Higher platelet cytochrome oxidase specific activity in surviving than in non-surviving septic patients View Full Text


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Article Info

DATE

2014-06-30

AUTHORS

Leonardo Lorente, María M Martín, Esther López-Gallardo, Ruth Iceta, José Blanquer, Jordi Solé-Violán, Lorenzo Labarta, César Díaz, Alejandro Jiménez, Julio Montoya, Eduardo Ruiz-Pesini

ABSTRACT

IntroductionIn a previous study with 96 septic patients, we found that circulating platelets in 6-months surviving septic patients showed higher activity and quantity of cytochrome c oxidase (COX) normalized by citrate synthase (CS) activity at moment of severe sepsis diagnosis than non-surviving septic patients. The objective of this study was to estimate whether COX specific activity during the first week predicts 1-month sepsis survival in a larger cohort of patients.MethodsUsing a prospective, multicenter, observational study carried out in six Spanish intensive care units with 198 severe septic patients, we determined COX activity per proteins (COXact/Prot) in circulating platelets at day 1, 4 and 8 of the severe sepsis diagnosis. Endpoints were 1-month and 6-months mortality.ResultsSurvivor patients (n = 130) showed higher COXact/Prot (P < 0.001) than non-survivors (n = 68) at day 1, 4 and 8 of severe sepsis diagnosis. More than a half of the 6-months survivor patients showed an increase in their COXact/Prot from day 1 to 8. However, most of the 1-month non-survivors exhibited a decrease in their COXact/Prot from day 1 to 8. Multiple logistic regression analyses showed that of platelet COXact/Prot > 0.30 mOD/min/mg at day 1 (P = 0.002), 4 (P = 0.006) and 8 (P = 0.02) was associated independently with 1-month mortality. Area under the curve of COXact/Prot at day 1, 4 and 8 to predict 30-day survival were 0.70 (95% CI = 0.63-0.76; P < 0.001), 0.71 (95% CI = 0.64-0.77; P < 0.001) and 0.71 (95% CI = 0.64-0.78; P < 0.001), respectively.ConclusionsThe new findings of our study, to our knowledge the largest series reporting data about mitochondrial function during follow-up in septic patients, were that septic patients that survive 1-month have a higher platelet cytochrome oxidase activity at moment of sepsis diagnosis and during the first week than non-survivors, and that platelet cytochrome oxidase activity at moment of sepsis diagnosis and during the first week could be used as biomarker to predict the clinical outcome in septic patients. More... »

PAGES

r136

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http://scigraph.springernature.com/pub.10.1186/cc13956

DOI

http://dx.doi.org/10.1186/cc13956

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https://app.dimensions.ai/details/publication/pub.1033055898

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24981786


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20 schema:description IntroductionIn a previous study with 96 septic patients, we found that circulating platelets in 6-months surviving septic patients showed higher activity and quantity of cytochrome c oxidase (COX) normalized by citrate synthase (CS) activity at moment of severe sepsis diagnosis than non-surviving septic patients. The objective of this study was to estimate whether COX specific activity during the first week predicts 1-month sepsis survival in a larger cohort of patients.MethodsUsing a prospective, multicenter, observational study carried out in six Spanish intensive care units with 198 severe septic patients, we determined COX activity per proteins (COXact/Prot) in circulating platelets at day 1, 4 and 8 of the severe sepsis diagnosis. Endpoints were 1-month and 6-months mortality.ResultsSurvivor patients (n = 130) showed higher COXact/Prot (P < 0.001) than non-survivors (n = 68) at day 1, 4 and 8 of severe sepsis diagnosis. More than a half of the 6-months survivor patients showed an increase in their COXact/Prot from day 1 to 8. However, most of the 1-month non-survivors exhibited a decrease in their COXact/Prot from day 1 to 8. Multiple logistic regression analyses showed that of platelet COXact/Prot > 0.30 mOD/min/mg at day 1 (P = 0.002), 4 (P = 0.006) and 8 (P = 0.02) was associated independently with 1-month mortality. Area under the curve of COXact/Prot at day 1, 4 and 8 to predict 30-day survival were 0.70 (95% CI = 0.63-0.76; P < 0.001), 0.71 (95% CI = 0.64-0.77; P < 0.001) and 0.71 (95% CI = 0.64-0.78; P < 0.001), respectively.ConclusionsThe new findings of our study, to our knowledge the largest series reporting data about mitochondrial function during follow-up in septic patients, were that septic patients that survive 1-month have a higher platelet cytochrome oxidase activity at moment of sepsis diagnosis and during the first week than non-survivors, and that platelet cytochrome oxidase activity at moment of sepsis diagnosis and during the first week could be used as biomarker to predict the clinical outcome in septic patients.
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27 Spanish intensive care units
28 activity
29 analysis
30 area
31 biomarkers
32 c oxidase
33 care unit
34 citrate synthase activity
35 clinical outcomes
36 cohort
37 curves
38 cytochrome c oxidase
39 cytochrome oxidase activity
40 cytochrome oxidase specific activity
41 data
42 day 1
43 decrease
44 diagnosis
45 endpoint
46 findings
47 first week
48 function
49 half
50 high activity
51 increase
52 intensive care unit
53 knowledge
54 large cohort
55 large series
56 logistic regression analysis
57 mOD/min/
58 min/
59 mitochondrial function
60 moment
61 mortality
62 multicenter
63 multiple logistic regression analysis
64 new findings
65 non-surviving septic patients
66 objective
67 observational study
68 outcomes
69 oxidase
70 oxidase activity
71 patients
72 platelets
73 previous studies
74 prot
75 protein
76 quantity
77 regression analysis
78 sepsis diagnosis
79 sepsis survival
80 septic patients
81 series
82 severe sepsis diagnosis
83 severe septic patients
84 specific activity
85 study
86 survival
87 synthase activity
88 units
89 weeks
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