The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04

AUTHORS

Jean-Pierre Quenot, Christine Binquet, Fady Kara, Olivier Martinet, Frederique Ganster, Jean-Christophe Navellou, Vincent Castelain, Damien Barraud, Joel Cousson, Guillaume Louis, Pierre Perez, Khaldoun Kuteifan, Alain Noirot, Julio Badie, Chaouki Mezher, Henry Lessire, Arnaud Pavon

ABSTRACT

INTRODUCTION: To provide up-to-date information on the prognostic factors associated with 28-day mortality in a cohort of septic shock patients in intensive care units (ICUs). METHODS: Prospective, multicenter, observational cohort study in ICUs from 14 French general (non-academic) and university teaching hospitals. All consecutive patients with septic shock admitted between November 2009 and March 2011 were eligible for inclusion. We prospectively recorded data regarding patient characteristics, infection, severity of illness, life support therapy, and discharge. RESULTS: Among 10,941 patients admitted to participating ICUs between October 2009 and September 2011, 1,495 (13.7%) patients presented inclusion criteria for septic shock and were included. Invasive mechanical ventilation was needed in 83.9% (n=1248), inotropes in 27.7% (n=412), continuous renal replacement therapy in 32.5% (n=484), and hemodialysis in 19.6% (n=291). Mortality at 28 days was 42% (n=625). Variables associated with time to mortality, right-censored at day 28: age (for each additional 10 years) (hazard ratio (HR)=1.29; 95% confidence interval (CI): 1.20-1.38), immunosuppression (HR=1.63; 95%CI: 1.37-1.96), Knaus class C/D score versus class A/B score (HR=1.36; 95%CI:1.14-1.62) and Sepsis-related Organ Failure Assessment (SOFA) score (HR=1.24 for each additional point; 95%CI: 1.21-1.27). Patients with septic shock and renal/urinary tract infection had a significantly longer time to mortality (HR=0.56; 95%CI: 0.42-0.75). CONCLUSION: Our observational data of consecutive patients from real-life practice confirm that septic shock is common and carries high mortality in general ICU populations. Our results are in contrast with the clinical trial setting, and could be useful for healthcare planning and clinical study design. More... »

PAGES

r65

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/cc12598

DOI

http://dx.doi.org/10.1186/cc12598

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012134941

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23561510


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410 https://www.grid.ac/institutes/grid.418044.d schema:alternateName Centre hospitalier de Rouffach
411 schema:name Presented in part the at the 31st International Symposium on Intensive Care and Emergency Medicine, Service de réanimation polyvalente, Centre Hospitalier, 39 Avenue de la Liberté, 68000, Colmar, France
412 Service de réanimation médicale, Centre Hospitalier, 2A Rue Jura, 68100, Mulhouse, France
413 rdf:type schema:Organization
414 https://www.grid.ac/institutes/grid.429536.f schema:alternateName Centre d'investigation clinique
415 schema:name Centre d'investigation clinique (INSERM CIE 1), 7 Boulevard Jeanne d'Arc, 21079, Dijon, France
416 Service de réanimation médicale, Centre Hospitalier Universitaire Dijon, 14 rue Paul Gaffarel, 21970, France
417 rdf:type schema:Organization
 




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