique
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225564344.52
187 rdf:type schema:Person
188 sg:person.012411215117.40 schema:affiliation https://www.grid.ac/institutes/grid.410566.0
189 schema:familyName Colardyn
190 schema:givenName Francis
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012411215117.40
192 rdf:type schema:Person
193 sg:person.01255004115.94 schema:affiliation https://www.grid.ac/institutes/grid.410566.0
194 schema:familyName Depuydt
195 schema:givenName Pieter
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255004115.94
197 rdf:type schema:Person
198 sg:person.01301312561.02 schema:affiliation https://www.grid.ac/institutes/grid.412437.7
199 schema:familyName Vandewoude
200 schema:givenName Koenraad H
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301312561.02
202 rdf:type schema:Person
203 sg:pub.10.1007/bf01709544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023497361
204 https://doi.org/10.1007/bf01709544
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/s00134-003-1648-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040261622
207 https://doi.org/10.1007/s00134-003-1648-8
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/s00134-003-1778-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1045947012
210 https://doi.org/10.1007/s00134-003-1778-z
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/s001340000768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022602753
213 https://doi.org/10.1007/s001340000768
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/s10096-002-0699-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1006067878
216 https://doi.org/10.1007/s10096-002-0699-z
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s10096-003-0970-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1010959160
219 https://doi.org/10.1007/s10096-003-0970-y
220 rdf:type schema:CreativeWork
221 sg:pub.10.1186/cc3488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013113022
222 https://doi.org/10.1186/cc3488
223 rdf:type schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1082316492 schema:CreativeWork
225 https://doi.org/10.1001/jama.1979.03290340021019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005395534
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1001/jama.241.8.803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054137926
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1001/jama.288.7.862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003730654
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0002-9343(81)90208-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003112115
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0002-9343(84)90853-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029490847
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/0002-9343(86)90259-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005459055
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0168-8278(91)90900-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1025931466
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.jhin.2004.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006564620
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0002-9343(97)89455-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052375578
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0140-6736(03)14904-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000664944
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0954-6111(06)80062-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033348172
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1046/j.1365-2044.2001.01841.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001225221
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1086/323335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010225317
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1086/323900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003663038
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1086/432470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027995690
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1086/513943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044120619
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1086/517672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058791252
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/clinids/27.5.1138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018702681
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/clinids/8.3.357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059475796
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1097/00003246-198510000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039110630
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1097/00013542-199307000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004067323
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1111/j.1469-0691.1998.tb00656.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034062083
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1128/jcm.43.5.2075-2079.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027386042
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1136/thx.46.1.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043207132
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1148/radiology.157.3.3864189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080000584
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1159/000186651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052306678
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1164/ajrccm.154.2.8756836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039061167
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1164/rccm.200401-093oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1014608330
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1179/acb.2004.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050460684
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1179/joc.2003.15.1.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029717711
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1182/blood.v97.6.1604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030795050
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1183/09031936.98.12030705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052301972
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1200/jco.1997.15.1.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083031473
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1378/chest.112.2.541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010413914
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1378/chest.123.4.1208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035847095
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1378/chest.87.5.691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025946286
296 rdf:type schema:CreativeWork
297 https://doi.org/10.7326/0003-4819-77-3-383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073730196
298 rdf:type schema:CreativeWork
299 https://doi.org/10.7326/0003-4819-90-1-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073736513
300 rdf:type schema:CreativeWork
301 https://www.grid.ac/institutes/grid.410566.0 schema:alternateName Ghent University Hospital
302 schema:name Department for Infectious Diseases, Ghent University Hospital, Ghent, Belgium
303 Department of Intensive Care, Ghent University Hospital, Ghent, Belgium
304 rdf:type schema:Organization
305 https://www.grid.ac/institutes/grid.412437.7 schema:alternateName University College Ghent
306 schema:name Department of Intensive Care, Ghent University Hospital, Ghent, Belgium
307 Hogeschool Gent, Health Care Department "Vesalius", Ghent, Belgium
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...