Ontology type: schema:ScholarlyArticle Open Access: True
2014-06
AUTHORSSebastian Hafner, Peter Radermacher, Manfred Frick, Paul Dietl, Enrico Calzia
ABSTRACTIt is well established that prolonged, controlled mechanical ventilation is associated with contractile dysfunction of the diaphragm due to impaired function of the mitochondrial respiratory chain as a result of aggravated oxidative and nitrosative stress. Sepsis and circulatory failure induce a similar response pattern. Callahan and Supinski now show that streptozotocin-induced insulin-dependent diabetes causes a comparable response pattern, both with respect to function and physiology - that is, reduced fiber force and, consequently, muscle contractility - but also as far as the underlying mechanisms are concerned. In other words, the authors elegantly demonstrate that the consequences of a chronic metabolic disease and that of acute critical illness may lead to the same phenotype response. It remains to be elucidated whether the underlying co-morbidity (for example, diabetes) adds to or even synergistically enhances the effect of an acute stress situation (for example, sepsis, mechanical ventilation). In addition, extending their previous work during shock states, the authors also show that administration of a preparation of the enzymatic anti-oxidant superoxide dismutase can reverse the deleterious effects of diabetes. These data are discussed in the context of the fundamental role of hyperglycemia in relation to metabolism-dependent formation of reactive oxygen species. More... »
PAGES149
http://scigraph.springernature.com/pub.10.1186/cc13913
DOIhttp://dx.doi.org/10.1186/cc13913
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1049221072
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25171553
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical Physiology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diaphragm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hyperglycemia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Muscle Weakness",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oxidative Stress",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University Hospital Ulm",
"id": "https://www.grid.ac/institutes/grid.410712.1",
"name": [
"Sektion An\u00e4sthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4tsklinikum, 89081, Ulm, Germany"
],
"type": "Organization"
},
"familyName": "Hafner",
"givenName": "Sebastian",
"id": "sg:person.0623201452.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623201452.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Ulm",
"id": "https://www.grid.ac/institutes/grid.410712.1",
"name": [
"Sektion An\u00e4sthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4tsklinikum, 89081, Ulm, Germany"
],
"type": "Organization"
},
"familyName": "Radermacher",
"givenName": "Peter",
"id": "sg:person.01206024201.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206024201.88"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Institut f\u00fcr Allgemeine Physiologie, 89081, Ulm, Germany"
],
"type": "Organization"
},
"familyName": "Frick",
"givenName": "Manfred",
"id": "sg:person.01165325037.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165325037.83"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Institut f\u00fcr Allgemeine Physiologie, 89081, Ulm, Germany"
],
"type": "Organization"
},
"familyName": "Dietl",
"givenName": "Paul",
"id": "sg:person.01330726706.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330726706.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Ulm",
"id": "https://www.grid.ac/institutes/grid.410712.1",
"name": [
"Sektion An\u00e4sthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4tsklinikum, 89081, Ulm, Germany"
],
"type": "Organization"
},
"familyName": "Calzia",
"givenName": "Enrico",
"id": "sg:person.01254137401.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254137401.32"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1164/ajrccm.153.6.8665049",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006078454"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3181/00379727-209-43885c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008412447"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3181/00379727-209-43885c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008412447"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/cc13855",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009302818",
"https://doi.org/10.1186/cc13855"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jss.2010.11.893",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009660864"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0b013e31823c8cc9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015376846"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0b013e31823c8cc9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015376846"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0b013e31819cec17",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015944315"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0b013e31819cec17",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015944315"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1164/rccm.201206-0982oc",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017442653"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/2197-425x-2-19",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018421019",
"https://doi.org/10.1186/2197-425x-2-19"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/aln.0000000000000125",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021304637"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/aln.0000000000000125",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021304637"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0891-5849(00)00454-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023303746"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/cc13051",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025617967",
"https://doi.org/10.1186/cc13051"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00134-002-1629-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026167063",
"https://doi.org/10.1007/s00134-002-1629-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/cc3992",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030430192",
"https://doi.org/10.1186/cc3992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1164/ajrccm.165.2.2108041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031362153"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/cc10023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037336704",
"https://doi.org/10.1186/cc10023"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2010/931903",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044272570"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0b013e318206cca9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044715806"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0b013e318206cca9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044715806"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/shk.0b013e31816a6e0f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046139335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/shk.0b013e31816a6e0f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046139335"
],
"type": "CreativeWork"
}
],
"datePublished": "2014-06",
"datePublishedReg": "2014-06-01",
"description": "It is well established that prolonged, controlled mechanical ventilation is associated with contractile dysfunction of the diaphragm due to impaired function of the mitochondrial respiratory chain as a result of aggravated oxidative and nitrosative stress. Sepsis and circulatory failure induce a similar response pattern. Callahan and Supinski now show that streptozotocin-induced insulin-dependent diabetes causes a comparable response pattern, both with respect to function and physiology - that is, reduced fiber force and, consequently, muscle contractility - but also as far as the underlying mechanisms are concerned. In other words, the authors elegantly demonstrate that the consequences of a chronic metabolic disease and that of acute critical illness may lead to the same phenotype response. It remains to be elucidated whether the underlying co-morbidity (for example, diabetes) adds to or even synergistically enhances the effect of an acute stress situation (for example, sepsis, mechanical ventilation). In addition, extending their previous work during shock states, the authors also show that administration of a preparation of the enzymatic anti-oxidant superoxide dismutase can reverse the deleterious effects of diabetes. These data are discussed in the context of the fundamental role of hyperglycemia in relation to metabolism-dependent formation of reactive oxygen species. ",
"genre": "research_article",
"id": "sg:pub.10.1186/cc13913",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1117766",
"issn": [
"1364-8535",
"1466-609X"
],
"name": "Critical Care",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "18"
}
],
"name": "Hyperglycemia, oxidative stress, and the diaphragm: a link between chronic co-morbidity and acute stress?",
"pagination": "149",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"ea7a91e18ec8617b5e5f42e1fa5ec54ba2073e8f791aac8bb136da547a8bf1ab"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25171553"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9801902"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/cc13913"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1049221072"
]
}
],
"sameAs": [
"https://doi.org/10.1186/cc13913",
"https://app.dimensions.ai/details/publication/pub.1049221072"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:02",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000537.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2Fcc13913"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/cc13913'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/cc13913'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/cc13913'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/cc13913'
This table displays all metadata directly associated to this object as RDF triples.
185 TRIPLES
21 PREDICATES
53 URIs
27 LITERALS
15 BLANK NODES