Study protocol: The DOse REsponse Multicentre International collaborative initiative (DO-RE-MI) View Full Text


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Article Info

DATE

2005-06-14

AUTHORS

Detlef Kindgen-Milles, Didier Journois, Roberto Fumagalli, Sergio Vesconi, Javier Maynar, Anibal Marinho, Irene Bolgan, Alessandra Brendolan, Marco Formica, Sergio Livigni, Mariella Maio, Mariano Marchesi, Filippo Mariano, Gianpaola Monti, Elena Moretti, Daniela Silengo, Claudio Ronco

ABSTRACT

IntroductionCurrent practices for renal replacement therapy in intensive care units (ICUs) remain poorly defined. The DOse REsponse Multicentre International collaborative initiative (DO-RE-MI) will address the issue of how the different modes of renal replacement therapy are currently chosen and performed. Here, we describe the study protocol, which was approved by the Scientific and Steering Committees.MethodsDO-RE-MI is an observational, multicentre study conducted in ICUs. The primary end-point will be the delivered dose of dialysis, which will be compared with ICU mortality, 28-day mortality, hospital mortality, ICU length of stay and number of days of mechanical ventilation. The secondary end-point will be the haemodynamic response to renal replacement therapy, expressed as percentage reduction in noradrenaline (norepinephrine) requirement. Based on the the sample analysis calculation, at least 162 patients must be recruited. Anonymized patient data will be entered online in electronic case report forms and uploaded to an internet website. Each participating centre will have 2 months to become acquainted with the electronic case report forms. After this period official recruitment will begin. Patient data belong to the respective centre, which may use the database for its own needs. However, all centres have agreed to participate in a joint effort to achieve the sample size needed for statistical analysis.ConclusionThe study will hopefully help to collect useful information on the current practice of renal replacement therapy in ICUs. It will also provide a centre-based collection of data that will be useful for monitoring all aspects of extracorporeal support, such as incidence, frequency, and duration. More... »

PAGES

r396

Journal

TITLE

Critical Care

ISSUE

4

VOLUME

9

Author Affiliations

  • Scientific Committee member; Leading Consultant, Anesthesiology Clinic, University of Düsseldorf, Germany
  • Scientific Committee member; Director, Anesthesiology and Intensive Care Service, Hospital European Georges-Pompidou, Paris, France
  • Scientific Committee member; Associate Professor, Department of Anesthesiology and Intensive Care, Medicine and Surgery Faculty, University of Milan, Italy
  • Scientific Committee member; Director, Department of Anesthesiology and Intensive Care, Ospedale Niguarda, Milan, Italy
  • Scientific Committee member; Vice-Head, Anesthesiology and Intensive Care Unit, Hospital Santiago Apostol, Vitoria, Spain
  • Scientific Committee member; Vice-Head, Anesthesiology and Intensive Care Unit, Hospital Geral Sant Antonio, Porto, Portugal
  • Steering Committee member; Epidemiology Consultant, Department of Nephrology, Hospital San Bortolo, Vicenza, Italy
  • Steering Committee member; Vice-Head, Department of Nephrology, Hospital San Bortolo, Vicenza, Italy
  • Steering Committee member; Director, Department of Nephrology, Hospital Santa Croce e Carle, Cuneo, Italy
  • Steering Committee member; Director, Intensive Care Unit, Hospital G.Bosco, Torino, Italy
  • Steering Committee member; Vice-Head, Intensive Care Unit, Hospital G.Bosco, Torino, Italy
  • Steering Committee member; Vice-Head, Department of Anesthesiology and Intensive Care, Hospital Riuniti di Bergamo, Bergamo, Italy
  • Steering Committee member; Vice-Head, Nephrology and Dialysis Unit, CTO Hospital, Turin, Italy
  • Steering Committee member; Vice-Head, Department of Anesthesiology and Intensive Care, Hospital Niguarda, Milan, Italy
  • Scientific Committee member; Director, Department of Nephrology, St. Bortolo Hospital, Vicenza, Italy
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/cc3718

    DOI

    http://dx.doi.org/10.1186/cc3718

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001644655

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16137353


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    24 schema:description IntroductionCurrent practices for renal replacement therapy in intensive care units (ICUs) remain poorly defined. The DOse REsponse Multicentre International collaborative initiative (DO-RE-MI) will address the issue of how the different modes of renal replacement therapy are currently chosen and performed. Here, we describe the study protocol, which was approved by the Scientific and Steering Committees.MethodsDO-RE-MI is an observational, multicentre study conducted in ICUs. The primary end-point will be the delivered dose of dialysis, which will be compared with ICU mortality, 28-day mortality, hospital mortality, ICU length of stay and number of days of mechanical ventilation. The secondary end-point will be the haemodynamic response to renal replacement therapy, expressed as percentage reduction in noradrenaline (norepinephrine) requirement. Based on the the sample analysis calculation, at least 162 patients must be recruited. Anonymized patient data will be entered online in electronic case report forms and uploaded to an internet website. Each participating centre will have 2 months to become acquainted with the electronic case report forms. After this period official recruitment will begin. Patient data belong to the respective centre, which may use the database for its own needs. However, all centres have agreed to participate in a joint effort to achieve the sample size needed for statistical analysis.ConclusionThe study will hopefully help to collect useful information on the current practice of renal replacement therapy in ICUs. It will also provide a centre-based collection of data that will be useful for monitoring all aspects of extracorporeal support, such as incidence, frequency, and duration.
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